diphenhydramine has been researched along with Neuroleptic Malignant Syndrome in 5 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case report of a patient with neuroleptic malignant syndrome is described." | 5.27 | Treatment of neuroleptic malignant syndrome with diphenhydramine. ( Baron, S; Engle, J; Hryhorczuk, DO; Leikin, JB; Zell, M, 1988) |
| "Diphenhydramine 50 mg i." | 1.30 | Management of neuroleptic malignant syndrome with anticholinergic medication. ( Hasan, MY; Holmes, CH; Schauben, JL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Park-Matsumoto, YC | 1 |
| Tazawa, T | 1 |
| Hasan, MY | 1 |
| Schauben, JL | 1 |
| Holmes, CH | 1 |
| Knight, ME | 1 |
| Roberts, RJ | 1 |
| Leikin, JB | 1 |
| Baron, S | 1 |
| Engle, J | 1 |
| Zell, M | 1 |
| Hryhorczuk, DO | 1 |
2 reviews available for diphenhydramine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
Phenothiazine and butyrophenone intoxication in children.
Topics: Absorption; Adolescent; Basal Ganglia Diseases; Benztropine; Butyrophenones; Cardiovascular System; | 1986 |
3 other studies available for diphenhydramine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Neuroleptic malignant syndrome associated with diphenhydramine and diprophyllin overdose in a depressed patient.
Topics: Adult; Bronchodilator Agents; Depressive Disorder; Diphenhydramine; Drug Overdose; Dyphylline; Hista | 1999 |
Management of neuroleptic malignant syndrome with anticholinergic medication.
Topics: Adolescent; Benztropine; Cholinergic Antagonists; Diphenhydramine; Female; Fever; Fluphenazine; Huma | 1999 |
Treatment of neuroleptic malignant syndrome with diphenhydramine.
Topics: Adult; Diphenhydramine; Humans; Male; Neuroleptic Malignant Syndrome; Time Factors | 1988 |