diphenhydramine has been researched along with Drug Overdose in 74 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 g diphenhydramine), so that a central anticholinergic syndrome due to an overdose with this drug could be assumed." | 8.79 | [An anticholinergic syndrome with hallucinatory psychosis after diphenhydramine poisoning]. ( Lang, K; Müller, S; Sigusch, H, 1995) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 7.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "Diphenhydramine overdose may cause status epilepticus and wide-complex tachycardia." | 7.76 | Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. ( Duque, D; Hoffman, RS; Jang, DH; Manini, AF; Nelson, LS; Nestor, NB; Trueger, NS, 2010) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 7.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| "To report a case of nontraumatic rhabdomyolysis complicated by oliguric, acute renal failure following an intentional overdose of ethanol and diphenhydramine." | 7.72 | Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose. ( Haas, CE; Magram, Y; Mishra, A, 2003) |
| " Further workup revealed urinary diphenhydramine levels suggesting drug overdose." | 7.69 | Diphenhydramine overdose during pregnancy: lessons from the past. ( Brost, BC; Newman, RB; Scardo, JA, 1996) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 5.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| " We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt." | 5.29 | Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose. ( Caravati, EM; Emadian, SM; Herr, RD, 1996) |
| "5 g diphenhydramine), so that a central anticholinergic syndrome due to an overdose with this drug could be assumed." | 4.79 | [An anticholinergic syndrome with hallucinatory psychosis after diphenhydramine poisoning]. ( Lang, K; Müller, S; Sigusch, H, 1995) |
| "Diphenhydramine is frequently misused and ingested recreationally for its antihistaminergic and antimuscarinic effects and is often involved in both serious and fatal poisonings, either in isolation or in combination with other xenobiotics." | 4.02 | Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity. ( Hendrickson, RG; Hughes, AR; Lin, A, 2021) |
| " While in the emergency department, she manifested a wide-complex tachycardia in the setting of hypotension that required repeated administration of sodium bicarbonate to overcome the sodium channel blockade caused by diphenhydramine." | 4.02 | A Case of Massive Diphenhydramine and Naproxen Overdose. ( Backus, T; Furlano, E; Howland, MA; Mohan, S; Smith, SW; Su, MK, 2021) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 3.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| " Initial electrocardiograms revealed sinus tachycardia at a rate of 180 beats per minute, a prolonged QRS of 130 milliseconds (from a baseline of 65 milliseconds), and a positive terminal R wave in aVR, which later resolved after sodium bicarbonate treatment." | 3.77 | Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate. ( Cole, JB; Gross, EA; Smith, SW; Stellpflug, SJ, 2011) |
| "Diphenhydramine overdose may cause status epilepticus and wide-complex tachycardia." | 3.76 | Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. ( Duque, D; Hoffman, RS; Jang, DH; Manini, AF; Nelson, LS; Nestor, NB; Trueger, NS, 2010) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 3.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| "To report a case of nontraumatic rhabdomyolysis complicated by oliguric, acute renal failure following an intentional overdose of ethanol and diphenhydramine." | 3.72 | Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose. ( Haas, CE; Magram, Y; Mishra, A, 2003) |
