Page last updated: 2024-10-26

diphenhydramine and Dermatitis, Contact

diphenhydramine has been researched along with Dermatitis, Contact in 19 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.

Research Excerpts

ExcerptRelevanceReference
"Three cases of contact dermatitis caused by an ethanolamine antihistamine, diphenhydramine hydrochloride (Benadryl), are described."7.66Contact dermatitis caused by diphenhydramine hydrochloride. ( Coskey, RJ, 1983)
"Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis."5.36Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. ( Ashurst, JV; Fritz, WT; Hauger, W; Wasson, MN, 2010)
"Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals."3.71Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. ( Ido, Y; Kubo, M; Matsuda, H; Tomohiro, N, 2002)
"Three cases of contact dermatitis caused by an ethanolamine antihistamine, diphenhydramine hydrochloride (Benadryl), are described."3.66Contact dermatitis caused by diphenhydramine hydrochloride. ( Coskey, RJ, 1983)
"A 52-year-old man developed contact and photoallergic dermatitis caused by diphenhydramine hydrochloride as well as contact dermatitis from paraphenylenediamine."3.65Allergic and photoallergic dermatitis from diphenhydramine. ( Horio, T, 1976)
"Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis."1.36Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. ( Ashurst, JV; Fritz, WT; Hauger, W; Wasson, MN, 2010)
"Chronic urticaria is plainly visible in clinical presentation but is more elusive in diagnosis and treatment."1.27Urticaria--a challenge in diagnosis and treatment. ( Wagner, WO, 1988)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199013 (68.42)18.7374
1990's1 (5.26)18.2507
2000's1 (5.26)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Fogel, AL1
Longmire, M1
Rieger, KE1
Sarin, KY1
Ashurst, JV1
Wasson, MN1
Hauger, W1
Fritz, WT1
Lin, TK1
Man, MQ1
Santiago, JL1
Park, K1
Roelandt, T1
Oda, Y1
Hupe, M1
Crumrine, D1
Lee, HJ1
Gschwandtner, M1
Thyssen, JP1
Trullas, C1
Tschachler, E1
Feingold, KR1
Elias, PM1
SCHAFFER, K1
JIRASEK, L1
SCHWANK, R1
MCMILLAN, CW1
PURCELL, WR1
Coskey, RJ1
Matsuda, H1
Tomohiro, N1
Ido, Y1
Kubo, M1
Panchenko, KI1
Horio, T1
Maibach, HI1
Johnson, HL1
Byerly, WG1
Winslow, R1
Griswold, DE1
Alessi, S1
Badger, AM1
Poste, G1
Hanna, N1
Wagner, WO1
Warshaw, TG1
Crosby, AD1
D'Andrea, GH1
Geller, RJ1
Jennings, BJ1
Logan, WS1
Perry, HO1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Skin Barrier Dysfunction and the Role of Skin Barrier Restoration on Cutaneous and Systemic Inflammation in the Aged Population[NCT03728569]Early Phase 114 participants (Actual)Interventional2018-05-16Terminated (stopped due to Enrollment and interactions/interventions paused due to COVID-19. Not expected to resume in the future. This is not a suspension of IRB approval)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

19 other studies available for diphenhydramine and Dermatitis, Contact

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
A subdermal source: contact dermatitis.
    The American journal of medicine, 2015, Volume: 128, Issue:6

    Topics: Anti-Inflammatory Agents; Cephalexin; Clobetasol; Dermatitis, Contact; Diphenhydramine; Female; Hist

2015
Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia.
    The Journal of the American Osteopathic Association, 2010, Volume: 110, Issue:1

    Topics: Aged; Anti-Allergic Agents; Dapsone; Dermatitis, Contact; Diphenhydramine; Female; Histamine H1 Anta

2010
Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:2

    Topics: Administration, Topical; Animals; Cell Differentiation; Cimetidine; Dermatitis, Atopic; Dermatitis,

2013
[Experiences with systral ointment in allergic skin diseases].
    Deutsches medizinisches Journal, 1957, Mar-15, Volume: 8, Issue:3

