diphenhydramine has been researched along with Disorders of Excessive Somnolence in 3 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Temsirolimus (CCI-779) is a novel inhibitor of the mammalian target of rapamycin." | 2.75 | A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors. ( Fujisaka, Y; Horiike, A; Tamura, T; Yamada, Y; Yamamoto, N, 2010) |
| " On this dosing regimen, tolerance was complete by the end of 3 days of administration." | 2.70 | Tolerance to daytime sedative effects of H1 antihistamines. ( Koshorek, G; Richardson, GS; Roehrs, TA; Rosenthal, L; Roth, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujisaka, Y | 1 |
| Yamada, Y | 1 |
| Yamamoto, N | 1 |
| Horiike, A | 1 |
| Tamura, T | 1 |
| Richardson, GS | 1 |
| Roehrs, TA | 1 |
| Rosenthal, L | 1 |
| Koshorek, G | 1 |
| Roth, T | 1 |
| Handel, DA | 1 |
| Raja, A | 1 |
| Lindsell, CJ | 1 |
2 trials available for diphenhydramine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents; Area Under Curve; Carcinoma, Renal Cell; C | 2010 |
Tolerance to daytime sedative effects of H1 antihistamines.
Topics: Adolescent; Adult; Cross-Over Studies; Diphenhydramine; Disorders of Excessive Somnolence; Double-Bl | 2002 |
1 other study available for diphenhydramine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
The use of sleep aids among Emergency Medicine residents: a web based survey.
Topics: Adult; Alcohol Drinking; Analgesics; Anti-Anxiety Agents; Diphenhydramine; Disorders of Excessive So | 2006 |