diphenyleneiodonium has been researched along with Inflammation in 27 studies
diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor
dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with ellagic acid, however, exerted significant cytoprotective effects in all events." | 5.36 | Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. ( Chou, MM; Hsu, SL; Hsu, WC; Lee, WJ; Ou, HC; Sheu, WH; Tsai, KL; Tseng, JJ, 2010) |
| "E-series resolvins are biosynthesized from eicosapentaenoic acid during the resolution phase of acute inflammation and enhance inflammation resolution." | 3.88 | Resolvin E1, but not resolvins E2 and E3, promotes fMLF-induced ROS generation in human neutrophils. ( Fukuda, H; Ikeda, H; Ishimura, K; Ono, Y; Sato, Y; Shuto, S; Tansho-Nagakawa, S; Ubagai, T; Unno, Y; Watanabe, M, 2018) |
| "We and others recently showed that soyasaponin Bb (SSBb ) inhibited lipopolysaccharide (LPS)-induced inflammation in macrophages." | 3.83 | Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species. ( Chen, F; Chen, J; Chu, X; Huang, J; Huang, S; Li, N; Sun, S; Zha, L; Zhang, Y, 2016) |
| " We aimed to determine if NADPH oxidase inhibitor diphenyleneiodonium sulfate (DPI) affects nuclear factor-kappaB (NF-kappaB) activation, liver tumor necrosis factor-alpha (TNF-alpha) mRNA expression, and early alcohol-induced liver injury in rats." | 3.71 | Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. ( Connor, HD; Dikalova, A; Kono, H; Mason, RP; Rusyn, I; Thurman, RG; Uesugi, T; Yamashina, S, 2001) |
| "Macrophage-mediated inflammation has been implicated in various kidney diseases." | 1.43 | Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. ( Aiba, A; Kurihara, H; Nagase, M; Sakai, T; Young, MJ, 2016) |
| "Chemical burns are a major cause of corneal injury." | 1.43 | Involvement of NADPH oxidases in alkali burn-induced corneal injury. ( Chen, YY; Gu, XJ; Han, XJ; Li, JM; Liu, QP; Liu, X; Xu, M; Yi, JL; Zhao, Y, 2016) |
| " Sevoflurane combined with ATP could increase the level of activated caspase-1, pyroptosis, and reactive oxygen species (ROS)." | 1.39 | Sevoflurane combined with ATP activates caspase-1 and triggers caspase-1-dependent pyroptosis in murine J774 macrophages. ( Chen, S; Fang, X; Jin, Y; Li, H; Wu, S; Xie, G, 2013) |
| "Pretreatment with ellagic acid, however, exerted significant cytoprotective effects in all events." | 1.36 | Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. ( Chou, MM; Hsu, SL; Hsu, WC; Lee, WJ; Ou, HC; Sheu, WH; Tsai, KL; Tseng, JJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 19 (70.37) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, WY | 1 |
| Liu, KH | 1 |
| Lin, S | 1 |
| Chen, TY | 1 |
| Tseng, CY | 1 |
| Chen, HY | 1 |
| Wu, HM | 1 |
| Hsu, KS | 1 |
| Sun, C | 2 |
| Wang, Z | 1 |
| Yue, L | 1 |
| Huang, Q | 1 |
| Lu, S | 1 |
| Wang, R | 1 |
| Sabbione, F | 1 |
| Keitelman, IA | 1 |
| Iula, L | 1 |
| Ferrero, M | 1 |
| Giordano, MN | 1 |
| Baldi, P | 1 |
| Rumbo, M | 1 |
| Jancic, C | 1 |
| Trevani, AS | 1 |
| Chen, CL | 1 |
| Cheng, MH | 1 |
| Kuo, CF | 1 |
| Cheng, YL | 1 |
| Li, MH | 1 |
| Chang, CP | 1 |
| Wu, JJ | 1 |
| Anderson, R | 1 |
| Wang, S | 1 |
| Tsai, PJ | 1 |
| Liu, CC | 1 |
| Lin, YS | 1 |
| Song, S | 1 |
| Jiang, L | 1 |
| Oyarzabal, EA | 1 |
| Wilson, B | 1 |
| Li, Z | 1 |
| Shih, YI | 1 |
| Wang, Q | 1 |
| Hong, JS | 1 |
| Unno, Y | 1 |
| Sato, Y | 1 |
| Fukuda, H | 1 |
| Ishimura, K | 1 |
