diphenhydramine hydrochloride has been researched along with Disease Models, Animal in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.86) | 18.7374 |
| 1990's | 6 (8.57) | 18.2507 |
| 2000's | 24 (34.29) | 29.6817 |
| 2010's | 30 (42.86) | 24.3611 |
| 2020's | 8 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, Z; Dong, Z; Fan, L; Liang, R; Qin, W; Tan, N; Tong, X; Wang, Z; Xiang, T; Zhang, Z | 1 |
| Dong, Z; Guo, Y; Han, M; Meng, Z; Wang, M; Wang, R; Wang, X | 1 |
| Huang, W; Li, X; Wang, M; Wen, Z; Xu, B; Zhou, B | 1 |
| Gao, Y; Huang, B; Jin, X; Liang, X; Liu, Y; Lv, J; Ma, J; Tang, K; Tong, W; Wang, J; Wang, X; Xie, J; Xu, P; Yao, F; Zhang, H; Zhang, Y; Zhou, N | 1 |
| Fan, X; Shang, E; Wang, P | 1 |
| An, Y; Cheng, L; Dai, H; Duan, Y; Li, P; Li, Y; Ma, Q; Ma, X; Wang, C; Wang, J; Wang, T; Zhang, M; Zhao, B | 1 |
| Forsberg, CIN; Franova, S; Joskova, M; Kazimierova, I; Molitorisova, M; Novakova, E; Sutovska, M | 1 |
| Lee, JY; Lee, SJ; Park, C; Yeom, SY | 1 |
| Chan, JN; Fung, TK; Lau, BW; Leung, JW; Po, KK; Sánchez-Vidaña, DI; Sin, EL; Siu, AM; So, KF | 1 |
| Bolser, DC; Jakus, J; Kotmanova, Z; Machac, P; Poliacek, I; Simera, M; Veternik, M | 1 |
| Chan, SW; Li, P; Lin, G; Ma, J; Shaw, PC; Wu, X | 1 |
| Fan, J; Kuang, Y; Li, B; Qiao, X; Ye, M | 1 |
| Lei, ZH; Li, J; Li, ZY; Qin, XM; Zhang, ZZ | 1 |
| Liu, L; Sun, T; Wang, L; Zhang, L | 1 |
| Hamasaki, R; Honda, I; Kawahara, R; Miki, R; Misumi, S; Shirasaki, T; Soeda, F; Takahama, K | 1 |
| Erbas, O; Erdogan, A; Erdogan, MA; Yusuf, D | 1 |
| Cui, S; Ito, I; Iwata, T; Izuhara, H; Kanemitsu, Y; Matsumoto, H; Mishima, M; Nagasaki, T; Nakaji, H; Niimi, A; Oguma, T; Tajiri, T | 1 |
| Chen, D; Guo, C; Jia, Y; Qin, W; Tan, N; Tong, X; Wang, Z; Wu, X | 1 |
| Biringerova, Z; Brozmanova, M; Gavliakova, S; Hanuskova, E; Plevkova, J; Poliacek, I; Tatar, M | 1 |
| Adcock, JJ; Belvisi, MG; Birrell, MA; Dubuis, E; Grace, MS; Maher, SA; Wortley, MA | 1 |
| Griesmaier, E; Keller, M; Kiechl-Kohlendorfer, U; Pinzer, K; Posod, A; Urbanek, M; Wegleiter, K | 1 |
| Fang, ZF; Gan, ZY; Huang, CQ; Lai, KF; Liu, XD; Nie, YC; Tian, J; Zhong, BN; Zhong, NS; Zhong, S | 1 |
| Bao, Y; Cui, X; Gao, Y; Jin, Y; Koch, E; Pan, X | 1 |
| Wu, QZ; Xiang, J; Xu, XH; Zhang, CF; Zhang, M; Zhao, DX | 1 |
| Ikegami, K; Ito, I; Iwata, T; Kamei, J; Kanemitsu, Y; Marumo, S; Matsumoto, H; Mishima, M; Nakaji, H; Niimi, A; Setou, M; Tanabe, N | 1 |
| Bongianni, F; Cinelli, E; Iovino, L; Mutolo, D; Pantaleo, T | 1 |
| Cao, H; Cheng, BC; Fu, XQ; Guo, H; Li, T; Li, YX; Su, T; Yu, ZL; Zhang, WW; Zhang, YM; Zhu, PL | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kim, KW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Pérez G, C; Pérez G, S; Ponce M, H; Ventura R, E; Zavala S, MA | 1 |
