Page last updated: 2024-10-26

diphenhydramine and Disease Models, Animal

diphenhydramine has been researched along with Disease Models, Animal in 32 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effects of diphenhydramine chloride (DPH) on mortality in a rat model of acute, severe organophosphate poisoning (OP)."7.71Diphenhydramine as a protective agent in a rat model of acute, lethal organophosphate poisoning. ( Bird, SB; Dickson, EW; Gaspari, RJ; Lee, WJ, 2002)
"Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice."7.69Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995)
"Baseline weight, hemodynamic parameters, QRS interval, time to hypotension, and diphenhydramine dose required to achieve hypotension were similar between groups."5.22Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model. ( Bebarta, VS; Boudreau, SM; Castaneda, M; Vargas, TE; Varney, SM; Zarzabal, LA, 2016)
" Then, we combined it with different doses of psychostimulants (d-amphetamine, modafinil, caffeine) to find the best combination for motion sickness."3.83The Combination of Scopolamine and Psychostimulants for the Prevention of Severe Motion Sickness. ( Han, B; Liu, AJ; Liu, HQ; Song, XR; Tian, JS; Yu, XH; Zhang, LL; Zhang, Y, 2016)
"3% w/v (weight of solute per volume of solution) monoethanolamine (MEA) into his lungs, causing asthma-like symptoms."3.75Effects of inhaled monoethanolamine on bronchoconstriction. ( Hayashi, I; Ide, A; Kamijo, Y; Majima, M; Soma, K; Yoshimura, K, 2009)
" This research first proposed that alterations of mast cell histamine release, gastric acid back-diffusion and mucosal microvascular permeability are important in modulating gastric ulcer and hemorrhage in Salmonella typhi-infected rats."3.72Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats. ( Hung, CR; Wang, PS, 2004)
"To evaluate the effects of diphenhydramine chloride (DPH) on mortality in a rat model of acute, severe organophosphate poisoning (OP)."3.71Diphenhydramine as a protective agent in a rat model of acute, lethal organophosphate poisoning. ( Bird, SB; Dickson, EW; Gaspari, RJ; Lee, WJ, 2002)
"Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice."3.69Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995)
"Although diphenhydramine hydrochloride is known to eliminate or reduce the symptoms of dystonia in human patients with acute dystonic reactions and idiopathic torsion dystonia, its mechanism of action is still unclear."3.69Evidence for the involvement of histamine in the antidystonic effects of diphenhydramine. ( Matsumoto, RR; Stone, MR; Truong, DD; van't Groenewout, JL; Vo, VN, 1995)
"In conclusion, pulmonary inflammation and peripheral thrombosis are correlated at 6 and 24 hours, but at 1 hour, the prothrombotic effects do not appear to result from pulmonary inflammation but possibly from the blood penetration of DEP-associated components or by DEP particles themselves."1.32Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine. ( Hoet, PH; Hoylaerts, MF; Nemery, B; Nemmar, A; Vermylen, J, 2003)
" Chronic administration of imipramine-HCl (1 and 5 mg/kg, i."1.27Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. ( Kameyama, T; Nagasaka, M; Yamada, K, 1985)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19905 (15.63)18.7374
1990's8 (25.00)18.2507
2000's8 (25.00)29.6817
