dipyridamole has been researched along with A-V Dissociation in 32 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe two cases of severe bradyarrhythmias (one complete AV dissociation; one sinus bradycardia) observed after the intravenous injection of dipyridamole." | 7.70 | [Severe bradyarrhythmia during myocardial perfusion scintigraphy with injection of dipyridamole (Persantine)]. ( Bielen, M; Karsera, D; Kulbertus, H; Mélon, P, 1999) |
| "A close or even causal relation between myocardial adenosine and bradyarrhythmias during acute myocardial hypoxia was testified in guinea pig, rabbit and dog mainly by using specific competitive antagonist and synchronous quantitative analysis of 3 variables: intensity of myocardial hypoxia, degree of endogenous adenosine increment and severity of bradyarrhythmias." | 7.68 | Adenosine's role in the genesis of bradyarrhythmias induced by acute myocardial hypoxia. ( Meng, FY; Sun, JW; Xu, J; Yuan, F, 1992) |
| " The ventilation was not affected by metoprolol, atropine, naloxone or cromolyn sodium but was attenuated by hyperventilation." | 5.06 | Adenosine receptor mediated stimulation of ventilation in man. ( Beermann, B; Brandt, R; Jonzon, B; Sylvén, C, 1989) |
| "We describe two cases of severe bradyarrhythmias (one complete AV dissociation; one sinus bradycardia) observed after the intravenous injection of dipyridamole." | 3.70 | [Severe bradyarrhythmia during myocardial perfusion scintigraphy with injection of dipyridamole (Persantine)]. ( Bielen, M; Karsera, D; Kulbertus, H; Mélon, P, 1999) |
| "A close or even causal relation between myocardial adenosine and bradyarrhythmias during acute myocardial hypoxia was testified in guinea pig, rabbit and dog mainly by using specific competitive antagonist and synchronous quantitative analysis of 3 variables: intensity of myocardial hypoxia, degree of endogenous adenosine increment and severity of bradyarrhythmias." | 3.68 | Adenosine's role in the genesis of bradyarrhythmias induced by acute myocardial hypoxia. ( Meng, FY; Sun, JW; Xu, J; Yuan, F, 1992) |
| " Information on safety and adverse events during and immediately after adenosine infusion was maintained in the Adenoscan Multicenter Trial Registry." | 2.67 | Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry. ( Cerqueira, MD; Heo, J; Iskandrian, AS; Schwaiger, M; Verani, MS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (53.13) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tse, HF | 1 |
| Yu, C | 1 |
| Wong, KK | 1 |
| Tsang, V | 1 |
| Leung, YL | 1 |
| Ho, WY | 1 |
| Lau, CP | 1 |
| GONZALEZ MENENDEZ, E | 1 |
| DEMIROGLU, C | 1 |
| BERKARDA, B | 1 |
| OZTUERK, M | 1 |
| GARAN, R | 1 |
| CHROBOK, H | 1 |
| Erdogan, O | 1 |
| Altun, A | 1 |
| Durmus-Altun, G | 1 |
| Ozbay, G | 1 |
| Kishimoto, C | 1 |
| Yoshida, Y | 1 |
| Zen, E | 1 |
| Nakamura, R | 1 |
| Ito, K | 1 |
| Stafford, A | 2 |
| Belardinelli, L | 6 |
| Shryock, J | 1 |
| West, GA | 1 |
| Clemo, HF | 1 |
| DiMarco, JP | 2 |
| Berne, RM | 2 |
| Chilian, WM | 1 |
| Marcus, ML | 1 |
| Mattos, EC | 1 |
| Taccola, A | 1 |
| Cipolli, PL | 1 |
| Bossi, MC | 1 |
| Shammas, RL | 1 |
| DeAntonio, HJ | 1 |
| Movahed, A | 1 |
| Pézard, P | 1 |
| Hélias, J | 1 |
| Victor, J | 1 |
| Dupuis, JM | 1 |
| Lejeune, JJ | 1 |
| Geslin, P | 1 |
| Jallet, P | 1 |
| Tadei, A | 1 |
| Cerqueira, MD | 1 |
| Verani, MS | 1 |
| Schwaiger, M | 1 |
| Heo, J | 1 |
| Iskandrian, AS | 1 |
| Miller, DD | 1 |
| Labovitz, AJ | 1 |
| Toft, J | 1 |
| Mortensen, J | 1 |
| Hesse, B | 1 |
| Preumont, N | 1 |
| Velez Roa, S | 1 |
| Berkenboom, G | 1 |
| Goldman, S | 1 |
| Lenaers, A | 1 |
| Bielen, M | 1 |
| Karsera, D | 1 |
| Mélon, P | 1 |
| Kulbertus, H | 1 |
| Chapelon-Abric, C | 1 |
| Alakhras, M | 1 |
| Baldari, D | 1 |
| El-Sherif, N | 1 |
| Turitto, G | 1 |
| Liusov, VA | 1 |
| Savchuk, VI | 1 |
| Belousov, IuB | 1 |
| Pozin, VM | 1 |
| Abdullaev, AA | 1 |
