diphenhydramine has been researched along with Seizures in 45 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| ", doses of individual drugs) that induced seizure-like events, and identified diphenhydramine, enoxacin, strychnine and theophylline as "seizure-inducing" drugs, which have indeed been reported to induce seizures in clinical situations." | 4.98 | [Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect]. ( Gao, M; Ikegaya, Y; Sato, M, 2018) |
| "A 13-month-old male who ingested 20 diphenhydramine (25 mg) tablets presented with seizures and ultimately progressed to status epilepticus and wide-complex tachycardia." | 3.77 | Survival after diphenhydramine ingestion with hemodialysis in a toddler. ( Hendrickson, RG; Horowitz, BZ; McKeown, NJ; West, PL, 2011) |
| " Initial electrocardiograms revealed sinus tachycardia at a rate of 180 beats per minute, a prolonged QRS of 130 milliseconds (from a baseline of 65 milliseconds), and a positive terminal R wave in aVR, which later resolved after sodium bicarbonate treatment." | 3.77 | Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate. ( Cole, JB; Gross, EA; Smith, SW; Stellpflug, SJ, 2011) |
| " Although physostigmine is considered an acceptable antidote for severe DPH toxicity, adverse effects such as seizures and cholinergic crisis may occur." | 3.71 | Physostigmine, sodium bicarbonate, or hypertonic saline to treat diphenhydramine toxicity. ( Engebretsen, KM; Harris, CR; Holger, JS, 2002) |
| "Overdosage of diphenhydramine may result in the development of anticholinergic symptoms, seizures, and coma." | 3.66 | Massive diphenhydramine overdose resulting in death. ( Anderson, GM; Krenzelok, EP; Mirick, M, 1982) |
| "Diphenhydramine has not been previously identified as a medication likely to form a pharmacobezoar and has not been shown to be radiopaque." | 1.46 | Adolescent with prolonged toxidrome. ( Banner, W; Johnson, J; Williams, K, 2017) |
| "Pretreatment of amitriptyline, but not diphenhydramine, before scopolamine treatment suppressed the incidence of convulsions." | 1.36 | Scopolamine-induced convulsions in fasted mice after food intake: evaluation of the sedative effect in the suppression of convulsions. ( Baran, E; Enginar, N; Karamürsel, Y; Nurten, A; Zengin, A, 2010) |
| "In this study, electroconvulsion was induced by stimulating rats using ear-clip electrodes, and the durations of electroencephalogram (EEG) seizure, tonic extensor (TE) seizure and clonic (CL) seizure induced by maximal electroshock were measured." | 1.34 | Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats. ( Ago, J; Ishikawa, T; Kamei, C; Matsumoto, N; Murakami, A; Rahman, A; Takechi, K, 2007) |
| "Diphenhydramine was administered orally in the dose schedules of once daily (10, 20 and 40 mg/kg) and twice daily (5, 10 and 20 mg/kg) in separate groups during the withdrawal period." | 1.30 | Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats. ( Gupta, MB; Nath, C; Patnaik, GK; Saxena, RC, 1997) |
| "Of 233 charts coded as involving seizures, 191 occurred in humans and were available for analysis." | 1.29 | Seizures associated with poisoning and drug overdose. ( Benowitz, NL; Blanc, PD; Dyer, JE; Kearney, TE; Olson, KR, 1993) |
