diphenhydramine has been researched along with Substance Withdrawal Syndrome in 21 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety." | 7.71 | Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. ( Jackman, SL; Olmstead, MC; Paine, TA, 2002) |
| "Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety." | 3.71 | Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. ( Jackman, SL; Olmstead, MC; Paine, TA, 2002) |
| "The effects of L-Dopa, Methysergid, Diphenhydramine hydrochloride and LSD on the development of morphine dependence and the abstience syndrome after its withdrawal, were tested in experiments on 200 male Wistar albino rats." | 3.65 | Pharmacological analysis of certain mechanisms of morphine addiction. ( Bantoutova, I; Kobourova, K; Ovcharov, R, 1976) |
| "Diphenhydramine was administered orally in the dose schedules of once daily (10, 20 and 40 mg/kg) and twice daily (5, 10 and 20 mg/kg) in separate groups during the withdrawal period." | 1.30 | Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats. ( Gupta, MB; Nath, C; Patnaik, GK; Saxena, RC, 1997) |
| "In one case, withdrawal symptoms were blocked with clonidine, an alpha-2 agonist." | 1.27 | P's and blues: potentiation of propoxyphene withdrawal by a variety of antihistamines. ( Andriano, JP; Giannini, AJ; Gregg, LO, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (57.14) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Erbe, S | 1 |
| Bschor, T | 1 |
| Lin, KH | 1 |
| Chen, YJ | 1 |
| Wei, CF | 1 |
| Yen, MH | 1 |
| Hsueh, WC | 1 |
| Liao, KC | 1 |
| Lu, CL | 1 |
| Paine, TA | 1 |
| Jackman, SL | 1 |
| Olmstead, MC | 1 |
| Giannini, AJ | 1 |
| Gregg, LO | 1 |
| Andriano, JP | 1 |
| Singh, N | 1 |
| Nath, R | 1 |
| Kulshrestha, VK | 1 |
| Kohli, RP | 1 |
| Covi, L | 1 |
| Hess, JM | 1 |
| Kreiter, NA | 1 |
| Haertzen, CA | 1 |
| Connor, DF | 1 |
| Benjamin, S | 1 |
| Ozbayrak, KR | 1 |
| de Nesnera, AP | 1 |
| Nath, C | 1 |
| Patnaik, GK | 1 |
| Saxena, RC | 1 |
| Gupta, MB | 1 |
| Ovcharov, R | 1 |
| Bantoutova, I | 1 |
| Kobourova, K | 1 |
| Feldman, MD | 1 |
| Behar, M | 1 |
| Glickman, L | 1 |
| McMahon, T | 1 |
| Jhamandas, K | 1 |
| Sutak, M | 1 |
| Bell, S | 1 |
| Evans, JI | 1 |
| Ogunremi, O | 1 |
| Parkin, DE | 1 |
| Sargant, W | 1 |
| Jäättelä, A | 1 |
| Männistö, P | 1 |
| Paatero, H | 1 |
| Tuomisto, J | 1 |
| Lorenzetti, OJ | 1 |
| Sancilio, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility and Efficacy of an Internet-delivered Cognitive-behavioral Intervention for Insomnia in a National Cohort of Danish Breast Cancer Survivors[NCT02444026] | 225 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diphenhydramine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
[Diphenhydramine addiction and detoxification. A systematic review and case report].
Topics: Adult; Aged; Alcoholism; Comorbidity; Diphenhydramine; Dose-Response Relationship, Drug; Drug Admini | 2013 |
3 trials available for diphenhydramine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Effects of combined fluoxetine and counseling in the outpatient treatment of cocaine abusers.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Cocaine; Combined Modality Therapy | 1995 |
Sleep and hypnotics: further experiments.
Topics: Adult; Amobarbital; Antipyrine; Chloral Hydrate; Diphenhydramine; Drug Tolerance; Humans; Male; Meth | 1970 |
The effects of diazepam or diphenhydramine on healthy human subjects.
Topics: Adult; Behavior; Depression; Depression, Chemical; Diazepam; Diphenhydramine; Euphoria; Female; Huma | 1971 |
16 other studies available for diphenhydramine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Sleep complaints: Whenever possible, avoid the use of sleeping pills.
Topics: Acupuncture Therapy; Adult; Aged; Behavior Therapy; Benzodiazepines; Clinical Trials as Topic; Conge | 2008 |
Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report.
Topics: Adult; Analgesics, Non-Narcotic; Delirium; Diphenhydramine; Humans; Hypnotics and Sedatives; Male; N | 2010 |
Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Cocaine; Conflict, Psychological; Diazepam; Dimenh | 2002 |
P's and blues: potentiation of propoxyphene withdrawal by a variety of antihistamines.
Topics: Adolescent; Adult; Dextropropoxyphene; Dimenhydrinate; Diphenhydramine; Drug Synergism; Female; Hist | 1984 |
An experimental evaluation of dependence liability of methaqualone diphenhydramine (combination) and methaqualone in rats.
Topics: Animals; Body Temperature; Body Weight; Diphenhydramine; Drug Combinations; Female; Humans; Male; Me | 1980 |
Case study: neuroleptic withdrawal dyskinesia exacerbated by ongoing stimulant treatment.
Topics: Antipsychotic Agents; Dextroamphetamine; Diphenhydramine; Fluoxetine; Humans; Male; Mental Disorders | 1995 |
Diphenhydramine dependence: a need for awareness.
Topics: Adult; Antipsychotic Agents; Delayed-Action Preparations; Diphenhydramine; Fluphenazine; Humans; Mal | 1996 |
Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats.
Topics: Acoustic Stimulation; Administration, Oral; Aggression; Animals; Anti-Anxiety Agents; Body Temperatu | 1997 |
Pharmacological analysis of certain mechanisms of morphine addiction.
Topics: Animals; Brain Chemistry; Diphenhydramine; Dopamine; Humans; Levodopa; Lysergic Acid Diethylamide; M | 1976 |
A case of massive diphenhydramine abuse and withdrawal from use of the drug.
Topics: Adult; Diphenhydramine; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Diphenhydramine abuse and withdrawal.
Topics: Diphenhydramine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Dyskinesia associated with amoxapine withdrawal and use of carbamazepine and antihistamines.
Topics: Amoxapine; Carbamazepine; Cimetidine; Dibenzoxazepines; Diphenhydramine; Drug Therapy, Combination; | 1986 |
Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.
Topics: Animals; Atropine; Autonomic Nervous System; Diphenhydramine; Dose-Response Relationship, Drug; Drug | 1973 |
Probable Benadryl withdrawal manifestations in a newborn infant.
Topics: Diphenhydramine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange | 1974 |
Prescribing Mandrax.
Topics: Amitriptyline; Dibenzazepines; Diphenhydramine; Electroconvulsive Therapy; Humans; Methaqualone; Sle | 1973 |
Morphine dependent rats as a model for evaluating potential addiction liability of analgesic compounds.
Topics: Analgesics; Animals; Apomorphine; Azepines; Behavior, Animal; Codeine; Dextropropoxyphene; Diphenhyd | 1970 |