diphenhydramine has been researched along with Depressive Disorder, Major in 4 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Recourt, K | 1 |
| de Boer, P | 1 |
| Zuiker, R | 1 |
| Luthringer, R | 1 |
| Kent, J | 1 |
| van der Ark, P | 1 |
| Van Hove, I | 1 |
| van Gerven, J | 1 |
| Jacobs, G | 1 |
| van Nueten, L | 1 |
| Drevets, W | 1 |
| Vearrier, D | 1 |
| Curtis, JA | 1 |
| HANKOFF, LD | 1 |
| GUNDLACH, RH | 1 |
| PALEY, HM | 1 |
| RUDORFER, L | 1 |
| Berman, RM | 1 |
| Sanacora, G | 1 |
| Anand, A | 1 |
| Roach, LM | 1 |
| Fasula, MK | 1 |
| Finkelstein, CO | 1 |
| Wachen, RM | 1 |
| Oren, DA | 1 |
| Heninger, GR | 1 |
| Charney, DS | 1 |
2 trials available for diphenhydramine and Depressive Disorder, Major
| Article | Year |
|---|---|
The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder.
Topics: Adult; Antidepressive Agents; Arousal; Depressive Disorder, Major; Diphenhydramine; Double-Blind Met | 2019 |
Monoamine depletion in unmedicated depressed subjects.
Topics: Adult; alpha-Methyltyrosine; Catecholamines; Depressive Disorder, Major; Diphenhydramine; Dopamine; | 2002 |
2 other studies available for diphenhydramine and Depressive Disorder, Major
| Article | Year |
|---|---|
Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose.
Topics: Adult; Blood Chemical Analysis; Central Nervous System Depressants; Compartment Syndromes; Depressiv | 2011 |
DIPHENHYDRAMINE AS AN ANTIDEPRESSANT: A NEGATIVE FINDING.
Topics: Antidepressive Agents; Biomedical Research; Bipolar Disorder; Depressive Disorder, Major; Diphenhydr | 1964 |