diphenhydramine has been researched along with Substance-Related Disorders in 66 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous." | 5.40 | Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval. ( Chang, CC; Chen, CY; Chen, TY; Kuo, SC; Lin, TP; Yeh, YW, 2014) |
| "Diphenhydramine is frequently misused and ingested recreationally for its antihistaminergic and antimuscarinic effects and is often involved in both serious and fatal poisonings, either in isolation or in combination with other xenobiotics." | 4.02 | Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity. ( Hendrickson, RG; Hughes, AR; Lin, A, 2021) |
| "We describe a patient who had consumed large quantities of a proprietary cough mixture containing diphenhydramine, ammonium chloride and sodium citrate (Benylin expectorant) daily for several months and subsequently presented with confusion, marked metabolic acidosis and non-ketotic hyperglycaemia." | 3.67 | Benylin dependence, metabolic acidosis and hyperglycaemia. ( Goodwin, K; MacRury, S; Neilson, R, 1987) |
| "Methaqualone is a potent quinazoline, a class of sedative-hypnotics, that has a high potential for abuse." | 2.43 | Treatment for methaqualone dependence in adults. ( McCarthy, G; Myers, B; Siegfried, N, 2005) |
| "Mandrax use was not significantly related to PrEP awareness (p>0." | 1.72 | Mandrax use, sexual risk, and opportunities for pre-exposure prophylaxis among out-of-school adolescent girls and young women in Cape Town, South Africa. ( Bonner, CP; Browne, FA; Carney, T; Myers, B; Ndirangu, JW; Shangase, N; Wechsberg, WM, 2022) |
| "Hair specimen is necessary to complement blood and/or urine analyses as it permits differentiation of a single exposure from chronic use of a drug by segmentation of the hair for a stated growth period." | 1.42 | Contribution of in utero drug exposure when interpreting hair results in young children. ( Kintz, P, 2015) |
| "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous." | 1.40 | Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval. ( Chang, CC; Chen, CY; Chen, TY; Kuo, SC; Lin, TP; Yeh, YW, 2014) |
| "Diphenhydramine was more frequently recorded among the false-positive group, but this was not statistically significant." | 1.39 | How often do false-positive phencyclidine urine screens occur with use of common medications? ( Mullins, ME; Rengarajan, A, 2013) |
| "Clonidine influx was saturable, followed by Michaelis-Menten kinetics (K(m)=0." | 1.35 | Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs. ( André, P; Cisternino, S; Debray, M; Scherrmann, JM, 2009) |
| " The interpretation of blood methadone concentrations alone or combined with other psychoactive drugs requires consideration of the subject's potential chronic use of and tolerance to the drug." | 1.34 | Methadone toxicity fatalities: a review of medical examiner cases in a large metropolitan area. ( Corey, TS; Hunsaker Iii, JC; Shields, LB; Stewart, D; Ward, MK, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (53.03) | 18.7374 |
| 1990's | 9 (13.64) | 18.2507 |
| 2000's | 9 (13.64) | 29.6817 |
| 2010's | 11 (16.67) | 24.3611 |
| 2020's | 2 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Bonner, CP | 1 |
| Browne, FA | 1 |
| Carney, T | 1 |
| Shangase, N | 1 |
| Ndirangu, JW | 1 |
| Myers, B | 3 |
| Wechsberg, WM | 1 |
| Hughes, AR | 1 |
| Lin, A | 1 |
| Hendrickson, RG | 1 |
