Page last updated: 2024-10-26

diphenhydramine and Hives

diphenhydramine has been researched along with Hives in 77 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Research Excerpts

ExcerptRelevanceReference
"Adult patients presenting to EDs and urgent care centers with acute urticaria requiring an intravenous antihistamine were randomized to either intravenous cetirizine 10 mg or intravenous diphenhydramine 50 mg."9.34Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial. ( Abella, BS; Berger, WE; Blaiss, MS; Caterino, JM; Du, J; Herres, JP; Kessler, A; Klausner, HA; Moellman, JJ; Stiell, IG; Suner, S, 2020)
"To evaluate the efficacy of a 4-day "burst" course of prednisone added to standard treatment with H1 antihistamines for the management of acute urticaria in outpatients."9.08Outpatient management of acute urticaria: the role of prednisone. ( Pollack, CV; Romano, TJ, 1995)
"Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)."9.05Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985)
"Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections)."7.81Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. ( Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E, 2015)
"Famotidine was found to reduce pruritus associated with acute urticaria, intensity of urticaria, and body surface area affected by urticaria without causing sedation."6.69Famotidine in the treatment of acute urticaria. ( Harter, PM; Watson, NT; Weiss, EL, 2000)
"Adult patients presenting to EDs and urgent care centers with acute urticaria requiring an intravenous antihistamine were randomized to either intravenous cetirizine 10 mg or intravenous diphenhydramine 50 mg."5.34Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial. ( Abella, BS; Berger, WE; Blaiss, MS; Caterino, JM; Du, J; Herres, JP; Kessler, A; Klausner, HA; Moellman, JJ; Stiell, IG; Suner, S, 2020)
"To evaluate the efficacy of a 4-day "burst" course of prednisone added to standard treatment with H1 antihistamines for the management of acute urticaria in outpatients."5.08Outpatient management of acute urticaria: the role of prednisone. ( Pollack, CV; Romano, TJ, 1995)
"Orally administered diphenhydramine, famotidine, and cromolyn sodium were compared for their abilities to alleviate symptoms of acute urticaria."5.07Oral agents in the management of urticaria: patient perception of effectiveness and level of satisfaction with treatment. ( Bradford, JC; Pontasch, MJ; White, LJ, 1993)
"Of the 35 patients with pruritus, all 12 receiving diphenhydramine placebo had clinically significant relief compared with six of ten (60%) receiving cimetidine plus placebo (P = ."5.07Histamine antagonists in the treatment of acute allergic reactions. ( Caravati, EM; Hartsell, SC; Martinez, JC; Runge, JW; Williamson, SG, 1992)
"The efficacy of astemizole, diphenhydramine, and hydroxyzine hydrochloride in the treatment of chronic idiopathic urticaria was evaluated in this 3-month double-blind, randomized, parallel group study."5.07Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria. ( Jancelewicz, Z; Sussman, G, 1991)
"Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)."5.05Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985)
" A combination of ranitidine with diphenhydramine was more effective at improving the resolution of urticaria than diphenhydramine administered alone (risk ratio (RR) 1."4.88Histamine H2-receptor antagonists for urticaria. ( Fedorowicz, Z; Hu, N; van Zuuren, EJ, 2012)
"Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections)."3.81Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. ( Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E, 2015)
" Within 30 minutes after initiation of PN and lipids, the patient developed a total-body pruritic urticarial rash that resolved after discontinuation of the infusions and administration of diphenhydramine."3.78Parenteral nutrition-induced hypersensitivity in an adolescent. ( Bartels, CL; Coulter, DW; Sanz, C; Stec, R, 2012)
"Leucocytes from healthy donors were isolated and incubated in varying concentrations of ciclosporin, ascomycin, methotrexate, diphenhydramine or hydroxyzine for 30 min prior to stimulation with serum from urticaria patients known to have functional immunoglobulin (Ig)G antibodies directed against the alpha subunit of the IgE receptor."3.73Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria. ( Joseph, K; Kaplan, AP; Marsland, AM; Soundararajan, S, 2005)
"In a single patient with severe essential acquired cold urticaria, the following drug regimes were assessed: diphenhydramine, cyproheptadine, hydroxyzine, terbutaline, cimetidine, hydroxyzine plus cimetidine, and hydroxyzine plus terbutaline."3.66Treatment of cold urticaria. ( Highet, AS; Titterington, DM, 1979)
"Famotidine was found to reduce pruritus associated with acute urticaria, intensity of urticaria, and body surface area affected by urticaria without causing sedation."2.69Famotidine in the treatment of acute urticaria. ( Harter, PM; Watson, NT; Weiss, EL, 2000)
"Dimenhydrinate is a salt of diphenhydramine and 8-chlorotheophylline, and has been reported to produce superior oral absorption of diphenhydramine."1.51Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. ( Bäumer, W; Ehling, S; Papich, MG, 2019)
"Differentiation of pemphigoid gestationis from pruritic urticarial papules and plaques of pregnancy is essential because management and outcomes differ."1.36Pemphigoid gestationis. ( Kamino, H; Lu, PD; Ralston, J; Stein, JA, 2010)
"Pretreatment with prednisone plus diphenhydramine or prednisone and diphenhydramine plus ephedrine decreased the reaction rate to 9."1.27Two pretreatment regimens for high-risk patients receiving radiographic contrast media. ( Greenberger, PA; Patterson, R; Radin, RC, 1984)
"There was no evidence of causes for the anaphylactic reactions over a two and a half year period."1.27Life-threatening idiopathic anaphylaxis associated with hyperimmunoglobulinemia E. ( Greenberger, PA, 1984)
"Chronic urticaria is plainly visible in clinical presentation but is more elusive in diagnosis and treatment."1.27Urticaria--a challenge in diagnosis and treatment. ( Wagner, WO, 1988)
"Patients with prior anaphylactoid reactions (AR) to radiographic contrast media (RCM) are at increased risk for another reaction upon repeat exposure to RCM."1.26Radiographic contrast media studies in high-risk patients. ( Kelly, JF; Lieberman, P; Mathison, DA; Patterson, R; Stevenson, DD, 1978)

