diphenhydramine has been researched along with Pain in 40 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among patients undergoing head and neck radiotherapy, the use of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash vs placebo significantly reduced oral mucositis pain during the first 4 hours after administration; however, the effect size was less than the minimal clinically important difference." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "Intradermal (ID) capsaicin injection in humans induces spontaneous pain, flare, primary hyperalgesia, secondary hyperalgesia, and allodynia." | 9.13 | Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. ( Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H, 2008) |
| "Previous injection of diphenhydramine with venous occlusion can be considered as an alternative to lidocaine for reducing the prevalence of pain caused by injection of propofol into peripheral veins." | 9.12 | Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study. ( Apiliogullari, B; Apiliogullari, S; Balasar, M; Duman, A; Keles, B; Yilmaz, H, 2007) |
| "To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine." | 9.12 | Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007) |
| "Intravenous lidocaine and diphenhydramine had no significant effect on the cool, warm, or cold pain thresholds." | 9.09 | Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. ( Gerayli, A; Leung, AY; Ridgeway, BM; Wallace, MS; Yaksh, TL, 2000) |
| "There was no statistically significant difference between buffered diphenhydramine and plain diphenhydramine for pain of injection (23." | 9.08 | Infiltration pain and local anesthetic effects of buffered vs plain 1% diphenhydramine. ( Hollander, JE; Singer, AJ, 1995) |
| "To establish RP-HPLC method for determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis." | 7.76 | [Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC]. ( Chen, B; Chu, Y; Jia, X; Liu, Q; Wei, Y; Zhang, J, 2010) |
| "Among patients undergoing head and neck radiotherapy, the use of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash vs placebo significantly reduced oral mucositis pain during the first 4 hours after administration; however, the effect size was less than the minimal clinically important difference." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "Intradermal (ID) capsaicin injection in humans induces spontaneous pain, flare, primary hyperalgesia, secondary hyperalgesia, and allodynia." | 5.13 | Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. ( Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H, 2008) |
| "Previous injection of diphenhydramine with venous occlusion can be considered as an alternative to lidocaine for reducing the prevalence of pain caused by injection of propofol into peripheral veins." | 5.12 | Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study. ( Apiliogullari, B; Apiliogullari, S; Balasar, M; Duman, A; Keles, B; Yilmaz, H, 2007) |
| "To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine." | 5.12 | Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007) |
| "05) less painful than either lidocaine hydrochloride or diphenhydramine and equivalent to placebo." | 5.10 | Comparison of effects of lidocaine hydrochloride, buffered lidocaine, diphenhydramine, and normal saline after intradermal injection. ( Chen, E; McSweeney, TD; Reilley, TE; Tibbits, DL; Xia, Y, 2002) |
| "Intravenous lidocaine and diphenhydramine had no significant effect on the cool, warm, or cold pain thresholds." | 5.09 | Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. ( Gerayli, A; Leung, AY; Ridgeway, BM; Wallace, MS; Yaksh, TL, 2000) |
| "There was no statistically significant difference between buffered diphenhydramine and plain diphenhydramine for pain of injection (23." | 5.08 | Infiltration pain and local anesthetic effects of buffered vs plain 1% diphenhydramine. ( Hollander, JE; Singer, AJ, 1995) |
| " The diphenhydramine median pain score was 55 mm, compared with 12." | 5.08 | Randomized trial of diphenhydramine versus benzyl alcohol with epinephrine as an alternative to lidocaine local anesthesia. ( Bartfield, JM; Jandreau, SW; Raccio-Robak, N, 1998) |