| Sun, JW | 1 |
| Yuan, F | 1 |
| Xu, J | 1 |
| Meng, FY | 1 |
| Roelke, M | 1 |
| Yurchak, PM | 1 |
| Froldi, G | 1 |
| Jonzon, B | 1 |
| Sylvén, C | 1 |
| Beermann, B | 1 |
| Brandt, R | 1 |
| Bubiński, R | 1 |
| Lerman, BB | 1 |
| Wesley, RC | 2 |
| Haines, DE | 1 |
| Jenkins, JR | 1 |
| Boykin, MT | 1 |
| Fukuda, T | 1 |
| Kawakami, Y | 1 |
| Furuno, K | 1 |
| Araki, Y | 1 |
| Nott, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Right Ventricular Septal Pacing to Minimized Right Ventricular Septal Stimulation in Patients With Sick Sinus Syndrome[NCT01477138] | 126 participants (Anticipated) | Observational | 2011-07-31 | Recruiting | |||
| A Phase 2, Open-Label, Randomized Multicenter Study for the Development of One-Day Rest/Stress Cardiac Positron Emission Tomography (PET) Perfusion Imaging Protocols of BMS747158[NCT00849108] | Phase 2 | 176 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Early Cardiac Magnetic Resonance Imaging in Suspected Non-ST-Elevation Myocardial Infarction: An Observational Two-Center Study[NCT04140019] | 87 participants (Anticipated) | Observational | 2018-10-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The stress flurpiridaz dose for subsequent same-day rest-stress efficacy studies was determined as a multiple of the rest dose by computer modeling. Images derived only from rest flurpiridaz administration were blended using image analysis with images derived only from administration of flurpiridaz following exercise or adenosine stress. The blending fraction that resulted in negligible change in reader interpretation of defect severity was determined for each subject. The minimum value that met this criterion for all subjects was used to calculate the ratio of the stress dose to the rest dose as a function of the delay between administration of the two doses for both adenosine stress and exercise stress separately. No statistical analysis was performed. (NCT00849108)
Timeframe: Dosing visit
| Intervention | Fraction of rest added to stress image (Number) |
|---|---|
| Cohort 1 Dose Ranging and Dose Interval | 0.228 |
The rest flurpiridaz dose to be used for subsequent efficacy studies was determined by a modeling method that simulated a range of injected doses using a single fixed injected dose at rest in each subject and a range of acquisition durations. From this, a dose acquisition time product (DATP was determined for each subject that specified the minimal dose for a given acquisition duration that yielded an image in that subject that was negligibly affected by photon counting statistics. Descriptive statistics were used to identify an appropriate rest dose for the population. No other statistical tests were performed (NCT00849108)
Timeframe: Dosing visit
| Intervention | MBq X Minutes (Mean) |
|---|---|
| Cohort 1: Dose Acquistion Time Product | 100 |
Diagnostic efficacy of one-day rest/stress BMS747158 PET MPI is measured by sensitivity as compared to single photon emission computed tomography (SPECT)MPI in the detection of coronary artery disease (CAD)using angiography or three-month cardiac events as the truth standard. (NCT00849108)
Timeframe: Dosing visit
| Intervention | Proportion of True Positive Cases (Number) | |
|---|---|---|
| PET MPI | SPECT MPI | |
| Cohort 2 Efficacy/Safety | 0.769 | 0.596 |
Diagnostic efficacy of one-day rest/stress BMS747158 PET MPI is measured by specificity as compared to single photon emission computed tomography (SPECT)MPI in the detection of coronary artery disease (CAD)using angiography or three-month cardiac events as the truth standard. (NCT00849108)
Timeframe: Dosing Visit
| Intervention | Proportion of True Negative Cases (Number) | |
|---|---|---|
| PET MPI | SPECT MPI | |
| Cohort 2: Efficacy/Safety | 0.877 | 0.836 |
1 review available for dipyridamole and A-V Dissociation
| Article | Year |
|---|---|
[Cardiac sarcoidosis].
