diphenhydramine has been researched along with Hives in 77 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adult patients presenting to EDs and urgent care centers with acute urticaria requiring an intravenous antihistamine were randomized to either intravenous cetirizine 10 mg or intravenous diphenhydramine 50 mg." | 9.34 | Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial. ( Abella, BS; Berger, WE; Blaiss, MS; Caterino, JM; Du, J; Herres, JP; Kessler, A; Klausner, HA; Moellman, JJ; Stiell, IG; Suner, S, 2020) |
| "To evaluate the efficacy of a 4-day "burst" course of prednisone added to standard treatment with H1 antihistamines for the management of acute urticaria in outpatients." | 9.08 | Outpatient management of acute urticaria: the role of prednisone. ( Pollack, CV; Romano, TJ, 1995) |
| "Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)." | 9.05 | Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985) |
| "Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections)." | 7.81 | Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. ( Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E, 2015) |
| "Famotidine was found to reduce pruritus associated with acute urticaria, intensity of urticaria, and body surface area affected by urticaria without causing sedation." | 6.69 | Famotidine in the treatment of acute urticaria. ( Harter, PM; Watson, NT; Weiss, EL, 2000) |
| "Adult patients presenting to EDs and urgent care centers with acute urticaria requiring an intravenous antihistamine were randomized to either intravenous cetirizine 10 mg or intravenous diphenhydramine 50 mg." | 5.34 | Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial. ( Abella, BS; Berger, WE; Blaiss, MS; Caterino, JM; Du, J; Herres, JP; Kessler, A; Klausner, HA; Moellman, JJ; Stiell, IG; Suner, S, 2020) |
| "To evaluate the efficacy of a 4-day "burst" course of prednisone added to standard treatment with H1 antihistamines for the management of acute urticaria in outpatients." | 5.08 | Outpatient management of acute urticaria: the role of prednisone. ( Pollack, CV; Romano, TJ, 1995) |
| "Orally administered diphenhydramine, famotidine, and cromolyn sodium were compared for their abilities to alleviate symptoms of acute urticaria." | 5.07 | Oral agents in the management of urticaria: patient perception of effectiveness and level of satisfaction with treatment. ( Bradford, JC; Pontasch, MJ; White, LJ, 1993) |
| "Of the 35 patients with pruritus, all 12 receiving diphenhydramine placebo had clinically significant relief compared with six of ten (60%) receiving cimetidine plus placebo (P = ." | 5.07 | Histamine antagonists in the treatment of acute allergic reactions. ( Caravati, EM; Hartsell, SC; Martinez, JC; Runge, JW; Williamson, SG, 1992) |
| "The efficacy of astemizole, diphenhydramine, and hydroxyzine hydrochloride in the treatment of chronic idiopathic urticaria was evaluated in this 3-month double-blind, randomized, parallel group study." | 5.07 | Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria. ( Jancelewicz, Z; Sussman, G, 1991) |
| "Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)." | 5.05 | Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985) |