2010's9 (28.13)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Walsh, DA1
Green, JB1
Franzyshen, SK1
Nolan, JC1
Yanni, JM1
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Qutob, HMH1
Saad, RA1
Bali, H1
Osailan, A1
Jaber, J1
Alzahrani, E1
Alyami, J1
Elsayed, H1
Alserihi, R1
Shaikhomar, OA1
Divya, KM1
Savitha, DP1
Krishna, GA1
Dhanya, TM1
Mohanan, PV1
Shah, SF1
Jafry, AT1
Hussain, G1
Kazim, AH1
Ali, M1
Rivani, E1
Endraswari, PD1
Widodo, ADW1
Khalil, MR1
Guldberg, R1
Nørgård, BM1
Uldbjerg, N1
Wehberg, S1
Fowobaje, KR1
Mashood, LO1
Ekholuenetale, M1
Ibidoja, OJ1
Romagnoli, A1
D'Agostino, M1
Pavoni, E1
Ardiccioni, C1
Motta, S1
Crippa, P1
Biagetti, G1
Notarstefano, V1
Rexha, J1
Perta, N1
Barocci, S1
Costabile, BK1
Colasurdo, G1
Caucci, S1
Mencarelli, D1
Turchetti, C1
Farina, M1
Pierantoni, L1
La Teana, A1
Al Hadi, R1
Cicconardi, F1
Chinappi, M1
Trucchi, E1
Mancia, F1
Menzo, S1
Morozzo Della Rocca, B1
D'Annessa, I1
Di Marino, D1
Choya, A1
de Rivas, B1
Gutiérrez-Ortiz, JI1
López-Fonseca, R1
Xu, S1
Cheng, B1
Huang, Z1
Liu, T1
Li, Y1
Jiang, L1
Guo, W1
Xiong, J1
Amirazodi, M1
Daryanoosh, F1
Mehrabi, A1
Gaeini, A1
Koushkie Jahromi, M1
Salesi, M1
Zarifkar, AH1
Studeny, P1
Netukova, M1
Nemcokova, M1
Klimesova, YM1
Krizova, D1
Kang, H1
Tao, Y1
Zhang, Q1
Sha, D1
Chen, Y1
Yao, J1
Gao, Y1
Liu, J1
Ji, L1
Shi, P1
Shi, C1
Wu, YL1
Wright, AI1
M El-Metwaly, N1
A Katouah, H1
El-Desouky, MG1
El-Bindary, AA1
El-Bindary, MA1
Kostakis, ID1
Raptis, DA1
Davidson, BR1
Iype, S1
Nasralla, D1
Imber, C1
Sharma, D1
Pissanou, T1
Pollok, JM1
Hughes, AM1
Sanderson, E1
Morris, T1
Ayorech, Z1
Tesli, M1
Ask, H1
Reichborn-Kjennerud, T1
Andreassen, OA1
Magnus, P1
Helgeland, Ø1
Johansson, S1
Njølstad, P1
Davey Smith, G1
Havdahl, A1
Howe, LD1
Davies, NM1
Amrillah, T1
Prasetio, A1
Supandi, AR1
Sidiq, DH1
Putra, FS1
Nugroho, MA1
Salsabilla, Z1
Azmi, R1
Grammatikopoulos, P1
Bouloumis, T1
Steinhauer, S1
Mironov, VS2
Bazhenova, TA2
Manakin, YV2
Yagubskii, EB2
Yakushev, IA1
Gilmutdinov, IF1
Simonov, SV1
Lan, K1
Yang, H1
Zheng, J1
Hu, H1
Zhu, T1
Zou, X1
Hu, B1
Liu, H1
Olokede, O1
Wu, H1
Holtzapple, M1
Gungor, O1
Kose, M1
Ghaemi, R1
Acker, M1
Stosic, A1
Jacobs, R1
Selvaganapathy, PR1
Ludwig, N1
Yerneni, SS1
Azambuja, JH1
Pietrowska, M1
Widłak, P1
Hinck, CS1
Głuszko, A1
Szczepański, MJ1
Kärmer, T1
Kallinger, I1
Schulz, D1
Bauer, RJ1
Spanier, G1
Spoerl, S1
Meier, JK1
Ettl, T1
Razzo, BM1
Reichert, TE1
Hinck, AP1
Whiteside, TL1
Wei, ZL1
Juan, W1
Tong, D1
Juan, LX1
Sa, LY1
Jie, HFM1
Xiao, G1
Xiang, LG1
Jie, HM1
Xu, C1
Yu, DN1
Yao, ZX1
Bigdeli, F1
Gao, XM1
Cheng, X1
Li, JZ1
Zhang, JW1
Wang, W2
Guan, ZJ1
Bu, Y1
Liu, KG1
Morsali, A1
Das, R1
Paul, R1
Parui, A1
Shrotri, A1
Atzori, C1
Lomachenko, KA1
Singh, AK1
Mondal, J1
Peter, SC1
Florimbio, AR1
Coughlin, LN1
Bauermeister, JA1
Young, SD1
Zimmerman, MA1
Walton, MA1
Bonar, EE1
Demir, D1
Balci, AB1
Kahraman, N1
Sunbul, SA1
Gucu, A1
Seker, IB1
Badem, S1
Yuksel, A1
Ozyazicioglu, AF1
Goncu, MT1
Zhang, H1
Zhou, H1
Deng, Z1
Luo, L1
Ong, SP1
Wang, C1
Xin, H1
Whittingham, MS1
Zhou, G1
Maemura, R1
Wakamatsu, M1
Matsumoto, K1
Sakaguchi, H1
Yoshida, N1
Hama, A1
Yoshida, T1
Miwata, S1
Kitazawa, H1
Narita, K1
Kataoka, S1
Ichikawa, D1
Hamada, M1
Taniguchi, R1
Suzuki, K1
Kawashima, N1
Nishikawa, E1
Narita, A1
Okuno, Y1
Nishio, N1
Kato, K1
Kojima, S1
Morita, K1
Muramatsu, H1
Takahashi, Y1
Yirgu, A1
Mekonnen, Y1
Eyado, A1
Staropoli, A1
Vinale, F1
Zac, J1
