diphenhydramine has been researched along with Complications, Pregnancy in 11 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison." | 9.27 | Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). ( Childress, KMS; Dothager, C; Gavard, JA; Laska, C; Lebovitz, S; Mostello, DJ, 2018) |
| "We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison." | 5.27 | Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). ( Childress, KMS; Dothager, C; Gavard, JA; Laska, C; Lebovitz, S; Mostello, DJ, 2018) |
| "Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment." | 2.78 | Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. ( Emamian, F; Ghadami, MR; Khazaie, H; Knight, DC; Tahmasian, M, 2013) |
| "Yet data are limited addressing treatment of headache in pregnancy." | 2.72 | Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review. ( Bushman, ET; Cozzi, G; Digre, K; Sinkey, RG; Smith, CH; Varner, MW, 2021) |
| " Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined." | 2.37 | Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986) |
| "Acetaminophen was the most frequent medicine administered first (53%, 38/72)." | 1.51 | Migraine Treatment in Pregnant Women Presenting to Acute Care: A Retrospective Observational Study. ( Hamilton, KT; Robbins, MS, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Bushman, ET | 1 |
| Cozzi, G | 1 |
| Sinkey, RG | 1 |
| Smith, CH | 1 |
| Varner, MW | 1 |
| Digre, K | 1 |
| Childress, KMS | 1 |
| Dothager, C | 1 |
| Gavard, JA | 1 |
| Lebovitz, S | 1 |
| Laska, C | 1 |
| Mostello, DJ | 1 |
| Hamilton, KT | 1 |
| Robbins, MS | 1 |
| Khazaie, H | 1 |
| Ghadami, MR | 1 |
| Knight, DC | 1 |
| Emamian, F | 1 |
| Tahmasian, M | 1 |
| PIOVANO, A | 1 |
| BENITEZ SANCHEZ, P | 1 |
| MISISCHIA, N | 1 |
| BARONIAN, DR | 1 |
| Charlton, BG | 1 |
| Garfield, RE | 1 |
| Irani, AM | 1 |
| Schwartz, LB | 1 |
| Bytautiene, E | 1 |
| Romero, R | 1 |
| Leathem, AM | 1 |
| Levy, W | 1 |
| Wisniewski, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT05753943] | 0 participants | Expanded Access | No longer available | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diphenhydramine and Complications, Pregnancy
| Article | Year |
|---|---|
Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review.
Topics: Acupuncture Analgesia; Analgesics; Biofeedback, Psychology; Codeine; Complementary Therapies; Diphen | 2021 |
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema | 1986 |
2 trials available for diphenhydramine and Complications, Pregnancy
| Article | Year |
|---|---|
Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study).
Topics: Acetaminophen; Adult; Analgesics; Antiemetics; Codeine; Diphenhydramine; Double-Blind Method; Drug A | 2018 |
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial.
Topics: Actigraphy; Adult; Antidepressive Agents, Second-Generation; Depression; Depression, Postpartum; Dip | 2013 |
7 other studies available for diphenhydramine and Complications, Pregnancy
| Article | Year |
|---|---|
Migraine Treatment in Pregnant Women Presenting to Acute Care: A Retrospective Observational Study.
Topics: Acetaminophen; Adult; Analgesics; Antiemetics; Diphenhydramine; Drug Therapy, Combination; Female; H | 2019 |
[Experience with 4,4'-diacetoxy-diphenyl-pyridyl-2-methane in obstetrics].
Topics: Biphenyl Compounds; Catecholamines; Diphenhydramine; Female; Humans; Methane; Obstetrics; Pregnancy; | 1960 |
Treatment of leg cramps during pregnancy: use of diphenhydramine HCl.
Topics: Diphenhydramine; Female; Humans; Leg; Muscle Cramp; Pregnancy; Pregnancy Complications | 1960 |
IDIOPATHIC JAUNDICE OF PREGNANCY--A CASE REPORT.
Topics: Diphenhydramine; Female; Jaundice; Pregnancy; Pregnancy Complications; Toxicology | 1965 |
Self-management and pregnancy--safe interventions for panic, phobia and other anxiety-disorders might include over-the-counter (OTC) 'SSRI' antihistamines such as diphenhydramine and chlorpheniramine.
Topics: Adult; Chlorpheniramine; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Nonprescription | 2005 |
Structural and functional comparison of mast cells in the pregnant versus nonpregnant human uterus.
Topics: Ambrosia; Antigens, Plant; Case-Control Studies; Cell Count; Cyclooxygenase Inhibitors; Diphenhydram | 2006 |
Chlorpromazine causing extrapyramidal dysfunction in newborn infant of psychotic mother.
Topics: Basal Ganglia Diseases; Chlorpromazine; Diphenhydramine; Female; Humans; Infant, Newborn; Infant, Ne | 1974 |