| Cheng, TY; Ke, CQ; Lin, G; Rudd, JA; Tang, CP; Yang, XZ; Ye, Y; Zhu, JY | 1 |
| Bassène, E; Diatta, W; Dièye, AM; Fall, AD; Faty, S; Faye, B | 1 |
| Chen, C; Pi, HF; Raun, HL; Wang, H; Wu, JZ; Zhang, JL; Zhang, P | 1 |
| Belvisi, MG; Birrell, MA; Freund-Michel, VC; Giembycz, MA; Haj-Yahia, S; Hele, DJ | 1 |
| Bolser, DC; Erickson, CH; Erskine, J; Fawzi, AB; Fernandez, X; Hey, JA; Ho, GD; Jayappa, H; Lehr, C; McLeod, RL; Parra, LE; Smith-Torhan, A; Tulshian, DB; Zhang, H; Zimmer, JC | 1 |
| Belvisi, MG; Nasra, J | 1 |
| Bolser, DC; Corrie, LW; Poliacek, I; Rose, MJ; Wang, C | 1 |
| Cai, S; Hu, J; Liu, X; Mao, Y; Ni, S; Tan, H; Yang, D; Zhang, N | 1 |
| Barken, I; Geller, J; Rogosnitzky, M | 1 |
| Cai, XH; Feng, T; Luo, XD; Shang, JH; Zhao, YL | 1 |
| But, PP; Chang, YS; Cheng, L; Khan, LA; Lam, H; Li, M; Ling, KH; Shaw, PC; Techen, N | 1 |
| Dai, Q; Hu, J; Lin, S; Pang, W; Zhang, H | 1 |
| Ahmad, VU; Farooq, U; Haq, Ru; Khan, RA; Raza, M; Wahab, A | 1 |
| McLeod, RL; Sadeh, J; Tulshian, DB | 1 |
| Edafiogho, IO; El-Hashim, AZ; Ezeamuzie, CI; Jaffal, SM; Kombian, SB; Yousif, MH | 1 |
| Jia, JP; Li, ZY; Qin, XM; Sun, HF; Xing, J; Xue, SY; Zhang, FS; Zhang, LZ; Zhi, HJ | 1 |
| Li, PB; Luo, YL; Nie, YC; Shen, JG; Su, WW; Wu, H; Zhang, CC | 1 |
| Benaissa, F; Mahmoudian, M; Mehrpour, M; Nobakht, M; Siadatpour, Z; Ziai, SA | 1 |
| Chen, S; Kong, W; Li, W; Li, Y; Min, L; Zhong, D | 1 |
| Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Korbonits, D; Korbonits, M; Patel, HJ; Usmani, OS | 1 |
| Goto, H; Haji, A; Minamizawa, K; Shimada, Y; Terasawa, K | 1 |
| Barnes, PJ | 1 |
| Chu, X; Jia, W; Qiu, M; Wu, D; Xu, Z; Zhao, A; Zhou, M | 1 |
| Ambrose, C; Banner, K; Battram, C; Butler, K; Giddings, J; Lewis, CA; Mok, J; Nasra, J; Poll, C; Winny, C | 1 |
| Chan, SW; Li, P; Lin, G; Rudd, JA | 1 |
| Belvisi, MG; Birring, SS; Chung, KF; Dicpinigaitis, PV; Fontana, GA; Kastelik, JA; McGarvey, LP; Morice, AH; Smith, JA; Tatar, M; Widdicombe, J | 1 |
| Belvisi, MG | 1 |
| Ke, CQ; Li, KM; Lin, G; Lin, LG; Rudd, JA; Tang, CP; Ye, Y | 1 |
| Folkerts, G; Nijkamp, FP; Omini, C; van der Linde, HJ | 1 |
| Ceserani, R; Dalla Rosa, C; Gallico, L; Oggioni, N; Tognella, S | 1 |
| Mukherjee, PK; Murugesan, T; Pal, M; Saha, BP; Saha, K | 1 |
| Kamei, J; Kashiwazaki, T; Morita, K; Ohsawa, M | 1 |
| Fuller, RW; Karlsson, JA | 1 |
| Einarson, A; Koren, G | 1 |
| Kamei, J; Morita, K | 1 |
| Akahane, M; Aoyagi, S; Hiratochi, M; Ichikawa, K; Kojima, M; Shinagawa, K | 1 |
| Ghosh, L; Mukherjee, PK; Murugesan, T; Pal, M; Saha, BP | 1 |
| Carey, GJ; Cuss, FM; Egan, RW; Erickson, CH; Fawzi, AB; Hey, JA; McLeod, RL; Mutter, JC; Parra, LE; Smith-Torhan, A; Tulshian, DB | 1 |
| Bolser, DC; Hey, JA; McLeod, RL; Tulshian, DB | 1 |
