diphenhydramine has been researched along with Parkinson Disease in 39 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The most disabling form of Parkinsonism is that occurring after encephalitis." | 1.23 | Therapy of Parkinson's disease. ( VAN METER, JR, 1950) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (97.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jacob, S | 1 |
| Ly, H | 1 |
| Villenueva, RJ | 1 |
| Gupta, HV | 1 |
| BUDNITZ, J | 1 |
| GILLHESPY, RO | 1 |
| RATCLIFFE, AH | 1 |
| KOSTER, S | 1 |
| DOSHAY, LJ | 2 |
| CONSTABLE, K | 2 |
| BERGGREEN, P | 1 |
| MASCIOCCHI, A | 1 |
| SFRONDINI, E | 1 |
| STEGER, R | 1 |
| HUFSCHMIDT, HJ | 1 |
| ROSENFELD, S | 1 |
| NAYAMPALLI, SS | 1 |
| GOLDNER, MG | 1 |
| FRANTZEN, E | 1 |
| MCGEER, PL | 1 |
| BOULDING, JE | 1 |
| GIBSON, WC | 1 |
| FOULKES, RG | 1 |
| ARKLESS, HA | 1 |
| ERNSTING, W | 1 |
| VAN METER, JR | 1 |
| DALSGAARD-NIELSEN, T | 1 |
| LEBLOND, S | 1 |
| PICHETTE, R | 1 |
| CHENA, W | 1 |
| BERCEL, NA | 1 |
| OWYANG, E | 1 |
| YOSS, RE | 1 |
| MOORE, MT | 1 |
| SCHWAB, RS | 1 |
| TILLMANN, WR | 1 |
| Winer, JA | 1 |
| Bahn, S | 1 |
| Derbez, R | 1 |
| Grauer, H | 1 |
| Butzer, JF | 1 |
| Silver, DE | 1 |
| Sahs, AL | 1 |
| Lipper, S | 1 |
| Bermanzohn, PC | 1 |
| Stone, DJ | 1 |
| DiFazio, CA | 1 |
| Klawans, HL | 1 |
| Schmutzler, F | 1 |
| Eichhorn, A | 1 |
| Patni, SK | 1 |
| Dandiya, PC | 2 |
| Mumenthaler, M | 1 |
| Ban, T | 1 |
| Hojo, M | 1 |
| Coyle, JT | 1 |
| Snyder, SH | 1 |
| Bhargava, LP | 1 |
| Bellows, JG | 1 |
3 reviews available for diphenhydramine and Parkinson Disease
| Article | Year |
|---|---|
The pharmacology of parkinsonism (a review).
Topics: Acetylcholine; Animals; Atropa belladonna; Atropine; Central Nervous System; Chlorpromazine; Dextroa | 1968 |
[Antiparkinson agents. 50].
Topics: Atropine; Dihydroxyphenylalanine; Diphenhydramine; Histamine H1 Antagonists; Humans; Mephenesin; Mon | 1970 |
[Clinical aspects and drug therapy of Parkinson's syndrome].
Topics: Amphetamine; Diphenhydramine; Humans; Parasympatholytics; Parkinson Disease; Parkinson Disease, Post | 1966 |
2 trials available for diphenhydramine and Parkinson Disease
| Article | Year |
|---|---|
A sleep study and investigation of a new hypnotic compound in a geriatric population.
Topics: Aged; Arteriosclerosis; Bronchitis; Chronic Disease; Diabetes Complications; Diphenhydramine; Female | 1967 |
Amantadine in Parkinson's disease. A double-blind, placebo-controlled, crossover study with long-term follow-up.
Topics: Activities of Daily Living; Aged; Amantadine; Benztropine; Clinical Trials as Topic; Diphenhydramine | 1975 |
34 other studies available for diphenhydramine and Parkinson Disease
| Article | Year |
|---|---|
Acute dystonic reaction in a patient with Parkinson's disease after diphenhydramine withdrawal.
Topics: Anesthetics, Local; Diphenhydramine; Dystonia; Female; Humans; Middle Aged; Parkinson Disease | 2017 |
The use of benadryl in Parkinson's disease; a preliminary report of eight cases.
Topics: Diphenhydramine; Humans; Parkinson Disease; Parkinsonian Disorders | 1948 |
Treatment of Parkinsonism with a new compound (B.S.5930).
Topics: Corticosterone; Diphenhydramine; Parkinson Disease; Parkinsonian Disorders | 1955 |
[Experience with disipal (BS 5930) in paralysis agitans].
Topics: Diphenhydramine; Orphenadrine; Parkinson Disease | 1955 |
Treatment of paralysis agitans with orphenadrine (disipal) hydrochloride; results in one hundred seventy-six cases.
Topics: Diphenhydramine; Orphenadrine; Parkinson Disease; Salts | 1957 |
[Keithon for therapy of parkinsonism].
Topics: Cardiovascular Agents; Diphenhydramine; Muscle Relaxants, Central; Parkinson Disease; Parkinsonian D | 1957 |
[Brocadisipal & therapy of parkinsonism].
Topics: Diphenhydramine; Parkinson Disease; Parkinsonian Disorders | 1958 |
[Disipal in the treatment of post-encephalitic parkinsonism].
