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diphenhydramine and Rhabdomyolysis

diphenhydramine has been researched along with Rhabdomyolysis in 13 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.

Research Excerpts

ExcerptRelevanceReference
"To report a case of nontraumatic rhabdomyolysis complicated by oliguric, acute renal failure following an intentional overdose of ethanol and diphenhydramine."7.72Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose. ( Haas, CE; Magram, Y; Mishra, A, 2003)
" We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt."5.29Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose. ( Caravati, EM; Emadian, SM; Herr, RD, 1996)
"To report a case of nontraumatic rhabdomyolysis complicated by oliguric, acute renal failure following an intentional overdose of ethanol and diphenhydramine."3.72Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose. ( Haas, CE; Magram, Y; Mishra, A, 2003)
" We report a case of a suicide attempt in a young adult male where ingestion of the antihistamines diphenhydramine and doxylamine was complicated by non-traumatic rhabdomyolysis and acute renal failure."3.68Non-traumatic rhabdomyolysis complicating antihistamine overdose. ( Dolgin, J; Frankel, D; Murray, BM, 1993)
" We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt."1.29Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose. ( Caravati, EM; Emadian, SM; Herr, RD, 1996)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's4 (30.77)18.2507
2000's5 (38.46)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Madey, JJ1
Price, AB1
Dobson, JV1
Stickler, DE1
McSwain, SD1
Irioka, T1
Yamanami, A1
Uchida, N1
Iwase, M1
Yasuhara, H1
Mizusawa, H1
Pyle, R1
Scott, M1
Bartholomew, J1
McGrath, S1
Moffett, B1
Vearrier, D1
Curtis, JA1
Stucka, KR1
Mycyk, MB2
Leikin, JB1
Pallasch, EM1
Haas, CE1
Magram, Y1
Mishra, A1
Mazor, SS1
Khosla, U1
Ruel, KS1
Hunt, DP1
Steidle, B1
Klein, M1
Viertel, A1
Sachunsky, I1
Wolf, G1
Blaser, C1
Frankel, D1
Dolgin, J1
Murray, BM1
Emadian, SM1
Caravati, EM1
Herr, RD1
Steinhoff, J1
Kirschstein, M1
Castan, H1
Sack, K1

Reviews

1 review available for diphenhydramine and Rhabdomyolysis

ArticleYear
[Computed tomography in acute rhabdomyolysis].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1995, Volume: 163, Issue:4

    Topics: Acute Disease; Adult; Cocaine; Diagnosis, Differential; Diphenhydramine; Heroin Dependence; Humans;

1995

Other Studies

12 other studies available for diphenhydramine and Rhabdomyolysis

ArticleYear
Facial diplegia, pharyngeal paralysis, and ophthalmoplegia after a timber rattlesnake envenomation.
    Pediatric emergency care, 2013, Volume: 29, Issue:11

    Topics: Animals; Antivenins; Child; Combined Modality Therapy; Crotalid Venoms; Crotalus; Crotoxin; Diphenhy

2013
Opsoclonus caused by diphenhydramine self-poisoning.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2009, Volume: 29, Issue:1

    Topics: Autonomic Nervous System Diseases; Coma; Diphenhydramine; Humans; Hypnotics and Sedatives; Male; Ocu

2009
Accidental polydipsia and hyponatremia from diphenhydramine urinary retention.
    The American journal of medicine, 2011, Volume: 124, Issue:10

    Topics: Aged; Diphenhydramine; Drinking; Fluid Therapy; Histamine H1 Antagonists; Humans; Hyponatremia; Male

2011
Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3

    Topics: Adult; Blood Chemical Analysis; Central Nervous System Depressants; Compartment Syndromes; Depressiv

2011
Rhabdomyolysis associated with unintentional antihistamine overdose in a child.
    Pediatric emergency care, 2003, Volume: 19, Issue:1

    Topics: Diphenhydramine; Drug Overdose; Histamine H1 Antagonists; Humans; Infant; Male; Rhabdomyolysis

2003
Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:4

    Topics: Adult; Creatinine; Diphenhydramine; Drug Overdose; Ethanol; Humans; Kidney; Male; Muscle, Skeletal;

2003
Comment: Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:9

    Topics: Acute Kidney Injury; Adult; Diphenhydramine; Drug Overdose; Ethanol; Humans; Male; Rhabdomyolysis; T

2003
Antihistamine-induced rhabdomyolysis.
    Southern medical journal, 2003, Volume: 96, Issue:10

    Topics: Adult; Diphenhydramine; Doxylamine; Drug Overdose; Histamine H1 Antagonists; Humans; Male; Rhabdomyo

2003
Treatment of diphenhydramine intoxication with haemoperfusion.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9, Issue:9

    Topics: Adult; Diphenhydramine; Hemoperfusion; Humans; Male; Poisoning; Rhabdomyolysis

1994
Non-traumatic rhabdomyolysis complicating antihistamine overdose.
    Journal of toxicology. Clinical toxicology, 1993, Volume: 31, Issue:3

    Topics: Acute Kidney Injury; Adult; Blood Urea Nitrogen; Creatinine; Diphenhydramine; Doxylamine; Drug Overd

1993
Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose.
    The American journal of emergency medicine, 1996, Volume: 14, Issue:6

    Topics: Adult; Diphenhydramine; Drug Overdose; Histamine H1 Antagonists; Humans; Male; Rhabdomyolysis; Suici

1996
[Acute oliguric kidney failure after rhabdomyolysis caused by diphenhydramine].
    Deutsche medizinische Wochenschrift (1946), 1985, Dec-20, Volume: 110, Issue:51-52

    Topics: Acute Kidney Injury; Adult; Diphenhydramine; Humans; Male; Oliguria; Rhabdomyolysis; Suicide, Attemp

1985