Zac, S1
Pérez-Padilla, R1
Remigio-Luna, A1
Guzmán-Boulloud, N1
Gochicoa-Rangel, L1
Guzmán-Valderrábano, C1
Thirión-Romero, I1
Statsenko, ME1
Turkina, SV1
Barantsevich, ER1
Karakulova, YV1
Baranova, NS1
Morzhukhina, MV1
Wang, Q1
Gu, Y1
Chen, C1
Qiao, L1
Pan, F1
Song, C1
Canetto, SS1
Entilli, L1
Cerbo, I1
Cipolletta, S1
Wu, Y2
Zhu, P1
Jiang, Y1
Zhang, X1
Wang, Z2
Xie, B1
Song, T1
Zhang, F1
Luo, A1
Li, S1
Xiong, X1
Han, J1
Peng, X1
Li, M1
Huang, L1
Chen, Q1
Fang, W1
Hou, Y1
Zhu, Y1
Ye, J1
Liu, L1
Islam, MR1
Sanderson, P1
Johansen, MP1
Payne, TE1
Naidu, R1
Cao, J1
Yang, J1
Niu, X1
Liu, X1
Zhai, Y1
Qiang, C1
Niu, Y1
Li, Z1
Dong, N1
Wen, B1
Ouyang, Z1
Zhang, Y2
Li, J2
Zhao, M2
Zhao, J1
Morici, P1
Rizzato, C1
Ghelardi, E1
Rossolini, GM1
Lupetti, A1
Gözüküçük, R1
Cakiroglu, B1
He, X1
Li, R1
Zhao, D1
Zhang, L1
Ji, X1
Fan, X1
Chen, J1
Wang, Y1
Luo, Y1
Zheng, D1
Xie, L1
Sun, S1
Cai, Z1
Liu, Q1
Ma, K1
Sun, X1
Drinkwater, JJ1
Davis, TME1
Turner, AW1
Davis, WA1
Suzuki, Y1
Mizuta, Y1
Mikagi, A1
Misawa-Suzuki, T1
Tsuchido, Y1
Sugaya, T1
Hashimoto, T1
Ema, K1
Hayashita, T1
Chen, YW1
Tzeng, JI1
Chen, TY1
Wang, JJ1
Chen, YC1
Hung, CH1
Varney, SM1
Bebarta, VS1
Boudreau, SM1
Vargas, TE1
Castaneda, M1
Zarzabal, LA1
Yamamoto, K1
Kato, N1
Isogai, Y1
Kuroda, T1
Ishida, T2
Yamatodani, A1
Zhang, LL1
Liu, HQ1
Yu, XH1
Tian, JS1
Song, XR1
Han, B1
Liu, AJ1
Sun, D1
Guan, Y1
Sang, D1
Liu, M1
Pu, Y1
Fang, X1
Wang, D1
Huang, A1
Bi, X1
Cao, L1
He, C1
Gosselin, S1
Hoegberg, LC1
Hoffman, RS1
Graudins, A1
Stork, CM1
Thomas, SH1
Stellpflug, SJ1
Hayes, BD1
Levine, M1
Morris, M1
Nesbitt-Miller, A1
Turgeon, AF1
Bailey, B1
Calello, DP1
Chuang, R1
Bania, TC1
Mégarbane, B1
Bhalla, A1
Lavergne, V1
Kamijo, Y1
Hayashi, I1
Ide, A1
Yoshimura, K1
Soma, K1
Majima, M1
Tokunaga, S1
Tsutsui, R1
Obara, Y1
Kamei, C1
Chen, D1
Xiong, Y1
Wang, L1
Lv, B1
Lin, Y1
Lin, TK1
Man, MQ1
Santiago, JL1
Park, K1
Roelandt, T1
Oda, Y1
Hupe, M1
Crumrine, D1
Lee, HJ1
Gschwandtner, M1
Thyssen, JP1
Trullas, C1
Tschachler, E1
Feingold, KR1
Elias, PM1
Bird, SB2
Gaspari, RJ2
Lee, WJ1
Dickson, EW2
Nemmar, A1
Nemery, B1
Hoet, PH1
Vermylen, J1
Hoylaerts, MF1
Hung, CR1
Wang, PS1
Chan, SW1
Rudd, JA1
Lin, G1
Li, P1
Rasti, M1
Parvaresh, E1
Tavajoh, S1
Talaei, M1
Wang, JP1
Raung, SL1
Chang, LC1
Kuo, SC1
van't Groenewout, JL1
Stone, MR1
Vo, VN1
Truong, DD1
Matsumoto, RR1
Moriuchi, H1
Arai, I1
Yuizono, T1
Weber, JR1
Angstwurm, K1
Rosenkranz, T1
Lindauer, U1
Bürger, W1
Einhäupl, KM1
Dirnagl, U1
Leeper-Woodford, SK1
Carey, D1
Byrne, K1
Walsh, C1
Fisher, B1
Sugerman, HJ1
Fowler, AA1
Adams, GK1
Davis, JW1
Phillips, PE1
Lucas, SR1
Yue, KT1
Piotrowski, RL1
Roush, AE1
Chand, N1
Nolan, K1
Diamantis, W1
Sofia, RD1
Ando, K1
Isono, E1
Kubota, T1
Imokawa, H1
Inoue, H1
Ishida, H1
Ogino, Y1
Kameyama, T1
Nagasaka, M1
Yamada, K1
Kontos, HA1
Richardson, DW1
Raper, AJ1
Patterson, JL1
Radostina, AI1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Skin Barrier Dysfunction and the Role of Skin Barrier Restoration on Cutaneous and Systemic Inflammation in the Aged Population[NCT03728569]Early Phase 114 participants (Actual)Interventional2018-05-16Terminated (stopped due to Enrollment and interactions/interventions paused due to COVID-19. Not expected to resume in the future. This is not a suspension of IRB approval)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for diphenhydramine and Disease Models, Animal

