Page last updated: 2024-10-26

diphenhydramine and Stevens-Johnson Syndrome

diphenhydramine has been researched along with Stevens-Johnson Syndrome in 9 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
"We selected adverse drug reaction (ADR) reports on H1-antihistamines in children (0-16 years) up to June 2014 from VigiBase."1.46Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase. ( Biagi, C; Calamelli, E; Cipriani, F; Donati, M; Melis, M; Monaco, L; Motola, D; Ricci, G; Vaccheri, A, 2017)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Motola, D1
Donati, M1
Biagi, C1
Calamelli, E1
Cipriani, F1
Melis, M1
Monaco, L1
Vaccheri, A1
Ricci, G1
Minor, DR1
Rodvien, R1
Kashani-Sabet, M1
PINDBORG, JJ1
PINDBORG, S1
Yusin, JS1
Crawford, WW1
Klaustermeyer, WB1
Ward, B1
McCulley, JP1
Segal, RJ1
Soskin, IaM1
Kruglikova, LI1
Epishin, AV1
Likhatskaia, VA1
Furtel', PA1
Kiĭko, FIu1
Vanat, IM1
Timperman, J1
Verbauwhede, W1

Other Studies

9 other studies available for diphenhydramine and Stevens-Johnson Syndrome

ArticleYear
Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
    Pharmacoepidemiology and drug safety, 2017, Volume: 26, Issue:10

    Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Cetirizine; Child; Child Mortality; Child, Pres

2017
Successful desensitization in a case of Stevens-Johnson syndrome due to vemurafenib.
    Melanoma research, 2012, Volume: 22, Issue:5

    Topics: Desensitization, Immunologic; Dexamethasone; Diphenhydramine; Female; Humans; Indoles; Middle Aged;

2012
[Erythema multiforme exsudativum (Stevens-Johnson syndrome) with special consideration on oral manifestations and benadryl therapy].
    Tandlaegebladet, 1953, Volume: 57, Issue:10

    Topics: Diphenhydramine; Erythema Multiforme; Humans; Stevens-Johnson Syndrome

1953
Facial edema, oral ulcers, and a cutaneous eruption following a dental procedure utilizing diflunisal and mepivacaine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:5

    Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diflunisal; Diphenhydram

1999
Dermatologic reaction in Stevens-Johnson syndrome after ophthalmic anesthesia with proparacaine hydrochloride.
    American journal of ophthalmology, 1978, Volume: 86, Issue:1

    Topics: Anesthetics, Local; Conjunctivitis; Diphenhydramine; Female; Furosemide; Humans; Middle Aged; Ophtha

1978
[Acute epidermal necrolysis (Lyell's syndrome) after diagnostic curettage of the uterus].
    Akusherstvo i ginekologiia, 1978, Issue:1

    Topics: Acute Disease; Aged; Dilatation and Curettage; Diphenhydramine; Drug Hypersensitivity; Female; Human

1978
[Recurrent Lyell's syndrome with secondary thrombocytopenia].
    Klinicheskaia meditsina, 1991, Volume: 69, Issue:10

    Topics: Adjuvants, Immunologic; Aminopyrine; Diphenhydramine; Dipyrone; Female; Humans; Middle Aged; Povidon

1991
[Case of cure of Lyell's syndrome].
    Vrachebnoe delo, 1974, Volume: 0, Issue:8

    Topics: Anti-Infective Agents, Local; Calcium Chloride; Diphenhydramine; Drug Therapy, Combination; Female;

1974
Toxic epidermal necrolysis (Lyell syndrome) and its medico-legal implications.
    Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1972, Nov-28, Volume: 71, Issue:2

    Topics: Child, Preschool; Diphenhydramine; Female; Forensic Medicine; Humans; Phenylbutazone; Phenylephrine;

1972