Topics: Diphenhydramine; Encephalitis; Humans; Orphenadrine; Parkinson Disease; Parkinson Disease, Postencep | 1958 |
[Myographic and clinical observations on two new antihistaminics used in the treatment of parkinsonism].
Topics: Anti-Allergic Agents; Diphenhydramine; Muscle Relaxants, Central; Myography; Parkinson Disease; Park | 1958 |
[Psychiatric significance of a new anti-parkinsonian drug].
Topics: Diphenhydramine; Parkinson Disease | 1959 |
Treatment of paralysis agitans with chlorphenoxamine hydrochloride.
Topics: Diphenhydramine; Ethylamines; Parkinson Disease | 1959 |
An evaluation of orphenadrine hydrochloride (disipal).
Topics: Aged; Diphenhydramine; Humans; Orphenadrine; Parkinson Disease | 1959 |
[Brocadisipal in the treatment of parkinsonism].
Topics: Diphenhydramine; Parkinson Disease; Parkinsonian Disorders | 1959 |
Drug-induced extrapyramidal reactions. Treatment with diphenhydramine hydrochloride and dihydroxyphenylalanine.
Topics: Dihydroxyphenylalanine; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Parkinson | 1961 |
Eradication of tremors affecting the electrocardiogram; a preliminary report.
Topics: Diphenhydramine; Electrocardiography; Humans; Parkinson Disease; Tremor | 1955 |
[The treatment of the Parkinson syndrome with disipal (BS 5930)].
Topics: Diphenhydramine; Orphenadrine; Parkinson Disease | 1955 |
Therapy of Parkinson's disease.
Topics: Diphenhydramine; Encephalitis; Humans; Mephenesin; Muscle Rigidity; Pain; Parkinson Disease; Parkins | 1950 |
[Benadryl therapy of paralysis agitans].
Topics: Diphenhydramine; Parkinson Disease; Parkinsonian Disorders | 1950 |
[Trial treatment of Parkinson's disease].
Topics: Diphenhydramine; Parkinson Disease; Parkinsonian Disorders; Phenothiazines | 1951 |
[Experimental studies on B-dimethylaminoethyl benzhydryl and its use in Parkinson's disease].
Topics: Diphenhydramine; Humans; Parkinson Disease; Parkinsonian Disorders | 1951 |
Clinical evaluation of benadryl in Parkinsonism.
Topics: Diphenhydramine; Parkinson Disease; Parkinsonian Disorders | 1951 |
The symptomatic treatment of paralysis agitans with benadryl; report of two cases.
Topics: Diphenhydramine; Paralysis; Parkinson Disease | 1950 |
Benadryl in the treatment of Parkinson's syndrome.
Topics: Diphenhydramine; Parkinson Disease; Parkinsonian Disorders | 1950 |
Use of diphenhydramine in treatment of paralysis agitans.
Topics: Diphenhydramine; Paralysis; Parkinson Disease | 1950 |
Artane in the treatment of Parkinson's disease; a report of its effectiveness alone and in combination with benadryl and parpanit.
Topics: Cyclopentanes; Diphenhydramine; Parkinson Disease; Parkinsonian Disorders; Trihexyphenidyl | 1949 |
Loss of teeth with antidepressant drug therapy.
Topics: Dental Caries; Diphenhydramine; Humans; Imipramine; Male; Middle Aged; Parkinson Disease; Psychophar | 1967 |
Letter: Electroconvulsive therapy in patients with parkinsonism.
Topics: Amantadine; Atropine; Depression; Diphenhydramine; Electroconvulsive Therapy; Female; Humans; Levodo | 1975 |
Sedation for patients with Parkinson's disease undergoing ophthalmologic surgery.
Topics: Diphenhydramine; Humans; Ophthalmologic Surgical Procedures; Parkinson Disease; Tremor | 1988 |
The influence of monoamine oxidase inhibitors and some other antidepressants on the anti-parkinsonian activity of sub-effective doses of diphenylhydramine in rats and mice.
Topics: Animals; Antidepressive Agents; Catatonia; Diphenhydramine; Humans; Mice; Monoamine Oxidase Inhibito | 1972 |
A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities.
Topics: Animals; Diphenhydramine; Drug Antagonism; Electroencephalography; Male; Muscle Tonus; Muscles; Orph | 1971 |
Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action.
Topics: Animals; Brain Chemistry; Caudate Nucleus; Diphenhydramine; Dopamine Antagonists; Hypothalamus; In V | 1969 |
The antiparkinsonian activity of monoamine oxidase inhibitors and other agents in rats and mice.
Topics: Animals; Dextroamphetamine; Diphenhydramine; Imipramine; Iproniazid; Isocarboxazid; Mice; Monoamine | 1968 |
Antiparkinsonism drugs.
Topics: Antidepressive Agents; Atropine; Diphenhydramine; Humans; Orphenadrine; Parasympatholytics; Parkinso | 1965 |
Method for cataract extraction in Parkinsonism.
Topics: Cataract Extraction; Diphenhydramine; Humans; Hydroxyzine; Male; Middle Aged; Parkinson Disease | 1965 |