dipsacoside-b has been researched along with Neointima* in 1 studies
1 other study(ies) available for dipsacoside-b and Neointima
| Article | Year |
|---|---|
Dipsacoside B Inhibits the Migration and Proliferation of VSMCs and Blunts Neointimal Formation by Upregulating PTEN Expression.
To investigate the effect and potential molecular mechanisms of Dipsacoside B (DB), an herb monomer extracted from. As compared to vehicle control balloon-injury group, DB treatment significantly inhibited the neointimal formation together up-regulated the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN). Cell proliferations (MTT and Edu incorporation) assays and wound migration measurement further revealed that treatment with DB significantly blunted Ang-II-induced proliferation and migration potential of VSMCs. Western blot analysis exhibited that DB upregulated the expression of PTEN. DB treatment suppresses the proliferation and migration of VSMCs and reduces neointimal formation by the mechanisms involving regulating the phenotype switch of VSMCs via upregulating PTEN expression. Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; PTEN Phosphohydrolase; Rats | 2022 |