| Ikeda, H | 1 |
| Watanabe, M | 1 |
| Tansho-Nagakawa, S | 1 |
| Ubagai, T | 1 |
| Shuto, S | 1 |
| Ono, Y | 1 |
| Issa, N | 1 |
| Lachance, G | 1 |
| Bellmann, K | 1 |
| Laplante, M | 1 |
| Stadler, K | 1 |
| Marette, A | 1 |
| Galbiati, V | 1 |
| Papale, A | 1 |
| Galli, CL | 1 |
| Marinovich, M | 1 |
| Corsini, E | 1 |
| Suzuki, H | 1 |
| Hatano, N | 1 |
| Muraki, Y | 1 |
| Itoh, Y | 1 |
| Kimura, S | 1 |
| Hayashi, H | 1 |
| Onozaki, K | 1 |
| Ohi, Y | 1 |
| Haji, A | 1 |
| Muraki, K | 1 |
| Behnen, M | 1 |
| Leschczyk, C | 1 |
| Möller, S | 1 |
| Batel, T | 1 |
| Klinger, M | 1 |
| Solbach, W | 1 |
| Laskay, T | 1 |
| Ding, Z | 1 |
| Liu, S | 1 |
| Wang, X | 1 |
| Deng, X | 1 |
| Fan, Y | 1 |
| Wang, Y | 1 |
| Mehta, JL | 1 |
| Nagase, M | 1 |
| Kurihara, H | 1 |
| Aiba, A | 1 |
| Young, MJ | 1 |
| Sakai, T | 1 |
| Zhang, Y | 1 |
| Chen, F | 1 |
| Chen, J | 2 |
| Huang, S | 1 |
| Huang, J | 1 |
| Li, N | 1 |
| Sun, S | 1 |
| Chu, X | 1 |
| Zha, L | 1 |
| Gu, XJ | 1 |
| Liu, X | 1 |
| Chen, YY | 1 |
| Zhao, Y | 1 |
| Xu, M | 1 |
| Han, XJ | 1 |
| Liu, QP | 1 |
| Yi, JL | 1 |
| Li, JM | 1 |
| Pan, Q | 1 |
| Yang, XH | 1 |
| Cheng, YX | 1 |
| Lee, WJ | 1 |
| Ou, HC | 1 |
| Hsu, WC | 1 |
| Chou, MM | 1 |
| Tseng, JJ | 1 |
| Hsu, SL | 1 |
| Tsai, KL | 1 |
| Sheu, WH | 1 |
| Marcos, V | 1 |
| Zhou, Z | 1 |
| Yildirim, AO | 1 |
| Bohla, A | 1 |
| Hector, A | 1 |
| Vitkov, L | 1 |
| Wiedenbauer, EM | 1 |
| Krautgartner, WD | 1 |
| Stoiber, W | 1 |
| Belohradsky, BH | 1 |
| Rieber, N | 1 |
| Kormann, M | 1 |
| Koller, B | 1 |
| Roscher, A | 1 |
| Roos, D | 1 |
| Griese, M | 1 |
| Eickelberg, O | 1 |
| Döring, G | 1 |
| Mall, MA | 1 |
| Hartl, D | 1 |
| Cho, SO | 1 |
| Lim, JW | 1 |
| Kim, KH | 1 |
| Kim, H | 1 |
| Ahmad, R | 1 |
| Sylvester, J | 1 |
| Ahmad, M | 1 |
| Zafarullah, M | 1 |
| Nakagawa, S | 1 |
| Arai, Y | 1 |
| Kishida, T | 1 |
| Hiraoka, N | 1 |
| Tsuchida, S | 1 |
| Inoue, H | 1 |
| Sakai, R | 1 |
| Mazda, O | 1 |
| Kubo, T | 1 |
| Jin, Y | 1 |
| Li, H | 1 |
| Xie, G | 1 |
| Chen, S | 1 |
| Wu, S | 1 |
| Fang, X | 1 |
| Nagel, S | 1 |
| Hadley, G | 1 |
| Pfleger, K | 1 |
| Grond-Ginsbach, C | 1 |
| Buchan, AM | 1 |
| Wagner, S | 1 |
| Papadakis, M | 1 |
| Mitsuhashi, H | 1 |
| Yamashita, S | 1 |
| Ikeuchi, H | 1 |
| Kuroiwa, T | 1 |
| Kaneko, Y | 1 |
| Hiromura, K | 1 |
| Ueki, K | 1 |
| Nojima, Y | 1 |
| Lin, FY | 1 |
| Chen, YH | 1 |
| Tasi, JS | 1 |
| Chen, JW | 1 |
| Yang, TL | 1 |
| Wang, HJ | 1 |
| Li, CY | 1 |
| Chen, YL | 1 |
| Lin, SJ | 1 |
| Matharu, NM | 1 |
| McGettrick, HM | 1 |
| Salmon, M | 1 |
| Kissane, S | 1 |
| Vohra, RK | 1 |
| Rainger, GE | 1 |
| Nash, GB | 1 |
| Miesel, R | 1 |
| Kurpisz, M | 1 |
| Kroger, H | 1 |
| Kono, H | 1 |
| Rusyn, I | 1 |
| Uesugi, T | 1 |
| Yamashina, S | 1 |
| Connor, HD | 1 |
| Dikalova, A | 1 |
| Mason, RP | 1 |
| Thurman, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Impact of PCSK9 Inhibitors on Coronary Microvascular Dysfunction in Patients With Atherosclerotic Cardiovascular Disease Proved by Myocardial Ischemia and Needing Coronarography : a Monocentric, Prospective, Randomized and Open-label Phase II Tr[NCT04338165] | Phase 2 | 66 participants (Anticipated) | Interventional | 2021-01-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 other studies available for diphenyleneiodonium and Inflammation
| Article | Year |
|---|---|
NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice.