| Iwase, H; Nishimura, T; Sato, S; Yanaura, S | 1 |
| Bucher, K | 1 |
4 review(s) available for diphenhydramine hydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Modulation of sensory nerve function and the cough reflex: understanding disease pathogenesis.
Topics: Animals; Antitussive Agents; Brain Stem; Cough; Disease Models, Animal; Drug Delivery Systems; Humans; Reflex; Respiratory System; Sensory Receptor Cells | 2009 |
Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757.
Topics: Animals; Antitussive Agents; Azabicyclo Compounds; Clinical Trials as Topic; Codeine; Cough; Dextromethorphan; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Nociceptin; Opioid Peptides; Pyrimidines; Rats; Receptors, Opioid | 2011 |
Preclinical assessment of novel therapeutics on the cough reflex: cannabinoid agonists as potential antitussives.
Topics: Animals; Antitussive Agents; Cannabinoid Receptor Agonists; Central Nervous System; Cough; Disease Models, Animal; Receptors, Cannabinoid; Reflex; Treatment Outcome | 2008 |
Pharmacological regulation of the cough reflex--from experimental models to antitussive effects in Man.
Topics: Animals; Antitussive Agents; Central Nervous System; Cough; Disease Models, Animal; Guinea Pigs; Humans; Reflex | 1999 |
1 trial(s) available for diphenhydramine hydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Theobromine inhibits sensory nerve activation and cough.
Topics: Adult; Animals; Antitussive Agents; Capsaicin; Citric Acid; Codeine; Cough; Cross-Over Studies; Disease Models, Animal; Double-Blind Method; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Neurons, Afferent; Theobromine; Vagus Nerve | 2005 |
65 other study(ies) available for diphenhydramine hydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Topics: Animals; Antitussive Agents; Basic Helix-Loop-Helix Transcription Factors; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Receptors, Aryl Hydrocarbon | 2022 |
Preparation of Naringenin Nanosuspension and Its Antitussive and Expectorant Effects.
Topics: Animals; Antitussive Agents; Biological Availability; Cough; Disease Models, Animal; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Liberation; Expectorants; Flavanones; Mice; Nanoparticles; Particle Size; Solubility; Suspensions | 2022 |
Anticomplement and antitussive activities of major compound extracted from Chimonanthus nitens Oliv. leaf.
Topics: Animals; Antitussive Agents; Calycanthaceae; Chromatography, High Pressure Liquid; Complement Inactivator Proteins; Cough; Disease Models, Animal; Guinea Pigs; Kaempferols; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plant Leaves; Tandem Mass Spectrometry | 2020 |
Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma.