| " Further workup revealed urinary diphenhydramine levels suggesting drug overdose." | 3.69 | Diphenhydramine overdose during pregnancy: lessons from the past. ( Brost, BC; Newman, RB; Scardo, JA, 1996) |
| " We report a case of a suicide attempt in a young adult male where ingestion of the antihistamines diphenhydramine and doxylamine was complicated by non-traumatic rhabdomyolysis and acute renal failure." | 3.68 | Non-traumatic rhabdomyolysis complicating antihistamine overdose. ( Dolgin, J; Frankel, D; Murray, BM, 1993) |
| "A 19-year-old woman presented with status epilepticus and ventricular dysrhythmias less than one hour after ingesting 5,000 mg dimenhydrinate (Dramamine)." | 3.68 | Fatality secondary to massive overdose of dimenhydrinate. ( McDonnell, KP; Winn, RE, 1993) |
| " Serum APAP concentrations (APAPs) were measured hourly from zero through eight hours and again at 24 hours, and basic noncompartmental pharmacokinetic parameters were compared." | 2.71 | Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. ( Goklaney, A; Halcomb, SE; Mullins, ME; Sivilotti, ML, 2005) |
| "When diagnosing and treating drug overdose caused by an unidentified substance, diphenhydramine toxicity should be considered when an anticholinergic toxidrome is present and a Brugada pattern is observed on the ECG." | 1.91 | Diphenhydramine overdose detected early by integration of toxidrome and electrocardiography and treated with venoarterial extracorporeal membrane oxygenation: a case report. ( Arai, R; Ihara, S; Kinoshita, K; Matsuoka, M; Murata, N; Okumura, Y; Yamaguchi, J, 2023) |
| "A 28-year-old man with type 1 diabetes mellitus was admitted for shock and coma due to diabetic ketoacidosis." | 1.51 | Persistent Vegetative State after Diabetic Ketoacidosis Triggered by an Overdose of Psychotropic Agents. ( Goto, H; H Kaszynski, R; Inoue, Y; Kawashita, T; Nakajima, M; Nakano, T; Ochiai, K; Shirokawa, M, 2019) |
| "Diphenhydramine has not been previously identified as a medication likely to form a pharmacobezoar and has not been shown to be radiopaque." | 1.46 | Adolescent with prolonged toxidrome. ( Banner, W; Johnson, J; Williams, K, 2017) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 1.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| "Amantadine hydrochloride is an antiviral medication used as therapy for parkinsonism and as a cognitive enhancer." | 1.35 | Cardiotoxicity after massive amantadine overdose. ( Kazzi, Z; Morgan, B; Patel, M; Schwartz, M, 2008) |
| "Serotonin syndrome is an under-reported and under-recognised condition that occurs on administration of selective serotonin re-uptake inhibitors alone, or in combination with other medication known to increase levels of 5-hydroxytryptamine." | 1.34 | Serotonin syndrome. ( Evans, CE; Sebastian, J, 2007) |
| "Diphenhydramine is a histamine-1 receptor antagonist of ethanolamine origin with anticholinergic, sedative, antivertigo, antiemetic, antidyskinetic, and local anesthetic properties." | 1.33 | Prolonged QT interval with markedly abnormal ventricular repolarization in diphenhydramine overdose. ( Khan, IA; Sype, JW, 2005) |
| "Fenproporex is a sympathomimetic agent with a pharmacological profile similar to that of amphetamine." | 1.31 | A contemporaneous finding of fenproporex in a polydrug suicide. ( Bell, RR; Crookham, SB; Dunn, WA; Grates, KM; Reiber, TM, 2001) |