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-199040 (51.95)18.7374
1990's7 (9.09)18.2507
2000's14 (18.18)29.6817
2010's14 (18.18)24.3611
2020's2 (2.60)2.80

Authors

AuthorsStudies
Blaiss, MS2
Bernstein, JA1
Kessler, A2
Pines, JM1
Camargo, CA1
Fulgham, P1
Haumschild, R1
Rupp, K1
Tyler, T1
Moellman, J1
Abella, BS1
Berger, WE1
Stiell, IG1
Herres, JP1
Moellman, JJ1
Suner, S1
Klausner, HA1
Caterino, JM1
Du, J1
Sinha, KR1
Duckwiler, G1
Rootman, DB1
Iweala, OI1
Copenhaver, C1
Wu, EY1
Moran, TP1
Ehling, S1
Bäumer, W1
Papich, MG1
Rodriguez-Nava, G1
Kesler, AM1
Carrillo-Martin, I1
Gonzalez-Estrada, A2
Vebriene, R1
Malinauskiene, L1
Blaziene, A1
Chomiciene, A1
Astudillo, PP1
Durairaj, P1
Chan, HS1
Héon, E1
Gallie, BL1
Cuervo-Pardo, L1
Fernandez, J1
Pien, LC1
Hirohata, A1
Yamaoka, T1
Hayashi, M1
Murota, H1
Tani, M1
Katayama, I1
Paraska, KK1
Myers, SR1
Lavelle, J1
WILLCOX, RR1
Sheth, SS1
Posner, MA1
O'LEARY, PA2
FARBER, EM2
CURTIS, AC2
OWENS, BB2
SHAFFER, LW1
CARRICK, L1
ZACKHEIM, HS1
FEINBERG, SM2
FRIEDLAENDER, S2
ARNOLD, HL2
TODD, LC1
BAREFOOT, SW1
RILEY, KA1
KUHN, BH1
ULBRICH, AP1
Lu, PD1
Ralston, J1
Kamino, H1
Stein, JA1
Eisenberg, S1
Bartels, CL1
Sanz, C1
Stec, R1
Coulter, DW1
Fedorowicz, Z1
van Zuuren, EJ1
Hu, N1
Barbalinardo, LH1
Holdiness, MR1
Wasserman, NH1
LAPIDES, J1
BOYD, RE1
LESLIE, G1
ROWE, RG1
YOUNG, MJ1
PORSIO, A1
BORGIA, M1
MacGinnitie, AJ1
Walensky, LD1
Turvey, SE1
Orange, JS1
Bonilla, FA1
Silverman, LB1
Oettgen, H1
Marsland, AM1
Soundararajan, S1
Joseph, K1
Kaplan, AP2
La Shell, MS1
Tankersley, MS1
Kobayashi, M1
Zhao, Y1
Steffensmeier, AC1
Azar, AE1
Fuller, JJ1
Muller, BA1
Russell, SR1
Johnston, WE1
Moss, J1
Philbin, DM1
Guiney, TE1
Sisson, JH1
Buckley, MJ1
Lowenstein, E1
Shelley, WB1
Novozhilov, VA1
Nizhnikova, KM1
Garafalo, J1
Greenberger, PA2
Patterson, R3
Radin, RC1
Pollack, CV1
Romano, TJ1
Pontasch, MJ1
White, LJ1
Bradford, JC1
Vaswani, SK1
Plack, RH1
Norman, PS1
Aelony, Y1
Watson, NT1
Weiss, EL1
Harter, PM1
Postovsky, S1
Elhasid, R1
Ben-Barak, A1
Levin, K1
Ben Arush, MW1
Brown, DL1
Login, IS1
Borish, L1
