diphenhydramine has been researched along with Chronic Disease in 25 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)." | 9.05 | Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985) |
| "A double-blind crossover study was conducted to evaluate the antitussive effectiveness of diphenhydramine (DPH) in chornic coughs related to bronchitis, at doses of 25 and 50 mg every 4 hr for four doses." | 9.04 | Antitussive activity of diphenhydramine in chronic cough. ( Lilienfield, LS; Princiotto, JV; Rose, JC, 1976) |
| "To understand the relative efficacy of noradrenergic and serotonergic antidepressants as analgesics in chronic back pain without depression, we conducted a randomized, double-blind, placebo-control head-to-head comparison of maprotiline (a norepinephrine reuptake blocker) and paroxetine (a serotonin reuptake blocker) in 103 patients with chronic low back pain." | 5.09 | Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity. ( Abramson, I; Atkinson, JH; Epping-Jordan, JE; Garfin, SR; Grant, I; Patterson, TL; Pruitt, SD; Slater, MA; Wahlgren, DR; Williams, RA; Zisook, S, 1999) |
| "The efficacy of astemizole, diphenhydramine, and hydroxyzine hydrochloride in the treatment of chronic idiopathic urticaria was evaluated in this 3-month double-blind, randomized, parallel group study." | 5.07 | Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria. ( Jancelewicz, Z; Sussman, G, 1991) |
| "Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)." | 5.05 | Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985) |
| "A double-blind crossover study was conducted to evaluate the antitussive effectiveness of diphenhydramine (DPH) in chornic coughs related to bronchitis, at doses of 25 and 50 mg every 4 hr for four doses." | 5.04 | Antitussive activity of diphenhydramine in chronic cough. ( Lilienfield, LS; Princiotto, JV; Rose, JC, 1976) |
| "Leucocytes from healthy donors were isolated and incubated in varying concentrations of ciclosporin, ascomycin, methotrexate, diphenhydramine or hydroxyzine for 30 min prior to stimulation with serum from urticaria patients known to have functional immunoglobulin (Ig)G antibodies directed against the alpha subunit of the IgE receptor." | 3.73 | Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria. ( Joseph, K; Kaplan, AP; Marsland, AM; Soundararajan, S, 2005) |
| "In one an anaphylactoid reaction developed, which was promptly terminated by intravenous methylprednisolone, subcutaneous epinephrine, and intravenous diphenhydramine." | 1.27 | Clinical use of the total dose intravenous infusion of iron dextran. ( Auerbach, M; Ballard, H; Fierstein, M; Lerner, RG; Toler, W; Witt, D, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (60.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iweala, OI | 1 |
| Copenhaver, C | 1 |
| Wu, EY | 1 |
| Moran, TP | 1 |
| ARNOLD, HL | 1 |
| Marsland, AM | 1 |
| Soundararajan, S | 1 |
| Joseph, K | 1 |
| Kaplan, AP | 1 |
| Khoromi, S | 1 |
| Patsalides, A | 1 |
| Parada, S | 1 |
| Salehi, V | 1 |
| Meegan, JM | 1 |
| Max, MB | 1 |
| Derbez, R | 1 |
| Grauer, H | 1 |
| Tsimmerman, IaS | 1 |
| Babushkina, GD | 1 |
| Kushnir, VE | 1 |
| Reĭngardt, BK | 1 |
| Spivak, AM | 1 |
| Chernin, VV | 1 |
| Bystrov, VN | 1 |
| Burns, M | 1 |
| Shanaman, JE | 1 |
| Shellenberger, CH | 1 |
| Dinndorf, PA | 1 |
| McCabe, MA | 1 |
| Frierdich, S | 1 |
| Tkachishin, VS | 1 |
| Atkinson, JH | 1 |
| Slater, MA | 1 |
| Wahlgren, DR | 1 |
| Williams, RA | 1 |
| Zisook, S | 1 |
| Pruitt, SD | 1 |
| Epping-Jordan, JE | 1 |
| Patterson, TL | 1 |
| Grant, I | 1 |
| Abramson, I | 1 |
| Garfin, SR | 1 |
| Midroni, G | 1 |
| Moulton, R | 1 |
| Lilienfield, LS | 1 |
| Rose, JC | 1 |
| Princiotto, JV | 1 |
| Saltz, BL | 1 |
| Sussman, G | 1 |
| Jancelewicz, Z | 1 |
| Auerbach, M | 1 |
| Witt, D | 1 |
| Toler, W | 1 |
| Fierstein, M | 1 |
| Lerner, RG | 1 |
| Ballard, H | 1 |
| Greene, SL | 1 |
| Reed, CE | 1 |
| Schroeter, AL | 1 |
| Barzaghi, E | 1 |
| Fontana, A | 1 |
| Lusena, S | 1 |
| Chillón, F | 1 |
| Harris, PG | 1 |
| Harenko, A | 1 |
| Klein, HG | 1 |
| Wilde, W | 1 |
| Smoligovets, PV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation of Balance and Gait in Neuropathic Pain Due to Lumbar Disc Degeneration[NCT05223439] | 42 participants (Anticipated) | Observational | 2022-01-05 | Recruiting | |||
| Cipralex in Treatment of Depressive Symptoms and Chronic Back Pain[NCT00227292] | Phase 4 | 0 participants (Actual) | Interventional | 2007-11-30 | Withdrawn (stopped due to Mutual agreement between Sponsor and Investigator.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for diphenhydramine and Chronic Disease
| Article | Year |
|---|---|
Topiramate in chronic lumbar radicular pain.