Topics: Animals; Antitussive Agents; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Bone Marrow; Cell Death; Cholangiocarcinoma; Cholestasis; Disease Models, Animal; Female; HEK293 Cells; Humans; Methotrexate; Mice; Mice, Inbred C57BL; Neutrophils; Perfusion | 2020 |
Effect of San'ao decoction with scorpio and bombyx batryticatus on CVA mice model via airway inflammation and regulation of TRPA1/TRPV1/TRPV5 channels.
Topics: Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Bombyx; Calcium Channels; Cough; Disease Models, Animal; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Mice; Mice, Inbred BALB C; Transient Receptor Potential Channels; Treatment Outcome; TRPA1 Cation Channel; TRPV Cation Channels | 2021 |
Therapeutic effects and mechanisms study of Hanchuan Zupa Granule in a Guinea pig model of cough variant asthma.
Topics: Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Body Weight; Capsaicin; Cough; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Flavonoids; GATA3 Transcription Factor; Glycyrrhizic Acid; Guinea Pigs; Lung; Medicine, Chinese Traditional; Ovalbumin; Respiratory Hypersensitivity; T-Box Domain Proteins; Th1 Cells; Th2 Cells; Toll-Like Receptor 4; Triterpenes | 2021 |
Pharmacodynamic evaluation of dihydroxyflavone derivate chrysin in a guinea pig model of allergic asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antitussive Agents; Asthma; Bronchoalveolar Lavage Fluid; Cough; Cytokines; Disease Models, Animal; Disease Progression; Flavonoids; Guinea Pigs; Inflammation; Male; Ovalbumin; Salmeterol Xinafoate | 2021 |
Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents.
Topics: Animals; Antineoplastic Agents; Antitussive Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Repositioning; Drug Screening Assays, Antitumor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Models, Molecular; Phenylbutyrates; Protein Binding; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2021 |
Protective effect of Lycium Barbarum polysaccharides on dextromethorphan-induced mood impairment and neurogenesis suppression.
Topics: Animals; Antitussive Agents; Anxiety Disorders; Depressive Disorder; Dextromethorphan; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Male; Neurogenesis; Neurons; Neuroprotective Agents; Psychotropic Drugs; Random Allocation; Rats, Sprague-Dawley; Social Behavior; Substance-Related Disorders | 2017 |
Role of the dorsomedial medulla in suppression of cough by codeine in cats.
Topics: Abdominal Muscles; Animals; Antitussive Agents; Blood Pressure; Cats; Codeine; Cough; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Female; Male; Medulla Oblongata; Microinjections; Respiratory Muscles | 2017 |
Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species.
Topics: Alkaloids; Animals; Antitussive Agents; Bronchi; Chromatography, Gas; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fritillaria; Male; Medicine, Chinese Traditional; Plant Extracts; Quality Control; Rats; Rats, Sprague-Dawley; Trachea | 2018 |
Antitussive and expectorant activities of licorice and its major compounds.
Topics: Administration, Oral; Ammonia; Animals; Antitussive Agents; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Expectorants; Glyburide; Glycyrrhiza; Male; Methysergide; Mice; Mice, Inbred ICR; Molecular Structure; Phenolsulfonphthalein; Plant Extracts; Structure-Activity Relationship | 2018 |
NMR based metabolomic comparison of the antitussive and expectorant effect of Farfarae Flos collected at different stages.
Topics: Ammonium Hydroxide; Animals; Antitussive Agents; Cough; Disease Models, Animal; Expectorants; Female; Flowers; Male; Metabolomics; Mice, Inbred ICR; Multivariate Analysis; Phytotherapy; Plant Extracts; Plants, Medicinal; Proton Magnetic Resonance Spectroscopy; Tussilago | 2018 |
The research of the possible mechanism and the treatment for capsaicin-induced cough.
Topics: Animals; Antitussive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Codeine; Cough; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Guinea Pigs; Male; Neurokinin A; Pyrrolidines; Substance P; TRPV Cation Channels; Urea | 2018 |
Effects of tipepidine on MK-801-induced cognitive impairment in mice.
