diphosphoric acid has been researched along with Hypophosphatasia in 5 studies
diphosphoric acid : An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid.
Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mutations in the liver/bone/kidney alkaline phosphatase (ALPL) gene in hypophosphatasia (HPP) reduce the function of tissue non-specific alkaline phosphatase (ALP), resulting in increased pyrophosphate (PP(i)) and a severe deficiency in acellular cementum." | 7.78 | Correction of hypophosphatasia-associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells. ( Casati, MZ; Foster, BL; Martins, L; Nociti, FH; Rodrigues, TL; Sallum, EA; Silverio, KG; Somerman, MJ, 2012) |
| "Mutations in the liver/bone/kidney alkaline phosphatase (ALPL) gene in hypophosphatasia (HPP) reduce the function of tissue non-specific alkaline phosphatase (ALP), resulting in increased pyrophosphate (PP(i)) and a severe deficiency in acellular cementum." | 3.78 | Correction of hypophosphatasia-associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells. ( Casati, MZ; Foster, BL; Martins, L; Nociti, FH; Rodrigues, TL; Sallum, EA; Silverio, KG; Somerman, MJ, 2012) |
| "Mutations in the gene ALPL in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase, and the resulting increase in pyrophosphate (PP(i)) contributes to bone and tooth mineralization defects by inhibiting physiologic calcium-phosphate (P(i)) precipitation." | 3.78 | Hypophosphatasia-associated deficiencies in mineralization and gene expression in cultured dental pulp cells obtained from human teeth. ( Casati, MZ; Foster, BL; Martins, L; Nociti, FH; Rodrigues, TL; Sallum, EA; Silverio, KG; Somerman, MJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, M | 1 |
| Wu, M | 1 |
| Crane, JL | 1 |
| Liedtke, D | 1 |
| Hofmann, C | 1 |
| Jakob, F | 1 |
| Klopocki, E | 1 |
| Graser, S | 1 |
| Rodrigues, TL | 2 |
| Foster, BL | 2 |
| Silverio, KG | 2 |
| Martins, L | 2 |
| Casati, MZ | 2 |
| Sallum, EA | 2 |
| Somerman, MJ | 2 |
| Nociti, FH | 2 |
| RUSSELL, RG | 1 |
1 review available for diphosphoric acid and Hypophosphatasia
| Article | Year |
|---|---|
Tissue-Nonspecific Alkaline Phosphatase-A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease.
Topics: Alkaline Phosphatase; Animals; Anxiety; Bone and Bones; Calcification, Physiologic; Depression; Diph | 2020 |
4 other studies available for diphosphoric acid and Hypophosphatasia
| Article | Year |
|---|---|
Asfotase alfa improved skeletal mineralization and fracture healing in a child with MCAHS.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Diseases, Metabolic; Calcinosis; Calcium; Calcium, Dietar | 2023 |
Correction of hypophosphatasia-associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells.
Topics: Adolescent; Alkaline Phosphatase; Case-Control Studies; Dental Cementum; Dental Pulp; Diphosphates; | 2012 |
Hypophosphatasia-associated deficiencies in mineralization and gene expression in cultured dental pulp cells obtained from human teeth.
Topics: Adolescent; Alkaline Phosphatase; Amino Acid Substitution; Analysis of Variance; Calcium; Case-Contr | 2012 |
EXCRETION OF INORGANIC PYROPHOSPHATE IN HYPOPHOSPHATASIA.
Topics: Alkaline Phosphatase; Calcification, Physiologic; Calcinosis; Chromatography; Diphosphates; Fluids a | 1965 |