diphenhydramine and Long QT Syndrome

diphenhydramine has been researched along with Long QT Syndrome in 6 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.

Research

Studies (6)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

24 Hour Follow up Amnesia Score

Patient were also asked to rate amnesia on a 10 point scale 24 after discharge. minimum= 0 (worse) maximum =10 (better) (NCT01967433)
Timeframe: At about 24 after the procedure

24 Hour Follow up Pain Score

"At 24 hr follow up patients were asked to rate the level of pain during the procedure using 10 point scale.~10 point visual analogue scale minimum= 0 (better) maximum =10 (worse)" (NCT01967433)
Timeframe: About 24 hours after the procedure

Dosage of Fentanyl

Moderate sedation (using the American Society of Anesthesiologists definition of maintaining purposeful response to verbal or tactile stimulation, adequate ventilation requiring no airway protection, and maintenance of cardiovascular function) was then achieved using incremental doses of the combination of intravenous midazolam (1 mg) and fentanyl (25 μg) given every 2 to 3 minutes. To minimize any crossover, additional diphenhydramine was not permitted. (NCT01967433)
Timeframe: From induction (first dose of sedative) to end of procedure

Dosage of Midazolam

Moderate sedation (using the American Society of Anesthesiologists definition of maintaining purposeful response to verbal or tactile stimulation, adequate ventilation requiring no airway protection, and maintenance of cardiovascular function) was then achieved using incremental doses of the combination of intravenous midazolam (1 mg) and fentanyl (25 μg) given every 2 to 3 minutes. To minimize any crossover, additional diphenhydramine was not permitted. (NCT01967433)
Timeframe: From induction (first dose of sedative) to end of procedure

Duration of Procedure

Induction period (time from first dose of fentanyl to scope insertion), procedural time (time from scope insertion to scope out), and recovery time (time from scope out to discharge) were recorded by the nursing staff in their standard documentation. (NCT01967433)
Timeframe: Time from induction (first dose of sedative) to discharge

Number of Participants With Adverse Events

Following adverse events will be recorded: (1)Hypoxia defined as O2 saturation less than 89% lasting for more than 30 seconds, (2)hypotension defined as systolic BP less than 90 mmhg and (3)use of reversal agents i.e Naloxone or Flumazenil (NCT01967433)
Timeframe: From induction (first dose of sedative) to discharge

Quality of Sedation

"Quality of sedation will be accessed by the nurse and the physician at the end of procedure.~Name: 10 point visual analogue scale Minimum score: 1 (worse) Maximum score: 10 (better)" (NCT01967433)
Timeframe: During the colonoscopy and 24 hours after discharge

Other Studies

6 other studies available for diphenhydramine and Long QT Syndrome