diphenhydramine has been researched along with Carcinoma, Non-Small Cell Lung in 9 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The usefulness of alprazolam (minor tranquilizer) used in combination with metoclopramide plus methylprednisolone for the prevention and control of emesis induced by chemotherapies, including 5-day continuous intravenous infusion of cisplatin (25 mg/m2/day) for advanced lung cancer, was evaluated using a double-blind randomized crossover design." | 9.07 | Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis. ( Mori, K; Saito, Y; Tominaga, K, 1993) |
| "To evaluate the efficacy of a combined therapy of prednisolone and alprazolam for controlling cisplatin-induced delayed emesis, a study involving 14 non-small cell lung cancer patients receiving cisplatin (80 mg/m2) was conducted." | 7.68 | [A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis]. ( Horio, Y; Iwahara, T; Minami, H; Sakai, S; Shibagaki, T; Shimokata, K; Watanabe, A, 1990) |
| "Intravenous antiemetic combinations containing a 5-HT3 receptor antagonist (like metoclopramide, ondansetron, or granisetron) with dexamethasone have become the standard therapy for the treatment of acute chemotherapy-induced vomiting." | 5.08 | Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin. ( Clark, RA; Cleri, LB; Gralla, RJ; Kris, MG; Pisters, KM; Tyson, LB, 1995) |
| "The usefulness of alprazolam (minor tranquilizer) used in combination with metoclopramide plus methylprednisolone for the prevention and control of emesis induced by chemotherapies, including 5-day continuous intravenous infusion of cisplatin (25 mg/m2/day) for advanced lung cancer, was evaluated using a double-blind randomized crossover design." | 5.07 | Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis. ( Mori, K; Saito, Y; Tominaga, K, 1993) |
| "To evaluate the efficacy of a combined therapy of prednisolone and alprazolam for controlling cisplatin-induced delayed emesis, a study involving 14 non-small cell lung cancer patients receiving cisplatin (80 mg/m2) was conducted." | 3.68 | [A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis]. ( Horio, Y; Iwahara, T; Minami, H; Sakai, S; Shibagaki, T; Shimokata, K; Watanabe, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sasada, S | 1 |
| Hirashima, T | 1 |
| Nakamura, Y | 1 |
| Takimoto, T | 1 |
| Furukawa, M | 1 |
| Kobayashi, M | 1 |
| Nitta, T | 1 |
| Matsui, K | 1 |
| Kawase, I | 1 |
| Kosmidis, PA | 1 |
| Kalofonos, HP | 1 |
| Christodoulou, C | 1 |
| Syrigos, K | 1 |
| Makatsoris, T | 1 |
| Skarlos, D | 1 |
| Bakogiannis, C | 1 |
| Nicolaides, C | 1 |
| Bafaloukos, D | 1 |
| Bamias, A | 1 |
| Samantas, E | 1 |
| Xiros, N | 1 |
| Boukovinas, I | 1 |
| Fountzilas, G | 1 |
| Dimopoulos, MA | 1 |
| Hainsworth, JD | 1 |
| Greco, FA | 1 |
| Murphy, WK | 1 |
| Fossella, FV | 1 |
| Winn, RJ | 1 |
| Shin, DM | 1 |
| Hynes, HE | 1 |
| Gross, HM | 1 |
| Davilla, E | 1 |
| Leimert, J | 1 |
| Dhingra, H | 1 |
| Raber, MN | 1 |
| Mori, K | 1 |
| Saito, Y | 1 |
| Tominaga, K | 1 |
| Cleri, LB | 1 |
| Kris, MG | 1 |
| Tyson, LB | 1 |
| Pisters, KM | 1 |
| Clark, RA | 1 |
| Gralla, RJ | 1 |
| Shepherd, FA | 1 |
| Latreille, J | 1 |
| Paul, K | 1 |
| Eisenhauer, E | 1 |
| Watanabe, A | 1 |
| Horio, Y | 1 |
| Minami, H | 1 |
| Shibagaki, T | 1 |
| Iwahara, T | 1 |
| Sakai, S | 1 |
| Shimokata, K | 1 |
| Navari, RM | 1 |
7 trials available for diphenhydramine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcino | 2008 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration Sche | 1993 |
Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis.
Topics: Adult; Aged; Alprazolam; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non | 1993 |
Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin.
Topics: Administration, Oral; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Sm | 1995 |
Phase I dose-escalation trial of paclitaxel and ifosfamide in patients with advanced non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Co | 1996 |
Comparison of intermittent versus continuous infusion metoclopramide in control of acute nausea induced by cisplatin chemotherapy.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Dexamethasone; Diphenhydramine; Dr | 1989 |
2 other studies available for diphenhydramine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Preliminary experience with a modified premedication protocol that included intravenous diphenhydramine and calcium bromide for the prophylaxis of paclitaxel-related hypersensitivity reactions.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Bromides; Calcium Compounds; Carcinoma, Non-Small-Ce | 2007 |
[A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis].
Topics: Administration, Oral; Adult; Aged; Alprazolam; Antineoplastic Combined Chemotherapy Protocols; Carci | 1990 |