| "In this study of 24 adult volunteers, diphenhydramine 1% was as effective as lidocaine 1% for achieving dermal local anesthesia, although injection was more painful." | 5.07 | Validation of diphenhydramine as a dermal local anesthetic. ( Gorchynski, J; Green, SM; Rothrock, SG, 1994) |
| "5% diphenhydramine for pain of injection or suturing for all other locations according to both patients and physicians." | 5.07 | 1% lidocaine versus 0.5% diphenhydramine for local anesthesia in minor laceration repair. ( Ernst, AA; Mall, G; Marvez-Valls, E; Patterson, J; Weiss, SJ; Xie, X, 1994) |
| "A prospective, double-blind study compared the effectiveness of sucralfate suspension with diphenhydramine syrup plus kaolin-pectin in reducing severity and pain of radiation-induced oropharyngeal mucositis." | 5.07 | The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis. ( Barker, B; Barker, G; Cuddy, P; Loftus, L, 1991) |
| "To establish RP-HPLC method for determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis." | 3.76 | [Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC]. ( Chen, B; Chu, Y; Jia, X; Liu, Q; Wei, Y; Zhang, J, 2010) |
| "The diphenhydramine solution was irritating on injection and postinjection and resulted in a very low level of anesthetic success." | 2.73 | The anesthetic efficacy of diphenhydramine and the combination diphenhydramine/lidocaine for the inferior alveolar nerve block. ( Beck, M; Drum, M; Nusstein, J; Reader, A; Willett, J, 2008) |
| "Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics." | 1.30 | Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine. ( Guler, N; Sumer, M; Uckan, S; Ungor, M, 1998) |
| "In one an anaphylactoid reaction developed, which was promptly terminated by intravenous methylprednisolone, subcutaneous epinephrine, and intravenous diphenhydramine." | 1.27 | Clinical use of the total dose intravenous infusion of iron dextran. ( Auerbach, M; Ballard, H; Fierstein, M; Lerner, RG; Toler, W; Witt, D, 1988) |
| "The most disabling form of Parkinsonism is that occurring after encephalitis." | 1.23 | Therapy of Parkinson's disease. ( VAN METER, JR, 1950) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (30.00) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 11 (27.50) | 29.6817 |
| 2010's | 7 (17.50) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, JR | 1 |
| Rescourio, G | 1 |
| Milgram, BC | 1 |
| Foti, RS | 1 |
| Kornecook, T | 1 |
| Ligutti, J | 1 |
| Moyer, BD | 1 |
| Taborn, K | 1 |
| Youngblood, BD | 1 |
| Yu, V | 1 |
| Shimanovich, R | 1 |
| Boezio, A | 1 |
| Weiss, M | 1 |
| Hawash, A | 1 |
| Nguyen, T | 1 |
| Mantilla, A | 1 |
| Emesiani, C | 1 |
| Meckfessel, M | 1 |
| Chessman, AW | 1 |
| Elad, S | 1 |
| Yarom, N | 1 |
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| Stokes, NA | 1 |
| Lemos, JP | 1 |
| Chen, YW | 1 |
| Tzeng, JI | 1 |
| Chen, TY | 1 |
| Wang, JJ | 1 |
| Chen, YC | 1 |
| Hung, CH | 1 |
| Willett, J | 1 |
| Reader, A | 1 |
| Drum, M | 1 |
| Nusstein, J | 1 |
| Beck, M | 1 |
| Wang, H | 1 |
| Bolognese, J | 1 |
| Calder, N | 1 |
| Baxendale, J | 1 |
| Kehler, A | 1 |
| Cummings, C | 1 |
| Connell, J | 1 |
| Herman, G | 1 |
| Ibrahimi, OA | 1 |
| Gunawardane, N | 1 |
| Sepehr, A | 1 |
| Reynolds, RV | 1 |
| Jia, X | 1 |
| Liu, Q | 1 |
| Wei, Y | 1 |
| Chen, B | 1 |
| Chu, Y | 1 |
| Zhang, J | 1 |
| Coulter, DW | 1 |
| Walko, C | 1 |
| Patel, J | 1 |
| Moats-Staats, BM | 1 |
| McFadden, A | 1 |
| Smith, SV | 1 |
| Khan, WA | 1 |
| Bridges, AS | 1 |
| Deal, AM | 1 |
| Oesterheld, J | 1 |
| Davis, IJ | 1 |
| Blatt, J | 1 |
| Xia, Y | 1 |
| Chen, E | 1 |
| Tibbits, DL | 1 |
| Reilley, TE | 1 |
| McSweeney, TD | 1 |
| Jacob, E | 1 |
| Miaskowski, C | 1 |
| Savedra, M | 1 |
| Beyer, JE | 1 |
| Treadwell, M | 1 |
| Styles, L | 1 |
| Cantrell, FL | 1 |
| STEIN, ID | 1 |
| MACAULAY, AI | 1 |
| VAN METER, JR | 1 |
| Apiliogullari, S | 1 |
| Keles, B | 1 |
| Apiliogullari, B | 1 |
| Balasar, M | 1 |
| Yilmaz, H | 1 |
| Duman, A | 1 |
| Rintala, DH | 1 |
| Holmes, SA | 1 |
| Courtade, D | 1 |
| Fiess, RN | 1 |
| Tastard, LV | 1 |
| Loubser, PG | 1 |
| Neubauer, M | 2 |
| Bach, GL | 2 |
| Green, SM | 1 |
| Rothrock, SG | 1 |
| Gorchynski, J | 1 |
| Ernst, AA | 1 |