| "Marked pulmonary edema with visceral congestion was a constant finding." | 1.30 | Diphenhydramine toxicity: comparisons of postmortem findings in diphenhydramine-, cocaine-, and heroin-related deaths. ( Karch, SB, 1998) |
| "Of 233 charts coded as involving seizures, 191 occurred in humans and were available for analysis." | 1.29 | Seizures associated with poisoning and drug overdose. ( Benowitz, NL; Blanc, PD; Dyer, JE; Kearney, TE; Olson, KR, 1993) |
| " We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt." | 1.29 | Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose. ( Caravati, EM; Emadian, SM; Herr, RD, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (21.62) | 18.2507 |
| 2000's | 20 (27.03) | 29.6817 |
| 2010's | 32 (43.24) | 24.3611 |
| 2020's | 6 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Clemons, J | 1 |
| Jandu, A | 1 |
| Stein, B | 1 |
| Chary, M | 1 |
| Hoang, R | 1 |
| Correia, MS | 1 |
| Castelli, R | 1 |
| Matsuoka, M | 1 |
| Arai, R | 1 |
| Ihara, S | 1 |
| Murata, N | 1 |
| Yamaguchi, J | 1 |
| Okumura, Y | 1 |
| Kinoshita, K | 1 |
| Hughes, AR | 1 |
| Lin, A | 1 |
| Hendrickson, RG | 1 |
| Nemanich, A | 1 |
| Liebelt, E | 1 |
| Sabbatini, AK | 1 |
| Mohan, S | 1 |
| Backus, T | 1 |
| Furlano, E | 1 |
| Howland, MA | 1 |
| Smith, SW | 2 |
| Su, MK | 1 |
| Varma, A | 1 |
| Ford, L | 1 |
| Patel, N | 1 |
| Vale, JA | 1 |
| Johnson, J | 1 |
| Williams, K | 1 |
| Banner, W | 1 |
| Kawashita, T | 1 |
| Nakajima, M | 1 |
| H Kaszynski, R | 1 |
| Shirokawa, M | 1 |
| Nakano, T | 1 |
| Ochiai, K | 1 |
| Inoue, Y | 1 |
| Goto, H | 1 |
| Ahmad, J | 1 |
| Hasan, MJ | 1 |
| Anam, AM | 1 |
| Barua, DK | 1 |
| Paul, IM | 1 |
| Reynolds, KM | 1 |
| Delva-Clark, H | 1 |
| Burnham, RI | 1 |
| Green, JL | 1 |
| Cherukuri, SV | 1 |
| Purvis, AW | 1 |
| Tosto, ST | 1 |
| Velayati, A | 1 |
| Vyas, D | 1 |
| Lackey, G | 1 |
| McCulloh, RJ | 1 |
| Punja, M | 1 |
| Neill, SG | 1 |
| Wong, S | 1 |
| Doyon, S | 1 |
| Klein-Schwartz, W | 1 |
| Lee, S | 1 |
| Beuhler, MC | 1 |
| Walker, A | 1 |
| Delle Donne, A | 1 |
| Douglas, E | 1 |
| Spicer, K | 1 |
| Pluim, T | 1 |
| Buchweitz, JP | 1 |
| Raverty, SA | 1 |
| Johnson, MB | 1 |
| Lehner, AF | 1 |
| Abdi, A | 1 |
| Rose, E | 1 |
| Levine, M | 1 |
| Baroke, E | 1 |
| Schmidt, JJ | 1 |
| Strunk, AK | 1 |
| Wiesner, O | 1 |
| Kühn-Velten, WN | 1 |
| Kielstein, JT | 1 |
| Serper, M | 1 |
| Wolf, MS | 1 |
| Parikh, NA | 1 |
| Tillman, H | 1 |
| Lee, WM | 1 |
| Ganger, DR | 1 |
| Li, K | 1 |
| Gugelmann, H | 1 |
| Tabas, JA | 1 |
| Scanlon, KA | 1 |
| Stoppacher, R | 1 |
| Blum, LM | 1 |
| Starkey, SJ | 1 |
| Yu, JH | 1 |
| Chen, DY | 1 |
| Chen, HY | 1 |
| Lee, KH | 1 |
| Ueda, T | 1 |
| Donkor, J | 1 |
| Armenian, P | 1 |
| Hartman, IN | 1 |
| Vohra, R | 1 |
| Oritani, S | 1 |
| Michiue, T | 1 |
| Chen, JH | 1 |
| Tani, N | 1 |
| Ishikawa, T | 1 |
| Schwartz, M | 1 |
| Patel, M | 1 |
| Kazzi, Z | 1 |
| Morgan, B | 1 |
| Schwartz, EA | 1 |
| Hayes, BD | 1 |
| Sarmiento, KF | 1 |
| Jeffery, AD | 1 |
| Lytle-Saddler, T | 1 |
| Kato, H | 1 |
| Yoshimoto, K | 1 |
| Ikegaya, H | 1 |
| Husain, Z | 1 |
| Hussain, K | 1 |
| Nair, R | 1 |
| Steinman, R | 1 |
| Jang, DH | 1 |
| Manini, AF | 1 |
| Trueger, NS | 1 |
| Duque, D | 1 |
| Nestor, NB | 1 |
| Nelson, LS | 1 |
| Hoffman, RS | 1 |
| Wang, GS | 1 |
| Monte, A | 1 |
| Bagdure, D | 1 |
| Heard, K | 1 |
| Burda, T | 1 |
| Sigg, T | 1 |
| Vearrier, D | 1 |
| Curtis, JA | 1 |
| Tanaka, T | 1 |
| Takasu, A | 1 |
| Yoshino, A | 1 |
| Terazumi, K | 1 |
| Ide, M | 1 |
| Nomura, S | 1 |