Powers, PL1
Skrebova, N1
Takiwaki, H1
Miyaoka, Y1
Arase, S1
Merk, HF1
Highet, AS1
Titterington, DM1
Kelly, JF1
Lieberman, P1
Mathison, DA1
Stevenson, DD1
Horio, T1
Maibach, HI2
Johnson, HL1
Schatz, M1
Smith, JD1
Odom, RB1
Runge, JW1
Martinez, JC1
Caravati, EM1
Williamson, SG1
Hartsell, SC1
Sussman, G1
Jancelewicz, Z1
Moscati, RM1
Moore, GP1
Wagner, WO1
Filloux, F1
Greene, SL1
Reed, CE1
Schroeter, AL1
Huggins, RA1
Smith, EL1
Deavers, S1
Dadiomova, VG1
Zastenker, FS1
Bakulina, KI1
Kundel', LM1
Sheffer, AL1
Daughters, D1
Zackheim, H1
Maibach, H1
Miller, R1
White, LW1
Schwartz, HJ1
Lockshin, NA1
Hurley, H1
Zwemer, R1
Hodge, S1
Owen, LG1
Fliegelman, MT1
Kopp, WL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase III, Multi-center, Double Blind, Randomized, Active Controlled Clinical Trial to Evaluate the Non-Inferiority Comparing Cetirizine Injection 10 mg to Diphenhydramine Injection, 50 mg, for the Treatment of Acute Urticaria[NCT02935699]Phase 3262 participants (Actual)Interventional2017-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change of Patient Rated Pruritus Score

"Change from baseline to 2 hours in patient-rated pruritus Severity score (values at 2 hours minus Baseline)~Patient Pruritus Severity Score Ask the patient How severely are your hives itching at the moment? 0 = none~= mild (minimal awareness, easily tolerated)~= moderate (definite awareness, quite bothersome)~= severe (difficult to tolerate)" (NCT02935699)
Timeframe: 2 hr

Interventionscore on a scale (Mean)
Test Drug-1.61
Control-1.50

Number of Patients Who Needed to Return to Treatment Center

Number of patients who needed to return to treatment center approximately 24 hours after discharge (NCT02935699)
Timeframe: up to 24 hrs

InterventionParticipants (Count of Participants)
Test Drug7
Control19

Patient Sedation Scores

"Patient Sedation Score at 2 hours~Ask the patient How drowsy do you feel at the moment? 0 = None (Not drowsy at all)~= Mild (Slightly drowsy)~= Moderate (Quite drowsy)~= Severe (Extremely drowsy)" (NCT02935699)
Timeframe: 2 hours