Topics: Animals; Antidepressive Agents; Antitussive Agents; Clozapine; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Dopaminergic Neurons; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Schizophrenia; Ventral Tegmental Area | 2019 |
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.
Topics: Analysis of Variance; Animals; Antitussive Agents; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Male; Pentylenetetrazole; Propylene Glycols; Rats; Rats, Sprague-Dawley | 2019 |
Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model.
Topics: Administration, Inhalation; Airway Remodeling; Animals; Antitussive Agents; Basement Membrane; Citric Acid; Codeine; Cough; Disease Models, Animal; Guinea Pigs; Male; Muscle, Smooth; Saline Solution; Stress, Mechanical | 2019 |
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Topics: Animals; Antitussive Agents; Asthma; Capsules; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Endoplasmic Reticulum Stress; Inflammasomes; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Ovalbumin; Rats, Wistar; Respiratory Function Tests | 2019 |
The effects of nasal irritant induced responses on breathing and cough in anaesthetized and conscious animal models.
Topics: Administration, Intranasal; Anesthesia; Animals; Anticoagulants; Antitussive Agents; Citric Acid; Consciousness; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Isothiocyanates; Male; Respiration | 2013 |
Theophylline inhibits the cough reflex through a novel mechanism of action.
Topics: Action Potentials; Animals; Antitussive Agents; Calcium; Capsaicin; Cough; Disease Models, Animal; Ganglia, Sensory; Guinea Pigs; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Male; Nerve Fibers, Unmyelinated; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Reflex; Sensory Receptor Cells; Small-Conductance Calcium-Activated Potassium Channels; Theophylline; Vagus Nerve | 2014 |
The common antitussive agent dextromethorphan protects against hyperoxia-induced cell death in established in vivo and in vitro models of neonatal brain injury.
Topics: Animals; Animals, Newborn; Antitussive Agents; Apoptosis; Brain; Brain Injuries; Caspase 3; Cell Line; Cell Survival; Cytokines; Dextromethorphan; Disease Models, Animal; Dose-Response Relationship, Drug; Gray Matter; Hyperoxia; Neuroprotective Agents; Oligodendroglia; Oxygen; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; White Matter | 2014 |
Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Antitussive Agents; Cell Line, Tumor; Chemokines; Chromatography, High Pressure Liquid; Cough; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Fruit; Guinea Pigs; Inhalation Exposure; Lung Neoplasms; Male; Respiratory Hypersensitivity; Respiratory System; Schisandra; Tobacco Smoke Pollution | 2015 |
Evaluation of pharmacodynamic activities of EPs® 7630, a special extract from roots of Pelargonium sidoides, in animals models of cough, secretolytic activity and acute bronchitis.
Topics: Animals; Anti-Inflammatory Agents; Antitussive Agents; Bronchitis; Cough; Disease Models, Animal; Female; Guinea Pigs; Male; Mice, Inbred ICR; Pelargonium; Phytotherapy; Plant Extracts; Rats, Wistar | 2015 |
Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara.
Topics: Acetates; Ammonia; Animals; Anti-Inflammatory Agents; Antitussive Agents; Cough; Disease Models, Animal; Expectorants; Flowers; Leukocytosis; Mice, Inbred ICR; Phenolsulfonphthalein; Phytotherapy; Plant Extracts; Plants, Medicinal; Pneumonia; Quinic Acid; Solvents; Tussilago | 2016 |
Mechanical Stimulation by Postnasal Drip Evokes Cough.
Topics: Animals; Antitussive Agents; Cough; Disease Models, Animal; Guinea Pigs; Humans; Inflammation; Larynx; Mechanical Phenomena; Mice; Nasal Mucosa; Respiration; Sneezing | 2015 |
Downregulation of the cough reflex by aclidinium and tiotropium in awake and anesthetized rabbits.
