diphenhydramine has been researched along with Injuries, Radiation in 10 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| LOFSTROM, JE | 1 |
| NURNBERGER, CE | 1 |
| TOSCH, R | 1 |
| KONIG, A | 1 |
| BRENNIG, K | 1 |
| KARAS, JS | 1 |
| STANBURY, JB | 1 |
| YAM, KM | 1 |
| HIETBRINK, BE | 1 |
| DUBOIS, KP | 1 |
| Meredith, R | 1 |
| Salter, M | 1 |
| Kim, R | 1 |
| Spencer, S | 1 |
| Weppelmann, B | 1 |
| Rodu, B | 1 |
| Smith, J | 1 |
| Lee, J | 1 |
| Tkachishin, VS | 1 |
| Ushakov, BN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
2 trials available for diphenhydramine and Injuries, Radiation
8 other studies available for diphenhydramine and Injuries, Radiation
| Article | Year |
|---|---|
Irradiation sickness; histamine effect treated with benadryl.
Topics: Diphenhydramine; Histamine; Histamine Agents; Radiation; Radiation Injuries; X-Rays | 1946 |
[Clinical experience with the antiemetic rodavan in the therapy of roentgen intoxication].
Topics: Antiemetics; Caffeine; Diphenhydramine; Radiation Injuries; Radiotherapy; Theophylline | 1958 |
[Medical therapy of radiation sickness and hyperemesis gravidarum].
Topics: Belladonna Alkaloids; Diphenhydramine; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Radiation | 1959 |
[CLINICAL STUDIES WITH VOYAL IN RADIATION INJURIES].
Topics: Breast Neoplasms; Diphenhydramine; Female; Humans; Lung Neoplasms; Radiation Injuries; Theophylline; | 1963 |
FATAL RADIATION SYNDROME FROM AN ACCIDENTAL NUCLEAR EXCURSION.
Topics: Accidents; Accidents, Occupational; Angiotensins; Blood Cell Count; Blood Chemical Analysis; Bone Ma | 1965 |
PHARMACOLOGICAL AND TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. 3. STUDIES ON THE TOXICITY AND MECHANISM OF ACTION OF MERCAPTOETHYLAMINE (MEA). QUART PROGR REP NO. 53.
Topics: Animals; Animals, Laboratory; Cysteamine; Cysteine; Diphenhydramine; Glutathione; Guinea Pigs; Merca | 1964 |
[Effectiveness of nondrug treatment of chronic bronchitis in persons exposed to radiation due to Chernobyl AES accident].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aminophylline; Bromhexine; Bronchitis; Bronchodilator Ag | 1999 |
[Weakening of the primary reaction to irradiation in curietherapy of patients with cancer of the cervix uteri].
Topics: Adult; Aged; Amphetamine; Chlorpromazine; Diphenhydramine; Female; Humans; Middle Aged; Perphenazine | 1967 |