diprenorphine has been researched along with Cerebrovascular-Disorders* in 2 studies
2 other study(ies) available for diprenorphine and Cerebrovascular-Disorders
| Article | Year |
|---|---|
Central pain after pontine infarction is associated with changes in opioid receptor binding: a PET study with 11C-diprenorphine.
Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C-diprenorphine PET provides unique information for the understanding of central poststroke pain. Topics: Adult; Aged; Carbon Radioisotopes; Cerebral Hemorrhage; Cerebral Infarction; Cerebrovascular Disorders; Diprenorphine; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Narcotic Antagonists; Pain; Pons; Radiopharmaceuticals; Receptors, Opioid; Sensation Disorders; Tomography, Emission-Computed | 1999 |
Treatment of experimental stroke with opiate antagonists. Effects on neurological function, infarct size, and survival.
The effects are reported of acute and long-term continuous administration of three opiate antagonists--naloxone, naltrexone, and diprenorphine--on neurological function, survival, and infarct size in a feline model of acute focal cerebral ischemia. All three drugs produced statistically significant improvement in motor function following acute administration without concomitant changes in level of consciousness; saline had no effect. Naloxone and naltrexone significantly prolonged survival (p less than 0.01); diprenorphine did not. Infarct size was not altered by any treatment administered. These findings confirm previous work suggesting that, with the appropriate methodology, treatment with opiate antagonists partially reverses neurological deficits. They also show that opiate antagonists prolong survival in certain conditions of acute and subacute focal cerebral ischemia without altering the area of infarcted tissue. Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Disorders; Consciousness; Diprenorphine; Disease Models, Animal; Male; Morphinans; Movement; Naloxone; Naltrexone; Pupil; Sensation | 1986 |