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:10

    Topics: Administration, Intravenous; Anesthetics; Animals; Calcium Channel Blockers; Cocaine; Diphenhydramin

2016

Trials

2 trials available for diphenhydramine and Disease Models, Animal

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model.
    Annals of emergency medicine, 2016, Volume: 67, Issue:2

    Topics: Animals; Diphenhydramine; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Hemodynamics;

2016

Other Studies

29 other studies available for diphenhydramine and Disease Models, Animal

ArticleYear
Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Anaphylaxis; Animals; Dimethylamines; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists;

1990
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:4

    Topics: Analgesia; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Diphen

2014
Induction and antagonism of pica induced by teriparatide in rats.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: Age Factors; Animals; Anorexia; Antiemetics; Diphenhydramine; Disease Models, Animal; Dopamine D2 Re

2015
The Combination of Scopolamine and Psychostimulants for the Prevention of Severe Motion Sickness.
    CNS neuroscience & therapeutics, 2016, Volume: 22, Issue:8

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Ch

2016
Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 08-31, Volume: 36, Issue:35

    Topics: Animals; Case-Control Studies; Cell Differentiation; Cells, Cultured; Diphenhydramine; Disease Model

2016
Effects of inhaled monoethanolamine on bronchoconstriction.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:1

    Topics: Aerosols; Air Pollutants, Occupational; Airway Obstruction; Airway Resistance; Animals; Asthma; Atro

2009
Effects of histamine H1-antagonists on sleep-awake state in rats placed on a grid suspended over water or on sawdust.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:1

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Chlorpheniramine; Diphenhydramine; Disease

2009
Characteristics of emodin on modulating the contractility of jejunal smooth muscle.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:4

    Topics: Animals; Atropine; Constipation; Diarrhea; Diphenhydramine; Disease Models, Animal; Dose-Response Re

2012
Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:2

    Topics: Administration, Topical; Animals; Cell Differentiation; Cimetidine; Dermatitis, Atopic; Dermatitis,

2013
Diphenhydramine as a protective agent in a rat model of acute, lethal organophosphate poisoning.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2002, Volume: 9, Issue:12

    Topics: Animals; Diphenhydramine; Disease Models, Animal; Histamine H1 Antagonists; Male; Organophosphate Po

2002
Early death due to severe organophosphate poisoning is a centrally mediated process.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2003, Volume: 10, Issue:4

