diphenidol has been researched along with Neuroblastoma in 2 studies
diphenidol: shows anti-arrhythmic activity; RN given refers to unlabeled parent cpd
diphenidol : A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenidol is a non-specific inhibitor of voltage-gated ion channels in neuronal cells." | 1.38 | Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. ( Chen, YW; Cheng, KS; Cheng, TH; Kuo, CS; Leung, YM; Su, TH; Wong, KL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leung, YM | 1 |
| Wong, KL | 1 |
| Cheng, KS | 1 |
| Kuo, CS | 1 |
| Su, TH | 1 |
| Chen, YW | 1 |
| Cheng, TH | 1 |
| Waelbroeck, M | 1 |
| Camus, J | 1 |
| Tastenoy, M | 1 |
| Mutschler, E | 1 |
| Strohmann, C | 1 |
| Tacke, R | 1 |
| Lambrecht, G | 1 |
| Christophe, J | 1 |
2 other studies available for diphenidol and Neuroblastoma
| Article | Year |
|---|---|
Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol.
Topics: Animals; Antiemetics; Calcium Channels; Cell Differentiation; Cell Line, Tumor; Electrophysiological | 2012 |
Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors.
Topics: Animals; Binding, Competitive; Corpus Striatum; Humans; Male; Myocardium; Neuroblastoma; Pancreas; P | 1991 |