Topics: Administration, Inhalation; Anesthesia; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Cough; Delayed-Action Preparations; Disease Models, Animal; Male; Methacholine Chloride; Muscarinic Antagonists; Rabbits; Tiotropium Bromide; Tropanes; Wakefulness | 2016 |
Standardization of the manufacturing procedure for Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine.
Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents, Phytogenic; Antitussive Agents; Cell Survival; Chromatography, Liquid; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Expectorants; Fruit and Vegetable Juices; Hep G2 Cells; Humans; Mass Spectrometry; Mice, Inbred ICR; Pinellia; Technology, Pharmaceutical; Zingiber officinale | 2016 |
Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.
Topics: Animals; Antitussive Agents; Calcium Signaling; Cyclopentanes; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Inflammation Mediators; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Spinal Cord | 2008 |
Evaluation of anti-tussive activity of Chamaedorea tepejilote.
Topics: Administration, Oral; Animals; Antitussive Agents; Arecaceae; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Male; Mice; Muscle Contraction; Plant Components, Aerial; Plant Extracts; Sulfur Dioxide; Theobromine; Time Factors; Trachea | 2008 |
Alkaloids from roots of Stemona sessilifolia and their antitussive activities.
Topics: 4-Butyrolactone; Alkaloids; Animals; Antitussive Agents; Azepines; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Molecular Structure; Phytotherapy; Plant Extracts; Plant Roots; Stemonaceae | 2009 |
[Experimental evidence of against cough activity of total alkaloids from Guiera senegalensis Lam. in guinea pig;].
Topics: Alkaloids; Animals; Antitussive Agents; Butanones; Codeine; Combretaceae; Cough; Disease Models, Animal; Drug Therapy, Combination; Female; Guinea Pigs; Male; Naphthalenes; Phytotherapy; Plant Extracts; Plant Leaves; Plant Preparations; Time Factors | 2007 |
Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor.
Topics: Animals; Antitussive Agents; Capsaicin; Cevanes; Cholic Acids; Cough; Disease Models, Animal; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Naloxone; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 2009 |
Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Antitussive Agents; Bronchodilator Agents; Cough; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Humans; In Vitro Techniques; Male; Terbutaline; Vagus Nerve | 2010 |
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
Topics: Animals; Antitussive Agents; Bordetella bronchiseptica; Bordetella Infections; Capsaicin; Cats; CHO Cells; Cough; Cricetinae; Cricetulus; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Male; Nociceptin Receptor; Receptors, Opioid; Species Specificity; Time Factors; Tropanes | 2009 |
Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats.
Topics: Abdominal Muscles; Analgesics, Opioid; Anesthesia; Animals; Antitussive Agents; Cats; Codeine; Cough; Disease Models, Animal; Electromyography; Female; Medulla Oblongata; Microinjections; Respiratory Muscles | 2010 |
[Antitussive activity comparison of three kinds of Stemonae Radix in Chinese Pharmacopoeia].
Topics: Animals; Antitussive Agents; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Mice; Mice, Inbred ICR; Stemonaceae | 2009 |
Prophylactic noscapine therapy inhibits human prostate cancer progression and metastasis in a mouse model.
Topics: Animals; Antitussive Agents; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Humans; Lymphatic Metastasis; Male; Mice; Mice, Nude; Noscapine; Prostatic Neoplasms; Xenograft Model Antitumor Assays | 2010 |
Pharmacological evaluation of Alstonia scholaris: anti-tussive, anti-asthmatic and expectorant activities.
Topics: Alkaloids; Alstonia; Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Expectorants; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Plant Leaves; Treatment Outcome | 2010 |
Cardiocrinum seeds as a replacement for Aristolochia fruits in treating cough.
Topics: Animals; Antitussive Agents; Aristolochia; Base Sequence; Citric Acid; Cough; Disease Models, Animal; DNA, Plant; Dose-Response Relationship, Drug; Fruit; Guinea Pigs; Liliaceae; Lilium; Plant Extracts; Seeds; Sequence Analysis, DNA | 2010 |
Antitussive activity of Pseudostellaria heterophylla (Miq.) Pax extracts and improvement in lung function via adjustment of multi-cytokine levels.