Interventionscore on a scale (Mean)
Test Drug0.46
Control0.88

Time to Discharge

Time spent (hours) at the treatment center (NCT02935699)
Timeframe: up to 24 hours

Interventionhours (Mean)
Test Drug1.71
Control2.07

Reviews

4 reviews available for diphenhydramine and Hives

ArticleYear
The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review.
    Advances in therapy, 2022, Volume: 39, Issue:1

    Topics: Administration, Intravenous; Adult; Cetirizine; Diphenhydramine; Histamine H1 Antagonists; Humans; U

2022
Histamine H2-receptor antagonists for urticaria.
    The Cochrane database of systematic reviews, 2012, Mar-14, Issue:3

    Topics: Cimetidine; Diphenhydramine; Drug Therapy, Combination; Famotidine; Histamine H1 Antagonists; Histam

2012
Cold urticaria: a case report and review of the literature.
    Cutis, 2005, Volume: 76, Issue:4

    Topics: Anti-Allergic Agents; Child; Cold Temperature; Diagnosis, Differential; Diphenhydramine; Epinephrine

2005
Standard treatment: the role of antihistamines.
    The journal of investigative dermatology. Symposium proceedings, 2001, Volume: 6, Issue:2

    Topics: Cyclizine; Cytochrome P-450 Enzyme System; Diphenhydramine; Electrocardiography; Histamine H1 Antago

2001

Trials

9 trials available for diphenhydramine and Hives

ArticleYear
Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial.
    Annals of emergency medicine, 2020, Volume: 76, Issue:4

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Canada; Cetirizine; Diphenh

2020
Acupuncture plus point-injection for 32 cases of obstinate urticaria.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2006, Volume: 26, Issue:1

    Topics: Acupuncture Points; Acupuncture Therapy; Adolescent; Adult; Aged; Child; Combined Modality Therapy;

2006
Outpatient management of acute urticaria: the role of prednisone.
    Annals of emergency medicine, 1995, Volume: 26, Issue:5

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agen

1995
Oral agents in the management of urticaria: patient perception of effectiveness and level of satisfaction with treatment.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:6

    Topics: Adult; Aged; Cromolyn Sodium; Diphenhydramine; Famotidine; Female; Follow-Up Studies; Humans; Male;

1993
Famotidine in the treatment of acute urticaria.
    Clinical and experimental dermatology, 2000, Volume: 25, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Antipruritics; Diphenhydramine; Double-Blind Method; Famotidine; F

2000
Histamine antagonists in the treatment of acute allergic reactions.
    Annals of emergency medicine, 1992, Volume: 21, Issue:3

    Topics: Adult; Anaphylaxis; Blood Pressure; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Therapy,

1992
Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.
    Annals of allergy, 1991, Volume: 67, Issue:4

    Topics: Adult; Aged; Astemizole; Chronic Disease; Diphenhydramine; Dose-Response Relationship, Drug; Double-

1991
Comparison of cimetidine and diphenhydramine in the treatment of acute urticaria.
    Annals of emergency medicine, 1990, Volume: 19, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Cimetidine; Diphenhydramine; Double-Blind Method; Humans; Middle A

1990
Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Autoantibodies; Blood Sedimentation; Child; Chroni

1985

Other Studies

64 other studies available for diphenhydramine and Hives

ArticleYear
Urticarial reaction following endovascular embolization of an orbital arteriovenous malformation (AVM) with n-butyl cyanoacrylate (nBCA) glue.
    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2017, Volume: 23, Issue:6

    Topics: Adult; Anti-Allergic Agents; Cerebral Angiography; Diagnosis, Differential; Diphenhydramine; Emboliz

2017
Hydroxychloroquine as a steroid-sparing agent in an infant with chronic urticaria.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2018, Volume: 120, Issue:1

    Topics: Acetates; Anti-Inflammatory Agents; Antimalarials; Cetirizine; Chronic Disease; Cyclopropanes; Diphe

2018
Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study.
    Veterinary dermatology, 2019, Volume: 30, Issue:2

    Topics: Administration, Intravenous; Administration, Oral; Animals; Cross-Over Studies; Dimenhydrinate; Diph

2019
Gadolinium-induced anaphylaxis with positive skin test results.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019, Volume: 122, Issue:6

