diphenhydramine has been researched along with Hypotension in 35 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We determined the roles of platelet-activating factor (PAF) and histamine in anaphylactic hypotension in ovalbumin-sensitized anesthetized BALB/c mice." | 7.74 | PAF, rather than histamine, participates in mouse anaphylactic hypotension. ( Cui, S; Kurata, Y; Liu, W; Shibamoto, T; Takano, H; Zhang, W, 2008) |
| "In order to evaluate the role of prostacyclin in d-tubocurarine-induced hypotension in human, the authors examined the relationship of changes of arterial blood pressure and plasma 6-keto-PGF1 alpha level following iv administration of d-tubocurarine (dTc), with or without prior administration of aspirin and H1 antagonist." | 7.68 | Contribution of prostacyclin to D-tubocurarine-induced hypotension in humans. ( Arai, T; Hatano, Y; Komatsu, K; Mori, K; Nakajima, Y; Noda, J; Sawada, M; Shinkura, R, 1990) |
| "Baseline weight, hemodynamic parameters, QRS interval, time to hypotension, and diphenhydramine dose required to achieve hypotension were similar between groups." | 5.22 | Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model. ( Bebarta, VS; Boudreau, SM; Castaneda, M; Vargas, TE; Varney, SM; Zarzabal, LA, 2016) |
| "Mouse anaphylactic hypotension is caused by a decrease in cardiac output but not vasodilatation, via actions of PAF and histamine." | 3.80 | Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine. ( Kuda, Y; Kurata, Y; Shibamoto, T; Tanida, M; Wang, M, 2014) |
| "We determined the roles of platelet-activating factor (PAF) and histamine in anaphylactic hypotension in ovalbumin-sensitized anesthetized BALB/c mice." | 3.74 | PAF, rather than histamine, participates in mouse anaphylactic hypotension. ( Cui, S; Kurata, Y; Liu, W; Shibamoto, T; Takano, H; Zhang, W, 2008) |
| " Stimulation of histamine H1 receptors of the vascular endothelium was suggested to be critical for mouse anaphylactic hypotension, because pretreatment with diphenhydramine but not with cimetidine completely inhibited the hypotension." | 3.69 | Participation of nitric oxide in mouse anaphylactic hypotension. ( Ichiki, H; Ishiguro, K; Kunitomo, M; Oku, H; Osada, S; Semma, M, 1994) |
| "In order to evaluate the role of prostacyclin in d-tubocurarine-induced hypotension in human, the authors examined the relationship of changes of arterial blood pressure and plasma 6-keto-PGF1 alpha level following iv administration of d-tubocurarine (dTc), with or without prior administration of aspirin and H1 antagonist." | 3.68 | Contribution of prostacyclin to D-tubocurarine-induced hypotension in humans. ( Arai, T; Hatano, Y; Komatsu, K; Mori, K; Nakajima, Y; Noda, J; Sawada, M; Shinkura, R, 1990) |
| "5 mg/kg) (six times the ED95) can result in significant histamine release, resulting in systemic hypotension." | 3.67 | Combined H1 and H2 receptor blockade attenuates the cardiovascular effects of high-dose atracurium for rapid sequence endotracheal intubation. ( Gronert, GA; Hosking, MP; Lennon, RL, 1988) |
| " Complications of drug therapy included six-beat ventricular tachycardia and ventricular bigeminy (epinephrine) and exacerbated hypotension (diphenhydramine hydrochloride)." | 3.67 | Life-threatening hypotensive reactions to contrast media administration: comparison of pharmacologic and fluid therapy. ( Neff, CC; Pfister, RC; vanSonnenberg, E, 1987) |
| "This report describes an unexpected adverse effect in three children receiving teniposide at 3-5 times the conventional dosage (i." | 1.28 | Somnolence, hypotension, and metabolic acidosis following high-dose teniposide treatment in children with leukemia. ( Baker, DK; McLeod, HL; Pui, CH; Rodman, JH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (45.71) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 7 (20.00) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Jeffers, T | 1 |
| Darling, B | 1 |
| Edwards, C | 1 |
| Vadiei, N | 1 |
| Wang, M | 1 |
| Shibamoto, T | 2 |
| Tanida, M | 1 |
| Kuda, Y | 1 |
| Kurata, Y | 2 |
| Bhatt, HV | 1 |
| Frost, EA | 1 |
