diphenhydramine has been researched along with Sleep Wake Disorders in 32 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the safety and efficacy of Linkus, Aminophylline with Diphenhydramine group and Acefyllin Piperazine with Diphenhydramine cough syrup on children having cough and sleep difficulty associated with cough." | 9.22 | Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children. ( Naveed, S; Rehman, H; Usmanghani, K, 2016) |
| "To evaluate the safety and efficacy of Linkus, Aminophylline with Diphenhydramine group and Acefyllin Piperazine with Diphenhydramine cough syrup on children having cough and sleep difficulty associated with cough." | 5.22 | Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children. ( Naveed, S; Rehman, H; Usmanghani, K, 2016) |
| "Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment." | 2.78 | Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. ( Emamian, F; Ghadami, MR; Khazaie, H; Knight, DC; Tahmasian, M, 2013) |
| "This report describes an unexpected adverse effect in three children receiving teniposide at 3-5 times the conventional dosage (i." | 1.28 | Somnolence, hypotension, and metabolic acidosis following high-dose teniposide treatment in children with leukemia. ( Baker, DK; McLeod, HL; Pui, CH; Rodman, JH, 1991) |
| " Possible explanations for the lower frequency of hypnotic use observed in this study as compared to the frequencies reported in the literature are discussed, as are possible hazards of high-dose and long-term use of hypnotics." | 1.27 | Survey of hypnotic drug use in nursing homes. ( James, DS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (53.13) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, Y | 1 |
| Raymer, BK | 1 |
| Abraham, O | 1 |
| Schleiden, L | 1 |
| Albert, SM | 1 |
| Khazaie, H | 1 |
| Ghadami, MR | 1 |
| Knight, DC | 1 |
| Emamian, F | 1 |
| Tahmasian, M | 1 |
| Rehman, H | 1 |
| Naveed, S | 1 |
| Usmanghani, K | 1 |
| Ho, TW | 1 |
| Backonja, M | 1 |
| Ma, J | 1 |
| Leibensperger, H | 1 |
| Froman, S | 1 |
| Polydefkis, M | 1 |
| Tsutsui, R | 1 |
| Shinomiya, K | 2 |
| Takeda, Y | 2 |
| Obara, Y | 1 |
| Kitamura, Y | 1 |
| Kamei, C | 2 |
| Lucey, BP | 1 |
| Noetzel, MJ | 1 |
| Duntley, SP | 1 |
| FLODMARK, S | 1 |
| TEPPER, PA | 1 |
| Simons, FE | 1 |
| Schindler, B | 1 |
| Tokunaga, S | 1 |
| Hirase, M | 1 |
| Derbez, R | 1 |
| Grauer, H | 1 |
| Roberts, K | 1 |
| Gruer, L | 1 |
| Gilhooly, T | 1 |
| Ochs, D | 1 |
| Jovanović, UJ | 1 |
| Summers, JA | 1 |
| Lynch, PS | 1 |
| Harris, JC | 1 |
| Burke, JC | 1 |
| Allison, DB | 1 |
| Sandler, L | 1 |
| McLeod, HL | 1 |
| Baker, DK | 1 |
| Pui, CH | 1 |
| Rodman, JH | 1 |
| Lisi, DM | 1 |
| James, DS | 1 |
| Schröder, R | 1 |
| Brown, CG | 1 |
| Carey, WB | 1 |
| Bel, MA | 1 |
| Passot, E | 1 |
| Boyer, MD | 1 |
| Johns, MW | 1 |
| Hepburn, M | 1 |
| Goodyear, MD | 1 |
| Hirth, R | 1 |
| Engel, J | 1 |
| Orlandi, OV | 1 |
| Vaisman, J | 1 |
| Weiss, L | 1 |
| Marsiaj, B | 1 |
| Paciornik, H | 1 |
| Mello, Ode O | 1 |
| Kertesz, R | 1 |
| Savorgnan, JA | 1 |
| Keen, CE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT05753943] | 0 participants | Expanded Access | No longer available | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diphenhydramine and Sleep Wake Disorders
| Article | Year |
|---|---|
Sleep modulating agents.
Topics: Animals; Humans; Sleep; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Wakefulness-Promoting Agen | 2019 |
8 trials available for diphenhydramine and Sleep Wake Disorders
| Article | Year |
|---|---|
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial.
Topics: Actigraphy; Adult; Antidepressive Agents, Second-Generation; Depression; Depression, Postpartum; Dip | 2013 |
Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children.
Topics: Age Factors; Aminophylline; Antitussive Agents; Bronchodilator Agents; Child; Child, Preschool; Coug | 2016 |
Efficient assessment of neuropathic pain drugs in patients with small fiber sensory neuropathies.
Topics: Adolescent; Adult; Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diphenhydram | 2009 |
A sleep study and investigation of a new hypnotic compound in a geriatric population.
Topics: Aged; Arteriosclerosis; Bronchitis; Chronic Disease; Diabetes Complications; Diphenhydramine; Female | 1967 |
[Double-blind clinical study of rohypnol (author's transl)].
Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Diphenhydramine; Drug Evaluation; Hu | 1975 |
[Polygraphic recording of sleep under the influence of Plantival plus].
Topics: Adult; Clinical Trials as Topic; Diphenhydramine; Drug Combinations; Drug Evaluation; Electroencepha | 1976 |
[Experiences with the soporific Mandrax].
Topics: Aged; Diphenhydramine; Drug Combinations; Evaluation Studies as Topic; Humans; Methaqualone; Middle | 1972 |
[Insomnia in old men. Double-blind study of a nonbarbiturate hypnotic agent].
Topics: Aged; Clinical Trials as Topic; Diphenhydramine; Female; Humans; Hypnotics and Sedatives; Male; Meth | 1971 |
23 other studies available for diphenhydramine and Sleep Wake Disorders
| Article | Year |
|---|---|
Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep.
Topics: Age Factors; Aged; Aged, 80 and over; Cross-Sectional Studies; Diphenhydramine; Doxylamine; Female; | 2017 |
Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats.
Topics: Animals; Delta Rhythm; Diphenhydramine; Electroencephalography; Electromyography; Hypnotics and Seda | 2009 |
Paroxysmal arousals and myoclonic movements associated with interictal epileptiform discharges in NREM and REM sleep.
Topics: Adolescent; Amines; Antiparkinson Agents; Arousal; Chromosome Disorders; Chromosome Inversion; Chrom | 2011 |
[Senidorm, a new combined hypnotic without barbiturate for aged patients].
Topics: Aged; Barbiturates; Codeine; Diphenhydramine; Disease; Humans; Hypnotics and Sedatives; Phenacetin; | 1954 |
[Dimedrol as a somnifacient].
Topics: Diphenhydramine; Health Services; Humans; Hypnotics and Sedatives; Sleep Wake Disorders | 1958 |
Do over-the-counter cough remedies work?
Topics: Antitussive Agents; Child; Dextromethorphan; Diphenhydramine; Humans; Nonprescription Drugs; Sleep W | 2004 |
Benadryl for infant sleep?
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Infant; Sleep Wake Disorders | 2006 |
Diphenhydramine in infants.
Topics: Central Nervous System; Child, Preschool; Diphenhydramine; Histamine H1 Antagonists; Humans; Infant; | 2007 |
[Diphenhydramine does not help the poor sleeper].
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Sleep Wake Disorders | 2007 |
Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats.
Topics: Animals; Chlorpheniramine; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Electr | 2007 |
Misuse of diphenhydramine soft gel capsules (Sleepia): a cautionary tale from Glasgow.
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Sleep Wake Disorders; Substance-Related Disorders | 1999 |
A combined behavioral/pharmacological treatment of sleep-wake schedule disorder in Angelman syndrome.
Topics: Behavior Therapy; Child; Chromosome Deletion; Chromosomes, Human, Pair 15; Circadian Rhythm; Combine | 1992 |
Somnolence, hypotension, and metabolic acidosis following high-dose teniposide treatment in children with leukemia.
Topics: Acidosis; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Diphe | 1991 |
Temazepam and diphenhydramine in nursing homes.
Topics: Aged; Anti-Anxiety Agents; Diphenhydramine; Female; Homes for the Aged; Humans; Male; Nursing Homes; | 1989 |
Survey of hypnotic drug use in nursing homes.
Topics: Aged; Diphenhydramine; Drug Administration Schedule; Drug Prescriptions; Drug Utilization; Female; F | 1985 |
Prescribing Mandrax.
Topics: Diphenhydramine; Humans; Methaqualone; Sleep Wake Disorders; State Medicine; Substance-Related Disor | 1973 |
Night waking and temperament in infancy.
Topics: Barbiturates; Chloral Hydrate; Diphenhydramine; Environment; Female; Humans; Infant; Male; Personali | 1974 |
Use of hypnotic drugs by hospital patients.
Topics: Adult; Aged; Amobarbital; Antipyrine; Barbiturates; Diphenhydramine; Female; Hospitalization; Humans | 1971 |
[Experience with the new soporific agent Mandrax].
Topics: Adult; Aged; Diphenhydramine; Electroencephalography; Humans; Methaqualone; Middle Aged; Sleep Wake | 1971 |
[Experience with a new form of Mandrix in sleep disorders in children].
Topics: Adolescent; Body Weight; Child; Diphenhydramine; Female; Humans; Male; Methaqualone; Sleep Wake Diso | 1969 |
[Mandrix. Clinical study].
Topics: Adolescent; Adult; Aged; Diphenhydramine; Female; Humans; Male; Methaqualone; Middle Aged; Sleep Wak | 1969 |
[Clinical use of Mandrix].
Topics: Adult; Aged; Ambulatory Care; Diphenhydramine; Female; Humans; Male; Methaqualone; Middle Aged; Slee | 1969 |
[Treatment of sleep disorders using a methaqualone-diphenhydramine combination].
Topics: Adolescent; Adult; Child; Child, Preschool; Diphenhydramine; Humans; Methaqualone; Middle Aged; Slee | 1969 |