    Topics: Adult; Allergens; Anaphylaxis; Angioedema; Contrast Media; Diphenhydramine; Drug Hypersensitivity; F

2019
Premedication for cold induced urticaria in a patient undergoing cold cardioplegia.
    Allergology international : official journal of the Japanese Society of Allergology, 2019, Volume: 68, Issue:4

    Topics: Aged; Cold Temperature; Diphenhydramine; Famotidine; Heart Arrest, Induced; Humans; Intraoperative C

2019
Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2015, Volume: 19, Issue:1

    Topics: Anti-Allergic Agents; Antineoplastic Agents; Child, Preschool; Conjunctival Diseases; Diphenhydramin

2015
A rash during surgery: rounding up the usual suspects.
    BMJ case reports, 2015, Mar-30, Volume: 2015

    Topics: Aged; Anti-Allergic Agents; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Chlorhexidine; D

2015
Unique case of postural cholinergic urticaria induced by a standing position.
    Clinical and experimental dermatology, 2016, Volume: 41, Issue:4

    Topics: Acetylcholine; Adolescent; Diphenhydramine; Humans; Male; Posture; Terfenadine; Urticaria

2016
Caterpillar stings: a case study.
    AAOHN journal : official journal of the American Association of Occupational Health Nurses, 2009, Volume: 57, Issue:10

    Topics: Adult; Agricultural Workers' Diseases; Animals; Anti-Inflammatory Agents; Dexamethasone; Diphenhydra

2009
Picture of the month--quiz case. Pneumonia with associated urticaria multiforme rash.
    Archives of pediatrics & adolescent medicine, 2009, Volume: 163, Issue:12

    Topics: Child; Diagnosis, Differential; Diphenhydramine; Histamine H1 Antagonists; Humans; Male; Pneumonia;

2009
Use of benadryl for penicillin urticaria; preliminary report.
    British medical journal, 1946, Nov-16, Volume: 2, Issue:4480

    Topics: Amino Acids; Diphenhydramine; Drug Combinations; Drug Eruptions; Ethers; Penicillins; Sorbitol; Urti

1946
Modified protocol for desensitization to glatiramer acetate.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2010, Volume: 105, Issue:2

    Topics: Adult; Chemotherapy, Adjuvant; Clinical Protocols; Desensitization, Immunologic; Diphenhydramine; Dr

2010
Evaluation of beta-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in the treatment of urticaria, scleroderma and allied disturbances.
    Proceedings of the staff meetings. Mayo Clinic, 1946, Aug-07, Volume: 21, Issue:16

    Topics: Amino Acids; Diphenhydramine; Drug Combinations; Ether; Ethers; Humans; Scleroderma, Systemic; Sorbi

1946
Benadryl in the treatment of urticaria.
    Proceedings of the staff meetings. Mayo Clinic, 1945, Nov-14, Volume: 20

    Topics: Diphenhydramine; Urticaria

1945
Beta dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in treatment of urticaria.
    Archives of dermatology and syphilology, 1945, Volume: 52

    Topics: Diphenhydramine; Ether; Ethers; Humans; Salts; Urticaria

1945
Use of benadryl for urticaria and related dermatoses; a preliminary report.
    Archives of dermatology and syphilology, 1945, Volume: 52

    Topics: Diphenhydramine; Humans; Skin Diseases; Urticaria

1945
Relief of dermographism and other urticarias of histamine origin by a synthetic benzhydryl alkamine ether.
    The Journal of allergy, 1945, Volume: 16

    Topics: Amino Acids; Diphenhydramine; Drug Combinations; Ether; Histamine; Humans; Sorbitol; Urticaria

1945
Symptomatic control of urticaria and its equivalents by benadryl; report of forty-seven consecutive treated cases.
    Proceedings of the staff meetings. Honolulu. Clinic, 1945, Volume: 11

    Topics: Diphenhydramine; Humans; Urticaria

1945
Urticaria; with observations on the use of the new anti-histamine drug, benadryl.
    Southern medicine and surgery, 1946, Volume: 108

    Topics: Anti-Allergic Agents; Diphenhydramine; Histamine Agents; Humans; Urticaria