| Ji, J | 1 |
| Barrett, EJ | 1 |
| Varney, SM | 1 |
| Bebarta, VS | 1 |
| Boudreau, SM | 1 |
| Vargas, TE | 1 |
| Castaneda, M | 1 |
| Zarzabal, LA | 1 |
| Mong, JS | 1 |
| Ooi, CK | 1 |
| Liu, W | 1 |
| Cui, S | 1 |
| Zhang, W | 1 |
| Takano, H | 1 |
| Manivannan, V | 1 |
| Li, JT | 1 |
| Prasad, A | 1 |
| Campbell, RL | 1 |
| Dewachter, P | 1 |
| Mouton-Faivre, C | 1 |
| Kumar, A | 1 |
| Qureshi, A | 1 |
| SHAIMARDANOV, KA | 1 |
| LI, KM | 1 |
| TRINKNER, RL | 1 |
| PERKINS, HA | 1 |
| Ratnoff, OD | 1 |
| Nossel, HL | 1 |
| Osada, S | 1 |
| Ichiki, H | 1 |
| Oku, H | 1 |
| Ishiguro, K | 1 |
| Kunitomo, M | 1 |
| Semma, M | 1 |
| Lossef, SV | 1 |
| Barth, KH | 1 |
| Renz, C | 1 |
| Lynch, J | 1 |
| Thurn, J | 1 |
| Moss, J | 1 |
| Nieri, P | 1 |
| Martinotti, E | 1 |
| Calderone, V | 1 |
| Breschi, MC | 1 |
| Tanaka, Y | 1 |
| Makiyama, Y | 1 |
| Mitsui, Y | 1 |
| Obeid, AI | 1 |
| Johnson, L | 1 |
| Potts, J | 1 |
| Mookherjee, S | 1 |
| Eich, RH | 1 |
| McLeod, HL | 1 |
| Baker, DK | 1 |
| Pui, CH | 2 |
| Rodman, JH | 2 |
| Kellie, SJ | 1 |
| Crist, WM | 1 |
| Crone, ME | 1 |
| Fairclough, DL | 1 |
| Rivera, GK | 1 |
| Hatano, Y | 1 |
| Arai, T | 1 |
| Noda, J | 1 |
| Komatsu, K | 1 |
| Shinkura, R | 1 |
| Nakajima, Y | 1 |
| Sawada, M | 1 |
| Mori, K | 1 |
| Casthely, PA | 1 |
| Yoganathan, D | 1 |
| Karyanis, B | 1 |
| Salem, M | 1 |
| Yoganathan, T | 1 |
| Komer, C | 1 |
| Uribe, M | 1 |
| Sclafani, S | 1 |
| Hudak, A | 1 |
| Hosking, MP | 1 |
| Lennon, RL | 1 |
| Gronert, GA | 1 |
| Lyon, GD | 1 |
| Bruce, DL | 1 |
| vanSonnenberg, E | 1 |
| Neff, CC | 1 |
| Pfister, RC | 1 |
| Collins, JV | 1 |
| Townsend, J | 1 |
| Harris, PW | 1 |
| Clark, TJ | 1 |
| Goulding, R | 1 |
| Foldes, FF | 1 |
| Lederis, K | 1 |
| Medaković, M | 1 |
| Rosner, S | 1 |
| Falleroni, AE | 1 |
| Sheffer, AL | 1 |
| Egdell, RW | 1 |
| Johnson, WD | 1 |
| Haber, K | 1 |
2 reviews available for diphenhydramine and Hypotension
| Article | Year |
|---|---|
Neuroleptanesthesia for general surgery.
Topics: Alphaprodine; Anesthesia, Inhalation; Diphenhydramine; Droperidol; Female; Fentanyl; Humans; Hyperte | 1973 |
Treatment of allergic emergencies.
Topics: Aminophylline; Anaphylaxis; Antigen-Antibody Reactions; Bronchial Spasm; Diphenhydramine; Drug Hyper | 1968 |
3 trials available for diphenhydramine and Hypotension
| Article | Year |
|---|---|
Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model.
Topics: Animals; Diphenhydramine; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Hemodynamics; | 2016 |
Histamine release during rapid vancomycin administration.
Topics: Anti-Bacterial Agents; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Exan | 1998 |
Histamine blockade and cardiovascular changes following heparin administration during cardiac surgery.
Topics: Blood Pressure; Calcium; Cardiac Output; Cimetidine; Coronary Artery Bypass; Diphenhydramine; Hepari | 1990 |
30 other studies available for diphenhydramine and Hypotension
| Article | Year |
|---|---|
Efficacy of Combination Haloperidol, Lorazepam, and Diphenhydramine vs. Combination Haloperidol and Lorazepam in the Treatment of Acute Agitation: A Multicenter Retrospective Cohort Study.
Topics: Adult; Antipsychotic Agents; Diphenhydramine; Haloperidol; Humans; Hypotension; Lorazepam; Muscarini | 2022 |
Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine.
Topics: Anaphylaxis; Animals; Arterial Pressure; Cardiac Output; Diphenhydramine; Hemodynamics; Histamine; H | 2014 |
Cardiovascular Collapse After Induction.
Topics: Adrenergic alpha-Agonists; Aged, 80 and over; Anaphylaxis; Anesthetics, Intravenous; Anti-Allergic A | 2015 |
Suspected intraoperative anaphylaxis to gelatin absorbable hemostatic sponge.
Topics: Anaphylaxis; Anti-Allergic Agents; Anti-Inflammatory Agents; Child, Preschool; Dental Care for Chron | 2015 |
Transient Coagulopathy Due to Wasp Sting: A Case Report.
Topics: Adult; Anaphylaxis; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Blood Coagulation Disor | 2017 |
PAF, rather than histamine, participates in mouse anaphylactic hypotension.