Topics: Adult; Aged; Analgesics; Anticonvulsants; Chronic Disease; Cross-Over Studies; Diphenhydramine; Dose | 2005 |
A sleep study and investigation of a new hypnotic compound in a geriatric population.
Topics: Aged; Arteriosclerosis; Bronchitis; Chronic Disease; Diabetes Complications; Diphenhydramine; Female | 1967 |
A laboratory study of patients with chronic allergic rhinitis: antihistamine effects on skilled performance.
Topics: Adult; Behavior; Capsules; Chronic Disease; Diphenhydramine; Female; Histamine; Humans; Male; Middle | 1994 |
Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Chronic Disease; Diphenhydramine; Double-Blind Method; Hu | 1999 |
Antitussive activity of diphenhydramine in chronic cough.
Topics: Adult; Aged; Antitussive Agents; Chronic Disease; Clinical Trials as Topic; Cough; Diphenhydramine; | 1976 |
Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.
Topics: Adult; Aged; Astemizole; Chronic Disease; Diphenhydramine; Dose-Response Relationship, Drug; Double- | 1991 |
Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria.
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Autoantibodies; Blood Sedimentation; Child; Chroni | 1985 |
A comparative trial of two expectorants in general practice.
Topics: Bronchitis; Chronic Disease; Clinical Trials as Topic; Diphenhydramine; Expectorants; Family Practic | 1970 |
17 other studies available for diphenhydramine and Chronic Disease
| Article | Year |
|---|---|
Hydroxychloroquine as a steroid-sparing agent in an infant with chronic urticaria.
Topics: Acetates; Anti-Inflammatory Agents; Antimalarials; Cetirizine; Chronic Disease; Cyclopropanes; Diphe | 2018 |
Benadryl in chronic urticaria.
Topics: Chronic Disease; Diphenhydramine; Urticaria | 1946 |
Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.
Topics: Basophils; Calcineurin Inhibitors; Cells, Cultured; Chronic Disease; Complement C5a; Cyclosporine; D | 2005 |
[Chronic noncalculous cholecystitis with refractory relapsing course (clinico-laboratory correlates)].
Topics: Anti-Bacterial Agents; Cholagogues and Choleretics; Cholecystitis; Chronic Disease; Diphenhydramine; | 1984 |
[Use of dimedrol in the combined treatment of peptic ulcer patients].
Topics: Adult; Aged; Chronic Disease; Diphenhydramine; Drug Evaluation; Drug Therapy, Combination; Female; H | 1983 |
[Pathogenetic bases for the use of histamine and dimedrol in the overall treatment of recurrent peptic ulcer].
Topics: Adult; Chronic Disease; Diphenhydramine; Drug Evaluation; Histamine; Humans; Middle Aged; Peptic Ulc | 1981 |
Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses.
Topics: Adolescent; Adult; Child; Chronic Disease; Diphenhydramine; Female; Hematologic Diseases; Histamine | 1998 |
[Effectiveness of nondrug treatment of chronic bronchitis in persons exposed to radiation due to Chernobyl AES accident].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aminophylline; Bromhexine; Bronchitis; Bronchodilator Ag | 1999 |
Radial entrapment neuropathy due to chronic injection-induced triceps fibrosis.
Topics: Adult; Chronic Disease; Diazepam; Dimenhydrinate; Diphenhydramine; Drug Therapy, Combination; Electr | 2001 |
Tardive dyskinesia in the elderly patient.
Topics: Aged; Chlorpromazine; Chronic Disease; Clonazepam; Clozapine; Depressive Disorder; Desipramine; Diph | 1992 |
Clinical use of the total dose intravenous infusion of iron dextran.
Topics: Anaphylaxis; Anemia; Bone Marrow; Chronic Disease; Diphenhydramine; Disease; Fever; Hemosiderin; Hum | 1988 |
[Clinical contribution to the treatment of chornic obstructive bronchopneumopathies].
Topics: Adult; Aged; Aluminum Hydroxide; Aminophylline; Anti-Bacterial Agents; Chronic Disease; Diphenhydram | 1974 |
[Therapeutical effect of a new antidyspnoeic drug in the chronic obstructive pulmonary disease (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Bronchitis; Bronchodilator Agents; Chronic Disease; Diphenhyd | 1973 |
Serum bromide level and its reduction in chronic bromisovalum poisoning. I.
Topics: Adult; Bromides; Chlorides; Chronic Disease; Diphenhydramine; Female; Humans; Male; Middle Aged; Ure | 1967 |
[Experiences in the treatment of bronchospastic diseases].
Topics: Adult; Aged; Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Diphenhydramine; Ephedrine; | 1967 |
[Long-term treatment of the bronchitis syndrome].
Topics: Aged; Bronchitis; Chronic Disease; Diphenhydramine; Ephedrine; Guaifenesin; Humans; Male; Middle Age | 1969 |
[Dimedrol in the complex therapy of patients with peptic ulcer and chronic gastritis].
Topics: Adult; Aged; Chronic Disease; Diet Therapy; Digestion; Diphenhydramine; Duodenal Ulcer; Female; Gast | 1966 |