1946
Beta dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in the treatment of urticaria and related dermatoses.
    North Carolina medical journal, 1946, Volume: 7

    Topics: Diphenhydramine; Ether; Ethers; Humans; North Carolina; Skin Diseases; Urticaria

1946
Histamine antagonists; the effect of oral and local use of beta-dimethylamincethyl benzhydryl ether hydrochloride on the whealing due to histamine, antigen-antibody reactions, and other whealing mechanisms; therapeutic results in allergic manifestations.
    The Journal of allergy, 1946, Volume: 17

    Topics: Anaphylaxis; Antigen-Antibody Reactions; Diphenhydramine; Ether; Histamine; Histamine Antagonists; H

1946
Case reports of urticaria treated with benadryl.
    The Journal of the American Osteopathic Association, 1946, Volume: 45

    Topics: Diphenhydramine; Humans; Urticaria

1946
Benadryl in chronic urticaria.
    Archives of dermatology and syphilology, 1946, Volume: 54

    Topics: Chronic Disease; Diphenhydramine; Urticaria

1946
Pemphigoid gestationis.
    Dermatology online journal, 2010, Nov-15, Volume: 16, Issue:11

    Topics: Adult; Autoimmune Diseases; Basement Membrane; Complement C3; Diphenhydramine; Eosinophils; Female;

2010
The case of the horrible hives.
    ONS connect, 2011, Volume: 26, Issue:5

    Topics: Cimetidine; Diphenhydramine; Erythrocyte Transfusion; Histamine H1 Antagonists; Histamine H2 Antagon

2011
Parenteral nutrition-induced hypersensitivity in an adolescent.
    JPEN. Journal of parenteral and enteral nutrition, 2012, Volume: 36, Issue:1

    Topics: Adolescent; Amino Acids; Diphenhydramine; Glucose; Humans; Leukemia, Myeloid, Acute; Lipids; Male; P

2012
Allergic response to lactogenesis 2?
    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2012, Volume: 7, Issue:2

    Topics: Adult; Breast Feeding; Diphenhydramine; Female; Humans; Hypersensitivity; Lactation; Urticaria

2012
Rare systemic dermatologic reaction after pneumococcal vaccine administration.
    Southern medical journal, 2003, Volume: 96, Issue:1

    Topics: Aged; Anti-Allergic Agents; Anti-Inflammatory Agents; Diphenhydramine; Drug Eruptions; Humans; Hydro

2003
Safety of first-generation antihistamines.
    The Journal of family practice, 2003, Volume: 52, Issue:9

    Topics: Diphenhydramine; Histamine H1 Antagonists; Humans; Trimethoprim, Sulfamethoxazole Drug Combination;

2003
The effect of intravenous benadryl in allaying allergic manifestations of 70 per cent urokon.
    The Journal of urology, 1956, Volume: 75, Issue:6

    Topics: Asthma; Contrast Media; Diphenhydramine; Humans; Shock; Urticaria

1956
MEBROPHENHYDRAMINE ("MEBRYL") IN THE TREATMENT OF ALLERGIC CONDITIONS.
    The British journal of dermatology, 1963, Volume: 75

    Topics: Acrylates; Angioedema; Anti-Allergic Agents; Diphenhydramine; Histamine H1 Antagonists; Humans; Urti

1963
CLINICAL EVALUATION OF A NEW ANTIHISTAMINE, MEBROPHENHYDRAMINE.
    Applied therapeutics, 1963, Volume: 5

    Topics: Asthma; Dermatitis; Diphenhydramine; Histamine H1 Antagonists; Humans; Insect Bites and Stings; Phar

1963
[ON THE THERAPEUTIC POSSIBILITIES OF A NEW DRUG ASSOCIATION WITH ANTIALLERGIC AND ANTIEXUDATIVE ACTIVITY].
    La Clinica terapeutica, 1964, Nov-15, Volume: 31

    Topics: Aminocaproates; Aminocaproic Acid; Anti-Allergic Agents; Diphenhydramine; Drug Hypersensitivity; Dru

1964
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2003, Volume: 14, Issue:5

    Topics: Adolescent; Anaphylaxis; Anti-Allergic Agents; Antimetabolites, Antineoplastic; Antipruritics; Diphe