| "Generalized tonic clonic seizures continued despite conventional therapy." | 1.28 | Accidental childhood death from diphenhydramine overdosage. ( Dean, BS; Goetz, CM; Krenzelok, EP; Lopez, G, 1990) |
| "Glycogen was depleted only by amphetamine-like compounds or by bemegride-induced convulsions." | 1.25 | Physiological and drug-induced changes in the glycogen content of mouse brain. ( Hutchins, DA; Rogers, KJ, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (48.89) | 18.7374 |
| 1990's | 7 (15.56) | 18.2507 |
| 2000's | 5 (11.11) | 29.6817 |
| 2010's | 10 (22.22) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Darracq, MA | 1 |
| Thornton, SL | 1 |
| Johnson, J | 1 |
| Williams, K | 1 |
| Banner, W | 1 |
| Gao, M | 2 |
| Sato, M | 1 |
| Ikegaya, Y | 2 |
| Vyas, D | 1 |
| Lackey, G | 1 |
| McCulloh, RJ | 1 |
| Li, K | 1 |
| Gugelmann, H | 1 |
| Tabas, JA | 1 |
| Ueda, T | 1 |
| Igata, H | 1 |
| Takeuchi, A | 1 |
| Sato, K | 1 |
| Irioka, T | 1 |
| Yamanami, A | 1 |
| Uchida, N | 1 |
| Iwase, M | 1 |
| Yasuhara, H | 1 |
| Mizusawa, H | 1 |
| Enginar, N | 1 |
| Nurten, A | 1 |
| Karamürsel, Y | 1 |
| Zengin, A | 1 |
| Baran, E | 1 |
| McKeown, NJ | 1 |
| West, PL | 1 |
| Hendrickson, RG | 1 |
| Horowitz, BZ | 1 |
| Pyle, R | 1 |
| Scott, M | 1 |
| Bartholomew, J | 1 |
| McGrath, S | 1 |
| Moffett, B | 1 |
| Cole, JB | 1 |
| Stellpflug, SJ | 1 |
| Gross, EA | 1 |
| Smith, SW | 1 |
| DE SALVA, S | 1 |
| WEINBERG, WA | 1 |
| BAUER, AR | 1 |
| HOWARD, PJ | 1 |
| CAHEN, R | 1 |
| BOUCHERLE, A | 1 |
| BESTER, JF | 1 |
| Nine, JS | 1 |
| Rund, CR | 1 |
| Saxena, M | 1 |
| Gaur, S | 1 |
| Prathipati, P | 1 |
| Saxena, AK | 1 |
| Ishikawa, T | 1 |
| Takechi, K | 1 |
| Rahman, A | 1 |
| Ago, J | 1 |
| Matsumoto, N | 1 |
| Murakami, A | 1 |
| Kamei, C | 1 |
| Krenzelok, EP | 2 |
| Anderson, GM | 1 |
| Mirick, M | 1 |
| Altorfer, R | 1 |
| Olson, KR | 1 |
| Kearney, TE | 1 |
| Dyer, JE | 1 |
| Benowitz, NL | 1 |
| Blanc, PD | 1 |
| Goodfellow, LM | 1 |
| Chan, AT | 1 |
| Yeo, W | 1 |
| Leung, WT | 1 |
| Johnson, PJ | 1 |
| Nath, C | 1 |
| Patnaik, GK | 1 |
| Saxena, RC | 1 |
| Gupta, MB | 1 |
| Holger, JS | 1 |
| Harris, CR | 1 |
| Engebretsen, KM | 1 |
| Lewis, D | 1 |
| Isaac, L | 1 |
| Verrill, PJ | 1 |
| Obeid, AI | 1 |
| Johnson, L | 1 |
| Potts, J | 1 |
| Mookherjee, S | 1 |
| Eich, RH | 1 |
| Lourwood, DL | 1 |
| Berchou, RC | 1 |
| Louis-Ferdinand, RT | 1 |
| Hue, V | 1 |
| Meneguz, C | 1 |
| Martinot, A | 1 |
| Leclerc, F | 1 |
| Goetz, CM | 1 |
| Lopez, G | 1 |
| Dean, BS | 1 |
| Iorio, LC | 1 |
| Cohen-Winston, M | 1 |
| Barnett, A | 1 |
| Sanderson, JH | 1 |
| Cowdell, RH | 1 |
| Higgins, G | 1 |
| Okuma, T | 1 |
| Kuba, K | 1 |
| Matsushita, T | 1 |
| Nakao, T | 1 |
| Fujii, S | 1 |
| Shimoda, Y | 1 |
| Dashputra, PG | 1 |
| Sharma, ML | 1 |
| Jagtap, MK | 1 |
| Khapre, MD | 1 |
| Rajapurkar, MV | 1 |
| Chusid, JG | 1 |
| Kopeloff, LM | 1 |
| Frank, GB | 2 |
| Jhamandas, K | 2 |
| Kita, T | 1 |
| Hata, T | 1 |
| Murakami, T | 1 |
| Siroky, N | 1 |
| McManus, WF | 1 |
| Hunt, JL | 1 |
| Pruitt, BA | 1 |
| Hutchins, DA | 1 |
| Rogers, KJ | 1 |
| Kato, M | 1 |
2 reviews available for diphenhydramine and Seizures
| Article | Year |
|---|---|
[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].