| Sakamoto, T | 1 |
| Cole, JB | 1 |
| Stellpflug, SJ | 1 |
| Gross, EA | 1 |
| Maxwell, JC | 1 |
| Coleman, JJ | 1 |
| Feng, SY | 1 |
| Goto, CS | 1 |
| Tirado, CF | 1 |
| Eckes, L | 1 |
| Tsokos, M | 1 |
| Herre, S | 1 |
| Gapert, R | 1 |
| Hartwig, S | 1 |
| Rollstin, AD | 1 |
| Seifert, SA | 1 |
| Padilla, RB | 1 |
| Pollack, ML | 1 |
| Stucka, KR | 1 |
| Mycyk, MB | 2 |
| Leikin, JB | 1 |
| Pallasch, EM | 1 |
| Haas, CE | 1 |
| Magram, Y | 1 |
| Mishra, A | 1 |
| Mazor, SS | 1 |
| Khosla, U | 1 |
| Ruel, KS | 1 |
| Hunt, DP | 1 |
| Joshi, AK | 1 |
| Sljapic, T | 1 |
| Borghei, H | 1 |
| Kowey, PR | 1 |
| Halcomb, SE | 1 |
| Sivilotti, ML | 1 |
| Goklaney, A | 1 |
| Mullins, ME | 1 |
| Sype, JW | 1 |
| Khan, IA | 1 |
| López-Barbeito, B | 1 |
| Lluis, M | 1 |
| Delgado, V | 1 |
| Jiménez, S | 1 |
| Díaz-Infante, E | 1 |
| Nogué-Xarau, S | 1 |
| Brugada, J | 1 |
| Frick, S | 1 |
| Roos, M | 1 |
| Fattinger, K | 1 |
| Evans, CE | 1 |
| Sebastian, J | 1 |
| Shobugawa, K | 1 |
| Hirose, Y | 1 |
| Hori, Y | 1 |
| Ito, M | 1 |
| Fujisawa, M | 1 |
| Kumagai, K | 1 |
| Lang, K | 1 |
| Sigusch, H | 1 |
| Müller, S | 1 |
| Christensen, RC | 1 |
| Olson, KR | 1 |
| Kearney, TE | 1 |
| Dyer, JE | 1 |
| Benowitz, NL | 1 |
| Blanc, PD | 1 |
| Frankel, D | 1 |
| Dolgin, J | 1 |
| Murray, BM | 1 |
| Winn, RE | 1 |
| McDonnell, KP | 1 |
| Cheslik, TA | 1 |
| Erramouspe, J | 1 |
| Emadian, SM | 1 |
| Caravati, EM | 1 |
| Herr, RD | 1 |
| Brost, BC | 1 |
| Scardo, JA | 1 |
| Newman, RB | 1 |
| Zareba, W | 1 |
| Moss, AJ | 1 |
| Rosero, SZ | 1 |
| Hajj-Ali, R | 1 |
| Konecki, J | 1 |
| Andrews, M | 1 |
| McDonough, J | 1 |
| Karch, SB | 1 |
| Park-Matsumoto, YC | 1 |
| Tazawa, T | 1 |
| Ho, SY | 1 |
| Arellano, M | 1 |
| Zolkowski-Wynne, J | 1 |
| Tsang, WO | 1 |
| Nadroo, AM | 1 |
| Radovanovic, D | 1 |
| Meier, PJ | 1 |
| Guirguis, M | 1 |
| Lorent, JP | 1 |
| Kupferschmidt, H | 1 |
| Karch, AM | 1 |
| Karch, FE | 1 |
| Bell, RR | 1 |
| Crookham, SB | 1 |
| Dunn, WA | 1 |
| Grates, KM | 1 |
| Reiber, TM | 1 |
| Moriya, F | 1 |
| Hashimoto, Y | 1 |
| Cobbs, LW | 1 |
| Eyer, P | 1 |
| Sprenger, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Use of Diphenhydramine as an Adjunctive Sedative for Colonoscopy in Patients Chronically on Opioids[NCT01967433] | Phase 4 | 120 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patient were also asked to rate amnesia on a 10 point scale 24 after discharge. minimum= 0 (worse) maximum =10 (better) (NCT01967433)
Timeframe: At about 24 after the procedure
| Intervention | score on a 10 point point scale (Mean) |
|---|---|
| Placebo | 7.8 |
| Diphenhydramine | 6.5 |
"At 24 hr follow up patients were asked to rate the level of pain during the procedure using 10 point scale.~10 point visual analogue scale minimum= 0 (better) maximum =10 (worse)" (NCT01967433)
Timeframe: About 24 hours after the procedure
| Intervention | score on a scale (Mean) |
|---|---|
| Diphenhydramine | 2.0 |
| Placebo | 3.09 |
Moderate sedation (using the American Society of Anesthesiologists definition of maintaining purposeful response to verbal or tactile stimulation, adequate ventilation requiring no airway protection, and maintenance of cardiovascular function) was then achieved using incremental doses of the combination of intravenous midazolam (1 mg) and fentanyl (25 μg) given every 2 to 3 minutes. To minimize any crossover, additional diphenhydramine was not permitted. (NCT01967433)
Timeframe: From induction (first dose of sedative) to end of procedure
| Intervention | (μg) (Mean) |