Topics: Animals; Antitussive Agents; Caryophyllaceae; Cough; Cytokines; Disease Models, Animal; Guinea Pigs; Lung; Plant Extracts; Rats | 2011 |
Investigation of antitussive and toxicological activity of Ballota limbata in mice.
Topics: Animals; Antitussive Agents; Ballota; Codeine; Cough; Dextromethorphan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Lethal Dose 50; Male; Medicine, Traditional; Mice; Mice, Inbred Strains; Pakistan; Phytotherapy; Plant Extracts | 2011 |
Anti-tussive and bronchodilator mechanisms of action for the enaminone E121.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Airway Obstruction; Aniline Compounds; Animals; Antitussive Agents; Bronchodilator Agents; Citric Acid; Cough; Cyclic AMP; Cyclohexanecarboxylic Acids; Disease Models, Animal; Eosinophils; Female; Glyburide; Guinea Pigs; Infusions, Intraventricular; KATP Channels; Male; Plethysmography; Propranolol; Random Allocation | 2011 |
Metabolomic profiling of the flower bud and rachis of Tussilago farfara with antitussive and expectorant effects on mice.
Topics: Ammonia; Animals; Antitussive Agents; Chlorogenic Acid; Cough; Disease Models, Animal; Drug Contamination; Drugs, Chinese Herbal; Expectorants; Female; Flowers; Magnetic Resonance Spectroscopy; Male; Metabolome; Metabolomics; Mice; Mice, Inbred ICR; Multivariate Analysis; Phenolsulfonphthalein; Phytotherapy; Plant Stems; Principal Component Analysis; Rutin; Severity of Illness Index; Trachea; Tussilago | 2012 |
Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Bronchial Hyperreactivity; Bronchitis, Chronic; Bronchoalveolar Lavage Fluid; Chemokines; Cough; Cytokines; Disease Models, Animal; Female; Flavanones; Guinea Pigs; Humans; Male; Nicotiana; Peroxidase; Smoke; Smoking; Superoxide Dismutase | 2012 |
Reduction of the prenatal hypoxic-ischemic brain edema with noscapine.
Topics: Animals; Antitussive Agents; Basal Ganglia; Brain Edema; Cerebral Cortex; Disease Models, Animal; Female; Fetus; Hypoxia-Ischemia, Brain; Male; Noscapine; Pregnancy; Rats | 2003 |
Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs.
Topics: Animals; Antitussive Agents; Benzhydryl Compounds; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Piperidines; Stereoisomerism; Time Factors | 2004 |
Effects of eppikahangeto, a Kampo formula, and Ephedrae herba against citric acid-induced laryngeal cough in guinea pigs.
Topics: Animals; Antitussive Agents; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ephedra; Guinea Pigs; Larynx; Male; Medicine, Chinese Traditional; Medicine, Kampo; Microinjections; Plant Extracts | 2006 |
The problem of cough and development of novel antitussives.
Topics: Acute Disease; Administration, Inhalation; Animals; Antitussive Agents; Chronic Disease; Cough; Disease Models, Animal; Drug Delivery Systems; Drug Design; Humans; Nerve Fibers; Nociceptors; Reflex; Respiratory System; Signal Transduction | 2007 |
In vitro and in vivo evaluation of the anti-asthmatic activities of fractions from Pheretima.
Topics: Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelium; Female; Guinea Pigs; Histamine; Inhibitory Concentration 50; Male; Materia Medica; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Muscle Contraction; Oligochaeta; Parasympatholytics; Rats; Rats, Sprague-Dawley; Trachea | 2007 |
Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig.
Topics: Animals; Antitussive Agents; Area Under Curve; Atropine; Capsaicin; Citric Acid; Codeine; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Inhalation Exposure; Male; Plethysmography, Whole Body; Reflex; Smoke; Terbutaline | 2007 |
Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).
