diphenhydramine has been researched along with Emesis, Postoperative in 12 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ondansetron is as effective as diphenhydramine in relieving pruritus caused by SA morphine in patients undergoing a cesarean delivery." | 9.14 | Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. ( Adham, AM; Aouad, MT; Dagher, CM; Saasouh, WA; Siddik-Sayyid, SM; Yazbeck-Karam, VG; Zahreddine, BW, 2010) |
| "PONV was assessed in recovery and 24 hours after surgery in the ward." | 7.01 | Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: a Randomized Controlled Trial. ( Aghabagheri, M; Khajavi, MR; Najjari, K; Pourfakhr, P; Talebpour, M; Zabihi Mahmoudabadi, H, 2021) |
| "Ondansetron is as effective as diphenhydramine in relieving pruritus caused by SA morphine in patients undergoing a cesarean delivery." | 5.14 | Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery. ( Adham, AM; Aouad, MT; Dagher, CM; Saasouh, WA; Siddik-Sayyid, SM; Yazbeck-Karam, VG; Zahreddine, BW, 2010) |
| "the objective of this study was to assess whether antiemetic drugs metoclopramide and diphenhydramine, administered together as opposed to alone, can have better efficacy in preventing postoperative nausea and vomiting when added to patient-controlled morphine analgesia." | 5.14 | Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. ( Jean, WH; Lin, TY; Lu, CW; Shieh, JS; Wu, CC, 2010) |
| "PONV was assessed in recovery and 24 hours after surgery in the ward." | 3.01 | Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: a Randomized Controlled Trial. ( Aghabagheri, M; Khajavi, MR; Najjari, K; Pourfakhr, P; Talebpour, M; Zabihi Mahmoudabadi, H, 2021) |
| "Diphenhydramine is an antihistamine with previously demonstrated analgesic and antiemetic properties." | 2.82 | Dose-ranging effect of systemic diphenhydramine on postoperative quality of recovery after ambulatory laparoscopic surgery: a randomized, placebo-controlled, double-blinded, clinical trial. ( Bialek, J; De Oliveira, GS; Marcus, RJ; McCarthy, R, 2016) |
| "The incidence of postoperative nausea (31." | 2.71 | Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia. ( Lin, CJ; Lin, TF; Sun, WZ; Wang, YP; Yeh, YC; Yen, YH, 2005) |
| "57% of patients having complications (52 patients having 60 adverse events)." | 1.37 | Safety of intravenous sedation administered by the operating oral surgeon: the second 7 years of office practice. ( Rodgers, MS; Rodgers, SF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pourfakhr, P | 1 |
| Aghabagheri, M | 1 |
| Zabihi Mahmoudabadi, H | 1 |
| Najjari, K | 1 |
| Talebpour, M | 1 |
| Khajavi, MR | 1 |
| Brookes, CD | 1 |
| Turvey, TA | 1 |
| Phillips, C | 1 |
| Kopp, V | 1 |
| Anderson, JA | 1 |
| De Oliveira, GS | 1 |
| Bialek, J | 1 |
| Marcus, RJ | 1 |
| McCarthy, R | 1 |
| Siddik-Sayyid, SM | 1 |
| Yazbeck-Karam, VG | 1 |
| Zahreddine, BW | 1 |
| Adham, AM | 1 |
| Dagher, CM | 1 |
| Saasouh, WA | 1 |
| Aouad, MT | 1 |
| Lu, CW | 1 |
| Jean, WH | 1 |
| Wu, CC | 1 |
| Shieh, JS | 1 |
| Lin, TY | 1 |
| Rodgers, SF | 1 |
| Rodgers, MS | 1 |
| Nakagawachi, A | 1 |
| Yoshino, J | 1 |
| Miura, D | 1 |
| Izumi, K | 1 |
| Jimi, N | 1 |
| Sumiyoshi, R | 1 |
| Mizuno, K | 1 |
| LO JACONO, F | 1 |
| WARRINGTON, WR | 1 |
| PASQUESI, TJ | 1 |
| KULASAVAGE, RJ | 1 |
| McCAWLEY, EL | 2 |
| DIDIER, EP | 1 |
| BARILA, TG | 1 |
| SLOCUM, HC | 1 |
| LINDGREN, VV | 1 |
| PODLESCH, I | 1 |
| MEYER, M | 1 |
| BARTH, L | 1 |
| Lin, TF | 1 |
| Yeh, YC | 1 |
| Yen, YH | 1 |
| Wang, YP | 1 |
| Lin, CJ | 1 |
| Sun, WZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708] | 233 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours
| Intervention | hours (Median) |
|---|---|
| Intervention Cohort | 26.4 |
| Comparison Cohort | 28.2 |
To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital
| Intervention | percentage of subjects with PDN (Number) |
|---|---|
| Intervention Cohort | 72 |
| Comparison Cohort | 60 |
(NCT01592708)
Timeframe: 1 week post discharge
| Intervention | percentage of subjects with PDV (Number) |
|---|---|
| Intervention Cohort | 22 |
| Comparison Cohort | 29 |
End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with PON (Number) |
|---|---|
| Intervention Cohort | 24 |
| Comparison Cohort | 70 |
(NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with POV (Number) |
|---|---|
| Intervention Cohort | 11 |
| Comparison Cohort | 28 |
7 trials available for diphenhydramine and Emesis, Postoperative
| Article | Year |
|---|---|
Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: a Randomized Controlled Trial.
Topics: Acetaminophen; Antiemetics; Diphenhydramine; Double-Blind Method; Gastrectomy; Humans; Laparoscopy; | 2021 |
Postdischarge Nausea and Vomiting Remains Frequent After Le Fort I Osteotomy Despite Implementation of a Multimodal Antiemetic Protocol Effective in Reducing Postoperative Nausea and Vomiting.
Topics: Adolescent; Adult; Age Factors; Anesthesia Recovery Period; Antiemetics; Cohort Studies; Diphenhydra | 2015 |
Dose-ranging effect of systemic diphenhydramine on postoperative quality of recovery after ambulatory laparoscopic surgery: a randomized, placebo-controlled, double-blinded, clinical trial.
Topics: Administration, Intravenous; Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Antiemetics; | 2016 |
Ondansetron is as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery.
Topics: Adult; Cesarean Section; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Hum | 2010 |
Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Dexamethasone; Diphenhydramin | 2010 |
[Prophylactic effect of diphenhydramine on postoperative vomiting in children after laparoscopic surgery].
Topics: Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, General; Antiemetics; Child; Child, Pr | 2012 |
Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Diphenhydramine; Double | 2005 |
5 other studies available for diphenhydramine and Emesis, Postoperative
| Article | Year |
|---|---|
Safety of intravenous sedation administered by the operating oral surgeon: the second 7 years of office practice.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthetics, Intravenous; Conscious | 2011 |
[Effect of diphenhydramine on postoperative vomiting].
Topics: Diphenhydramine; Humans; Postoperative Care; Postoperative Nausea and Vomiting; Vomiting | 1953 |
Benadryl hydrochloride given intravenously to control postoperative nausea and vomiting.
Topics: Diphenhydramine; Humans; Nausea; Postoperative Nausea and Vomiting; Vomiting | 1953 |
An evaluation of antiemetic drugs in the control of postoperative nausea and vomiting.
Topics: Anti-Allergic Agents; Antiemetics; Chlorpromazine; Diphenhydramine; Histamine H1 Antagonists; Humans | 1955 |
[Prophylaxis and therapy of postoperative vomiting with the diphenhydramine derivative combination Rodavan; a clinical-statistical evaluation].
Topics: Caffeine; Diphenhydramine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Theoph | 1961 |