| " A combination of ranitidine with diphenhydramine was more effective at improving the resolution of urticaria than diphenhydramine administered alone (risk ratio (RR) 1." | 4.88 | Histamine H2-receptor antagonists for urticaria. ( Fedorowicz, Z; Hu, N; van Zuuren, EJ, 2012) |
| "Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections)." | 3.81 | Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. ( Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E, 2015) |
| " Within 30 minutes after initiation of PN and lipids, the patient developed a total-body pruritic urticarial rash that resolved after discontinuation of the infusions and administration of diphenhydramine." | 3.78 | Parenteral nutrition-induced hypersensitivity in an adolescent. ( Bartels, CL; Coulter, DW; Sanz, C; Stec, R, 2012) |
| "Leucocytes from healthy donors were isolated and incubated in varying concentrations of ciclosporin, ascomycin, methotrexate, diphenhydramine or hydroxyzine for 30 min prior to stimulation with serum from urticaria patients known to have functional immunoglobulin (Ig)G antibodies directed against the alpha subunit of the IgE receptor." | 3.73 | Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria. ( Joseph, K; Kaplan, AP; Marsland, AM; Soundararajan, S, 2005) |
| "In a single patient with severe essential acquired cold urticaria, the following drug regimes were assessed: diphenhydramine, cyproheptadine, hydroxyzine, terbutaline, cimetidine, hydroxyzine plus cimetidine, and hydroxyzine plus terbutaline." | 3.66 | Treatment of cold urticaria. ( Highet, AS; Titterington, DM, 1979) |
| "Famotidine was found to reduce pruritus associated with acute urticaria, intensity of urticaria, and body surface area affected by urticaria without causing sedation." | 2.69 | Famotidine in the treatment of acute urticaria. ( Harter, PM; Watson, NT; Weiss, EL, 2000) |
| "Dimenhydrinate is a salt of diphenhydramine and 8-chlorotheophylline, and has been reported to produce superior oral absorption of diphenhydramine." | 1.51 | Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. ( Bäumer, W; Ehling, S; Papich, MG, 2019) |
| "Differentiation of pemphigoid gestationis from pruritic urticarial papules and plaques of pregnancy is essential because management and outcomes differ." | 1.36 | Pemphigoid gestationis. ( Kamino, H; Lu, PD; Ralston, J; Stein, JA, 2010) |
| "Pretreatment with prednisone plus diphenhydramine or prednisone and diphenhydramine plus ephedrine decreased the reaction rate to 9." | 1.27 | Two pretreatment regimens for high-risk patients receiving radiographic contrast media. ( Greenberger, PA; Patterson, R; Radin, RC, 1984) |
| "There was no evidence of causes for the anaphylactic reactions over a two and a half year period." | 1.27 | Life-threatening idiopathic anaphylaxis associated with hyperimmunoglobulinemia E. ( Greenberger, PA, 1984) |
| "Chronic urticaria is plainly visible in clinical presentation but is more elusive in diagnosis and treatment." | 1.27 | Urticaria--a challenge in diagnosis and treatment. ( Wagner, WO, 1988) |
