Page last updated: 2024-10-26

diphenhydramine and Melanoma

diphenhydramine has been researched along with Melanoma in 4 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Vemurafenib and dabrafenib are both orally bioavailable small molecule agents that block mitogen activated protein kinase signalling in patients with melanoma and BRAF(V600E) mutation."7.81Successful desensitization protocol for hypersensitivity reaction probably caused by dabrafenib in a patient with metastatic melanoma. ( Abu-Amna, M; Bar-Sela, G; Hadad, S; Haim, N; Shahar, E, 2015)
"Vemurafenib and dabrafenib are both orally bioavailable small molecule agents that block mitogen activated protein kinase signalling in patients with melanoma and BRAF(V600E) mutation."3.81Successful desensitization protocol for hypersensitivity reaction probably caused by dabrafenib in a patient with metastatic melanoma. ( Abu-Amna, M; Bar-Sela, G; Hadad, S; Haim, N; Shahar, E, 2015)
" Regimen B, employing a lower dosage of metoclopramide and steroids and using a more simple schedule of administration should be the preferred treatment."2.67Antiemetic activity of two different high doses and schedules of metoclopramide in dacarbazine-treated cancer patients. ( Basurto, C; Boschetti, E; Bracarda, S; Del Favero, A; Lupattelli, M; Picciafuoco, M; Roila, F; Sassi, M; Tonato, M, 1992)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bar-Sela, G1
Abu-Amna, M1
Hadad, S1
Haim, N1
Shahar, E1
Roila, F1
Bracarda, S1
Basurto, C1
Sassi, M1
Lupattelli, M1
Picciafuoco, M1
Boschetti, E1
Del Favero, A1
Tonato, M1
Wiernik, PH1
Schwartz, EL1
Einzig, A1
Strauman, JJ1
Lipton, RB1
Dutcher, JP1
Silverstein, MJ1
DeKernion, J1
Morton, DL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534]29 participants (Actual)Observational2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for diphenhydramine and Melanoma

ArticleYear
Antiemetic activity of two different high doses and schedules of metoclopramide in dacarbazine-treated cancer patients.
    American journal of clinical oncology, 1992, Volume: 15, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dexamethasone; Diphenhydramine; Double-

1992

Other Studies

3 other studies available for diphenhydramine and Melanoma

ArticleYear
Successful desensitization protocol for hypersensitivity reaction probably caused by dabrafenib in a patient with metastatic melanoma.
    Japanese journal of clinical oncology, 2015, Volume: 45, Issue:9

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Brain Neoplasms; Desensitization, Immunologic; Dexa

2015
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin

1987
Malignant melanoma metastatic to the bladder. Regression following intratumor injection of BCG vaccine.
    JAMA, 1974, Aug-05, Volume: 229, Issue:6

    Topics: Aspirin; BCG Vaccine; Biopsy; Cystoscopy; Diphenhydramine; Humans; Immunotherapy; Male; Melanoma; Mi

1974