diphenhydramine has been researched along with Flushing in 7 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Flushing: A transient reddening of the face that may be due to fever, certain drugs, exertion, or stress.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The red man syndrome (RMS) is the most common toxicity of vancomycin therapy." | 5.07 | Red man syndrome: incidence, etiology, and prophylaxis. ( Mascola, JR; Oldfield, EC; Wallace, MR, 1991) |
| " Blood acetaldehyde and blood ethanol analyses were performed together with recordings of blood pressure, pulse rate, and flushing intensity during the hour after ethanol infusion." | 5.06 | Diphenhydramine and the calcium carbimide-ethanol reaction: a placebo-controlled clinical study. ( Johnsen, J; Mørland, J; Ripel, A; Stowell, A, 1986) |
| "When compared at 2 and 24 hours, aggressive (20 mg dosed up to four times) IV metoclopramide and 6 mg of subcutaneous sumatriptan relieved migraine headache pain comparably." | 2.71 | A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. ( Bijur, PE; Corbo, J; Esses, D; Friedman, BW; Gallagher, EJ; Lipton, RB; Solorzano, C, 2005) |
| "Diphenhydramine was similar to placebo in its effect on the flushing reaction." | 2.66 | Histamine receptor antagonism of intolerance to alcohol in the Oriental population. ( Anand, MM; Gabrielli, WF; Goodwin, DW; Hall, TB; Jones, FC; Miller, NS; Pardo, MP, 1987) |
| " A variety of adverse events (AEs) of varying severity have been noted during HPC infusions." | 1.40 | Infusion technique of hematopoietic progenitor cells and related adverse events (CME). ( Bryant, SC; Gastineau, DA; Greiner, CW; Hogan, WJ; Jacob, EK; Lingineni, RK; Mohr, A; Mulay, SB; Padley, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mulay, SB | 1 |
| Greiner, CW | 1 |
| Mohr, A | 1 |
| Bryant, SC | 1 |
| Lingineni, RK | 1 |
| Padley, D | 1 |
| Hogan, WJ | 1 |
| Gastineau, DA | 1 |
| Jacob, EK | 1 |
| Friedman, BW | 1 |
| Corbo, J | 1 |
| Lipton, RB | 1 |
| Bijur, PE | 1 |
| Esses, D | 1 |
| Solorzano, C | 1 |
| Gallagher, EJ | 1 |
| Conrad, H | 1 |
| Gausche-Hill, M | 1 |
| Burbulys, D | 1 |
| Wallace, MR | 1 |
| Mascola, JR | 1 |
| Oldfield, EC | 1 |
| Miller, NS | 2 |
| Goodwin, DW | 2 |
| Jones, FC | 2 |
| Gabrielli, WF | 2 |
| Pardo, MP | 2 |
| Anand, MM | 2 |
| Hall, TB | 2 |
| Stowell, A | 1 |
| Johnsen, J | 1 |
| Ripel, A | 1 |
| Mørland, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326] | 300 participants (Anticipated) | Interventional | 2012-03-01 | Completed | |||
| Treatment of Asian Flushing Syndrome With Topical Alpha Agonists[NCT03497442] | Early Phase 1 | 20 participants (Actual) | Interventional | 2018-07-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for diphenhydramine and Flushing
| Article | Year |
|---|---|
A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines.
Topics: Adult; Akathisia, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dizziness; | 2005 |
Red man syndrome: incidence, etiology, and prophylaxis.
Topics: Adult; Diphenhydramine; Double-Blind Method; Female; Flushing; Histamine; Humans; Male; Prospective | 1991 |
Antihistamine blockade of alcohol-induced flushing in orientals.
Topics: Adolescent; Adult; Alcoholism; Asian People; Blood Pressure; Cimetidine; Diphenhydramine; Ethanol; F | 1988 |
Diphenhydramine and the calcium carbimide-ethanol reaction: a placebo-controlled clinical study.
Topics: Acetaldehyde; Administration, Oral; Adult; Blood Pressure; Clinical Trials as Topic; Cyanamide; Cyan | 1986 |
Histamine receptor antagonism of intolerance to alcohol in the Oriental population.
Topics: Adolescent; Adult; Asian People; Blood Pressure; Cimetidine; Diphenhydramine; Drug Synergism; Ethano | 1987 |
2 other studies available for diphenhydramine and Flushing
| Article | Year |
|---|---|
Infusion technique of hematopoietic progenitor cells and related adverse events (CME).
Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Preservation; Child; Child, Preschool; Cryopreservatio | 2014 |
A 6-month old with total body flushing and a macular-papular lesion.
Topics: Diagnosis, Differential; Diphenhydramine; Flushing; Histamine H1 Antagonists; Histamine Release; Hum | 2007 |