Topics: Analysis of Variance; Animals; Antiemetics; Antitussive Agents; Baclofen; Cevanes; Codeine; Copper Sulfate; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Motion Sickness; Nicotine; Reflex; Scopolamine; Shrews; Vomiting | 2007 |
ERS guidelines on the assessment of cough.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Citric Acid; Clinical Trials as Topic; Cough; Disease Models, Animal; Humans; Lung Diseases; Practice Guidelines as Topic; Quality of Life; Tachyphylaxis; Treatment Outcome; Water | 2007 |
Antitussive stemoninine alkaloids from the roots of Stemona tuberosa.
Topics: Alkaloids; Animals; Antitussive Agents; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Guinea Pigs; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Stemonaceae | 2008 |
Virus-induced airway inflammation and hyperresponsiveness in the guinea-pig is inhibited by levodropropizine.
Topics: Animals; Antitussive Agents; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Guinea Pigs; Histamine; Leukocytes; Male; Methacholine Chloride; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Premedication; Propylene Glycols; Specific Pathogen-Free Organisms | 1993 |
Effects of moguisteine, a peripheral nonnarcotic antitussive agent, on airway inflammation in guinea-pigs in vivo.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Antitussive Agents; Bronchial Hyperreactivity; Capsaicin; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Inflammation; Male; Regression Analysis; Respiratory System; Smoke; Thiazoles; Thiazolidines | 1996 |
Studies on in vivo antitussive activity of Leucas lavandulaefolia using a cough model induced by sulfur dioxide gas in mice.
Topics: Animals; Antitussive Agents; Codeine; Cough; Disease Models, Animal; Female; Male; Mice; Plants, Medicinal; Sulfur Dioxide | 1997 |
Antitussive effect of moguisteine on allergic coughs in the guinea pig.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Codeine; Cough; Disease Models, Animal; Guinea Pigs; Hypersensitivity; Male; Thiazoles; Thiazolidines | 1998 |
Dextromethorphan. Extrapolation of findings from reproductive studies in animals to humans.
Topics: Abnormalities, Drug-Induced; Animals; Antitussive Agents; Chick Embryo; Dextromethorphan; Disease Models, Animal; Female; Humans; Pregnancy; Risk Assessment; Teratogens; Toxicity Tests | 1999 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug Interactions; Glyburide; Guinea Pigs; KATP Channels; Male; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Thiazoles; Thiazolidines | 2000 |
Participation of thromboxane A(2) in the cough response in guinea-pigs: antitussive effect of ozagrel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antitussive Agents; Capsaicin; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Male; Methacrylates; Thromboxane A2; Thromboxane-A Synthase | 2000 |
Evaluation of antitussive potential of Jussiaea suffruticosa linn. extract in albino mice.
Topics: Animals; Antitussive Agents; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Female; India; Male; Medicine, Traditional; Mice; Mice, Inbred Strains; Phytotherapy; Plant Extracts; Plant Leaves; Rosales; Sulfur Dioxide | 2000 |
Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors.
Topics: Animals; Antitussive Agents; Capsaicin; CHO Cells; Cough; Cricetinae; Disease Models, Animal; Guinea Pigs; Male; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid | 2001 |
Antitussive action of nociceptin in the cat.
Topics: Abdominal Muscles; Animals; Antitussive Agents; Benzimidazoles; Cats; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Injections, Intravenous; Nociceptin; Opioid Peptides; Piperidines | 2001 |
A new method for induction of the cough reflex.
Topics: Animals; Antitussive Agents; Chlorobenzenes; Codeine; Cough; Disease Models, Animal; Dogs; Electric Stimulation; Electrodes; Electrodes, Implanted; Guinea Pigs; Methyl Ethers; Morphine; Mucous Membrane; Piperidines; Pyridines; Reflex; Species Specificity; Thebaine; Time Factors; Trachea | 1974 |
Cough and antitussives: considerations and experiments.
Topics: Animals; Antitussive Agents; Bronchitis; Columbidae; Cough; Decerebrate State; Disease Models, Animal; Hypoxia; Muscles; Rabbits; Reflex; Trachea | 1974 |