| "Patients with prior anaphylactoid reactions (AR) to radiographic contrast media (RCM) are at increased risk for another reaction upon repeat exposure to RCM." | 1.26 | Radiographic contrast media studies in high-risk patients. ( Kelly, JF; Lieberman, P; Mathison, DA; Patterson, R; Stevenson, DD, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (51.95) | 18.7374 |
| 1990's | 7 (9.09) | 18.2507 |
| 2000's | 14 (18.18) | 29.6817 |
| 2010's | 14 (18.18) | 24.3611 |
| 2020's | 2 (2.60) | 2.80 |
| Authors | Studies |
|---|---|
| Blaiss, MS | 2 |
| Bernstein, JA | 1 |
| Kessler, A | 2 |
| Pines, JM | 1 |
| Camargo, CA | 1 |
| Fulgham, P | 1 |
| Haumschild, R | 1 |
| Rupp, K | 1 |
| Tyler, T | 1 |
| Moellman, J | 1 |
| Abella, BS | 1 |
| Berger, WE | 1 |
| Stiell, IG | 1 |
| Herres, JP | 1 |
| Moellman, JJ | 1 |
| Suner, S | 1 |
| Klausner, HA | 1 |
| Caterino, JM | 1 |
| Du, J | 1 |
| Sinha, KR | 1 |
| Duckwiler, G | 1 |
| Rootman, DB | 1 |
| Iweala, OI | 1 |
| Copenhaver, C | 1 |
| Wu, EY | 1 |
| Moran, TP | 1 |
| Ehling, S | 1 |
| Bäumer, W | 1 |
| Papich, MG | 1 |
| Rodriguez-Nava, G | 1 |
| Kesler, AM | 1 |
| Carrillo-Martin, I | 1 |
| Gonzalez-Estrada, A | 2 |
| Vebriene, R | 1 |
| Malinauskiene, L | 1 |
| Blaziene, A | 1 |
| Chomiciene, A | 1 |
| Astudillo, PP | 1 |
| Durairaj, P | 1 |
| Chan, HS | 1 |
| Héon, E | 1 |
| Gallie, BL | 1 |
| Cuervo-Pardo, L | 1 |
| Fernandez, J | 1 |
| Pien, LC | 1 |
| Hirohata, A | 1 |
| Yamaoka, T | 1 |
| Hayashi, M | 1 |
| Murota, H | 1 |
| Tani, M | 1 |
| Katayama, I | 1 |
| Paraska, KK | 1 |
| Myers, SR | 1 |
| Lavelle, J | 1 |
| WILLCOX, RR | 1 |
| Sheth, SS | 1 |
| Posner, MA | 1 |
| O'LEARY, PA | 2 |
| FARBER, EM | 2 |
| CURTIS, AC | 2 |
| OWENS, BB | 2 |
| SHAFFER, LW | 1 |
| CARRICK, L | 1 |
| ZACKHEIM, HS | 1 |
| FEINBERG, SM | 2 |
| FRIEDLAENDER, S | 2 |
| ARNOLD, HL | 2 |
| TODD, LC | 1 |
| BAREFOOT, SW | 1 |
| RILEY, KA | 1 |
| KUHN, BH | 1 |
| ULBRICH, AP | 1 |
| Lu, PD | 1 |
| Ralston, J | 1 |
| Kamino, H | 1 |
| Stein, JA | 1 |
| Eisenberg, S | 1 |
| Bartels, CL | 1 |
| Sanz, C | 1 |
| Stec, R | 1 |
| Coulter, DW | 1 |
| Fedorowicz, Z | 1 |
| van Zuuren, EJ | 1 |
| Hu, N | 1 |
| Barbalinardo, LH | 1 |
| Holdiness, MR | 1 |
| Wasserman, NH | 1 |
| LAPIDES, J | 1 |
| BOYD, RE | 1 |
| LESLIE, G | 1 |
| ROWE, RG | 1 |
| YOUNG, MJ | 1 |
| PORSIO, A | 1 |
| BORGIA, M | 1 |
| MacGinnitie, AJ | 1 |
| Walensky, LD | 1 |
| Turvey, SE | 1 |
| Orange, JS | 1 |
| Bonilla, FA | 1 |
| Silverman, LB | 1 |
| Oettgen, H | 1 |
| Marsland, AM | 1 |
| Soundararajan, S | 1 |
| Joseph, K | 1 |
| Kaplan, AP | 2 |
| La Shell, MS | 1 |
| Tankersley, MS | 1 |
| Kobayashi, M | 1 |
| Zhao, Y | 1 |
| Steffensmeier, AC | 1 |
| Azar, AE | 1 |
| Fuller, JJ | 1 |
| Muller, BA | 1 |
| Russell, SR | 1 |
| Johnston, WE | 1 |
| Moss, J | 1 |
| Philbin, DM | 1 |
| Guiney, TE | 1 |
| Sisson, JH | 1 |
| Buckley, MJ | 1 |
| Lowenstein, E | 1 |
| Shelley, WB | 1 |
| Novozhilov, VA | 1 |
| Nizhnikova, KM | 1 |
| Garafalo, J | 1 |
| Greenberger, PA | 2 |
| Patterson, R | 3 |
| Radin, RC | 1 |
| Pollack, CV | 1 |
| Romano, TJ | 1 |
| Pontasch, MJ | 1 |
| White, LJ | 1 |
| Bradford, JC | 1 |
| Vaswani, SK | 1 |
| Plack, RH | 1 |