Topics: Animals; Chronic Disease; Cognitive Dysfunction; Enzyme Activation; Enzyme Inhibitors; Inflammation; | 2020 |
ROS-initiated chemiluminescence-driven payload release from macrocycle-based Azo-containing polymer nanocapsules.
Topics: Animals; Anti-Inflammatory Agents; Azo Compounds; Bridged-Ring Compounds; Drug Carriers; Drug Libera | 2020 |
Neutrophil Extracellular Traps Stimulate Proinflammatory Responses in Human Airway Epithelial Cells.
Topics: Antibodies, Blocking; Bronchi; Cells, Cultured; Cigarette Smoking; Extracellular Traps; HMGB1 Protei | 2017 |
Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection.
Topics: Animals; Dextromethorphan; Glycogen Synthase Kinase 3; Humans; Inflammation; Mice; Mice, Inbred BALB | 2018 |
Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration.
Topics: Animals; Benzylamines; Brain; Disease Progression; Dopaminergic Neurons; Gliosis; Inflammation; Lipo | 2019 |
Resolvin E1, but not resolvins E2 and E3, promotes fMLF-induced ROS generation in human neutrophils.
Topics: Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Humans; Inflammation; N-Formylmethionine Leucyl-Phe | 2018 |
Cytokines promote lipolysis in 3T3-L1 adipocytes through induction of NADPH oxidase 3 expression and superoxide production.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytokines; Inflammation; Insulin Resistance; Lipolysis; Mice; NAD | 2018 |
Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes.
Topics: Acyclic Monoterpenes; Allergens; Caspase 1; Cell Line; Cell Survival; Cytokines; Dermatitis, Allergi | 2014 |
The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor.
Topics: Animals; Behavior, Animal; Calcium; Calcium Channels; Dose-Response Relationship, Drug; Enzyme Inhib | 2014 |
Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1.
Topics: Aminopyrine; Antigen-Antibody Complex; Antioxidants; Ascorbic Acid; Autoimmune Diseases; Butadienes; | 2014 |
Hemodynamic shear stress via ROS modulates PCSK9 expression in human vascular endothelial and smooth muscle cells and along the mouse aorta.
Topics: Acetophenones; Animals; Antioxidants; Aorta; Endothelium, Vascular; Hemodynamics; Humans; Inflammati | 2015 |
Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice.
Topics: Animals; Biomarkers; Cell Line; Cell Lineage; Chemokine CCL2; Chemokine CXCL1; Chemokine CXCL2; Cult | 2016 |
Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species.
Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Animals; ATPases Associated with Diverse Cell | 2016 |
Involvement of NADPH oxidases in alkali burn-induced corneal injury.
Topics: Acetophenones; Alkalies; Animals; Burns, Chemical; Corneal Injuries; Corneal Neovascularization; Enz | 2016 |
Angiotensin II stimulates MCP-1 production in rat glomerular endothelial cells via NAD(P)H oxidase-dependent nuclear factor-kappa B signaling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blottin | 2009 |
Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells.
Topics: Anti-Inflammatory Agents; Antioxidants; Cell Adhesion Molecules; Cells, Cultured; Dose-Response Rela | 2010 |
CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation.
Topics: Animals; Cell Death; Chemokine CXCL2; Cystic Fibrosis; Enzyme Inhibitors; Extracellular Space; Human | 2010 |
Diphenyleneiodonium inhibits the activation of mitogen-activated protein kinases and the expression of monocyte chemoattractant protein-1 in Helicobacter pylori-infected gastric epithelial AGS cells.
Topics: Cell Line; Chemokine CCL2; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Epithelia | 2011 |
Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes.
Topics: Antioxidants; Chondrocytes; Cytokines; Gene Expression Regulation, Enzymologic; Humans; Inflammation | 2011 |
Lansoprazole inhibits nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents; Cell Line; Dinoprostone; | 2012 |
Sevoflurane combined with ATP activates caspase-1 and triggers caspase-1-dependent pyroptosis in murine J774 macrophages.
Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Caspase 1; Caspase | 2013 |
Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Cytokines; Gene Expression Profiling; Gene | 2012 |
Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neutrophils.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Humans; Hydrogen Sulfide; Inflammation; Lipopolysacchar | 2005 |
Endotoxin induces toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways.
Topics: Acetophenones; Acetylcysteine; Animals; Aorta; Atherosclerosis; Cells, Cultured; Endotoxins; Enzyme | 2006 |
Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress.
Topics: Animals; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Gene Expression Profiling; Human | 2008 |
Suppression of inflammatory arthritis by simultaneous inhibition of nitric oxide synthase and NADPH oxidase.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Chromates; Enzyme Inhibitors; Glutathione Reductase; I | 1996 |
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.
Topics: Animals; Dietary Fats; Enteral Nutrition; Enzyme Inhibitors; Ethanol; Gene Expression Regulation; He | 2001 |