diphenhydramine has been researched along with Sensitivity and Specificity in 15 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenhydramine was used as the internal standard." | 1.39 | Development and validation of UPLC-MS/MS method for determination of domperidone in human plasma and its pharmacokinetic application. ( Jing, L; Li, F; Qin, F; Wang, X; Xiong, Z; Zhu, Q, 2013) |
| " The results demonstrated that the present LC-MS/MS method was sensitive enough for pharmacokinetic study of stachydrine and leonurine following oral administration of Herba Leonuri extract." | 1.39 | Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS. ( Li, B; Li, X; Wu, J, 2013) |
| "A novel, stability-indicating gradient reverse-phase ultra-performance liquid chromatographic method was developed for the simultaneous determination of ibuprofen and diphenhydramine citrate in the presence of degradation products and process related impurities in combined dosage form." | 1.37 | Development and validation of an UPLC method for rapid determination of ibuprofen and diphenhydramine citrate in the presence of impurities in combined dosage form. ( Mukkanti, K; Rao, DD; Sait, SS, 2011) |
| " The method was successfully applied to pharmacokinetic study of the QAAMC in beagle dogs." | 1.34 | Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of D-amphetamine and diphenhydramine in beagle dog plasma and its application to a pharmacokinetic study. ( Chen, Y; Fan, G; Lin, M; Wang, C; Wu, Y; Zhao, W, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hofer, A | 1 |
| Kovacs, G | 1 |
| Zappatini, A | 1 |
| Leuenberger, M | 1 |
| Hediger, MA | 1 |
| Lochner, M | 1 |
| Li, J | 1 |
| Zhang, L | 2 |
| Cheng, X | 1 |
| Shen, B | 1 |
| Qing, C | 1 |
| Fan, G | 2 |
| Ismaiel, OA | 1 |
| Halquist, MS | 1 |
| Elmamly, MY | 1 |
| Shalaby, A | 1 |
| Thomas Karnes, H | 1 |
| Rao, DD | 1 |
| Sait, SS | 1 |
| Mukkanti, K | 1 |
| Frag, EY | 1 |
| Mohamed, GG | 1 |
| El-Sayed, WG | 1 |
| Zhu, D | 1 |
| Li, X | 2 |
| Sun, J | 1 |
| You, T | 1 |
| Wang, X | 1 |
| Qin, F | 1 |
| Jing, L | 1 |
| Zhu, Q | 1 |
| Li, F | 1 |
| Xiong, Z | 1 |
| Li, B | 1 |
| Wu, J | 1 |
| Uebel, RA | 1 |
| Wium, CA | 1 |
| LOEW, ER | 1 |
| Wang, C | 1 |
| Lin, M | 1 |
| Chen, Y | 1 |
| Zhao, W | 1 |
| Wu, Y | 1 |
| Sarter, M | 1 |
| Bushnell, PJ | 1 |
| Robinson, MK | 1 |
| Cruze, CA | 1 |
| Sporkert, F | 1 |
| Pragst, F | 1 |
| Caturla, MC | 1 |
| Salomo, J | 1 |
| Soler, M | 1 |
| Martinez, L | 1 |
| Roser, R | 1 |
15 other studies available for diphenhydramine and Sensitivity and Specificity
| Article | Year |
|---|---|
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.
Topics: Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Drug Design; HEK293 Cells; Hum | 2013 |
Determination of d-amphetamine and diphenhydramine in beagle dog plasma by a 96-well formatted liquid-liquid extraction and capillary zone electrophoresis with field-amplified sample stacking.
Topics: Animals; Calibration; Capsules; Chromatography, High Pressure Liquid; Dextroamphetamine; Diphenhydra | 2018 |
Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations.
Topics: Chlorpheniramine; Chromatography, Liquid; Diphenhydramine; Glycerylphosphorylcholine; Histamine H1 A | 2008 |
Development and validation of an UPLC method for rapid determination of ibuprofen and diphenhydramine citrate in the presence of impurities in combined dosage form.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Diphenhydramine; Drug Combinati | 2011 |
Potentiometric determination of antihistaminic diphenhydramine hydrochloride in pharmaceutical preparations and biological fluids using screen-printed electrode.
Topics: Anti-Allergic Agents; Diphenhydramine; Electrodes; Humans; Pharmaceutical Preparations; Potentiometr | 2011 |
Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.
Topics: Buffers; Chlorpheniramine; Cyproheptadine; Diphenhydramine; Doxylamine; Electrochemistry; Electropho | 2012 |
Development and validation of UPLC-MS/MS method for determination of domperidone in human plasma and its pharmacokinetic application.
Topics: Chromatography, High Pressure Liquid; Diphenhydramine; Domperidone; Drug Stability; Humans; Linear M | 2013 |
Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Diphenhydramine; Gallic Acid; L | 2013 |
Toxicological screening for drugs of abuse in samples adulterated with household chemicals.
Topics: Adult; Cannabis; Detergents; Diphenhydramine; Drug Combinations; Drug Contamination; False Negative | 2002 |
The pharmacology of benadryl and the specificity of antihistamine drugs.
Topics: Diphenhydramine; Histamine; Histamine Antagonists; Sensitivity and Specificity | 1950 |
Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of D-amphetamine and diphenhydramine in beagle dog plasma and its application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Dextroamphetamine; Diphenhydramine; Dogs; Reference S | 2007 |
Testing vigilance: validity, reliability and sensitivity in methods development.
Topics: Attention; Caffeine; Diphenhydramine; Humans; Reproducibility of Results; Research Design; Sensitivi | 1995 |
Preclinical skin sensitization testing of antihistamines: guinea pig and local lymph node assay responses.
Topics: Animals; Chlorpheniramine; Dermatitis, Allergic Contact; Diphenhydramine; Evaluation Studies as Topi | 1996 |
Use of headspace solid-phase microextraction (HS-SPME) in hair analysis for organic compounds.
Topics: Antidepressive Agents, Tricyclic; Cannabinoids; Chlormethiazole; Diphenhydramine; Gas Chromatography | 2000 |
Validation of GC method to measure a new analgesic (E-4018) in biological samples. Comparison between HPLC and GC method.
Topics: Analgesics; Animals; Body Fluids; Calibration; Chromatography, Gas; Chromatography, High Pressure Li | 1991 |