| Norman, PS | 1 |
| Aelony, Y | 1 |
| Watson, NT | 1 |
| Weiss, EL | 1 |
| Harter, PM | 1 |
| Postovsky, S | 1 |
| Elhasid, R | 1 |
| Ben-Barak, A | 1 |
| Levin, K | 1 |
| Ben Arush, MW | 1 |
| Brown, DL | 1 |
| Login, IS | 1 |
| Borish, L | 1 |
| Powers, PL | 1 |
| Skrebova, N | 1 |
| Takiwaki, H | 1 |
| Miyaoka, Y | 1 |
| Arase, S | 1 |
| Merk, HF | 1 |
| Highet, AS | 1 |
| Titterington, DM | 1 |
| Kelly, JF | 1 |
| Lieberman, P | 1 |
| Mathison, DA | 1 |
| Stevenson, DD | 1 |
| Horio, T | 1 |
| Maibach, HI | 2 |
| Johnson, HL | 1 |
| Schatz, M | 1 |
| Smith, JD | 1 |
| Odom, RB | 1 |
| Runge, JW | 1 |
| Martinez, JC | 1 |
| Caravati, EM | 1 |
| Williamson, SG | 1 |
| Hartsell, SC | 1 |
| Sussman, G | 1 |
| Jancelewicz, Z | 1 |
| Moscati, RM | 1 |
| Moore, GP | 1 |
| Wagner, WO | 1 |
| Filloux, F | 1 |
| Greene, SL | 1 |
| Reed, CE | 1 |
| Schroeter, AL | 1 |
| Huggins, RA | 1 |
| Smith, EL | 1 |
| Deavers, S | 1 |
| Dadiomova, VG | 1 |
| Zastenker, FS | 1 |
| Bakulina, KI | 1 |
| Kundel', LM | 1 |
| Sheffer, AL | 1 |
| Daughters, D | 1 |
| Zackheim, H | 1 |
| Maibach, H | 1 |
| Miller, R | 1 |
| White, LW | 1 |
| Schwartz, HJ | 1 |
| Lockshin, NA | 1 |
| Hurley, H | 1 |
| Zwemer, R | 1 |
| Hodge, S | 1 |
| Owen, LG | 1 |
| Fliegelman, MT | 1 |
| Kopp, WL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III, Multi-center, Double Blind, Randomized, Active Controlled Clinical Trial to Evaluate the Non-Inferiority Comparing Cetirizine Injection 10 mg to Diphenhydramine Injection, 50 mg, for the Treatment of Acute Urticaria[NCT02935699] | Phase 3 | 262 participants (Actual) | Interventional | 2017-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change from baseline to 2 hours in patient-rated pruritus Severity score (values at 2 hours minus Baseline)~Patient Pruritus Severity Score Ask the patient How severely are your hives itching at the moment? 0 = none~= mild (minimal awareness, easily tolerated)~= moderate (definite awareness, quite bothersome)~= severe (difficult to tolerate)" (NCT02935699)
Timeframe: 2 hr
| Intervention | score on a scale (Mean) |
|---|---|
| Test Drug | -1.61 |
| Control | -1.50 |
Number of patients who needed to return to treatment center approximately 24 hours after discharge (NCT02935699)
Timeframe: up to 24 hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Test Drug | 7 |
| Control | 19 |
"Patient Sedation Score at 2 hours~Ask the patient How drowsy do you feel at the moment? 0 = None (Not drowsy at all)~= Mild (Slightly drowsy)~= Moderate (Quite drowsy)~= Severe (Extremely drowsy)" (NCT02935699)
Timeframe: 2 hours
| Intervention | score on a scale (Mean) |
|---|---|
| Test Drug | 0.46 |
| Control | 0.88 |
Time spent (hours) at the treatment center (NCT02935699)
Timeframe: up to 24 hours
| Intervention | hours (Mean) |
|---|---|
| Test Drug | 1.71 |
| Control | 2.07 |
4 reviews available for diphenhydramine and Hives
| Article | Year |
|---|---|
The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review.
Topics: Administration, Intravenous; Adult; Cetirizine; Diphenhydramine; Histamine H1 Antagonists; Humans; U | 2022 |
Histamine H2-receptor antagonists for urticaria.
