diphenhydramine has been researched along with Status Epilepticus in 7 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "While seizures and sodium channel blockade are recognized complications of diphenhydramine toxicity, reported cases of status epilepticus from diphenhydramine overdose are rare." | 7.76 | Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. ( Duque, D; Hoffman, RS; Jang, DH; Manini, AF; Nelson, LS; Nestor, NB; Trueger, NS, 2010) |
| " He developed partial complex status epilepticus, requiring benzodiazepines, phenytoin, propofol and intubation." | 3.81 | Medication-induced acute dystonic reaction: the challenge of diagnosing movement disorders in the intensive care unit. ( Digby, G; Jalini, S; Taylor, S, 2015) |
| "A 13-month-old male who ingested 20 diphenhydramine (25 mg) tablets presented with seizures and ultimately progressed to status epilepticus and wide-complex tachycardia." | 3.77 | Survival after diphenhydramine ingestion with hemodialysis in a toddler. ( Hendrickson, RG; Horowitz, BZ; McKeown, NJ; West, PL, 2011) |
| "While seizures and sodium channel blockade are recognized complications of diphenhydramine toxicity, reported cases of status epilepticus from diphenhydramine overdose are rare." | 3.76 | Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. ( Duque, D; Hoffman, RS; Jang, DH; Manini, AF; Nelson, LS; Nestor, NB; Trueger, NS, 2010) |
| "A 19-year-old woman presented with status epilepticus and ventricular dysrhythmias less than one hour after ingesting 5,000 mg dimenhydrinate (Dramamine)." | 3.68 | Fatality secondary to massive overdose of dimenhydrinate. ( McDonnell, KP; Winn, RE, 1993) |
| "This report describes the first case of an adult to survive all the major complications of diphenhydramine hydrochloride overdose, including hyperpyrexia, status epilepticus, coma, and cardiac arrhythmias." | 3.67 | Survival in complicated diphenhydramine overdose. ( Cox, PM; D'Amato, SL; Rinder, CS; Rinder, HM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Digby, G | 1 |
| Jalini, S | 1 |
| Taylor, S | 1 |
| Kamijo, Y | 1 |
| Soma, K | 1 |
| Sato, C | 1 |
| Kurihara, K | 1 |
| McKeown, NJ | 1 |
| West, PL | 1 |
| Hendrickson, RG | 1 |
| Horowitz, BZ | 1 |
| Jang, DH | 1 |
| Manini, AF | 1 |
| Trueger, NS | 1 |
| Duque, D | 1 |
| Nestor, NB | 1 |
| Nelson, LS | 1 |
| Hoffman, RS | 1 |
| Moss, W | 1 |
| Ojukwu, C | 1 |
| Chiriboga, CA | 1 |
| Winn, RE | 1 |
| McDonnell, KP | 1 |
| Rinder, CS | 1 |
| D'Amato, SL | 1 |
| Rinder, HM | 1 |
| Cox, PM | 1 |
7 other studies available for diphenhydramine and Status Epilepticus
| Article | Year |
|---|---|
Medication-induced acute dystonic reaction: the challenge of diagnosing movement disorders in the intensive care unit.
Topics: Antipsychotic Agents; Benzodiazepines; Brain; Diphenhydramine; Dyskinesia, Drug-Induced; Haloperidol | 2015 |
Fatal diphenhydramine poisoning with increased vascular permeability including late pulmonary congestion refractory to percutaneous cardiovascular support.
Topics: Acidosis; Adult; Capillary Permeability; Dehydration; Diphenhydramine; Fatal Outcome; Histamine H1 A | 2008 |
Survival after diphenhydramine ingestion with hemodialysis in a toddler.
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Infant; Injections, Intramuscular; Male; Midazolam | 2011 |
Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose.
Topics: Adult; Diphenhydramine; Drug Overdose; Electrocardiography; Female; Histamine H1 Antagonists; Humans | 2010 |
Phenytoin-induced movement disorder. Unilateral presentation in a child and response to diphenhydramine.
Topics: Child, Preschool; Diphenhydramine; Dyskinesia, Drug-Induced; Dystonia; Facial Muscles; Female; Hemip | 1994 |
Fatality secondary to massive overdose of dimenhydrinate.
Topics: Adult; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Charcoal; Colon; Dimenhydrinate; Diphenh | 1993 |
Survival in complicated diphenhydramine overdose.
Topics: Adult; Arrhythmias, Cardiac; Coma; Diphenhydramine; Female; Fever; Humans; Nonprescription Drugs; Ph | 1988 |