diphenhydramine has been researched along with Delirium in 8 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of delirium with hallucinations presumably caused by the combination of diphenhydramine and linezolid." | 7.72 | Acute delirium associated with combined diphenhydramine and linezolid use. ( Serio, RN, 2004) |
| "Physostigmine was superior to lorazepam in controlling antimuscarinic delirium and agitation after bolus dosing, and control of delirium after a 4-h infusion." | 5.41 | A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome. ( Baker, K; Heard, K; Janis, GC; Leonard, J; Mistry, RD; Ng, P; Wang, GS, 2021) |
| "To report a case of delirium with hallucinations presumably caused by the combination of diphenhydramine and linezolid." | 3.72 | Acute delirium associated with combined diphenhydramine and linezolid use. ( Serio, RN, 2004) |
| "Of the 426 patients, 114 (27%) received diphenhydramine during hospitalization and shared similar baseline characteristics including age, sex, delirium risk, and Mini-Mental State Examination scores compared with nonexposed patients." | 3.71 | Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. ( Agostini, JV; Inouye, SK; Leo-Summers, LS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, GS | 1 |
| Baker, K | 1 |
| Ng, P | 1 |
| Janis, GC | 1 |
| Leonard, J | 1 |
| Mistry, RD | 1 |
| Heard, K | 1 |
| Lin, KH | 1 |
| Chen, YJ | 1 |
| Wei, CF | 1 |
| Yen, MH | 1 |
| Hsueh, WC | 1 |
| Liao, KC | 1 |
| Lu, CL | 1 |
| Ochs, KL | 1 |
| Zell-Kanter, M | 1 |
| Mycyk, MB | 1 |
| Serio, RN | 1 |
| Christensen, RC | 1 |
| Agostini, JV | 1 |
| Leo-Summers, LS | 1 |
| Inouye, SK | 1 |
| Meuleman, JR | 1 |
| Bernhardt, DT | 1 |
1 trial available for diphenhydramine and Delirium
| Article | Year |
|---|---|
A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome.
Topics: Adolescent; Akathisia, Drug-Induced; Anti-Anxiety Agents; Delirium; Diphenhydramine; Double-Blind Me | 2021 |
7 other studies available for diphenhydramine and Delirium
| Article | Year |
|---|---|
Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report.
Topics: Adult; Analgesics, Non-Narcotic; Delirium; Diphenhydramine; Humans; Hypnotics and Sedatives; Male; N | 2010 |
Hot, blind, and mad: avoidable geriatric anticholinergic delirium.
Topics: Aged, 80 and over; Anesthetics, Local; Delirium; Diphenhydramine; Female; Humans | 2012 |
Acute delirium associated with combined diphenhydramine and linezolid use.
Topics: Acetamides; Acute Disease; Delirium; Diphenhydramine; Drug Combinations; Drug Interactions; Duty to | 2004 |
Misdiagnosis of anticholinergic delerium as schizophrenic psychosis.
Topics: Adult; Delirium; Diagnostic Errors; Diphenhydramine; Drug Overdose; Humans; Male; Schizophrenia | 1995 |
Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients.
Topics: Aged; Aged, 80 and over; Cohort Studies; Connecticut; Delirium; Diphenhydramine; Female; Geriatric A | 2001 |
Association of diphenhydramine use with adverse effects in hospitalized older patients: possible confounders.
Topics: Age Factors; Aged; Confounding Factors, Epidemiologic; Delirium; Diphenhydramine; Hospitalization; H | 2002 |
Topical diphenhydramine toxicity.
Topics: Administration, Topical; Chickenpox; Child; Delirium; Diphenhydramine; Humans; Male; Pruritus | 1991 |