|---|---|
| Diphenhydramine | 125.4 |
| Placebo | 126.9 |
Moderate sedation (using the American Society of Anesthesiologists definition of maintaining purposeful response to verbal or tactile stimulation, adequate ventilation requiring no airway protection, and maintenance of cardiovascular function) was then achieved using incremental doses of the combination of intravenous midazolam (1 mg) and fentanyl (25 μg) given every 2 to 3 minutes. To minimize any crossover, additional diphenhydramine was not permitted. (NCT01967433)
Timeframe: From induction (first dose of sedative) to end of procedure
| Intervention | mg (Mean) |
|---|---|
| Diphenhydramine | 4.9 |
| Placebo | 5.0 |
Induction period (time from first dose of fentanyl to scope insertion), procedural time (time from scope insertion to scope out), and recovery time (time from scope out to discharge) were recorded by the nursing staff in their standard documentation. (NCT01967433)
Timeframe: Time from induction (first dose of sedative) to discharge
| Intervention | minutes (Mean) | ||
|---|---|---|---|
| Procedure time | Recovery | Induction | |
| Diphenhydramine | 34.8 | 34.4 | 6.4 |
| Placebo | 34.7 | 32.4 | 6.3 |
Following adverse events will be recorded: (1)Hypoxia defined as O2 saturation less than 89% lasting for more than 30 seconds, (2)hypotension defined as systolic BP less than 90 mmhg and (3)use of reversal agents i.e Naloxone or Flumazenil (NCT01967433)
Timeframe: From induction (first dose of sedative) to discharge
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| Hypotension | Hypertension | Desaturation | Apnea | Arrhythmia | Reversal agent use | Tachypnea | |
| Diphenhydramine | 12 | 5 | 0 | 0 | 0 | 0 | 0 |
| Placebo | 22 | 3 | 0 | 0 | 0 | 0 | 0 |
"Quality of sedation will be accessed by the nurse and the physician at the end of procedure.~Name: 10 point visual analogue scale Minimum score: 1 (worse) Maximum score: 10 (better)" (NCT01967433)
Timeframe: During the colonoscopy and 24 hours after discharge
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Physician rating | Nurse rating | |
| Diphenhydramine | 6.2 | 5.6 |
| Placebo | 5.3 | 5.1 |
3 reviews available for diphenhydramine and Drug Overdose
| Article | Year |
|---|---|
Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports.
Topics: Cardiotoxicity; Diphenhydramine; Drug Overdose; Eating; Fat Emulsions, Intravenous; Humans; Lipids | 2022 |
Diphenhydramine overdose with intraventricular conduction delay treated with hypertonic sodium bicarbonate and i.v. lipid emulsion.
Topics: Antidotes; Diphenhydramine; Drug Overdose; Drug Therapy, Combination; Fat Emulsions, Intravenous; Hi | 2014 |
[An anticholinergic syndrome with hallucinatory psychosis after diphenhydramine poisoning].
Topics: Adult; Combined Modality Therapy; Diagnosis, Differential; Diphenhydramine; Drug Overdose; Emergenci | 1995 |
1 trial available for diphenhydramine and Drug Overdose
| Article | Year |
|---|---|
Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose.
Topics: Absorption; Acetaminophen; Analysis of Variance; Area Under Curve; Cross-Over Studies; Diphenhydrami | 2005 |
70 other studies available for diphenhydramine and Drug Overdose
| Article | Year |
|---|---|
Diphenhydramine overdose with neuromuscular excitation.
Topics: Diphenhydramine; Drug Overdose; Histamine H1 Antagonists; Humans | 2022 |
Diphenhydramine overdose detected early by integration of toxidrome and electrocardiography and treated with venoarterial extracorporeal membrane oxygenation: a case report.