    Topics: Animals; Central Nervous System Diseases; Cholinergic Antagonists; Dichlorvos; Diphenhydramine; Dise

2003
Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine.
    American journal of respiratory and critical care medicine, 2003, Dec-01, Volume: 168, Issue:11

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cricetinae; Diphenhydramine; Disease Models, Animal; Histamin

2003
Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats.
    Life sciences, 2004, Mar-05, Volume: 74, Issue:16

    Topics: Amine Oxidase (Copper-Containing); Animals; Capillary Permeability; Diphenhydramine; Disease Models,

2004
Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).
    European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3

    Topics: Analysis of Variance; Animals; Antiemetics; Antitussive Agents; Baclofen; Cevanes; Codeine; Copper S

2007
The comparison of diphenhydramine HCl and Nedocromil sodium in prevention of abdominal postoperative adhesion formation in rat models: an experimental study.
    International journal of surgery (London, England), 2007, Volume: 5, Issue:6

    Topics: Abdominal Cavity; Animals; Anti-Inflammatory Agents; Diphenhydramine; Disease Models, Animal; Female

2007
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.
    European journal of pharmacology, 1995, Jan-05, Volume: 272, Issue:1

    Topics: Adrenalectomy; Animals; Anthraquinones; Bradykinin; Capillary Permeability; Cell Degranulation; Dexa

1995
Evidence for the involvement of histamine in the antidystonic effects of diphenhydramine.
    Experimental neurology, 1995, Volume: 134, Issue:2

    Topics: Animals; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Halope

1995
Tranexamic acid attenuates oleic-acid-induced pulmonary extravasation.
    Intensive care medicine, 1995, Volume: 21, Issue:12

    Topics: Analysis of Variance; Animals; Capillary Permeability; Diphenhydramine; Disease Models, Animal; Dose

1995
Histamine (H1) receptor antagonist inhibits leukocyte rolling in pial vessels in the early phase of bacterial meningitis in rats.
    Neuroscience letters, 1997, Apr-18, Volume: 226, Issue:1

    Topics: Animals; Diphenhydramine; Disease Models, Animal; Histamine; Leukocytes; Male; Meningitis, Bacterial

1997
Histamine receptor antagonists, cyclooxygenase blockade, and tumor necrosis factor during acute septic insult.
    Shock (Augusta, Ga.), 1998, Volume: 9, Issue:2

    Topics: Animals; Bacteremia; Blood Pressure; Cardiac Output; Cimetidine; Cyclooxygenase Inhibitors; Diphenhy

1998
In vitro studies of antigen-induced bronchospasm.
    Monographs in allergy, 1979, Volume: 14

    Topics: Airway Obstruction; Animals; Antigens; Bronchi; Bronchial Spasm; Chromones; Diphenhydramine; Disease

1979
Failure of diphenhydramine hydrochloride to prevent thrombosis at sites of endarterectomy in dogs.
    The Journal of international medical research, 1978, Volume: 6, Issue:1

    Topics: Animals; Carotid Arteries; Diphenhydramine; Disease Models, Animal; Dogs; Endarterectomy; Female; Fe

1978
Repeated aeroallergen challenge induces lung dysfunction but not bronchial hyperresponsiveness in conscious guinea pigs.
    Agents and actions, 1992, Volume: 37, Issue:3-4

    Topics: Acetylcholine; Aerosols; Airway Resistance; Allergens; Animals; Bronchial Hyperreactivity; Diphenhyd

1992
[Study on ear burn model in mice and its significant application].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 96, Issue:6

    Topics: Animals; Bradykinin; Burns; Capillary Permeability; Dexamethasone; Diphenhydramine; Disease Models,

1990
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
    Neuropharmacology, 1985, Volume: 24, Issue:4

    Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhy

1985
Mechanisms of action of hypocapnic alkalosis on limb blood vessels in man and dog.
    The American journal of physiology, 1972, Volume: 223, Issue:6

    Topics: Alkalosis; Alkalosis, Respiratory; Animals; Blood Pressure; Carbon Dioxide; Diphenhydramine; Disease

1972
[Effect of an antihistamic preparation (dimedrol) on the morphology and function of connective tissue cellular elements under conditions of aseptic inflammation].
    Arkhiv patologii, 1970, Volume: 32, Issue:9

    Topics: Animals; Capillary Permeability; Cell Migration Inhibition; Cell Movement; Connective Tissue; Connec

1970