Topics: Cimetidine; Diphenhydramine; Drug Therapy, Combination; Famotidine; Histamine H1 Antagonists; Histam | 2012 |
Cold urticaria: a case report and review of the literature.
Topics: Anti-Allergic Agents; Child; Cold Temperature; Diagnosis, Differential; Diphenhydramine; Epinephrine | 2005 |
Standard treatment: the role of antihistamines.
Topics: Cyclizine; Cytochrome P-450 Enzyme System; Diphenhydramine; Electrocardiography; Histamine H1 Antago | 2001 |
9 trials available for diphenhydramine and Hives
| Article | Year |
|---|---|
Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Canada; Cetirizine; Diphenh | 2020 |
Acupuncture plus point-injection for 32 cases of obstinate urticaria.
Topics: Acupuncture Points; Acupuncture Therapy; Adolescent; Adult; Aged; Child; Combined Modality Therapy; | 2006 |
Outpatient management of acute urticaria: the role of prednisone.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agen | 1995 |
Oral agents in the management of urticaria: patient perception of effectiveness and level of satisfaction with treatment.
Topics: Adult; Aged; Cromolyn Sodium; Diphenhydramine; Famotidine; Female; Follow-Up Studies; Humans; Male; | 1993 |
Famotidine in the treatment of acute urticaria.
Topics: Acute Disease; Adolescent; Adult; Antipruritics; Diphenhydramine; Double-Blind Method; Famotidine; F | 2000 |
Histamine antagonists in the treatment of acute allergic reactions.
Topics: Adult; Anaphylaxis; Blood Pressure; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Therapy, | 1992 |
Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.
Topics: Adult; Aged; Astemizole; Chronic Disease; Diphenhydramine; Dose-Response Relationship, Drug; Double- | 1991 |
Comparison of cimetidine and diphenhydramine in the treatment of acute urticaria.
Topics: Acute Disease; Adolescent; Adult; Cimetidine; Diphenhydramine; Double-Blind Method; Humans; Middle A | 1990 |
Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria.
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Autoantibodies; Blood Sedimentation; Child; Chroni | 1985 |
64 other studies available for diphenhydramine and Hives
| Article | Year |
|---|---|
Urticarial reaction following endovascular embolization of an orbital arteriovenous malformation (AVM) with n-butyl cyanoacrylate (nBCA) glue.
Topics: Adult; Anti-Allergic Agents; Cerebral Angiography; Diagnosis, Differential; Diphenhydramine; Emboliz | 2017 |
Hydroxychloroquine as a steroid-sparing agent in an infant with chronic urticaria.
Topics: Acetates; Anti-Inflammatory Agents; Antimalarials; Cetirizine; Chronic Disease; Cyclopropanes; Diphe | 2018 |
Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study.
Topics: Administration, Intravenous; Administration, Oral; Animals; Cross-Over Studies; Dimenhydrinate; Diph | 2019 |
Gadolinium-induced anaphylaxis with positive skin test results.
Topics: Adult; Allergens; Anaphylaxis; Angioedema; Contrast Media; Diphenhydramine; Drug Hypersensitivity; F | 2019 |
Premedication for cold induced urticaria in a patient undergoing cold cardioplegia.
Topics: Aged; Cold Temperature; Diphenhydramine; Famotidine; Heart Arrest, Induced; Humans; Intraoperative C | 2019 |
Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma.
Topics: Anti-Allergic Agents; Antineoplastic Agents; Child, Preschool; Conjunctival Diseases; Diphenhydramin | 2015 |
A rash during surgery: rounding up the usual suspects.
Topics: Aged; Anti-Allergic Agents; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Chlorhexidine; D | 2015 |
Unique case of postural cholinergic urticaria induced by a standing position.
Topics: Acetylcholine; Adolescent; Diphenhydramine; Humans; Male; Posture; Terfenadine; Urticaria | 2016 |
Caterpillar stings: a case study.