2003
Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:5

    Topics: Basophils; Calcineurin Inhibitors; Cells, Cultured; Chronic Disease; Complement C5a; Cyclosporine; D

2005
Vitreous injections of pegaptanib sodium triggering allergic reactions.
    American journal of ophthalmology, 2007, Volume: 143, Issue:3

    Topics: Aged, 80 and over; Anaphylaxis; Angiogenesis Inhibitors; Aptamers, Nucleotide; Choroidal Neovascular

2007
Management of cold urticaria during hypothermic cardiopulmonary bypass.
    The New England journal of medicine, 1982, Jan-28, Volume: 306, Issue:4

    Topics: Cardiopulmonary Bypass; Cimetidine; Cold Temperature; Diphenhydramine; Histamine; Histamine H1 Antag

1982
Commentary: antihistamines and the treatment of urticaria.
    Archives of dermatology, 1983, Volume: 119, Issue:5

    Topics: Dermatology; Diphenhydramine; Histamine H1 Antagonists; History, 20th Century; Humans; Urticaria

1983
[Resuscitation in acute allergic reactions to drugs].
    Vestnik khirurgii imeni I. I. Grekova, 1980, Volume: 125, Issue:11

    Topics: Adult; Aged; Aminopyrine; Anaphylaxis; Angioedema; Dextrans; Diphenhydramine; Drug Hypersensitivity;

1980
Histamine release and therapy of severe dermatographism.
    The Journal of allergy and clinical immunology, 1981, Volume: 68, Issue:2

    Topics: Adolescent; Animals; Cyproheptadine; Diphenhydramine; Female; Histamine; Histamine Release; Humans;

1981
Centennial paper: Beta dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in treatment of urticaria by Arthur C. Curtis and Betty Brechner Owens.
    Archives of dermatology, 1983, Volume: 119, Issue:5

    Topics: Adolescent; Adult; Aged; Dermatology; Diphenhydramine; Female; History, 20th Century; Humans; Male;

1983
Two pretreatment regimens for high-risk patients receiving radiographic contrast media.
    The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:4 Pt 1

    Topics: Anaphylaxis; Contrast Media; Diphenhydramine; Ephedrine; Humans; Prednisone; Premedication; Risk; Ur

1984
Life-threatening idiopathic anaphylaxis associated with hyperimmunoglobulinemia E.
    The American journal of medicine, 1984, Volume: 76, Issue:3

    Topics: Anaphylaxis; Cimetidine; Coronary Disease; Diphenhydramine; Humans; Hydroxyzine; Hypergammaglobuline

1984
Acute severe urticaria and angioedema leading to myocardial infarction.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 77, Issue:2

    Topics: Adult; Angioedema; Angioplasty, Balloon, Coronary; Cell Degranulation; Diphenhydramine; Electrocardi

1996
First-generation vs second-generation antihistamines.
    Archives of internal medicine, 1998, Sep-28, Volume: 158, Issue:17

    Topics: Anti-Allergic Agents; Conflict of Interest; Diphenhydramine; Drug Industry; Histamine H1 Antagonists

1998
Allergic reaction to high-dose methotrexate.
    Medical and pediatric oncology, 2000, Volume: 35, Issue:2

    Topics: Adolescent; Anti-Anxiety Agents; Antimetabolites, Antineoplastic; Antipruritics; Bone Neoplasms; Dip

2000
An urticarial IgE-mediated reaction to interferon beta-1b.
    Neurology, 2001, May-22, Volume: 56, Issue:10

    Topics: Adult; Anti-Allergic Agents; Diphenhydramine; Drug Hypersensitivity; Female; Humans; Hypersensitivit

2001
Localized heat urticaria: a clinical study using laser Doppler flowmetry.
    Journal of dermatological science, 2001, Volume: 26, Issue:2

    Topics: Administration, Topical; Aged; Cimetidine; Diphenhydramine; Female; Histamine; Histamine H1 Antagoni

2001
Treatment of cold urticaria.
    The British journal of dermatology, 1979, Volume: 101, Issue:1

    Topics: Adult; Cimetidine; Cold Temperature; Cyproheptadine; Diphenhydramine; Drug Therapy, Combination; Hum