Topics: Anti-Inflammatory Agents; Biopsy; Cardiomyopathies; Cardiomyopathy, Restrictive; Cardiovascular Agen | 2001 |
4 trials available for dipyridamole and A-V Dissociation
| Article | Year |
|---|---|
Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation.
Topics: Aged; Aged, 80 and over; Cardiac Pacing, Artificial; Coronary Circulation; Dipyridamole; Electrocard | 2002 |
Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry.
Topics: Adenosine; Aged; Coronary Disease; Dipyridamole; Female; Heart; Heart Block; Humans; Infusions, Intr | 1994 |
Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry.
Topics: Adenosine; Aged; Coronary Disease; Dipyridamole; Female; Heart; Heart Block; Humans; Infusions, Intr | 1994 |
Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry.
Topics: Adenosine; Aged; Coronary Disease; Dipyridamole; Female; Heart; Heart Block; Humans; Infusions, Intr | 1994 |
Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry.
Topics: Adenosine; Aged; Coronary Disease; Dipyridamole; Female; Heart; Heart Block; Humans; Infusions, Intr | 1994 |
Dipyridamole and adenosine vasodilator stress for myocardial imaging: vive la différence!
Topics: Adenosine; Coronary Disease; Dipyridamole; Heart; Heart Block; Humans; Radionuclide Imaging; Registr | 1994 |
Adenosine receptor mediated stimulation of ventilation in man.
Topics: Adenosine; Adult; Afferent Pathways; Atropine; Chemoreceptor Cells; Cromolyn Sodium; Dipyridamole; F | 1989 |
27 other studies available for dipyridamole and A-V Dissociation
| Article | Year |
|---|---|
[Incomplete AV block. Further aspects of its therapy].
Topics: Adrenal Cortex Hormones; Atrioventricular Block; Cardiovascular Diseases; Dipyridamole; Heart Block; | 1963 |
[ON AN INTERESTING ACTION OF PERSANTIN ON HEART CONDUCTION DISORDERS].
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dipyridamole; Electrocard | 1964 |
[3 CASES OF TRANSIENT BUNDLE BRANCH BLOCK].
Topics: Bundle-Branch Block; Cardiac Conduction System Disease; Dipyridamole; Drug Therapy; Heart Block; Hum | 1965 |
Inferolateral myocardial perfusion defect caused by right ventricular outflow tract pacing.
Topics: Bradycardia; Coronary Angiography; Diagnosis, Differential; Dipyridamole; Electrodes, Implanted; Flu | 2004 |
[Dipyridamole-induced regular R-R intervals in a case of old myocardial infarction with atrial fibrillation-flutter].
Topics: Atrial Fibrillation; Atrial Flutter; Dipyridamole; Electrocardiography; Heart; Heart Block; Humans; | 2006 |
Potentiation of adenosine by dipyridamole.
Topics: Animals; Dipyridamole; Drug Synergism; Electrocardiography; Electroencephalography; Female; Guinea P | 1967 |
Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminop | 1984 |
Phasic coronary blood flow velocity in intramural and epicardial coronary arteries.
Topics: Animals; Arterial Occlusive Diseases; Blood Flow Velocity; Cardiac Pacing, Artificial; Coronary Circ | 1982 |
Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium.
