diprenorphine and Lymphoma

diprenorphine has been researched along with Lymphoma* in 1 studies

Other Studies

1 other study(ies) available for diprenorphine and Lymphoma

ArticleYear
Long-term regulation of opioid receptors in neuroblastoma and lymphoma cell lines.
    Journal of neuroimmunology, 1997, Volume: 76, Issue:1-2

    Long-term regulation of opioid binding was studied in the human neuroblastoma NMB and in the murine lymphoma R1.1 and R1.EGO cell lines. Binding was down-regulated following prolonged exposure to opioid agonists and up-regulated following exposure to antagonist. Down-regulation was inhibited by the metabolic blocker sodium-azide and by the protein kinase H-7. Up-regulation was blocked by the protein and mRNA synthesis blockers cycloheximide, alpha-amanitin and actinomycin D. A significant difference was found between the response of neuronal and immune cells to ethanol exposure: while opioid binding in neuroblastoma culture underwent a pronounced (75%) up-regulation, no effect of ethanol on opioid receptors in lymphoma cultures was detected. The described cell lines present an excellent experimental model to study long-term regulation of opioid receptors in the nervous and immune systems and to elucidate the biological effects of chronic use of opiates and alcohol.

    Topics: Diprenorphine; Down-Regulation; Ethanol; Humans; Lymphoma; Neuroblastoma; Receptors, Opioid; Tumor Cells, Cultured

1997