diphenhydramine has been researched along with Delayed Hypersensitivity in 17 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H1-antihistaminic structures were synthesized and their effects were investigated on lipid peroxidation in rat brain homogenates, antiinflammatory effection arachidonic acid- and 12-O-tetradecanoylphorbol-13- acetate-induced mouse ear edema and antiallergic effect on 48-h homologous passive cutaneous anaphylaxis in rats." | 3.69 | Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives. ( Akahoshi, F; Fukaya, C; Kajii, M; Kuwahara, S; Sakaue, Y; Sugiura, M; Sugiyama, N; Yakumaru, H, 1994) |
| "Diphenhydramine treatment alone partially inhibited the histologic intensity of LPR in a dose-dependent manner." | 1.27 | The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions. ( Barr, L; Guthman, DA; Kaliner, M; Lemanske, RF, 1983) |
| "The histamine suppression of cutaneous delayed hypersensitivity could be accounted for in part by its inhibitory effect on certain lymphocyte responses including antigen-induced migration inhibitory factor (MIF) production and proliferation." | 1.26 | Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. ( Rocklin, RE, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugiyama, N | 1 |
| Akahoshi, F | 1 |
| Kuwahara, S | 1 |
| Kajii, M | 1 |
| Sakaue, Y | 1 |
| Yakumaru, H | 1 |
| Sugiura, M | 1 |
| Fukaya, C | 1 |
| Han, SH | 1 |
| Weiser, RS | 1 |
| Mashkovskiĭ, MD | 1 |
| Veksler, IG | 1 |
| Kaminka, ME | 1 |
| Iakimenko, VA | 1 |
| Lemanske, RF | 1 |
| Barr, L | 1 |
| Guthman, DA | 1 |
| Kaliner, M | 1 |
| Lossef, SV | 1 |
| Barth, KH | 1 |
| Biron, CR | 1 |
| Inagaki, N | 1 |
| Sakurai, T | 1 |
| Abe, T | 1 |
| Musoh, K | 1 |
| Kawasaki, H | 1 |
| Tsunematsu, M | 1 |
| Nagai, H | 1 |
| Simons, FE | 1 |
| Silver, NA | 1 |
| Gu, X | 1 |
| Simons, KJ | 1 |
| Swanson-Biearman, B | 1 |
| Krenzelok, EP | 1 |
| Rocklin, RE | 1 |
| Schreibman, DL | 1 |
| Loeb, JA | 1 |
| Herold, KC | 1 |
| Barton, KP | 1 |
| Robinson, LE | 1 |
| Jaspan, JB | 1 |
| Kolbusz, RV | 1 |
| Micetich, K | 1 |
| Armin, AR | 1 |
| Massa, MC | 1 |
| Griswold, DE | 1 |
| Alessi, S | 1 |
| Badger, AM | 1 |
| Poste, G | 1 |
| Hanna, N | 1 |
| Durie, BG | 1 |
| Peters, GA | 1 |
| Shelley, WB | 1 |
| Bennett, RG | 1 |
| Iurenev, PN | 1 |
| Semenovich, NI | 1 |
1 trial available for diphenhydramine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Skin concentrations of H1-receptor antagonists.
Topics: Adult; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Hypersensitivity, Del | 2001 |
16 other studies available for diphenhydramine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives.
Topics: Administration, Topical; Aminophenols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidant | 1994 |
Systemic tuberculin sensitivity in mice. 3. The effects of adrenalectomy and treatment with antianaphylactic agents.
Topics: Adrenal Glands; Adrenalectomy; Animals; Cortisone; Diphenhydramine; Hypersensitivity, Delayed; Mice; | 1967 |
[Effect of new antihistaminic preparations on the body's immunologic reactivity].
Topics: Animals; Antibody Formation; Benzhydryl Compounds; Dinitrochlorobenzene; Diphenhydramine; Guinea Pig | 1981 |
The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions.
Topics: Animals; Antibodies, Anti-Idiotypic; Ascitic Fluid; Capillary Permeability; Cimetidine; Cytoplasmic | 1983 |
Severe delayed hypotensive reaction after Ethiodol lymphangiography despite premedication.
Topics: Adult; Diphenhydramine; Drug Hypersensitivity; Ethiodized Oil; Female; Humans; Hypersensitivity, Del | 1993 |
Allergic reactions to dental materials, drugs require an alert response from practitioner.
Topics: Adolescent; Anesthetics, Local; Anti-Bacterial Agents; Contraindications; Dental Materials; Dermatit | 1997 |
Characterization of antihistamines using biphasic cutaneous reaction in BALB/c mice.
Topics: Animals; Cyproheptadine; Dermatitis, Allergic Contact; Diphenhydramine; Dose-Response Relationship, | 1998 |
Delayed life-threatening reaction to anthrax vaccine.
Topics: Adult; Anthrax Vaccines; Anti-Allergic Agents; Diphenhydramine; Emergency Service, Hospital; Humans; | 2001 |
Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.
Topics: Animals; Antigens; Burimamide; Cell Division; Chlorpheniramine; Depression, Chemical; Diphenhydramin | 1976 |
Treatment of a delayed reaction to droperidol with diphenhydramine.
Topics: Adolescent; Anxiety; Diphenhydramine; Droperidol; Female; Humans; Hypersensitivity, Delayed | 1990 |
Systematic approach to diagnosis and management of biphasic insulin allergy with local anti-inflammatory agents.
Topics: Aged; Diabetes Mellitus; Diphenhydramine; Drug Hypersensitivity; Female; Humans; Hydrocortisone; Hyp | 1989 |
Exaggerated response to insect bites. An unusual cutaneous manifestation of chronic lymphocytic leukemia.
Topics: Diphenhydramine; Female; Humans; Hypersensitivity, Delayed; Insect Bites and Stings; Leukemia, Lymph | 1989 |
Differential sensitivity of T suppressor cell expression to inhibition by histamine type 2 receptor antagonists.
Topics: Animals; Benzenesulfonates; Cimetidine; Dermatitis, Contact; Diphenhydramine; Dose-Response Relation | 1986 |
Cardiac arrhythmia following a hornet sting.
Topics: Adult; Cardiac Complexes, Premature; Creatine Kinase; Diphenhydramine; Humans; Hypersensitivity, Del | 1970 |
Primary contact sensitization site. A determinant for the localization of a diphenhydramine eruption.
Topics: Administration, Oral; Adult; Dermatitis, Toxicodendron; Diphenhydramine; Drug Eruptions; Drug Hypers | 1972 |
[Desensitization therapy in myocardial infarct].
Topics: Adrenal Glands; Amines; Aminopyrine; Aspirin; Autoimmune Diseases; Desensitization, Immunologic; Dip | 1970 |