diphenhydramine has been researched along with Pyrexia in 18 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions." | 9.13 | A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. ( Case, LD; Cruz, JM; Hurd, DD; Kennedy, LD; Pomper, GJ, 2008) |
| "Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions." | 5.13 | A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. ( Case, LD; Cruz, JM; Hurd, DD; Kennedy, LD; Pomper, GJ, 2008) |
| "Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications in an attempt to reduce the incidence and severity of these events." | 5.08 | Pretreatment regimens for adverse events related to infusion of amphotericin B. ( Cleary, JD; Goodwin, SD; Grasela, TH; Taylor, JW; Walawander, CA, 1995) |
| "This report describes the first case of an adult to survive all the major complications of diphenhydramine hydrochloride overdose, including hyperpyrexia, status epilepticus, coma, and cardiac arrhythmias." | 3.67 | Survival in complicated diphenhydramine overdose. ( Cox, PM; D'Amato, SL; Rinder, CS; Rinder, HM, 1988) |
| "Temsirolimus (CCI-779) is a novel inhibitor of the mammalian target of rapamycin." | 2.75 | A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors. ( Fujisaka, Y; Horiike, A; Tamura, T; Yamada, Y; Yamamoto, N, 2010) |
| "Diphenhydramine 50 mg i." | 1.30 | Management of neuroleptic malignant syndrome with anticholinergic medication. ( Hasan, MY; Holmes, CH; Schauben, JL, 1999) |
| "In one an anaphylactoid reaction developed, which was promptly terminated by intravenous methylprednisolone, subcutaneous epinephrine, and intravenous diphenhydramine." | 1.27 | Clinical use of the total dose intravenous infusion of iron dextran. ( Auerbach, M; Ballard, H; Fierstein, M; Lerner, RG; Toler, W; Witt, D, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duran, J | 1 |
| Siddique, S | 1 |
| Cleary, M | 1 |
| Kennedy, LD | 1 |
| Case, LD | 1 |
| Hurd, DD | 1 |
| Cruz, JM | 1 |
| Pomper, GJ | 1 |
| Tobian, AA | 1 |
| King, KE | 1 |
| Ness, PM | 1 |
| Fujisaka, Y | 1 |
| Yamada, Y | 1 |
| Yamamoto, N | 1 |
| Horiike, A | 1 |
| Tamura, T | 1 |
| Martí-Carvajal, AJ | 1 |
| Solà, I | 1 |
| González, LE | 1 |
| Leon de Gonzalez, G | 1 |
| Rodriguez-Malagon, N | 1 |
| Thomas, RR | 1 |
| Quinn, MG | 1 |
| Schuler, B | 1 |
| Grem, JL | 1 |
| FUNCKE, AB | 1 |
| MULDER, D | 1 |
| DEJONGE, MC | 1 |
| TERSTEEGE, HM | 1 |
| HARMS, AF | 1 |
| NAUTA, WT | 1 |
| DONNER, R | 1 |
| RUEMKE, CL | 1 |
| Sanders, RP | 1 |
| Maddirala, SD | 1 |
| Geiger, TL | 2 |
| Pounds, S | 1 |
| Sandlund, JT | 1 |
| Ribeiro, RC | 1 |
| Pui, CH | 1 |
| Howard, SC | 2 |
| Goodwin, SD | 1 |
| Cleary, JD | 1 |
| Walawander, CA | 1 |
| Taylor, JW | 1 |
| Grasela, TH | 1 |
| First, MR | 1 |
| Schroeder, TJ | 1 |
| Hariharan, S | 1 |
| Weiskittel, P | 1 |
| Hasan, MY | 1 |
| Schauben, JL | 1 |
| Holmes, CH | 1 |
| Oken, MM | 1 |
| Loch, J | 1 |
| Borkenstein, M | 1 |
| Haidvogl, M | 1 |
| Morg-Heimering, S | 1 |
| Nemec, A | 1 |
| Wang, JS | 1 |
| Sackett, DJ | 1 |
| Yuan, YM | 1 |
| Rinder, CS | 1 |
| D'Amato, SL | 1 |
| Rinder, HM | 1 |
| Cox, PM | 1 |
| Auerbach, M | 1 |
| Witt, D | 1 |
| Toler, W | 1 |
| Fierstein, M | 1 |
| Lerner, RG | 1 |
| Ballard, H | 1 |
4 reviews available for diphenhydramine and Pyrexia
| Article | Year |
|---|---|
Effects of Leukoreduction and Premedication With Acetaminophen and Diphenhydramine in Minimizing Febrile Nonhemolytic Transfusion Reactions and Allergic Transfusion Reactions During and After Blood Product Administration: A Literature Review With Recommen
Topics: Acetaminophen; Diphenhydramine; Drug Administration Schedule; Erythrocyte Transfusion; Evidence-Base | 2014 |
Pharmacological interventions for the prevention of allergic and febrile non-haemolytic transfusion reactions.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Fever; Histamine H1 Antagon | 2010 |
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Cim | 2003 |
Acetaminophen and diphenhydramine premedication for allergic and febrile nonhemolytic transfusion reactions: good prophylaxis or bad practice?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Allergic Agents; Blood Component Transfusion; Diphenhy | 2007 |
5 trials available for diphenhydramine and Pyrexia
| Article | Year |
|---|---|
A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Do | 2008 |
A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents; Area Under Curve; Carcinoma, Renal Cell; C | 2010 |
Pretreatment regimens for adverse events related to infusion of amphotericin B.