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Chu, CW | 1 |
| Liang, CS | 1 |
| Erbe, S | 1 |
| Bschor, T | 1 |
| Rengarajan, A | 1 |
| Mullins, ME | 1 |
| Chen, TY | 1 |
| Yeh, YW | 1 |
| Kuo, SC | 1 |
| Chen, CY | 1 |
| Lin, TP | 1 |
| Chang, CC | 1 |
| Kintz, P | 1 |
| Stephens, TT | 1 |
| Gardner, D | 1 |
| Jones, K | 1 |
| Sifunda, S | 1 |
| Braithwaite, R | 1 |
| Smith, SE | 1 |
| Brubacher, JR | 1 |
| Chan, H | 1 |
| Martz, W | 1 |
| Schreiber, W | 1 |
| Asbridge, M | 1 |
| Eppler, J | 1 |
| Lund, A | 1 |
| Macdonald, S | 1 |
| Drummer, O | 1 |
| Purssell, R | 1 |
| Andolfatto, G | 1 |
| Mann, R | 1 |
| Brant, R | 1 |
| André, P | 1 |
| Debray, M | 1 |
| Scherrmann, JM | 1 |
| Cisternino, S | 1 |
| Rogers, SC | 1 |
| Pruitt, CW | 1 |
| Crouch, DJ | 1 |
| Caravati, EM | 1 |
| Canfield, DV | 1 |
| Dubowski, KM | 1 |
| Chaturvedi, AK | 1 |
| Whinnery, JE | 1 |
| Bhana, A | 1 |
| Parry, CD | 1 |
| Plüddemann, A | 1 |
| Morojele, NK | 1 |
| Flisher, AJ | 1 |
| Uebel, RA | 1 |
| Wium, CA | 1 |
| McCarthy, G | 1 |
| Siegfried, N | 1 |
| Shields, LB | 1 |
| Hunsaker Iii, JC | 1 |
| Corey, TS | 1 |
| Ward, MK | 1 |
| Stewart, D | 1 |
| Tanda, G | 1 |
| Kopajtic, TA | 1 |
| Katz, JL | 1 |
| Kelner, MJ | 1 |
| Singh, N | 1 |
| Nath, R | 1 |
| Kulshrestha, VK | 1 |
| Kohli, RP | 1 |
| Coleman, JB | 1 |
| Barcone, JA | 1 |
| Stallworth, HF | 1 |
| Doenecke, AL | 1 |
| Heuermann, RC | 1 |
| Shipko, S | 1 |
| Mancini, JL | 1 |
| Gulmann, NC | 1 |
| Petersen, E | 1 |
| Nielsen, U | 1 |
| Skovgaard-Petersen, K | 1 |
| Covi, L | 1 |
| Hess, JM | 1 |
| Kreiter, NA | 1 |
| Haertzen, CA | 1 |
| Steidle, B | 1 |
| Klein, M | 1 |
| de Nesnera, AP | 1 |
| Stine, SM | 1 |
| Krystal, JH | 1 |
| Petrakis, IL | 1 |
| Jatlow, PI | 1 |
| Heninger, GR | 1 |
| Kosten, TR | 1 |
| Charney, DS | 1 |
| Dinndorf, PA | 1 |
| McCabe, MA | 1 |
| Frierdich, S | 1 |
| Roberts, K | 1 |
| Gruer, L | 1 |
| Gilhooly, T | 1 |
| Barsoum, A | 1 |
| Kolivakis, TT | 1 |
| Margolese, HC | 1 |
| Chouinard, G | 1 |
| Cox, D | 1 |
| Ahmed, Z | 1 |
| McBride, AJ | 1 |
| Moriya, F | 1 |
| Hashimoto, Y | 1 |
| Poser, W | 1 |
| Poser, S | 1 |
| Kellermann, B | 1 |
| Müller-Oerlinghausen, B | 1 |
| Bjørndal, N | 1 |
| Nørgaard, P | 1 |
| Lee, AS | 1 |
| Plueckhahn, VD | 1 |
| Braga, JC | 1 |
| Cobbs, LW | 1 |
| Preston, KL | 2 |
| Wolf, B | 2 |
| Guarino, JJ | 2 |
| Griffiths, RR | 2 |
| Levine, BS | 1 |
| Smith, ML | 1 |
| Goldin, K | 1 |
| Fuchs, V | 1 |
| Coper, H | 1 |
| MacRury, S | 1 |
| Neilson, R | 1 |
| Goodwin, K | 1 |
| Feldman, MD | 1 |
| Behar, M | 1 |
| Glickman, L | 1 |
| Brower, KJ | 1 |
| Westin, S | 1 |
| Power, DJ | 1 |
| Tennant, FS | 1 |
| Matthew, H | 1 |
| Brown, CG | 1 |
| Sargant, W | 1 |
| Ruedy, J | 1 |
| Forrest, JA | 1 |
| Tarala, RA | 1 |
| Whitlock, FA | 1 |
| Lockshin, NA | 1 |
| Hurley, H | 1 |
| Ager, SA | 1 |
| Mathew, H | 1 |
| Johns, MW | 1 |
| Hepburn, M | 1 |
| Goodyear, MD | 1 |
| McCarthy, JP | 1 |
| Harenko, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Expanding HIV Testing and Prevention to Reach Vulnerable Young Women[NCT02974998] | 500 participants (Actual) | Interventional | 2016-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for diphenhydramine and Substance-Related Disorders
| Article | Year |
|---|---|
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
[Diphenhydramine addiction and detoxification. A systematic review and case report].
