diphenhydramine has been researched along with Hypoxia in 12 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5) diphenhydramine did not affect the ventilatory response to hypercapnia." | 3.69 | Diphenhydramine enhances the interaction of hypercapnic and hypoxic ventilatory drive. ( Alexander, CM; Blouin, RT; Conard, PF; Gross, JB; Seifert, HA, 1994) |
| " During pentobarbital anesthesia, 2 pulmonary hemodynamic studies were conducted on each dog with a sequence of baseline, hypoxia with FlO2 = 10%, hyperoxia with FlO2 = 100%, a second baseline, treatment with either diphenhydramine (D) or cimetidine (C), and another hypoxia." | 3.68 | Postadulticide pulmonary hypertension of canine heartworm disease: successful treatment with oxygen and failure of antihistamines. ( Rawlings, CA; Tackett, RL, 1990) |
| "Exercise-induced arterial hypoxemia (EIAH) has been observed in highly trained endurance athletes during near maximal exercise, which may be influenced by a histamine-mediated inflammatory response at the pulmonary capillary-alveolar membrane." | 1.72 | Nedocromil sodium and diphenhydramine HCl ameliorate exercise-induced arterial hypoxemia in highly trained athletes. ( Chapman, RF; Coyle, MA; Goss, CS; Greenshields, JT; Manz, WJ; Stager, JM, 2022) |
| "Azelastine is a new anti-allergic agent which inhibits leukotriene C4 synthesis and release." | 1.29 | Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor. ( Panizzon, KL; Wallis, RA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Coyle, MA | 1 |
| Goss, CS | 1 |
| Manz, WJ | 1 |
| Greenshields, JT | 1 |
| Chapman, RF | 1 |
| Stager, JM | 1 |
| Alexander, CM | 1 |
| Seifert, HA | 1 |
| Blouin, RT | 1 |
| Conard, PF | 1 |
| Gross, JB | 1 |
| Wallis, RA | 1 |
| Panizzon, KL | 1 |
| Gopalan, K | 1 |
| Dhandha, SK | 1 |
| Hyman, AL | 1 |
| Kadowitz, PJ | 1 |
| Daoud, FS | 1 |
| Reeves, JT | 1 |
| Kelly, DB | 1 |
| Giordano, J | 1 |
| Zinner, M | 1 |
| Guba, A | 1 |
| Lynch, N | 1 |
| Woods, JR | 1 |
| Brinkman, CR | 1 |
| Assali, NS | 1 |
| Rawlings, CA | 1 |
| Tackett, RL | 1 |
| Susmano, A | 1 |
| Carleton, RA | 1 |
| McManus, WF | 1 |
| Hunt, JL | 1 |
| Pruitt, BA | 1 |
| Bernardini, AT | 1 |
| Taub, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Nedocromil Sodium and Cetirizine HCl on Exercise-induced Arterial Hypoxemia in Highly-trained Swimmers[NCT05095311] | Phase 4 | 4 participants (Actual) | Interventional | 2021-05-19 | Terminated (stopped due to The recruited population was no longer made available to participate in the study.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for diphenhydramine and Hypoxia
| Article | Year |
|---|---|
Nedocromil sodium and diphenhydramine HCl ameliorate exercise-induced arterial hypoxemia in highly trained athletes.
Topics: Adult; Athletes; Diphenhydramine; Exercise; Exercise Test; Humans; Hypoxia; Male; Nedocromil; Oxygen | 2022 |
Diphenhydramine enhances the interaction of hypercapnic and hypoxic ventilatory drive.
Topics: Adult; Carbon Dioxide; Diphenhydramine; Female; Humans; Hypercapnia; Hypoxia; Male; Respiration | 1994 |
Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor.
Topics: Animals; Diphenhydramine; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Leukotriene | 1993 |
Hypoxia following perioperative administration of vancomycin.
Topics: Child; Diphenhydramine; Humans; Hypoxia; Infant; Intraoperative Complications; Male; Vancomycin | 1993 |
Effects of alveolar and perfusion hypoxia and hypercapnia on pulmonary vascular resistance in the lamb.
Topics: Animals; Blood Pressure; Carbon Dioxide; Diphenhydramine; Histamine; Hydrogen-Ion Concentration; Hyp | 1975 |
Isoproterenol as a potential pulmonary vasodilator in primary pulmonary hypertension.
Topics: Administration, Oral; Adolescent; Adult; Azathioprine; Cardiac Catheterization; Cardiac Output; Diph | 1978 |
Effects of H1 and H2 histamine antagonists on the pulmonary pressor response to alveolar hypoxia.
Topics: Animals; Blood Pressure; Diphenhydramine; Dogs; Female; Femoral Artery; Hypoxia; Male; Metiamide; Mi | 1977 |
Fetal and neonatal cardiopulmonary response to histamine.
Topics: Animals; Animals, Newborn; Aorta; Blood Pressure; Diphenhydramine; Ductus Arteriosus; Female; Fetus; | 1976 |
Postadulticide pulmonary hypertension of canine heartworm disease: successful treatment with oxygen and failure of antihistamines.
Topics: Animals; Arsenamide; Blood Pressure; Cimetidine; Diphenhydramine; Dirofilariasis; Dog Diseases; Dogs | 1990 |
Effect of antihistaminic drugs on hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Chlorpheniramine; Diphenhydramine; Dogs; Female; Histamine H1 Antagonists; | 1973 |
Postburn convulsive disorders in children.
Topics: Adolescent; Age Factors; Autopsy; Brain Edema; Burns; Carbenicillin; Child; Child, Preschool; Diphen | 1974 |
Effects of reduced pressure and drug administration on the glucose tolerance test in the dog.
Topics: Aerospace Medicine; Altitude; Animals; Atmospheric Pressure; Blood Glucose; Dextroamphetamine; Diphe | 1969 |