diphenhydramine has been researched along with Recrudescence in 19 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches." | 9.17 | A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches. ( Adewunmi, V; Bijur, PE; Campbell, C; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2013) |
| "Ondansetron is as effective as diphenhydramine in relieving pruritus caused by SA morphine in patients undergoing a cesarean delivery." | 9.14 | Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. ( Adham, AM; Aouad, MT; Dagher, CM; Saasouh, WA; Siddik-Sayyid, SM; Yazbeck-Karam, VG; Zahreddine, BW, 2010) |
| "We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches." | 5.17 | A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches. ( Adewunmi, V; Bijur, PE; Campbell, C; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2013) |
| "Ondansetron is as effective as diphenhydramine in relieving pruritus caused by SA morphine in patients undergoing a cesarean delivery." | 5.14 | Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. ( Adham, AM; Aouad, MT; Dagher, CM; Saasouh, WA; Siddik-Sayyid, SM; Yazbeck-Karam, VG; Zahreddine, BW, 2010) |
| "Leucocytes from healthy donors were isolated and incubated in varying concentrations of ciclosporin, ascomycin, methotrexate, diphenhydramine or hydroxyzine for 30 min prior to stimulation with serum from urticaria patients known to have functional immunoglobulin (Ig)G antibodies directed against the alpha subunit of the IgE receptor." | 3.73 | Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria. ( Joseph, K; Kaplan, AP; Marsland, AM; Soundararajan, S, 2005) |
| "Anaphylactoid reactions are nonimmune mediated, but histamine release and other mediators produce a clinical presentation indistinguishable from anaphylaxis." | 2.39 | Systemic anaphylactoid reactions to iodinated contrast media during cardiac catheterization procedures: guidelines for prevention, diagnosis, and treatment. Laboratory Performance Standards Committee of the Society for Cardiac Angiography and Intervention ( Chambers, CE; Goss, JE; Heupler, FA, 1995) |
| "The majority of children with migraines are successfully discharged from the ED and only 1 in 18 required a revisit within 3 days." | 1.42 | A comparison of acute treatment regimens for migraine in the emergency department. ( Bachur, RG; Monuteaux, MC; Neuman, MI, 2015) |
| "Patients with a history of anaphylactoid reaction to radiographic contrast medium (RCM) are at increased risk for subsequent reaction." | 1.26 | Severe anaphylactoid reaction to radiographic contrast media. Recurrences despites premedication with diphenhydramine and prednisone. ( Madowitz, JS; Schweiger, MJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friedman, BW | 1 |
| Adewunmi, V | 1 |
| Campbell, C | 1 |
| Solorzano, C | 1 |
| Esses, D | 1 |
| Bijur, PE | 1 |
| Gallagher, EJ | 1 |
| Bachur, RG | 1 |
| Monuteaux, MC | 1 |
| Neuman, MI | 1 |
| Siddik-Sayyid, SM | 1 |
| Yazbeck-Karam, VG | 1 |
| Zahreddine, BW | 1 |
| Adham, AM | 1 |
| Dagher, CM | 1 |
| Saasouh, WA | 1 |
| Aouad, MT | 1 |
| Trottier, ED | 1 |
| Bailey, B | 1 |
| Lucas, N | 1 |
| Lortie, A | 1 |
| Garasiuta, EG | 1 |
| Marsland, AM | 1 |
| Soundararajan, S | 1 |
| Joseph, K | 1 |
| Kaplan, AP | 1 |
| Corre, KA | 1 |
| Niemann, JT | 1 |
| Bessen, HA | 1 |
| Chernin, VV | 1 |
| Bystrov, VN | 1 |
| Goss, JE | 1 |
| Chambers, CE | 1 |
| Heupler, FA | 1 |
| Moffitt, JE | 1 |
| Yates, AB | 1 |
| Stafford, CT | 1 |
| Sarris, AH | 1 |
| Younes, A | 1 |
| McLaughlin, P | 1 |
| Moore, D | 1 |
| Hagemeister, F | 1 |
| Swan, F | 1 |
| Rodriguez, MA | 1 |
| Romaguera, J | 1 |
| North, L | 1 |
| Mansfield, P | 1 |
| Callendar, D | 1 |
| Mesina, O | 1 |
| Cabanillas, F | 1 |
| Oh, CK | 1 |
| Kim, YS | 1 |
| Kim, MS | 1 |
| Kim, SI | 1 |
| Park, K | 1 |
| Madowitz, JS | 1 |
| Schweiger, MJ | 1 |
| Cobbs, LW | 1 |
| Barnes, DP | 1 |
| Primosch, RE | 1 |
| Epishin, AV | 1 |
| Likhatskaia, VA | 1 |
| Furtel', PA | 1 |
| Leone, MR | 1 |
| Barry, JM | 1 |
| Alexander, SR | 1 |
| Melvin, T | 1 |
| Striegel, J | 1 |
| Reller, K | 1 |
| Henell, KR | 1 |
| Kimball, J | 1 |
| Funnell, MB | 1 |
| Goldstein, G | 1 |
| Greenberger, PA | 1 |
| Patterson, R | 1 |
| Tapio, CM | 1 |
| Khlestkov, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache[NCT01011673] | Phase 4 | 123 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| A Randomized Double Blinded Study Comparing Use of Prochlorperazine Versus Prochlorperazine and Ketorolac in the Treatment of Pediatric Migraine in the Emergency Department[NCT01534806] | Phase 4 | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn (stopped due to Drug is backordered;) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