Topics: Adult; Aged; Alcoholism; Comorbidity; Diphenhydramine; Dose-Response Relationship, Drug; Drug Admini | 2013 |
Treatment for methaqualone dependence in adults.
Topics: Adult; Diphenhydramine; Drug Combinations; Humans; Hypnotics and Sedatives; Methaqualone; Substance- | 2005 |
[Computed tomography in acute rhabdomyolysis].
Topics: Acute Disease; Adult; Cocaine; Diagnosis, Differential; Diphenhydramine; Heroin Dependence; Humans; | 1995 |
Diphenhydramine dependence.
Topics: Adult; Diphenhydramine; Histamine H1 Antagonists; Humans; Male; Nonprescription Drugs; Substance-Rel | 2001 |
4 trials available for diphenhydramine and Substance-Related Disorders
| Article | Year |
|---|---|
Effects of combined fluoxetine and counseling in the outpatient treatment of cocaine abusers.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Cocaine; Combined Modality Therapy | 1995 |
Effect of alpha-methyl-para-tyrosine on response to cocaine challenge.
Topics: Administration, Oral; Adult; alpha-Methyltyrosine; Arousal; Cocaine; Diphenhydramine; Dopamine; Doub | 1997 |
Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability.
Topics: Adult; Cognition; Diphenhydramine; Dose-Response Relationship, Drug; Humans; Lorazepam; Male; Methoc | 1992 |
Abuse liability of diphenhydramine in sedative abusers.
Topics: Adult; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Clinical Trials as Topic; Diphenhydramine | 1989 |
57 other studies available for diphenhydramine and Substance-Related Disorders
| Article | Year |
|---|---|
Mandrax use, sexual risk, and opportunities for pre-exposure prophylaxis among out-of-school adolescent girls and young women in Cape Town, South Africa.
Topics: Adolescent; Anti-HIV Agents; Diphenhydramine; Drug Combinations; Female; HIV Infections; Humans; Met | 2022 |
Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Databases, Factual; Diphenhydra | 2021 |
Diphenhydramine dependence via port-a-cath in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Diphenhydramine; Female; Humans; Hypnotics and Sedatives; Infusions, Intraven | 2019 |
How often do false-positive phencyclidine urine screens occur with use of common medications?
Topics: Alprazolam; Carbazoles; Carvedilol; Clonazepam; Dextromethorphan; Diphenhydramine; Drug Interactions | 2013 |
Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Depression; Diphenhydrami | 2014 |
Contribution of in utero drug exposure when interpreting hair results in young children.
Topics: Amitriptyline; Bromazepam; Cannabinoids; Diazepam; Diphenhydramine; Female; Forensic Toxicology; Hai | 2015 |
Correlates of Mandrax use and condom beliefs in preventing sexually transmitted infections among a cohort of South African prison inmates.
Topics: Adolescent; Adult; Condoms; Diphenhydramine; Drug Combinations; Health Knowledge, Attitudes, Practic | 2016 |
Diphenhydramine, dimenhydrinate: misuse.
Topics: Dimenhydrinate; Diphenhydramine; France; Histamine H1 Antagonists; Humans; Substance-Related Disorde | 2015 |
Prevalence of alcohol and drug use in injured British Columbia drivers.
Topics: Accidents, Traffic; Adult; Alcohol Drinking; Antidepressive Agents; Benzodiazepines; British Columbi | 2016 |
Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs.
Topics: Analgesics; Animals; Antiporters; Biological Transport; Blood-Brain Barrier; Brain; Clonidine; Diphe | 2009 |
Rapid urine drug screens: diphenhydramine and methadone cross-reactivity.
Topics: Analgesics, Opioid; Child; Diphenhydramine; Humans; Hypnotics and Sedatives; Immunoassay; Male; Meth | 2010 |
Drugs and alcohol found in civil aviation accident pilot fatalities from 2004-2008.
Topics: Accidents, Aviation; Adult; Alcohol Drinking; Diphenhydramine; Female; Humans; Male; Middle Aged; No | 2012 |
The South African Community Epidemiology Network on Drug Use (SACENDU) project, phases 1-8--cannabis and Mandrax.