Topics: Acetaminophen; Adrenal Cortex Hormones; Amphotericin B; Diphenhydramine; Fever; Headache; Heparin; H | 1995 |
Reduction of the initial febrile response to OKT3 with indomethacin.
Topics: Acetaminophen; Adult; Creatinine; Diphenhydramine; Drug Administration Schedule; Female; Fever; Graf | 1993 |
[Randomized clinical controlled cross-over trial (RCT) in the prevention of blood transfusion febrile reactions with small dose hydrocortisone versus anti-histamines].
Topics: Adolescent; Adult; Aged; Diphenhydramine; Female; Fever; Humans; Hydrocortisone; Male; Middle Aged; | 1992 |
9 other studies available for diphenhydramine and Pyrexia
| Article | Year |
|---|---|
Prevention of febrile nonhemolytic and allergic transfusion reactions with pretransfusion medication: is this evidence-based medicine?
Topics: Acetaminophen; Anemia, Hemolytic; Diphenhydramine; Evidence-Based Medicine; Fever; Humans; Leukocyte | 2008 |
INVESTIGATION OF 3-(10,11-DIHYDRO-5H-DIBENZO (A,D) CYCLOHEPTEN-5-YLOXY) TROPANE CITRATE (DIBENZHEPTROPINE CITRATE, BRONTINE). I. PHARMACOLOGICAL PROPERTIES. II. TOXICOLOGICAL PROPERTIES.
Topics: Acetylcholine; Albumins; Animals; Asthma; Atropine; Bronchi; Citric Acid; Cyproheptadine; Diphenhydr | 1964 |
Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Allergic Agents; Blood Component Removal; Blood Compon | 2005 |
Management of neuroleptic malignant syndrome with anticholinergic medication.
Topics: Adolescent; Benztropine; Cholinergic Antagonists; Diphenhydramine; Female; Fever; Fluphenazine; Huma | 1999 |
Corticosteroid and antihistamine modification of bleomycin-induced fever.
Topics: Animals; Bleomycin; Diphenhydramine; Female; Fever; Hydrocortisone; Rabbits; Time Factors | 1979 |
Treatment of ingestion of diphenhydramine.
Topics: Diphenhydramine; Fever; Gastric Lavage; Humans; Infant; Male; Phenytoin; Physostigmine; Respiration, | 1978 |
[Symptomatic antipyretic and analgesic treatment with Verlapyrin in children].
Topics: Acetaminophen; Child; Child, Preschool; Diphenhydramine; Drug Combinations; Drug Evaluation; Fever; | 1978 |
Survival in complicated diphenhydramine overdose.
Topics: Adult; Arrhythmias, Cardiac; Coma; Diphenhydramine; Female; Fever; Humans; Nonprescription Drugs; Ph | 1988 |
Clinical use of the total dose intravenous infusion of iron dextran.
Topics: Anaphylaxis; Anemia; Bone Marrow; Chronic Disease; Diphenhydramine; Disease; Fever; Hemosiderin; Hum | 1988 |