1979
Radiographic contrast media studies in high-risk patients.
    The Journal of allergy and clinical immunology, 1978, Volume: 62, Issue:3

    Topics: Adult; Aged; Anaphylaxis; Angioedema; Contrast Media; Diphenhydramine; Female; Humans; Male; Prednis

1978
Photoallergic urticaria induced by visible light. Additional cases and further studies.
    Archives of dermatology, 1978, Volume: 114, Issue:12

    Topics: Adult; Allergens; Diphenhydramine; Epinephrine; Humans; Immunization, Passive; Light; Male; Middle A

1978
Contact urticaria syndrome. Contact urticaria to diethyltoluamide (immediate-type hypersensitivity).
    Archives of dermatology, 1975, Volume: 111, Issue:6

    Topics: Adult; Ammonium Sulfate; Atropine; Benzamides; Benzocaine; Chlorpheniramine; DEET; Dermatitis, Conta

1975
Administration of radiographic contrast medium after a prior adverse reaction.
    Annals of internal medicine, 1975, Volume: 83, Issue:2

    Topics: Contrast Media; Diphenhydramine; Humans; Premedication; Urticaria

1975
Contact urticaria from cobalt chloride.
    Archives of dermatology, 1975, Volume: 111, Issue:12

    Topics: 1-Propanol; Adult; Child; Cobalt; Diphenhydramine; Female; Humans; Male; p-Methoxy-N-methylphenethyl

1975
Urticaria--a challenge in diagnosis and treatment.
    Postgraduate medicine, 1988, Volume: 83, Issue:5

    Topics: Cold Temperature; Dermatitis, Contact; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Food Hyp

1988
Toxic encephalopathy caused by topically applied diphenhydramine.
    The Journal of pediatrics, 1986, Volume: 108, Issue:6

    Topics: Administration, Topical; Chickenpox; Child; Diphenhydramine; Hallucinations; Humans; Male; Psychoses

1986
Some effects of autologous and homologous blood or plasma overtransfusions in the dog.
    The American journal of physiology, 1965, Volume: 209, Issue:4

    Topics: Animals; Blood Proteins; Blood Volume; Dextrans; Diphenhydramine; Dogs; Histamine Release; Transfusi

1965
[Nasal electrophoresis of dimedrol and calcium in pruritic dermatosis].
    Vestnik dermatologii i venerologii, 1969, Volume: 43, Issue:7

    Topics: Adult; Dermatitis, Exfoliative; Dermatomycoses; Diphenhydramine; Humans; Iontophoresis; Male; Middle

1969
Treatment of anaphylaxis.
    Postgraduate medicine, 1973, Volume: 53, Issue:4

    Topics: Anaphylaxis; Desensitization, Immunologic; Diphenhydramine; Drug Hypersensitivity; Ephedrine; Epinep

1973
Urticaria and anaphylactoid reactions after topical application of mechlorethamine.
    Archives of dermatology, 1973, Volume: 107, Issue:3

    Topics: Aged; Anaphylaxis; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Female; Humans; Mechloretham

1973
A case of episodic urticaria due to saccharin ingestion.
    The Journal of allergy and clinical immunology, 1974, Volume: 53, Issue:4

    Topics: Allergens; Bronchial Spasm; Diphenhydramine; Drug Hypersensitivity; Female; Hirsutism; Humans; Obesi

1974
Urticaria as a sign of viral hepatitis.
    Archives of dermatology, 1972, Volume: 105, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Diphenhydramine; Hepatitis A; Hepatitis B; Heroin; Humans; Liver;

1972
Persistent toxic erythema and chronic urticaria. Possible association with the use of measles virus vaccine.
    Archives of dermatology, 1971, Volume: 104, Issue:4

    Topics: Child, Preschool; Diphenhydramine; Erythema; Female; Humans; Immunoglobulin A; Measles Vaccine; Skin

1971
Anaphylaxis from alphazurine 2G during lymphography.
    JAMA, 1966, Nov-07, Volume: 198, Issue:6

    Topics: Adult; Coloring Agents; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Hodgkin Disease; Humans

1966