Topics: Adolescent; Adult; Age Distribution; Cannabis; Community Networks; Developing Countries; Diphenhydra | 2002 |
Toxicological screening for drugs of abuse in samples adulterated with household chemicals.
Topics: Adult; Cannabis; Detergents; Diphenhydramine; Drug Combinations; Drug Contamination; False Negative | 2002 |
Methadone toxicity fatalities: a review of medical examiner cases in a large metropolitan area.
Topics: Adolescent; Adult; Antidepressive Agents; Benzodiazepines; Cannabinoids; Coroners and Medical Examin | 2007 |
Cocaine-like neurochemical effects of antihistaminic medications.
Topics: Animals; Central Nervous System Stimulants; Chlorpheniramine; Cocaine; Diphenhydramine; Dopamine; Do | 2008 |
Positive diphenhydramine interference in the EMIT-d.a.u. assay.
Topics: Diphenhydramine; False Positive Reactions; Humans; Immunoenzyme Techniques; Methadone; Substance-Rel | 1984 |
An experimental evaluation of dependence liability of methaqualone diphenhydramine (combination) and methaqualone in rats.
Topics: Animals; Body Temperature; Body Weight; Diphenhydramine; Drug Combinations; Female; Humans; Male; Me | 1980 |
Abuse potential of methaqualone-diphenhydramine combination.
Topics: Adult; Diphenhydramine; Drug Combinations; Humans; Male; Methaqualone; Substance-Related Disorders | 1981 |
Acute dystonia secondary to illicit phenothiazine usage: a report of two cases.
Topics: Adult; Diphenhydramine; Dystonia; Humans; Male; Phenothiazines; Substance-Related Disorders | 1981 |
Treatment of haloperidol abuse with diphenhydramine.
Topics: Adolescent; Adult; Alcohol Drinking; Diazepam; Diphenhydramine; Female; Haloperidol; Humans; Male; S | 1980 |
Simulated dystonia.
Topics: Adult; Diphenhydramine; Dystonia; Emergency Service, Hospital; Female; Humans; Malingering; Substanc | 1980 |
[Epidemic of antihistamine abuse in a psychiatric unit].
Topics: Adolescent; Adult; Diphenhydramine; Female; Humans; Male; Mental Disorders; Psychiatric Department, | 1980 |
[Antihistamine abuse. Prolonged abuse of diphenhydramine in a patient with psychotic episodes].
Topics: Adult; Diphenhydramine; Female; Humans; Psychoses, Substance-Induced; Psychotic Disorders; Substance | 1980 |
Diphenhydramine dependence: a need for awareness.
Topics: Adult; Antipsychotic Agents; Delayed-Action Preparations; Diphenhydramine; Fluphenazine; Humans; Mal | 1996 |
Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses.
Topics: Adolescent; Adult; Child; Chronic Disease; Diphenhydramine; Female; Hematologic Diseases; Histamine | 1998 |
Misuse of diphenhydramine soft gel capsules (Sleepia): a cautionary tale from Glasgow.
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Sleep Wake Disorders; Substance-Related Disorders | 1999 |
Diphenhydramine (Unisom), a central anticholinergic and antihistaminic: abuse with massive ingestion in a patient with schizophrenia.
Topics: Adult; Cholinergic Antagonists; Diphenhydramine; Histamine H1 Antagonists; Humans; Male; Schizophren | 2000 |
Postmortem diffusion of drugs from the bladder into femoral venous blood.
Topics: Adolescent; Chlorpheniramine; Codeine; Diffusion; Diphenhydramine; Drowning; Drug Overdose; Femoral | 2001 |
[A new addiction problem--diethylallylacetamide (author's transl)].
Topics: Acetamides; Alkaline Phosphatase; Allyl Compounds; Diphenhydramine; Drug Combinations; gamma-Glutamy | 1979 |
[Koffinautin abuse: an increasing problem].
Topics: Adult; Caffeine; Denmark; Diphenhydramine; Drug and Narcotic Control; Humans; Male; Substance-Relate | 1979 |
Treatment of drug-induced dystonic reactions.
Topics: Adolescent; Adult; Benztropine; Diphenhydramine; Dystonia; Female; Haloperidol; Humans; Injections, | 1979 |
Alcohol and road safety: Geelong experience 1967 to 1978.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Australia; Automobile Dri | 1978 |
[Dependence on metaquolone-diphenyldramine combination].