Topics: Adult; Agricultural Workers' Diseases; Animals; Anti-Inflammatory Agents; Dexamethasone; Diphenhydra | 2009 |
Picture of the month--quiz case. Pneumonia with associated urticaria multiforme rash.
Topics: Child; Diagnosis, Differential; Diphenhydramine; Histamine H1 Antagonists; Humans; Male; Pneumonia; | 2009 |
Use of benadryl for penicillin urticaria; preliminary report.
Topics: Amino Acids; Diphenhydramine; Drug Combinations; Drug Eruptions; Ethers; Penicillins; Sorbitol; Urti | 1946 |
Modified protocol for desensitization to glatiramer acetate.
Topics: Adult; Chemotherapy, Adjuvant; Clinical Protocols; Desensitization, Immunologic; Diphenhydramine; Dr | 2010 |
Evaluation of beta-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in the treatment of urticaria, scleroderma and allied disturbances.
Topics: Amino Acids; Diphenhydramine; Drug Combinations; Ether; Ethers; Humans; Scleroderma, Systemic; Sorbi | 1946 |
Benadryl in the treatment of urticaria.
Topics: Diphenhydramine; Urticaria | 1945 |
Beta dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in treatment of urticaria.
Topics: Diphenhydramine; Ether; Ethers; Humans; Salts; Urticaria | 1945 |
Use of benadryl for urticaria and related dermatoses; a preliminary report.
Topics: Diphenhydramine; Humans; Skin Diseases; Urticaria | 1945 |
Relief of dermographism and other urticarias of histamine origin by a synthetic benzhydryl alkamine ether.
Topics: Amino Acids; Diphenhydramine; Drug Combinations; Ether; Histamine; Humans; Sorbitol; Urticaria | 1945 |
Symptomatic control of urticaria and its equivalents by benadryl; report of forty-seven consecutive treated cases.
Topics: Diphenhydramine; Humans; Urticaria | 1945 |
Urticaria; with observations on the use of the new anti-histamine drug, benadryl.
Topics: Anti-Allergic Agents; Diphenhydramine; Histamine Agents; Humans; Urticaria | 1946 |
Beta dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in the treatment of urticaria and related dermatoses.
Topics: Diphenhydramine; Ether; Ethers; Humans; North Carolina; Skin Diseases; Urticaria | 1946 |
Histamine antagonists; the effect of oral and local use of beta-dimethylamincethyl benzhydryl ether hydrochloride on the whealing due to histamine, antigen-antibody reactions, and other whealing mechanisms; therapeutic results in allergic manifestations.
Topics: Anaphylaxis; Antigen-Antibody Reactions; Diphenhydramine; Ether; Histamine; Histamine Antagonists; H | 1946 |
Case reports of urticaria treated with benadryl.
Topics: Diphenhydramine; Humans; Urticaria | 1946 |
Benadryl in chronic urticaria.
Topics: Chronic Disease; Diphenhydramine; Urticaria | 1946 |
Pemphigoid gestationis.
Topics: Adult; Autoimmune Diseases; Basement Membrane; Complement C3; Diphenhydramine; Eosinophils; Female; | 2010 |
The case of the horrible hives.
Topics: Cimetidine; Diphenhydramine; Erythrocyte Transfusion; Histamine H1 Antagonists; Histamine H2 Antagon | 2011 |
Parenteral nutrition-induced hypersensitivity in an adolescent.
Topics: Adolescent; Amino Acids; Diphenhydramine; Glucose; Humans; Leukemia, Myeloid, Acute; Lipids; Male; P | 2012 |
Allergic response to lactogenesis 2?
Topics: Adult; Breast Feeding; Diphenhydramine; Female; Humans; Hypersensitivity; Lactation; Urticaria | 2012 |
Rare systemic dermatologic reaction after pneumococcal vaccine administration.
Topics: Aged; Anti-Allergic Agents; Anti-Inflammatory Agents; Diphenhydramine; Drug Eruptions; Humans; Hydro | 2003 |
Safety of first-generation antihistamines.