Topics: Arrhythmias, Cardiac; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Electrocardiography; | 2023 |
Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Databases, Factual; Diphenhydra | 2021 |
Increased rates of diphenhydramine overdose, abuse, and misuse in the United States, 2005-2016.
Topics: Adolescent; Adult; Aged; Child; Diphenhydramine; Drug Misuse; Drug Overdose; Female; Humans; Illicit | 2021 |
A Case of Massive Diphenhydramine and Naproxen Overdose.
Topics: Diphenhydramine; Drug Overdose; Female; Humans; Naproxen; Sodium Bicarbonate; Tachycardia; Young Adu | 2021 |
Elimination half-life of diphenhydramine in overdose.
Topics: Adult; Diphenhydramine; Drug Overdose; Female; Half-Life; Humans; Male | 2017 |
Adolescent with prolonged toxidrome.
Topics: Adolescent; Bezoars; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Emergency Service, Hos | 2017 |
Persistent Vegetative State after Diabetic Ketoacidosis Triggered by an Overdose of Psychotropic Agents.
Topics: Adult; Azepines; Diabetes Mellitus, Type 1; Diabetic Coma; Diabetic Ketoacidosis; Diphenhydramine; D | 2019 |
Donepezil: an unusual therapy for acute diphenhydramine overdose.
Topics: Administration, Oral; Aged, 80 and over; Cholinesterase Inhibitors; Diphenhydramine; Donepezil; Drug | 2019 |
Flow Restrictors and Reduction of Accidental Ingestions of Over-the-Counter Medications.
Topics: Accidents; Acetaminophen; Age Factors; Antitussive Agents; Child, Preschool; Diphenhydramine; Drug O | 2019 |
IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine Overdose.
Topics: Arrhythmias, Cardiac; Diphenhydramine; Drug Overdose; Fat Emulsions, Intravenous; Female; Histamine | 2019 |
Acute overdose: suicide attempt.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Diphenhydramine; Drug Overdose; Educ | 2013 |
Caution with interpreting laboratory results after lipid rescue therapy.
Topics: Acetaminophen; Amitriptyline; Aspartate Aminotransferases; Diphenhydramine; Drug Overdose; False Neg | 2013 |
Fatalities involving acetaminophen combination products reported to United States poison centers.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Databases, Factual; Dextromethor | 2013 |
Novel use of dexmedetomidine for the treatment of anticholinergic toxidrome.
Topics: Adolescent; Cholinergic Antagonists; Dexmedetomidine; Diphenhydramine; Drug Overdose; Female; Humans | 2014 |
Fatal diphenhydramine poisoning in a dog.
Topics: Animals; Diagnosis, Differential; Diphenhydramine; Dog Diseases; Dogs; Drug Overdose; Ethanol; Hista | 2014 |
Saving two lives with one dialysis treatment.
Topics: Bipolar Disorder; Cholinesterase Inhibitors; Diphenhydramine; Drug Overdose; Female; Humans; Hypnoti | 2015 |
Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Databases, Factual | 2016 |
Young Woman With Seizures.
Topics: Adult; Diagnosis, Differential; Diphenhydramine; Drug Overdose; Electrocardiography; Emergency Servi | 2015 |
Comprehensive Duloxetine Analysis in a Fatal Overdose.
Topics: Aged; Alcoholism; Amitriptyline; Depression; Diphenhydramine; Drug Overdose; Duloxetine Hydrochlorid | 2016 |
Intravenous lipid-emulsion therapy in a patient with cardiac arrest after overdose of diphenhydramine.
Topics: Adult; Diphenhydramine; Drug Overdose; Fat Emulsions, Intravenous; Fatal Outcome; Heart Arrest; Huma | 2016 |
[A case of opsoclonus due to diphenhydramine overdose in which ECG change could be used to predict convulsion].
Topics: Administration, Oral; Adult; Diphenhydramine; Drug Overdose; Electrocardiography; Female; Humans; Oc | 2014 |
Analysis of Gastric Lavage Reported to a Statewide Poison Control System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2016 |
Biodistribution of diphenhydramine in reproductive organs in an overdose case.
Topics: Adult; Autopsy; Diphenhydramine; Drug Overdose; Humans; Male; Prostate; Testis; Tissue Distribution | 2017 |
Cardiotoxicity after massive amantadine overdose.