Topics: Adult; Diphenhydramine; Drug Combinations; Female; Homosexuality; Humans; Male; Methaqualone; Person | 1975 |
Shakes and flashes in a relapsed alcoholic.
Topics: Alcoholic Intoxication; Chlordiazepoxide; Diphenhydramine; Drug Overdose; Hallucinations; Humans; Ma | 1992 |
Effects of diphenhydramine on immunoassays of phencyclidine in urine.
Topics: Diphenhydramine; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay | 1990 |
Cocaine or perhaps antihistamine abuse.
Topics: Adult; Chest Pain; Cocaine; Diphenhydramine; Humans; Male; Substance-Related Disorders | 1989 |
The influence of antihistamine compounds on the oral intake of different addictive drugs.
Topics: Amphetamine; Animals; Benzimidazoles; Diphenhydramine; Ethanol; Female; Histamine H1 Antagonists; Il | 1986 |
Benylin dependence, metabolic acidosis and hyperglycaemia.
Topics: Acidosis; Aged; Ammonium Chloride; Diphenhydramine; Expectorants; Humans; Hyperglycemia; Male; Subst | 1987 |
A case of massive diphenhydramine abuse and withdrawal from use of the drug.
Topics: Adult; Diphenhydramine; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Diphenhydramine abuse and withdrawal.
Topics: Diphenhydramine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Smoking of prescription anticholinergic drugs.
Topics: Adult; Benztropine; Diphenhydramine; Humans; Male; Schizophrenic Psychology; Smoking; Substance-Rela | 1987 |
[Abuse of travel sickness remedies among young drug addicts].
Topics: Adolescent; Adult; Caffeine; Cannabis; Diphenhydramine; Drug Interactions; Drug Prescriptions; Femal | 1972 |
Illicit drug taking.
Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Crime; Diphenhydramine; Humans; Lys | 1974 |
Complications of methaqualone-diphenhydramine (Mandrax R) abuse.
Topics: Diphenhydramine; Germany, West; Hospitalization; Humans; Male; Methaqualone; Military Medicine; Psyc | 1973 |
Prescribing mandrax.
Topics: Diphenhydramine; Humans; Methaqualone; Substance-Related Disorders; Suicide; United Kingdom | 1973 |
Prescribing Mandrax.
Topics: Diphenhydramine; Humans; Methaqualone; Sleep Wake Disorders; State Medicine; Substance-Related Disor | 1973 |
Prescribing Mandrax.
Topics: Amitriptyline; Dibenzazepines; Diphenhydramine; Electroconvulsive Therapy; Humans; Methaqualone; Sle | 1973 |
Acute drug poisoning in the adult.
Topics: Adult; Amphetamine; Antidepressive Agents; Cocaine; Diazepam; Diphenhydramine; Diuresis; Emergency S | 1973 |
Abuse of drugs "for kicks": a review of 252 admissions.
Topics: Adolescent; Adult; Age Factors; Ambulances; Barbiturates; Diphenhydramine; Female; Hospitalization; | 1973 |
Editorial: Misuse of methaqualone and Mandrax.
Topics: Barbiturates; Diphenhydramine; Drug Combinations; Humans; Methaqualone; Substance-Related Disorders | 1973 |
Urticaria as a sign of viral hepatitis.
Topics: Acute Disease; Adolescent; Adult; Diphenhydramine; Hepatitis A; Hepatitis B; Heroin; Humans; Liver; | 1972 |
Luding out.
Topics: Adolescent; Adult; Diphenhydramine; Humans; Methaqualone; Substance-Related Disorders; Wine | 1972 |
A clinical comparison of two nonbarbiturate hypnotics, mogadon and mandrax.
Topics: Benzazepines; Diphenhydramine; Drug Combinations; Humans; Methaqualone; Substance-Related Disorders | 1972 |
Use of hypnotic drugs by hospital patients.
Topics: Adult; Aged; Amobarbital; Antipyrine; Barbiturates; Diphenhydramine; Female; Hospitalization; Humans | 1971 |
Some less familiar drugs of abuse.
Topics: Amyl Nitrite; Australia; Basidiomycota; Diphenhydramine; Fruit; Humans; Mescaline; Methaqualone; New | 1971 |
[Cough syrup containing diphenhydramine causing toxicomania and acute psychosis].
Topics: Antitussive Agents; Diphenhydramine; Humans; Psychoses, Substance-Induced; Substance-Related Disorde | 1965 |