Topics: Animals; Diphenhydramine; Drug Discovery; Drug Evaluation, Preclinical; Drug-Related Side Effects an | 2018 |
Fatality from diphenhydramine monointoxication: a case report and review of the infant, pediatric, and adult literature.
Topics: Accidents; Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Child, Preschool | 2006 |
43 other studies available for diphenhydramine and Seizures
| Article | Year |
|---|---|
A different challenge with Benadryl: adolescent diphenhydramine ingestions reported to National Poison Database System, 2007-2020.
Topics: Adolescent; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Eating; Humans; Poison | 2022 |
Adolescent with prolonged toxidrome.
Topics: Adolescent; Bezoars; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Emergency Service, Hos | 2017 |
Acute overdose: suicide attempt.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Diphenhydramine; Drug Overdose; Educ | 2013 |
Young Woman With Seizures.
Topics: Adult; Diagnosis, Differential; Diphenhydramine; Drug Overdose; Electrocardiography; Emergency Servi | 2015 |
[A case of opsoclonus due to diphenhydramine overdose in which ECG change could be used to predict convulsion].
Topics: Administration, Oral; Adult; Diphenhydramine; Drug Overdose; Electrocardiography; Female; Humans; Oc | 2014 |
Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.
Topics: Animals; CA1 Region, Hippocampal; Diphenhydramine; Enoxacin; In Vitro Techniques; Male; Mice; Mice, | 2017 |
Opsoclonus caused by diphenhydramine self-poisoning.
Topics: Autonomic Nervous System Diseases; Coma; Diphenhydramine; Humans; Hypnotics and Sedatives; Male; Ocu | 2009 |
Scopolamine-induced convulsions in fasted mice after food intake: evaluation of the sedative effect in the suppression of convulsions.
Topics: Amitriptyline; Animals; Body Weight; Chlorpromazine; Diphenhydramine; Eating; Food Deprivation; Hypn | 2010 |
Survival after diphenhydramine ingestion with hemodialysis in a toddler.
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Infant; Injections, Intramuscular; Male; Midazolam | 2011 |
Accidental polydipsia and hyponatremia from diphenhydramine urinary retention.
Topics: Aged; Diphenhydramine; Drinking; Fluid Therapy; Histamine H1 Antagonists; Humans; Hyponatremia; Male | 2011 |
Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate.
Topics: Anticonvulsants; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Electrocardiography; Emerg | 2011 |
Effect of drugs on EST in various endocrine deficient states.
Topics: Adrenalectomy; Diphenhydramine; Ephedrine; Hydantoins; Hypophysectomy; Lysergic Acid Diethylamide; M | 1963 |
CONTROL OF THE NEUROMUSCULAR AND CONVULSIVE MANIFESTATIONS OF SEVERE SYSTEMIC TETANUS: CASE REPORT WITH A NEW DRUG, VALIUM (DIAZEPAM).
Topics: Amobarbital; Child; Diazepam; Diphenhydramine; Humans; Neurologic Manifestations; Penicillins; Pheno | 1964 |
ENCEPHALITIS FOLLOWING MODIFIED MEASLES.
Topics: Child; Diphenhydramine; Drug Therapy; Electroencephalography; Encephalitis; Encephalomyelitis, Acute | 1964 |
[CENTRAL EFFECT OF (TRICHLORO-1',1',1'-HYDROXY-2'-ETHYL)-3-DIPHENYL-5,5-TETRAHYDROGLYOXALINE-ONE 4].
Topics: Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Biphenyl Compounds; Diphenhydramine; Elect | 1964 |
SCREENING OF FIVE NEW SYNTHETIC COMPOUNDS FOR ANTICONVULSANT ACTIVITY.
Topics: Anticonvulsants; Benzoates; Diphenhydramine; Pharmacology; Rats; Research; Seizures; Sulfanilamide; | 1965 |
Synthesis of some substituted pyrazinopyridoindoles and 3D QSAR studies along with related compounds: piperazines, piperidines, pyrazinoisoquinolines, and diphenhydramine, and its semi-rigid analogs as antihistamines (H1).
Topics: Animals; Diphenhydramine; Guinea Pigs; Histamine Antagonists; Ileum; Indoles; Male; Mice; Molecular | 2006 |
Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.
Topics: Administration, Oral; Animals; Animals, Suckling; Chlorpheniramine; Cyproheptadine; Dibenzazepines; | 2007 |
Massive diphenhydramine overdose resulting in death.