Topics: Adult; Amantadine; Antiparkinson Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; C | 2008 |
Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2009 |
Diphenhydramine overdose in a 26-year-old woman.
Topics: Adult; Diphenhydramine; Drug Overdose; Emergency Medical Services; Female; Humans; Hypnotics and Sed | 2008 |
Two cases of oral aspirin overdose.
Topics: Administration, Oral; Adult; Aspirin; Chromatography, High Pressure Liquid; Diphenhydramine; Drug Ov | 2010 |
Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug.
Topics: Adult; Alcoholic Intoxication; Diphenhydramine; Drug Overdose; Electrocardiography; Female; Histamin | 2010 |
Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose.
Topics: Adult; Diphenhydramine; Drug Overdose; Electrocardiography; Female; Histamine H1 Antagonists; Humans | 2010 |
Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Child; Cholinergic An | 2011 |
Double peak and prolonged absorption after large acetaminophen extended release and diphenhydramine ingestion.
Topics: Acetaminophen; Adult; Delayed-Action Preparations; Diphenhydramine; Drug Overdose; Female; Humans; P | 2012 |
Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose.
Topics: Adult; Blood Chemical Analysis; Central Nervous System Depressants; Compartment Syndromes; Depressiv | 2011 |
RN administered 125 mg of benadryl to two-year-old. Case on point: K. D. v. Adrianne Chambers, RN, 49A04-1010-CT-636 (7/13/2011)-IN.
Topics: Child, Preschool; Diphenhydramine; Drug Overdose; Histamine H1 Antagonists; Humans; Indiana; Malprac | 2011 |
Diphenhydramine overdose mimicking serotonin syndrome.
Topics: Adolescent; Diphenhydramine; Drug Overdose; Female; Humans; Selective Serotonin Reuptake Inhibitors; | 2011 |
Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate.
Topics: Anticonvulsants; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Electrocardiography; Emerg | 2011 |
Cheese: an old drug in a new wrapper.
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Animals; Data Interpretation, Stat | 2012 |
Toxicological identification of diphenhydramine (DPH) in suicide.
Topics: Adult; Aged, 80 and over; Autopsy; Cause of Death; Diphenhydramine; Drug Overdose; Fatal Outcome; Fe | 2013 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2013 |
The use of physostigmine in diphenhydramine overdose.
Topics: Adult; Anti-Allergic Agents; Cholinesterase Inhibitors; Diphenhydramine; Drug Overdose; Humans; Male | 2002 |
Rhabdomyolysis associated with unintentional antihistamine overdose in a child.
Topics: Diphenhydramine; Drug Overdose; Histamine H1 Antagonists; Humans; Infant; Male; Rhabdomyolysis | 2003 |
Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose.
Topics: Adult; Creatinine; Diphenhydramine; Drug Overdose; Ethanol; Humans; Kidney; Male; Muscle, Skeletal; | 2003 |
Comment: Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose.
Topics: Acute Kidney Injury; Adult; Diphenhydramine; Drug Overdose; Ethanol; Humans; Male; Rhabdomyolysis; T | 2003 |
Antihistamine-induced rhabdomyolysis.
Topics: Adult; Diphenhydramine; Doxylamine; Drug Overdose; Histamine H1 Antagonists; Humans; Male; Rhabdomyo | 2003 |
Case of polymorphic ventricular tachycardia in diphenhydramine poisoning.
Topics: Adult; Anti-Allergic Agents; Diphenhydramine; Drug Overdose; Electric Countershock; Electrocardiogra | 2004 |
Pharmaceutical drug overdose case reports. From the World Literature.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amlodipine; Child, Preschool; Diphenhydramine; Dizocilpine M | 2003 |
Prolonged QT interval with markedly abnormal ventricular repolarization in diphenhydramine overdose.
Topics: Adult; Diphenhydramine; Drug Overdose; Electrocardiography; Female; Heart Ventricles; Histamine H1 A | 2005 |
Diphenhydramine overdose and Brugada sign.
Topics: Adult; Death, Sudden, Cardiac; Diphenhydramine; Drug Overdose; Electrocardiography; Humans; Male; Su | 2005 |
How much is too much? Oligosymptomatic presentation after 11.5 g of diphenhydramine.
