diphenhydramine has been researched along with Stomatitis in 11 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "A prospective, double-blind study compared the effectiveness of sucralfate suspension with diphenhydramine syrup plus kaolin-pectin in reducing severity and pain of radiation-induced oropharyngeal mucositis." | 5.07 | The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis. ( Barker, B; Barker, G; Cuddy, P; Loftus, L, 1991) |
| "Temsirolimus (CCI-779) is a novel inhibitor of the mammalian target of rapamycin." | 2.75 | A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors. ( Fujisaka, Y; Horiike, A; Tamura, T; Yamada, Y; Yamamoto, N, 2010) |
| "Severe stomatitis is a common problem encountered during either radiation therapy or chemotherapy." | 2.67 | Treatment of radiation- and chemotherapy-induced stomatitis. ( Barnes, M; Blakeslee, DB; Carnel, SB; Oswald, SG, 1990) |
| " Utilizing a 90-day BUD, lidocaine can be packaged separately from other magic mouthwash ingredients in individual dosage units and applied to the oral cavity using the swish-and-spit method." | 1.46 | Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations. ( Brown, SD; Huffman, J; Kirk, LM; Lewis, PO; Luu, Y; Ogle, A, 2017) |
| " One patient experienced a life-threatening adverse reaction within minutes of receiving the first dose." | 1.31 | Pegylated liposomal doxorubicin: tolerability and toxicity. ( Goram, AL; Richmond, PL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirk, LM | 1 |
| Brown, SD | 1 |
| Luu, Y | 1 |
| Ogle, A | 1 |
| Huffman, J | 1 |
| Lewis, PO | 1 |
| Elad, S | 1 |
| Yarom, N | 1 |
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| Fujisaka, Y | 1 |
| Yamada, Y | 1 |
| Yamamoto, N | 1 |
| Horiike, A | 1 |
| Tamura, T | 1 |
| Asakura, A | 1 |
| Kotani, R | 1 |
| Hasegawa, K | 1 |
| Isobe, S | 1 |
| Ishizuka, N | 1 |
| Bondi, E | 1 |
| Baroni, C | 1 |
| Prete, A | 1 |
| Gatti, M | 1 |
| Carrassi, A | 1 |
| Lodi, G | 1 |
| Porter, SR | 1 |
| Turhal, NS | 1 |
| Erdal, S | 1 |
| Karacay, S | 1 |
| Dodd, MJ | 1 |
| Dibble, SL | 1 |
| Miaskowski, C | 1 |
| MacPhail, L | 1 |
| Greenspan, D | 1 |
| Paul, SM | 1 |
| Shiba, G | 1 |
| Larson, P | 1 |
| Goram, AL | 1 |
| Richmond, PL | 1 |
| Barker, G | 1 |
| Loftus, L | 1 |
| Cuddy, P | 1 |
| Barker, B | 1 |
| Carnel, SB | 1 |
| Blakeslee, DB | 1 |
| Oswald, SG | 1 |
| Barnes, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia During Subcutaneous Implantable Venous Access Devices Insertion: Double Blind Randomized Study.[NCT03628430] | 120 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer: A Randomized Clinical Trial[NCT04221165] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-08-04 | Recruiting | ||
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
7 trials available for diphenhydramine and Stomatitis
| Article | Year |
|---|---|
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents; Area Under Curve; Carcinoma, Renal Cell; C | 2010 |
A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents; Area Under Curve; Carcinoma, Renal Cell; C | 2010 |
Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.
Topics: Adolescent; Aluminum Hydroxide; Amphotericin B; Antineoplastic Agents; Bone Marrow Transplantation; | 1997 |
Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.
Topics: Adolescent; Aluminum Hydroxide; Amphotericin B; Antineoplastic Agents; Bone Marrow Transplantation; | 1997 |
Efficacy of treatment to relieve mucositis-induced discomfort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Antineoplastic Agents; Diphenhydrami | 2000 |
Efficacy of treatment to relieve mucositis-induced discomfort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Antineoplastic Agents; Diphenhydrami | 2000 |
Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis.
Topics: Aluminum Hydroxide; Analysis of Variance; Anesthetics, Local; Antacids; Anti-Infective Agents, Local | 2000 |
Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis.
Topics: Aluminum Hydroxide; Analysis of Variance; Anesthetics, Local; Antacids; Anti-Infective Agents, Local | 2000 |
The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis.
Topics: Adult; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Cobalt; Diphenhydramine; Double-Blind Me | 1991 |
The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis.
Topics: Adult; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Cobalt; Diphenhydramine; Double-Blind Me | 1991 |
Treatment of radiation- and chemotherapy-induced stomatitis.
Topics: Administration, Topical; Cocaine; Diphenhydramine; Drug Combinations; Humans; Kaolin; Lidocaine; Mou | 1990 |
Treatment of radiation- and chemotherapy-induced stomatitis.
Topics: Administration, Topical; Cocaine; Diphenhydramine; Drug Combinations; Humans; Kaolin; Lidocaine; Mou | 1990 |
4 other studies available for diphenhydramine and Stomatitis
| Article | Year |
|---|---|
Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics; Antineoplastic Agents; Diphenhydramine; Drug C | 2017 |
Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics; Antineoplastic Agents; Diphenhydramine; Drug C | 2017 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
["Despa-kowa", orodental ointment for oral mucosal diseases].
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Benzalkonium Compounds; Chlorhexidin | 1982 |
["Despa-kowa", orodental ointment for oral mucosal diseases].
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Benzalkonium Compounds; Chlorhexidin | 1982 |
Pegylated liposomal doxorubicin: tolerability and toxicity.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Diphenhydram | 2001 |
Pegylated liposomal doxorubicin: tolerability and toxicity.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Diphenhydram | 2001 |