diphenhydramine has been researched along with Liver Failure in 2 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 7.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 5.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 3.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 1.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwartz, EA | 1 |
| Hayes, BD | 1 |
| Sarmiento, KF | 1 |
| Wang, GS | 1 |
| Monte, A | 1 |
| Bagdure, D | 1 |
| Heard, K | 1 |
2 other studies available for diphenhydramine and Liver Failure
| Article | Year |
|---|---|
Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2009 |
Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Child; Cholinergic An | 2011 |