| Marvez-Valls, E | 1 |
| Mall, G | 1 |
| Patterson, J | 1 |
| Xie, X | 1 |
| Weiss, SJ | 1 |
| Dire, DJ | 1 |
| Hogan, DE | 1 |
| Singer, AJ | 1 |
| Hollander, JE | 1 |
| Tyler, BM | 1 |
| Groshan, K | 1 |
| Cusack, B | 1 |
| Richelson, E | 1 |
| Uckan, S | 1 |
| Guler, N | 1 |
| Sumer, M | 1 |
| Ungor, M | 1 |
| Bartfield, JM | 1 |
| Jandreau, SW | 1 |
| Raccio-Robak, N | 1 |
| Wallace, MS | 1 |
| Ridgeway, BM | 1 |
| Leung, AY | 1 |
| Gerayli, A | 1 |
| Yaksh, TL | 1 |
| Renbäck, K | 1 |
| Inoue, M | 1 |
| Yoshida, A | 1 |
| Nyberg, F | 1 |
| Ueda, H | 1 |
| Galeotti, N | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Sögtrop, HH | 1 |
| Weise, HT | 1 |
| Barker, G | 1 |
| Loftus, L | 1 |
| Cuddy, P | 1 |
| Barker, B | 1 |
| Yeh, SY | 1 |
| Auerbach, M | 1 |
| Witt, D | 1 |
| Toler, W | 1 |
| Fierstein, M | 1 |
| Lerner, RG | 1 |
| Ballard, H | 1 |
| Middleton, RS | 1 |
| Clyne, MJ | 1 |
| Okuma, T | 1 |
| Kuba, K | 1 |
| Matsushita, T | 1 |
| Nakao, T | 1 |
| Fujii, S | 1 |
| Shimoda, Y | 1 |
| Chetverikov, NS | 1 |
| Urusmambetov, ShN | 1 |
| Taira, N | 1 |
| Nakayama, K | 1 |
| Hashimoto, K | 1 |
| Rhonheimer, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer: A Randomized Clinical Trial[NCT04221165] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-08-04 | Recruiting | ||
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
17 trials available for diphenhydramine and Pain
| Article | Year |
|---|---|
Individual Article: Evaluation of Efficacy and Tolerability of Two Over-the-Counter Eczema Itch Relief Products.
Topics: Adult; Diphenhydramine; Eczema; Female; Humans; Male; Middle Aged; Nonprescription Drugs; Pain; Pare | 2023 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
The anesthetic efficacy of diphenhydramine and the combination diphenhydramine/lidocaine for the inferior alveolar nerve block.
Topics: Adult; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Local; Bicuspid; Cross-Over Studies; | 2008 |
Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects.
Topics: Adolescent; Adult; Alkaloids; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Cross | 2008 |
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diphenhydramine | 2013 |
Comparison of effects of lidocaine hydrochloride, buffered lidocaine, diphenhydramine, and normal saline after intradermal injection.
Topics: Adult; Analysis of Variance; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Female; Hand; | 2002 |
Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Diphenhydramine; Double-B | 2007 |
Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury.
Topics: Adult; Aged; Amines; Amitriptyline; Analgesics; Analysis of Variance; Antidepressive Agents, Tricycl | 2007 |
[Short-term therapy of painful muscular disorders. Results of a multicenter double-blind test of 2 new suppository preparations with and without codeine].
Topics: Arthritis; Aspirin; Clinical Trials as Topic; Codeine; Diphenhydramine; Double-Blind Method; Drug Co | 1983 |
Validation of diphenhydramine as a dermal local anesthetic.
Topics: Adult; Anesthesia, Local; Diphenhydramine; Double-Blind Method; Female; Humans; Injections, Intrader | 1994 |
1% lidocaine versus 0.5% diphenhydramine for local anesthesia in minor laceration repair.
Topics: Adult; Anesthesia, Local; Diphenhydramine; Double-Blind Method; Emergency Service, Hospital; Female; | 1994 |
Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic.
Topics: Adult; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Humans; Inje | 1993 |
Infiltration pain and local anesthetic effects of buffered vs plain 1% diphenhydramine.
Topics: Adult; Anesthetics, Local; Buffers; Diphenhydramine; Double-Blind Method; Female; Humans; Hydrogen-I | 1995 |
Randomized trial of diphenhydramine versus benzyl alcohol with epinephrine as an alternative to lidocaine local anesthesia.
Topics: Adult; Anesthetics, Local; Benzyl Alcohol; Diphenhydramine; Double-Blind Method; Drug Combinations; | 1998 |
Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II.
Topics: Adult; Aged; Anesthetics, Local; Blood Pressure; Cold Temperature; Complex Regional Pain Syndromes; | 2000 |
The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis.