Topics: Anaphylaxis; Animals; Blood Pressure; Diphenhydramine; Histamine; Histamine H1 Antagonists; Hypotens | 2008 |
Apical ballooning syndrome after administration of intravenous epinephrine during an anaphylactic reaction.
Topics: Adult; Anaphylaxis; Anti-Allergic Agents; Bee Venoms; Bites and Stings; Diphenhydramine; Epinephrine | 2009 |
Possible link between apical ballooning syndrome during anaphylaxis and inappropriate administration of epinephrine.
Topics: Adult; Anaphylaxis; Anti-Allergic Agents; Bee Venoms; Bites and Stings; Diphenhydramine; Epinephrine | 2010 |
Possible link between apical ballooning syndrome during anaphylaxis and inappropriate administration of epinephrine-1.
Topics: Adult; Anaphylaxis; Anti-Allergic Agents; Bee Venoms; Bites and Stings; Diphenhydramine; Epinephrine | 2010 |
[ON PHYSIOLOGICAL ANALYSIS OF THE PREVENTIVE ACTION OF DIMEDROL IN HEMOHETEROTRANSFUSION SHOCK].
Topics: Acetylcholine; Animals; Blood Group Incompatibility; Blood Transfusion; Diphenhydramine; Dogs; Epine | 1963 |
ACTION OF PUFFER FISH POISON.
Topics: Animals; Antitoxins; Cats; Cell Respiration; Diphenhydramine; Dogs; Fishes; Gonads; Hypotension; Liv | 1963 |
SEVERE ACUTE FIBRINOGENOPENIA APPARENTLY CAUSED BY REACTION TO DRUGS.
Topics: Afibrinogenemia; Blood Coagulation Tests; Diatrizoate; Diphenhydramine; Diuretics; Drug Hypersensiti | 1964 |
Wasp sting anaphylaxis.
Topics: Adult; Anaphylaxis; Blood Coagulation; Diphenhydramine; Dopamine; Epinephrine; Fibrinolysis; Humans; | 1983 |
Participation of nitric oxide in mouse anaphylactic hypotension.
Topics: Anaphylaxis; Animals; Arginine; Blood Pressure; Diphenhydramine; Female; Hypotension; Male; Mice; Mu | 1994 |
Severe delayed hypotensive reaction after Ethiodol lymphangiography despite premedication.
Topics: Adult; Diphenhydramine; Drug Hypersensitivity; Ethiodized Oil; Female; Humans; Hypersensitivity, Del | 1993 |
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Respons | 2001 |
Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antibodies, Monoclonal; Azepines; Capillary Permeability | 2002 |
Fluid therapy in severe systemic reaction to radiopaque dye.
Topics: Anaphylaxis; Blood Pressure; Cardiac Catheterization; Contrast Media; Diphenhydramine; Drug Hypersen | 1975 |
Somnolence, hypotension, and metabolic acidosis following high-dose teniposide treatment in children with leukemia.
Topics: Acidosis; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Diphe | 1991 |
Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Bronchial Spasm | 1991 |
Contribution of prostacyclin to D-tubocurarine-induced hypotension in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Pressure; Depression, Chemical; Diphenhydramine; | 1990 |
Combined H1 and H2 receptor blockade attenuates the cardiovascular effects of high-dose atracurium for rapid sequence endotracheal intubation.
Topics: Atracurium; Blood Pressure; Cimetidine; Diphenhydramine; Heart Rate; Histamine; Histamine H1 Antagon | 1988 |
Diphenhydramine reversal of vancomycin-induced hypotension.
Topics: Bronchial Spasm; Child, Preschool; Diphenhydramine; Humans; Hypotension; Infusions, Intravenous; Mal | 1988 |
Life-threatening hypotensive reactions to contrast media administration: comparison of pharmacologic and fluid therapy.
Topics: Adolescent; Adult; Aged; Diatrizoate; Diphenhydramine; Drug Therapy, Combination; Epinephrine; Femal | 1987 |
Plasma-11-hydroxycorticosteroid levels in drug-induced coma.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Amitriptyline; Barbiturates; Blood Pressure; Body Temperatu | 1971 |
Pharmacological observations on the hypotensive action of extracts of teleost fish Urophyses (urotensin I) in the rat.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Blood Pressure; Bradykinin; Diphenhydramine; Epine | 1974 |
The diagnosis and treatment of cerebral concussion.
Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele | 1967 |
Treatment of anaphylaxis.
Topics: Anaphylaxis; Desensitization, Immunologic; Diphenhydramine; Drug Hypersensitivity; Ephedrine; Epinep | 1973 |
Postpartum hypotension and erythema: an adverse reaction to soap enema.
Topics: Adult; Atropine; Bradycardia; Diphenhydramine; Enema; Erythema; Female; Hematocrit; Humans; Hypotens | 1973 |
Changes in renal size as related to blood pressure during an idiosyncratic reaction to radiographic contrast.
Topics: Blood Pressure; Diatrizoate; Diphenhydramine; Drug Hypersensitivity; Edema; Female; Humans; Hydrocor | 1974 |