Topics: Adenosine; Aminophylline; Animals; Coronary Disease; Dipyridamole; Dogs; Electrocardiography; Female | 1981 |
[Platelet hyperaggregation premonitory of myocardial infarct? A clinical case report].
Topics: Anticoagulants; Aspirin; Dipyridamole; Heart Block; Humans; Male; Middle Aged; Myocardial Infarction | 1981 |
High-grade atrioventricular block during dipyridamole stress testing.
Topics: Aged; Aminophylline; Coronary Disease; Dipyridamole; Electrocardiography; Heart Block; Humans; Male | 1994 |
[Thallium 201 myocardial scintigraphy and left branch block. Comparative value of exercise test and dipyridamole test].
Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Dipyridamole; Exercise Test; False Positive Reacti | 1993 |
Risk of atrioventricular block during adenosine pharmacologic stress testing in heart transplant recipients.
Topics: Adenosine; Adolescent; Adult; Cardiovascular Agents; Dipyridamole; Dose-Response Relationship, Drug; | 1998 |
Transient second-degree heart block during dipyridamole myocardial perfusion imaging.
Topics: Aged; Dipyridamole; Female; Heart Block; Humans; Infusions, Intravenous; Male; Middle Aged; Tomograp | 1998 |
[Severe bradyarrhythmia during myocardial perfusion scintigraphy with injection of dipyridamole (Persantine)].
Topics: Aged; Arrhythmia, Sinus; Bradycardia; Dipyridamole; Electrocardiography; Female; Heart; Heart Block; | 1999 |
Location and clinical implications of high-degree atrioventricular block during dipyridamole infusion: a case report.
Topics: Aged; Dipyridamole; Electrocardiography; Female; Heart Block; Humans; Hypertension; Osteoarthritis; | 2002 |
[Role of changes in rheological properties of blood in the pathogenesis of disorders of cardiac rhythm and conductivity].
Topics: Animals; Blood Viscosity; Dipyridamole; Drug Antagonism; Erythrocyte Aggregation; Erythrocytes, Abno | 1979 |
Adenosine's role in the genesis of bradyarrhythmias induced by acute myocardial hypoxia.
Topics: Adenosine; Aminophylline; Animals; Bradycardia; Dipyridamole; Dogs; Electrocardiography; Guinea Pigs | 1992 |
Adenosine and supraventricular tachycardia.
Topics: Adenosine; Aged; Dipyridamole; Drug Interactions; Heart Block; Humans; Tachycardia, Supraventricular | 1992 |
Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Atrioventricular Node; Bundle of His; D | 1990 |
[Effect of dipyridamole on the functional state of the atrioventricular node].
Topics: Action Potentials; Adult; Atrioventricular Node; Dipyridamole; Female; Heart Block; Heart Conduction | 1989 |
Antiadrenergic effects of adenosine on His-Purkinje automaticity. Evidence for accentuated antagonism.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Aminophylline; Animals; Atropine; Bundle of His; Dipyrida | 1988 |
Atrioventricular nodal accommodation in isolated guinea pig hearts: physiological significance and role of adenosine.
Topics: Acetylcholine; Adenosine; Animals; Atrioventricular Node; Atropine; Dipyridamole; Guinea Pigs; Heart | 1988 |
Role of adenosine as mediator of bradyarrhythmias during hypoxia in isolated guinea pig hearts.
Topics: Adenosine; Aminophylline; Animals; Atrioventricular Node; Dipyridamole; Female; Guinea Pigs; Heart B | 1986 |
Determination of the onset of beta-methyl-digoxin action by potentiation of the adenosine response in guinea pigs.
Topics: Adenosine; Animals; Digoxin; Dipyridamole; Drug Synergism; Guinea Pigs; Heart; Heart Block; Intestin | 1985 |
The possible role of adenosine in the coronary dilator action of some pyrimidopyrimidines and pteridines.
Topics: Animals; Cats; Coronary Vessels; Dipyridamole; Drug Synergism; Guinea Pigs; Heart Atria; Heart Block | 1970 |
Potentiation of adenosine and the adenine nucleotides by dipyridamole.
Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Azaguanin | 1966 |