Topics: Adult; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Cobalt; Diphenhydramine; Double-Blind Me | 1991 |
A comparative study of Propain and a dextropropoxyphene/paracetamol combination analgesic.
Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Dextropropoxyphene; Diphenhydramine; Drug | 1985 |
23 other studies available for diphenhydramine and Pain
| Article | Year |
|---|---|
Discovery of pyridyl urea sulfonamide inhibitors of Na
Topics: Humans; NAV1.7 Voltage-Gated Sodium Channel; Pain; Quinolones; Structure-Activity Relationship; Sulf | 2022 |
IV prochlorperazine + diphenhydramine improved migraine pain relief more than IV hydromorphone in the ED.
Topics: Diphenhydramine; Humans; Hydromorphone; Migraine Disorders; Pain; Prochlorperazine | 2018 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
Male patient with throat swelling and painful swallowing.
Topics: Adenoids; Adult; Angioedema; Anti-Inflammatory Agents; Deglutition Disorders; Dexamethasone; Diphenh | 2013 |
Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat.
Topics: Analgesia; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Diphen | 2014 |
Terbinafine-induced acute generalized exanthematous pustulosis (AGEP) responsive to high dose intravenous corticosteroid.
Topics: Acute Generalized Exanthematous Pustulosis; Anti-Inflammatory Agents; Antifungal Agents; Clobetasol; | 2009 |
[Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC].
Topics: Arthritis; Atropine; Capsaicin; Chromatography, High Pressure Liquid; Diphenhydramine; Drugs, Chines | 2010 |
Management of vaso-occlusive pain in children with sickle cell disease.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Infl | 2003 |
Envenomation by the Mexican beaded lizard: a case report.
Topics: Adult; Anaphylaxis; Animals; Bites and Stings; Diphenhydramine; Edema; Emergency Treatment; Humans; | 2003 |
CONTROL OF PAIN IN CERTAIN PERIPHERAL VASCULAR DISORDERS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Diphenhydramine; Drug Therapy; Foot Diseases; Ge | 1964 |
Therapy of Parkinson's disease.
Topics: Diphenhydramine; Encephalitis; Humans; Mephenesin; Muscle Rigidity; Pain; Parkinson Disease; Parkins | 1950 |
[Treatment of painful muscular disorders of various degrees of severity. Comparison of 2 new suppository preparations].
Topics: Aspirin; Codeine; Diphenhydramine; Drug Combinations; Female; Gout; Humans; Male; Meprobamate; Middl | 1983 |
In vivo studies with low doses of levocabastine and diphenhydramine, but not pyrilamine, antagonize neurotensin-mediated antinociception.
Topics: Animals; Body Temperature Regulation; Diphenhydramine; Drug Evaluation, Preclinical; Histamine H1 An | 1998 |
Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bicuspid; Dental Pulp; | 1998 |
Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission.
Topics: Anesthetics, Local; Animals; Diphenhydramine; Lysophospholipids; Male; Mast Cells; Mice; Oligodeoxyr | 2000 |
Antihistamine antinociception is mediated by Gi-protein activation.
Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Diphenhydramine; Dose-Response Relati | 2002 |
[Results of treatment with DoloVisano for non-specific pain syndrome related to body movement. Concluding report on a field study of 3326 patients by 314 orthopedists].
Topics: Aspirin; Codeine; Diphenhydramine; Drug Combinations; Drug Evaluation; Humans; Meprobamate; Movement | 1979 |
The effect of antihistaminic drugs on pentazocine antinociception in the rat.
Topics: Animals; Brain Chemistry; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Injections, | 1986 |
Clinical use of the total dose intravenous infusion of iron dextran.
Topics: Anaphylaxis; Anemia; Bone Marrow; Chronic Disease; Diphenhydramine; Disease; Fever; Hemosiderin; Hum | 1988 |
Study on 14 and 6 per second positive spikes during nocturnal sleep.
Topics: Adolescent; Adult; Age Factors; Brain; Brain Diseases; Craniocerebral Trauma; Diphenhydramine; Elect | 1968 |
[On the clinical picture and treatment of gangliosolaritis].
Topics: Antihypertensive Agents; Celiac Plexus; Diphenhydramine; Female; Ganglia, Autonomic; Ganglionic Bloc | 1969 |
Vocalization response of puppies to intra-arterial administration of bradykinin and other algesic agents, and mode of actions of blocking agents.
Topics: Acetylcholine; Age Factors; Analgesics; Animals; Atropine; Barium; Bradykinin; Catheterization; Chlo | 1968 |
[On the effect of Spondylon in the treatment of painful conditions of the locomotor system].
Topics: Antipyrine; Diphenhydramine; Flavonoids; Humans; Muscular Diseases; Pain | 1968 |