Topics: Diphenhydramine; Histamine H1 Antagonists; Humans; Trimethoprim, Sulfamethoxazole Drug Combination; | 2003 |
The effect of intravenous benadryl in allaying allergic manifestations of 70 per cent urokon.
Topics: Asthma; Contrast Media; Diphenhydramine; Humans; Shock; Urticaria | 1956 |
MEBROPHENHYDRAMINE ("MEBRYL") IN THE TREATMENT OF ALLERGIC CONDITIONS.
Topics: Acrylates; Angioedema; Anti-Allergic Agents; Diphenhydramine; Histamine H1 Antagonists; Humans; Urti | 1963 |
CLINICAL EVALUATION OF A NEW ANTIHISTAMINE, MEBROPHENHYDRAMINE.
Topics: Asthma; Dermatitis; Diphenhydramine; Histamine H1 Antagonists; Humans; Insect Bites and Stings; Phar | 1963 |
[ON THE THERAPEUTIC POSSIBILITIES OF A NEW DRUG ASSOCIATION WITH ANTIALLERGIC AND ANTIEXUDATIVE ACTIVITY].
Topics: Aminocaproates; Aminocaproic Acid; Anti-Allergic Agents; Diphenhydramine; Drug Hypersensitivity; Dru | 1964 |
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
Topics: Adolescent; Anaphylaxis; Anti-Allergic Agents; Antimetabolites, Antineoplastic; Antipruritics; Diphe | 2003 |
Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.
Topics: Basophils; Calcineurin Inhibitors; Cells, Cultured; Chronic Disease; Complement C5a; Cyclosporine; D | 2005 |
Vitreous injections of pegaptanib sodium triggering allergic reactions.
Topics: Aged, 80 and over; Anaphylaxis; Angiogenesis Inhibitors; Aptamers, Nucleotide; Choroidal Neovascular | 2007 |
Management of cold urticaria during hypothermic cardiopulmonary bypass.
Topics: Cardiopulmonary Bypass; Cimetidine; Cold Temperature; Diphenhydramine; Histamine; Histamine H1 Antag | 1982 |
Commentary: antihistamines and the treatment of urticaria.
Topics: Dermatology; Diphenhydramine; Histamine H1 Antagonists; History, 20th Century; Humans; Urticaria | 1983 |
[Resuscitation in acute allergic reactions to drugs].
Topics: Adult; Aged; Aminopyrine; Anaphylaxis; Angioedema; Dextrans; Diphenhydramine; Drug Hypersensitivity; | 1980 |
Histamine release and therapy of severe dermatographism.
Topics: Adolescent; Animals; Cyproheptadine; Diphenhydramine; Female; Histamine; Histamine Release; Humans; | 1981 |
Centennial paper: Beta dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in treatment of urticaria by Arthur C. Curtis and Betty Brechner Owens.
Topics: Adolescent; Adult; Aged; Dermatology; Diphenhydramine; Female; History, 20th Century; Humans; Male; | 1983 |
Two pretreatment regimens for high-risk patients receiving radiographic contrast media.
Topics: Anaphylaxis; Contrast Media; Diphenhydramine; Ephedrine; Humans; Prednisone; Premedication; Risk; Ur | 1984 |
Life-threatening idiopathic anaphylaxis associated with hyperimmunoglobulinemia E.
Topics: Anaphylaxis; Cimetidine; Coronary Disease; Diphenhydramine; Humans; Hydroxyzine; Hypergammaglobuline | 1984 |
Acute severe urticaria and angioedema leading to myocardial infarction.
Topics: Adult; Angioedema; Angioplasty, Balloon, Coronary; Cell Degranulation; Diphenhydramine; Electrocardi | 1996 |
First-generation vs second-generation antihistamines.
Topics: Anti-Allergic Agents; Conflict of Interest; Diphenhydramine; Drug Industry; Histamine H1 Antagonists | 1998 |
Allergic reaction to high-dose methotrexate.