Topics: Adolescent; Arrhythmias, Cardiac; Diphenhydramine; Female; Gastric Lavage; Heart Arrest; Humans; Res | 1982 |
[Diphenhydramine poisoning (author's transl)].
Topics: Adolescent; Adult; Antidotes; Diphenhydramine; Female; Humans; Hypertension; Male; Psychoses, Substa | 1981 |
Seizures associated with poisoning and drug overdose.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Caus | 1993 |
Action stat. Adverse reaction to benadryl.
Topics: Adult; Amoxicillin; Anti-Allergic Agents; Coma; Diphenhydramine; Drug Eruptions; Emergency Nursing; | 1996 |
Thromboembolic events with paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cerebral Infarction; Diphenhydramine; Female; H | 1996 |
Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats.
Topics: Acoustic Stimulation; Administration, Oral; Aggression; Animals; Anti-Anxiety Agents; Body Temperatu | 1997 |
Physostigmine, sodium bicarbonate, or hypertonic saline to treat diphenhydramine toxicity.
Topics: Animals; Antidotes; Diphenhydramine; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Seizures; Sodi | 2002 |
Effects of antihistaminic drugs on feline brain monoamine metabolism.
Topics: Animals; Body Temperature; Cats; Diphenhydramine; Dopamine; Electroencephalography; Histamine H1 Ant | 1977 |
Adverse reactions to local anaesthetics and vasoconstrictor drugs.
Topics: Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Arteriosclerosis; Blood Pressure; Coronary Dise | 1975 |
Fluid therapy in severe systemic reaction to radiopaque dye.
Topics: Anaphylaxis; Blood Pressure; Cardiac Catheterization; Contrast Media; Diphenhydramine; Drug Hypersen | 1975 |
Diminished mephobarbital anticonvulsant action following diphenhydramine pretreatment.
Topics: Animals; Diphenhydramine; Drug Interactions; Female; Mephobarbital; Mice; Pentylenetetrazole; Seizur | 1992 |
[Antihistamines and antidepressants: poisoning with similar symptoms].
Topics: Arrhythmias, Cardiac; Child, Preschool; Diphenhydramine; Drug Combinations; Humans; Male; Methaqualo | 1990 |
Accidental childhood death from diphenhydramine overdosage.
Topics: Diphenhydramine; Humans; Infant; Male; Seizures | 1990 |
Interaction studies in mice of SCH 29851, a potential non-sedating antihistamine, with commonly used therapeutic agents.
Topics: Animals; Benzhydryl Compounds; Diphenhydramine; Dose-Response Relationship, Drug; Electroshock; Hexo | 1986 |
Fatal poisoning with methaqualone and diphenhydramine.
Topics: Diphenhydramine; Female; Humans; Injections, Intramuscular; Methaqualone; Middle Aged; Paraldehyde; | 1966 |
Study on 14 and 6 per second positive spikes during nocturnal sleep.
Topics: Adolescent; Adult; Age Factors; Brain; Brain Diseases; Craniocerebral Trauma; Diphenhydramine; Elect | 1968 |
Modification of metrazol induced convulsions in rats by antihistaminics.
Topics: Animals; Diphenhydramine; Histamine H1 Antagonists; Pentylenetetrazole; Pheniramine; Piperazines; Pr | 1966 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; C | 1969 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central | 1970 |
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous Sy | 1970 |
The management of difficult cases of epilepsy with mandrax.
Topics: Adolescent; Diphenhydramine; Epilepsy, Tonic-Clonic; Humans; Methaqualone; Seizures | 1972 |
Postburn convulsive disorders in children.
Topics: Adolescent; Age Factors; Autopsy; Brain Edema; Burns; Carbenicillin; Child; Child, Preschool; Diphen | 1974 |
Physiological and drug-induced changes in the glycogen content of mouse brain.
Topics: Amphetamine; Animals; Bemegride; Body Temperature; Brain Chemistry; Caffeine; Catecholamines; Circad | 1970 |
[Case of tonic seizure].
Topics: Adult; Arm; Benzazepines; Diphenhydramine; Electroencephalography; Epilepsy; Humans; Injections, Int | 1970 |
Effects of general depressant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
Topics: Action Potentials; Aminobutyrates; Anesthesia, General; Anesthesia, Local; Animals; Cats; Cerebral C | 1970 |