diphenhydramine has been researched along with Drug-Related Side Effects and Adverse Reactions in 31 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| ", doses of individual drugs) that induced seizure-like events, and identified diphenhydramine, enoxacin, strychnine and theophylline as "seizure-inducing" drugs, which have indeed been reported to induce seizures in clinical situations." | 4.98 | [Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect]. ( Gao, M; Ikegaya, Y; Sato, M, 2018) |
| "A pregnant patient consulted her physician after discovering that a diphenhydramine preparation (Benadryl elixir) she used for allergy symptoms during the first trimester of her pregnancy contained 15% alcohol." | 3.73 | Exposure to alcohol-containing medications during pregnancy. ( Finkelstein, Y; Garcia-Bournissen, F; Koren, G; Rezvani, M, 2006) |
| ", migraines) in the emergency department, but can cause serious adverse effects." | 2.72 | Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis. ( Alain, J; Berthelot, S; Mokhtari, A; Yip, O, 2021) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "57% of patients having complications (52 patients having 60 adverse events)." | 1.37 | Safety of intravenous sedation administered by the operating oral surgeon: the second 7 years of office practice. ( Rodgers, MS; Rodgers, SF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (51.61) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 6 (19.35) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Halmo, LS | 1 |
| Wang, GS | 1 |
| Reynolds, KM | 1 |
| Delva-Clark, H | 1 |
| Rapp-Olsson, M | 1 |
| Banner, W | 1 |
| Bond, GR | 1 |
| Kauffman, RE | 1 |
| Palmer, RB | 1 |
| Paul, IM | 1 |
| Green, JL | 1 |
| Dart, RC | 1 |
| Darracq, MA | 1 |
| Thornton, SL | 1 |
| Wolfson, AR | 1 |
| Wong, D | 1 |
| Abrams, EM | 1 |
| Waserman, S | 1 |
| Sussman, GL | 1 |
| Corrêa Benedet Baesso, K | 1 |
| Zapelini do Nascimento, D | 1 |
| De Sá Soares, A | 1 |
| Schuelter-Trevisol, F | 1 |
| Mokhtari, A | 1 |
| Yip, O | 1 |
| Alain, J | 1 |
| Berthelot, S | 1 |
| Hamano, H | 1 |
| Chuma, M | 1 |
| Takechi, K | 1 |
| Ikeda, Y | 1 |
| Gao, M | 1 |
| Sato, M | 1 |
| Ikegaya, Y | 1 |
| Ngo, SY | 1 |
| Rabbat, JC | 1 |
| Arnall, JR | 1 |
| Moore, DC | 1 |
| Hill, HL | 1 |
| Griffin, S | 1 |
| Mueller, MK | 1 |
| Lavery, LA | 1 |
| Voorhees, PM | 1 |
| Usmani, SZ | 1 |
| SWARTZ, H | 1 |
| STARR, MP | 1 |
| RANKIN, RM | 1 |
| Rodgers, SF | 1 |
| Rodgers, MS | 1 |
| JUDGE, DJ | 1 |
| DUMARS, KW | 1 |
| BERSACK, SR | 1 |
| WHITAKER, TE | 1 |
| AARON, FE | 1 |
| GILG, E | 2 |
| GOTTLIEB, A | 1 |
| MUNZ, M | 1 |
| MCGEER, PL | 1 |
| BOULDING, JE | 1 |
| GIBSON, WC | 1 |
| FOULKES, RG | 1 |
| HUXTABLE, RF | 1 |
| LANDWIRTH, J | 1 |
| BURNS, JJ | 1 |
| CUCINELL, SA | 1 |
| KOSTER, R | 1 |
| CONNEY, AH | 1 |
| REICHELDERFER, TE | 1 |
| LIVINGSTON, S | 1 |
| AULD, RM | 1 |
| PECK, JL | 1 |
| Garcia-Bournissen, F | 1 |
| Finkelstein, Y | 1 |
| Rezvani, M | 1 |
| Koren, G | 1 |
| Fraterrigo, CC | 1 |
| Estep, JM | 1 |
| Palmer, MA | 1 |
| Vogel, CU | 1 |
| Peiter, A | 1 |
| Feuring, M | 1 |
| Wehling, M | 1 |
| Kalow, W | 1 |
| Wilson, D | 1 |
| May, FE | 1 |
| Stewart, RB | 1 |
| Cluff, LE | 1 |
3 reviews available for diphenhydramine and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Diphenhydramine; Drug-Related Side Effects and Adverse | 2021 |
[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].