Topics: Anti-Allergic Agents; Diphenhydramine; Dose-Response Relationship, Drug; Drug Overdose; Histamine H1 | 2007 |
Serotonin syndrome.
Topics: Adult; Diphenhydramine; Drug Overdose; Female; Glasgow Coma Scale; Humans; Paroxetine; Serotonin Syn | 2007 |
[Diphenhydramine poisoning presented with psychotic-like symptoms and choreic involuntary movement: report of two cases].
Topics: Adult; Chorea; Chromatography, Liquid; Diphenhydramine; Drug Overdose; Female; Humans; Hypnotics and | 2007 |
Misdiagnosis of anticholinergic delerium as schizophrenic psychosis.
Topics: Adult; Delirium; Diagnostic Errors; Diphenhydramine; Drug Overdose; Humans; Male; Schizophrenia | 1995 |
Seizures associated with poisoning and drug overdose.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Caus | 1993 |
Non-traumatic rhabdomyolysis complicating antihistamine overdose.
Topics: Acute Kidney Injury; Adult; Blood Urea Nitrogen; Creatinine; Diphenhydramine; Doxylamine; Drug Overd | 1993 |
Fatality secondary to massive overdose of dimenhydrinate.
Topics: Adult; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Charcoal; Colon; Dimenhydrinate; Diphenh | 1993 |
Extrapyramidal symptoms following accidental ingestion of risperidone in a child.
Topics: Antiparkinson Agents; Antipsychotic Agents; Basal Ganglia Diseases; Child, Preschool; Diphenhydramin | 1996 |
Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose.
Topics: Adult; Diphenhydramine; Drug Overdose; Histamine H1 Antagonists; Humans; Male; Rhabdomyolysis; Suici | 1996 |
Diphenhydramine overdose during pregnancy: lessons from the past.
Topics: Adult; Diphenhydramine; Drug Overdose; Female; Humans; Oxytocin; Pregnancy; Uterine Contraction | 1996 |
Electrocardiographic findings in patients with diphenhydramine overdose.
Topics: Adult; Case-Control Studies; Diphenhydramine; Dose-Response Relationship, Drug; Drug Overdose; Elect | 1997 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
Diphenhydramine toxicity: comparisons of postmortem findings in diphenhydramine-, cocaine-, and heroin-related deaths.
Topics: Adolescent; Adult; Cardiomyopathy, Dilated; Cocaine; Diphenhydramine; Drug Overdose; Fatal Outcome; | 1998 |
Neuroleptic malignant syndrome associated with diphenhydramine and diprophyllin overdose in a depressed patient.
Topics: Adult; Bronchodilator Agents; Depressive Disorder; Diphenhydramine; Drug Overdose; Dyphylline; Hista | 1999 |
Delayed increase in acetaminophen concentration after Tylenol PM overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Diphenhydramine; Drug Overdose; Female; Gastric Empt | 1999 |
An unusual case of acetaminophen overdose.
Topics: Absorption; Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Diphenhydramine; Drug Combinations; | 1999 |
Dose-dependent toxicity of diphenhydramine overdose.
Topics: Adolescent; Adult; Aged; Diphenhydramine; Dose-Response Relationship, Drug; Drug Overdose; Female; H | 2000 |
Let the user beware. OTC drugs aren't necessarily 'safe when taken as directed.'.
Topics: Acetaminophen; Adult; Common Cold; Diphenhydramine; Drug Combinations; Drug Overdose; Female; Humans | 2001 |
A contemporaneous finding of fenproporex in a polydrug suicide.
Topics: Adult; Amphetamines; Anti-Allergic Agents; Anticonvulsants; Appetite Depressants; Autopsy; Diazepam; | 2001 |
Postmortem diffusion of drugs from the bladder into femoral venous blood.
Topics: Adolescent; Chlorpheniramine; Codeine; Diffusion; Diphenhydramine; Drowning; Drug Overdose; Femoral | 2001 |
Shakes and flashes in a relapsed alcoholic.
Topics: Alcoholic Intoxication; Chlordiazepoxide; Diphenhydramine; Drug Overdose; Hallucinations; Humans; Ma | 1992 |
[Oral administration of activated charcoal-sorbitol suspension as first aid in prevention of poison resorption?].
Topics: Acetaminophen; Charcoal; Codeine; Diphenhydramine; Drug Overdose; Humans; Intestinal Absorption; Met | 1991 |