Topics: Adolescent; Anti-Anxiety Agents; Antimetabolites, Antineoplastic; Antipruritics; Bone Neoplasms; Dip | 2000 |
An urticarial IgE-mediated reaction to interferon beta-1b.
Topics: Adult; Anti-Allergic Agents; Diphenhydramine; Drug Hypersensitivity; Female; Humans; Hypersensitivit | 2001 |
Localized heat urticaria: a clinical study using laser Doppler flowmetry.
Topics: Administration, Topical; Aged; Cimetidine; Diphenhydramine; Female; Histamine; Histamine H1 Antagoni | 2001 |
Treatment of cold urticaria.
Topics: Adult; Cimetidine; Cold Temperature; Cyproheptadine; Diphenhydramine; Drug Therapy, Combination; Hum | 1979 |
Radiographic contrast media studies in high-risk patients.
Topics: Adult; Aged; Anaphylaxis; Angioedema; Contrast Media; Diphenhydramine; Female; Humans; Male; Prednis | 1978 |
Photoallergic urticaria induced by visible light. Additional cases and further studies.
Topics: Adult; Allergens; Diphenhydramine; Epinephrine; Humans; Immunization, Passive; Light; Male; Middle A | 1978 |
Contact urticaria syndrome. Contact urticaria to diethyltoluamide (immediate-type hypersensitivity).
Topics: Adult; Ammonium Sulfate; Atropine; Benzamides; Benzocaine; Chlorpheniramine; DEET; Dermatitis, Conta | 1975 |
Administration of radiographic contrast medium after a prior adverse reaction.
Topics: Contrast Media; Diphenhydramine; Humans; Premedication; Urticaria | 1975 |
Contact urticaria from cobalt chloride.
Topics: 1-Propanol; Adult; Child; Cobalt; Diphenhydramine; Female; Humans; Male; p-Methoxy-N-methylphenethyl | 1975 |
Urticaria--a challenge in diagnosis and treatment.
Topics: Cold Temperature; Dermatitis, Contact; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Food Hyp | 1988 |
Toxic encephalopathy caused by topically applied diphenhydramine.
Topics: Administration, Topical; Chickenpox; Child; Diphenhydramine; Hallucinations; Humans; Male; Psychoses | 1986 |
Some effects of autologous and homologous blood or plasma overtransfusions in the dog.
Topics: Animals; Blood Proteins; Blood Volume; Dextrans; Diphenhydramine; Dogs; Histamine Release; Transfusi | 1965 |
[Nasal electrophoresis of dimedrol and calcium in pruritic dermatosis].
Topics: Adult; Dermatitis, Exfoliative; Dermatomycoses; Diphenhydramine; Humans; Iontophoresis; Male; Middle | 1969 |
Treatment of anaphylaxis.
Topics: Anaphylaxis; Desensitization, Immunologic; Diphenhydramine; Drug Hypersensitivity; Ephedrine; Epinep | 1973 |
Urticaria and anaphylactoid reactions after topical application of mechlorethamine.
Topics: Aged; Anaphylaxis; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Female; Humans; Mechloretham | 1973 |
A case of episodic urticaria due to saccharin ingestion.
Topics: Allergens; Bronchial Spasm; Diphenhydramine; Drug Hypersensitivity; Female; Hirsutism; Humans; Obesi | 1974 |
Urticaria as a sign of viral hepatitis.
Topics: Acute Disease; Adolescent; Adult; Diphenhydramine; Hepatitis A; Hepatitis B; Heroin; Humans; Liver; | 1972 |
Persistent toxic erythema and chronic urticaria. Possible association with the use of measles virus vaccine.
Topics: Child, Preschool; Diphenhydramine; Erythema; Female; Humans; Immunoglobulin A; Measles Vaccine; Skin | 1971 |
Anaphylaxis from alphazurine 2G during lymphography.
Topics: Adult; Coloring Agents; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Hodgkin Disease; Humans | 1966 |