Topics: Animals; Diphenhydramine; Drug Discovery; Drug Evaluation, Preclinical; Drug-Related Side Effects an | 2018 |
Ethnic differences in reactions to drugs and xenobiotics. Caffeine and other drugs.
Topics: Acetylation; Caffeine; Cytochrome P-450 Enzyme System; Diphenhydramine; Drug-Related Side Effects an | 1986 |
28 other studies available for diphenhydramine and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications.
Topics: Antitussive Agents; Brompheniramine; Child; Child, Preschool; Chlorpheniramine; Dextromethorphan; Di | 2021 |
A different challenge with Benadryl: adolescent diphenhydramine ingestions reported to National Poison Database System, 2007-2020.
Topics: Adolescent; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Eating; Humans; Poison | 2022 |
Diphenhydramine: Time to Move on?
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Histamine Antagonists; Histamine H | 2022 |
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study.
Topics: Adverse Drug Reaction Reporting Systems; Cross-Sectional Studies; Diphenhydramine; Drug-Related Side | 2022 |
The authors reply.
Topics: Cisplatin; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Humans; Kidney; Renal I | 2021 |
Systemic IgE-mediated hypersensitivity reaction to topical polymyxin B.
Topics: Anti-Bacterial Agents; Bacitracin; Child; Diphenhydramine; Drug Combinations; Drug Hypersensitivity; | 2019 |
Enhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses.
Topics: Acetaminophen; Ambulatory Care; Antibodies, Monoclonal; Antineoplastic Agents; Cancer Care Facilitie | 2019 |
Untoward side-effect following benadryl administration.
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Iatrogenic Disease | 1948 |
Acute benadryl intoxication; case report.
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Psychoses, Substance-Induced | 1948 |
Safety of intravenous sedation administered by the operating oral surgeon: the second 7 years of office practice.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthetics, Intravenous; Conscious | 2011 |
Diphenhydramine (benadryl) and tripelennamine (pyribenzamine) intoxication in children.
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Humans; Tripelennamine | 1953 |
Effect of diphenhydramine (benadryl) on side reactions in intravenous urography.
Topics: Contrast Media; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Humans; Kidney Pel | 1953 |
A case of acute diphenhydramine hydrochloride poisoning.
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Humans; Salts | 1953 |
The influence of diphenhydramine (benadryl) on the side-effects of diodone in urography.
Topics: Contrast Media; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Humans; Iodopyrace | 1953 |
[Intravenous diphenhydramine (benadryl) and the side effects of diodone in intravenous urography].
Topics: Administration, Intravenous; Contrast Media; Diphenhydramine; Drug-Related Side Effects and Adverse | 1953 |
[Benadryl poisoning in children].
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Humans | 1958 |
Drug-induced extrapyramidal reactions. Treatment with diphenhydramine hydrochloride and dihydroxyphenylalanine.
Topics: Dihydroxyphenylalanine; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Parkinson | 1961 |
DIPHENHYDRAMINE POISONING TREATED BY EXCHANGE TRANSFUSION.
Topics: Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Electroenceph | 1963 |
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES.
Topics: Aspirin; Blood; Chromatography; Dicumarol; Diphenhydramine; Dogs; Drug-Related Side Effects and Adve | 1965 |
Treatment of acute benadryl (diphenhydramine hydrochloride) intoxication with severe central nervous system changes and recovery.
Topics: Central Nervous System; Central Nervous System Diseases; Diphenhydramine; Drug-Related Side Effects | 1955 |
Exposure to alcohol-containing medications during pregnancy.
Topics: Adjuvants, Pharmaceutic; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Ethanol; | 2006 |
Unreported adverse drug reactions determined by screening physician orders for diphenhydramine.
Topics: Data Collection; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Hospital Bed Capa | 1981 |
[Drug therapy in the old age. Drug effects in the elderly].
Topics: Age Factors; Aged; Aged, 80 and over; Algorithms; Anti-Infective Agents; Anti-Infective Agents, Urin | 2001 |
Experience with drugs and driving in Queensland, Australia.
Topics: Australia; Automobile Driving; Diazepam; Diphenhydramine; Drug Interactions; Drug-Related Side Effec | 1985 |
Drug use in the hospital: evaluation of determinants.
Topics: Acetaminophen; Aluminum Hydroxide; Analgesics; Antacids; Anti-Bacterial Agents; Chloral Hydrate; Dex | 1974 |