Page last updated: 2024-10-26

diphenhydramine and Epilepsy

diphenhydramine has been researched along with Epilepsy in 13 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"We selected adverse drug reaction (ADR) reports on H1-antihistamines in children (0-16 years) up to June 2014 from VigiBase."1.46Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase. ( Biagi, C; Calamelli, E; Cipriani, F; Donati, M; Melis, M; Monaco, L; Motola, D; Ricci, G; Vaccheri, A, 2017)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19908 (61.54)18.7374
1990's0 (0.00)18.2507
2000's2 (15.38)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Motola, D1
Donati, M1
Biagi, C1
Calamelli, E1
Cipriani, F1
Melis, M1
Monaco, L1
Vaccheri, A1
Ricci, G1
Lucey, BP1
Noetzel, MJ1
Duntley, SP1
Verma, R1
Tiwari, N1
Ketkar, M1
Shrier, D1
OTAWARA, S1
KAJIYA, T1
SHIMO, M1
ISHIDA, T1
KATANO, R1
Fujii, Y1
Tanaka, T1
Harada, C1
Hirai, T1
Kamei, C1
CASTELLUCCIO, R1
Riehl, JL1
Lee, DK1
Andrews, JM1
Brown, WJ1
Kitagawa, T1
Takahashi, K1
Okuma, T1
Kawahara, R1
Umezawa, Y1
Kashiwagi, T1
Brick, DL1
de Sena, PG1
Rizzo, Ade O1
Kato, M1

Other Studies

13 other studies available for diphenhydramine and Epilepsy

ArticleYear
Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
    Pharmacoepidemiology and drug safety, 2017, Volume: 26, Issue:10

    Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Cetirizine; Child; Child Mortality; Child, Pres

2017
Paroxysmal arousals and myoclonic movements associated with interictal epileptiform discharges in NREM and REM sleep.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:5

    Topics: Adolescent; Amines; Antiparkinson Agents; Arousal; Chromosome Disorders; Chromosome Inversion; Chrom

2011
Phenytoin intoxication induced by Mandrax (methaqualone).
    Epilepsy research, 2012, Volume: 98, Issue:2-3

    Topics: Anticonvulsants; Cerebellar Diseases; Diphenhydramine; Drug Combinations; Epilepsy; Humans; Male; Me

2012
An allergic reaction to intraarterial nonionic contrast material.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Adult; Airway Obstruction; Bronchial Hyperreactivity; Carotid Artery, Common; Cerebral Angiography;

2003
[STUDIES ON ACTIVATION OF CLINICAL BRAIN WAVES IN CHILDREN WITH DIPHENHYDRAMINE].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1963, Volume: 67

    Topics: Adolescent; Bemegride; Brain Waves; Child; Diphenhydramine; Electroencephalography; Epilepsy; Humans

1963
Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.
    Brain research, 2003, Nov-21, Volume: 991, Issue:1-2

    Topics: Amygdala; Animals; Cetirizine; Diphenhydramine; Electroencephalography; Epilepsy; Histamine H1 Antag

2003
[Clinical experiences with a new anti-epileptic drug: hydotin (3-methyl-5,5-diphenyl-hydantoin)].
    La Semana medica, 1952, Apr-03, Volume: 100, Issue:14

    Topics: Anticonvulsants; Biphenyl Compounds; Diphenhydramine; Epilepsy; Hydantoins

1952
Electrophysiological and neuropharmacological studies in a patient with Unverricht-Lafora's disease.
    Neurology, 1967, Volume: 17, Issue:5

    Topics: Amphetamine; Atropine; Child; Chlordiazepoxide; Cytoplasmic Granules; Diphenhydramine; Electroenceph

1967
EEG activation of 3 Hz spike and wave complexes, especially activation with diphenhydramine (benadryl).
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Child; Diphenhydramine; Electroencephalography; Epilepsy; Female; Humans; Male

1980
An electroencephalographic study on the tolerance of psychiatric and neurologic patients to the hypnotic effect of diphenhydramine.
    Folia psychiatrica et neurologica japonica, 1973, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Bipolar Disorder; Diphenhydramine; Drug Tolerance; Electroencephalography; Epilep

1973
The management of difficult cases of epilepsy with mandrax.
    The Medical journal of Australia, 1972, Jun-10, Volume: 1, Issue:24

    Topics: Diphenhydramine; Drug Combinations; Epilepsy; Humans; Methaqualone

1972
[Mandrix in epilepsy].
    Hospital (Rio de Janeiro, Brazil), 1969, Volume: 76, Issue:6

    Topics: Adolescent; Adult; Child; Diphenhydramine; Electroencephalography; Epilepsy; Female; Humans; Male; M

1969
[Case of tonic seizure].
    No to shinkei = Brain and nerve, 1970, Volume: 22, Issue:6

    Topics: Adult; Arm; Benzazepines; Diphenhydramine; Electroencephalography; Epilepsy; Humans; Injections, Int

1970