    Topics: Dermatitis; Dermatitis, Atopic; Dermatitis, Contact; Diphenhydramine; Ethylamines; Humans

1957
[OCCUPATIONAL CONTACT HYPERSENSITIVITY TO ANTIHISTAMINICS (BROMADRYL)].
    Ceskoslovenska dermatologie, 1963, Volume: 38

    Topics: Anti-Allergic Agents; Dermatitis, Contact; Dermatitis, Occupational; Diphenhydramine; Drug Eruptions

1963
HAZARDS TO HEALTH. THE PUSS CATERPILLAR, ALIAS WOOLLY SLUG.
    The New England journal of medicine, 1964, Jul-16, Volume: 271

    Topics: Animals; Aspirin; Child; Codeine; Dermatitis; Dermatitis, Contact; Diphenhydramine; Gastropoda; Heal

1964
Contact dermatitis caused by diphenhydramine hydrochloride.
    Journal of the American Academy of Dermatology, 1983, Volume: 8, Issue:2

    Topics: Child; Dermatitis, Contact; Diphenhydramine; Drug Eruptions; Humans; Male; Middle Aged

1983
Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:6

    Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cnidium; Coumarins; Dermatit

2002
[Effect of vasoactive substances on the morphogenesis of allergic contact dermatitis].
    Vestnik dermatologii i venerologii, 1979, Issue:4

    Topics: Animals; Atropine; Cardiovascular Agents; Dermatitis, Contact; Dinitrochlorobenzene; Diphenhydramine

1979
Allergic and photoallergic dermatitis from diphenhydramine.
    Archives of dermatology, 1976, Volume: 112, Issue:8

    Topics: Dermatitis, Contact; Diphenhydramine; Drug Hypersensitivity; Humans; Male; Middle Aged; Photosensiti

1976
Contact urticaria syndrome. Contact urticaria to diethyltoluamide (immediate-type hypersensitivity).
    Archives of dermatology, 1975, Volume: 111, Issue:6

    Topics: Adult; Ammonium Sulfate; Atropine; Benzamides; Benzocaine; Chlorpheniramine; DEET; Dermatitis, Conta

1975
Adverse reaction from topical exposure to muromonab-CD3.
    American journal of hospital pharmacy, 1991, Volume: 48, Issue:7

    Topics: Adult; Antibodies, Monoclonal; Dermatitis, Contact; Dermatitis, Occupational; Diphenhydramine; Human

1991
Differential sensitivity of T suppressor cell expression to inhibition by histamine type 2 receptor antagonists.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Sep-15, Volume: 137, Issue:6

    Topics: Animals; Benzenesulfonates; Cimetidine; Dermatitis, Contact; Diphenhydramine; Dose-Response Relation

1986
Urticaria--a challenge in diagnosis and treatment.
    Postgraduate medicine, 1988, Volume: 83, Issue:5

    Topics: Cold Temperature; Dermatitis, Contact; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Food Hyp

1988
Primary irritant effect of 3,4,5-trichloropyridazine.
    Contact dermatitis, 1988, Volume: 18, Issue:5

    Topics: Administration, Cutaneous; Clobetasol; Dermatitis, Contact; Dermatitis, Occupational; Diphenhydramin

1988
Human effects of veterinary biological products.
    Veterinary and human toxicology, 1986, Volume: 28, Issue:6

    Topics: Adolescent; Dermatitis, Contact; Dexamethasone; Diphenhydramine; Female; Humans; Infectious bursal d

1986
Allergic contact dermatitis.
    Journal of the American Optometric Association, 1985, Volume: 56, Issue:6

    Topics: Aged; Blepharitis; Dermatitis, Contact; Diphenhydramine; Eyelid Diseases; Female; Hair Dyes; Humans

1985
Cast dermatitis due to formaldehyde sensitivity.
    Archives of dermatology, 1972, Volume: 106, Issue:5

    Topics: Adrenocorticotropic Hormone; Adult; Casts, Surgical; Cyproheptadine; Dermatitis, Contact; Diphenhydr

1972