At baseline at at 60 minutes, all patients were asked to describe their pain on a scale from 0 to 10, with 0 representing no pain and 10 the worst imaginable. The primary outcome is the 60 minute score subtracted from the baseline score (NCT01011673)
Timeframe: Baseline, 60 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketorolac | 3.8 |
| Metoclopramide | 5.1 |
"24 hours after the emergency department visit, patients were asked, The next time you come to the Er with this type of headache, do you want to receive the same medication? Affirmative answers are tabulated here." (NCT01011673)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketorolac | 45 |
| Metoclopramide | 53 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
3 reviews available for diphenhydramine and Recrudescence
| Article | Year |
|---|---|
Systemic anaphylactoid reactions to iodinated contrast media during cardiac catheterization procedures: guidelines for prevention, diagnosis, and treatment. Laboratory Performance Standards Committee of the Society for Cardiac Angiography and Intervention
Topics: Anaphylaxis; Cardiac Catheterization; Combined Modality Therapy; Coronary Angiography; Critical Care | 1995 |
Allergy to insect stings. A need for improved preventive management.
Topics: Anaphylaxis; Desensitization, Immunologic; Diagnosis, Differential; Diphenhydramine; Epinephrine; Ho | 1993 |
Therapeutic recommendations for aphthous ulcerations in children.
Topics: Adrenal Cortex Hormones; Analgesics; Child; Child, Preschool; Chlorhexidine; Diphenhydramine; Humans | 1990 |
5 trials available for diphenhydramine and Recrudescence
| Article | Year |
|---|---|
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery.
Topics: Adult; Cesarean Section; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Hum | 2010 |
Prochlorperazine in children with migraine: a look at its effectiveness and rate of akathisia.
Topics: Adolescent; Akathisia, Drug-Induced; Child; Diphenhydramine; Dopamine Antagonists; Drug Therapy, Com | 2012 |
Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Cross-Over Studies; Cyclosp | 1996 |
Treatment of steroid resistant acute rejection after renal transplantation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antilymphocyte Serum; Cyclosporine; Diphenhydramine; Drug R | 1996 |
11 other studies available for diphenhydramine and Recrudescence
| Article | Year |
|---|---|
A comparison of acute treatment regimens for migraine in the emergency department.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Comparative Effectiveness Research; Diphenhydrami | 2015 |
[Surgical treatment of ulnar and pre-patellar bursitis under ambulatory conditions].
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anti-Infective Agents; Azithromycin; Bursitis; Combined | 2000 |
Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.
Topics: Basophils; Calcineurin Inhibitors; Cells, Cultured; Chronic Disease; Complement C5a; Cyclosporine; D | 2005 |
Extended therapy for acute dystonic reactions.
Topics: Acute Disease; Adult; Benztropine; Biperiden; Diphenhydramine; Dystonia; Female; Humans; Jaw; Male; | 1984 |
[Pathogenetic bases for the use of histamine and dimedrol in the overall treatment of recurrent peptic ulcer].
Topics: Adult; Chronic Disease; Diphenhydramine; Drug Evaluation; Histamine; Humans; Middle Aged; Peptic Ulc | 1981 |
Severe anaphylactoid reaction to radiographic contrast media. Recurrences despites premedication with diphenhydramine and prednisone.
Topics: Anaphylaxis; Contrast Media; Diphenhydramine; Humans; Male; Middle Aged; Prednisone; Premedication; | 1979 |
Shakes and flashes in a relapsed alcoholic.
Topics: Alcoholic Intoxication; Chlordiazepoxide; Diphenhydramine; Drug Overdose; Hallucinations; Humans; Ma | 1992 |
[Recurrent Lyell's syndrome with secondary thrombocytopenia].
Topics: Adjuvants, Immunologic; Aminopyrine; Diphenhydramine; Dipyrone; Female; Humans; Middle Aged; Povidon | 1991 |
Monoclonal antibody OKT3 therapy in pediatric kidney transplant recipients.
Topics: Acetaminophen; Adolescent; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antigens, CD; Antigen | 1990 |
Prophylaxis against repeated radiocontrast media reactions in 857 cases. Adverse experience with cimetidine and safety of beta-adrenergic antagonists.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anaphylaxis; Cimetidine; Contrast Media; Diphenhydra | 1985 |
[Use of specific gamma-globulin in the treatment of erysipelas and the prevention of relapse].
Topics: Adolescent; Adult; Aged; Diphenhydramine; Erysipelas; Female; gamma-Globulins; Humans; Injections, I | 1973 |