diphenhydramine has been researched along with Cancer of Lung in 20 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The usefulness of alprazolam (minor tranquilizer) used in combination with metoclopramide plus methylprednisolone for the prevention and control of emesis induced by chemotherapies, including 5-day continuous intravenous infusion of cisplatin (25 mg/m2/day) for advanced lung cancer, was evaluated using a double-blind randomized crossover design." | 9.07 | Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis. ( Mori, K; Saito, Y; Tominaga, K, 1993) |
| "To evaluate the efficacy of a combined therapy of prednisolone and alprazolam for controlling cisplatin-induced delayed emesis, a study involving 14 non-small cell lung cancer patients receiving cisplatin (80 mg/m2) was conducted." | 7.68 | [A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis]. ( Horio, Y; Iwahara, T; Minami, H; Sakai, S; Shibagaki, T; Shimokata, K; Watanabe, A, 1990) |
| "Paclitaxel was administered by 1 h intravenous infusion at a dose of 80 mg/m2 every week." | 6.71 | Multicenter phase II trial of weekly paclitaxel for advanced or metastatic breast cancer: the Saitama Breast Cancer Clinical Study Group (SBCCSG-01). ( Inoue, K; Kai, T; Koh, J; Mihara, H; Mochizuki, H; Okubo, K; Saito, T; Sato, K; Tabei, T, 2003) |
| "Intravenous antiemetic combinations containing a 5-HT3 receptor antagonist (like metoclopramide, ondansetron, or granisetron) with dexamethasone have become the standard therapy for the treatment of acute chemotherapy-induced vomiting." | 5.08 | Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin. ( Clark, RA; Cleri, LB; Gralla, RJ; Kris, MG; Pisters, KM; Tyson, LB, 1995) |
| "The usefulness of alprazolam (minor tranquilizer) used in combination with metoclopramide plus methylprednisolone for the prevention and control of emesis induced by chemotherapies, including 5-day continuous intravenous infusion of cisplatin (25 mg/m2/day) for advanced lung cancer, was evaluated using a double-blind randomized crossover design." | 5.07 | Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis. ( Mori, K; Saito, Y; Tominaga, K, 1993) |
| "To evaluate the efficacy of a combined therapy of prednisolone and alprazolam for controlling cisplatin-induced delayed emesis, a study involving 14 non-small cell lung cancer patients receiving cisplatin (80 mg/m2) was conducted." | 3.68 | [A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis]. ( Horio, Y; Iwahara, T; Minami, H; Sakai, S; Shibagaki, T; Shimokata, K; Watanabe, A, 1990) |
| "Temsirolimus (CCI-779) is a novel inhibitor of the mammalian target of rapamycin." | 2.75 | A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors. ( Fujisaka, Y; Horiike, A; Tamura, T; Yamada, Y; Yamamoto, N, 2010) |
| "Paclitaxel was administered by 1 h intravenous infusion at a dose of 80 mg/m2 every week." | 2.71 | Multicenter phase II trial of weekly paclitaxel for advanced or metastatic breast cancer: the Saitama Breast Cancer Clinical Study Group (SBCCSG-01). ( Inoue, K; Kai, T; Koh, J; Mihara, H; Mochizuki, H; Okubo, K; Saito, T; Sato, K; Tabei, T, 2003) |
| "Paclitaxel 135 mg/m2 was infused as a single dose over 1 hour or was divided into three doses infused over 1 hour on 3 consecutive days." | 2.68 | One-hour paclitaxel infusion schedules: a phase I/II comparative trial. ( Greco, FA; Hainsworth, JD, 1995) |
| "Diphenhydramine was used because of its possible antiemetic properties and its ability to control acute dystonic reactions." | 2.66 | Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients. ( Bosl, GJ; Clark, RA; Gralla, RJ; Groshen, S; Kalman, LA; Kelsen, DP; Kris, MG; Reilly, LK; Tyson, LB, 1985) |
| "Four consecutive trials were undertaken to study lorazepam at each of three dosage levels and diphenhydramine when used in combination with iv metoclopramide and dexamethasone in patients receiving cisplatin at 120 mg/m2." | 2.66 | Consecutive dose-finding trials adding lorazepam to the combination of metoclopramide plus dexamethasone: improved subjective effectiveness over the combination of diphenhydramine plus metoclopramide plus dexamethasone. ( Clark, RA; Fiore, JJ; Gralla, RJ; Groshen, S; Kelsen, DP; Kris, MG; Tyson, LB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 11 (55.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, TT | 1 |
| Chang, YC | 1 |
| Lee, JM | 1 |
| Hung, MH | 1 |
| Fujisaka, Y | 1 |
| Yamada, Y | 1 |
| Yamamoto, N | 1 |
| Horiike, A | 1 |
| Tamura, T | 1 |
| BRENNIG, K | 1 |
| Sato, K | 1 |
| Inoue, K | 1 |
| Saito, T | 1 |
| Kai, T | 1 |
| Mihara, H | 1 |
| Okubo, K | 1 |
| Koh, J | 1 |
| Mochizuki, H | 1 |
| Tabei, T | 1 |
| Sasada, S | 1 |
| Hirashima, T | 1 |
| Nakamura, Y | 1 |
| Takimoto, T | 1 |
| Furukawa, M | 1 |
| Kobayashi, M | 1 |
| Nitta, T | 1 |
| Matsui, K | 1 |
| Kawase, I | 1 |
| Kosmidis, PA | 1 |
| Kalofonos, HP | 1 |
| Christodoulou, C | 1 |
| Syrigos, K | 1 |
| Makatsoris, T | 1 |
| Skarlos, D | 1 |
| Bakogiannis, C | 1 |
| Nicolaides, C | 1 |
| Bafaloukos, D | 1 |
| Bamias, A | 1 |
| Samantas, E | 1 |
| Xiros, N | 1 |
| Boukovinas, I | 1 |
| Fountzilas, G | 1 |
| Dimopoulos, MA | 1 |
| Greco, FA | 2 |
| Hainsworth, JD | 2 |
| Saville, MW | 1 |
| Lietzau, J | 1 |
| Pluda, JM | 1 |
| Feuerstein, I | 1 |
| Odom, J | 1 |
| Wilson, WH | 1 |
| Humphrey, RW | 1 |
| Feigal, E | 1 |
| Steinberg, SM | 1 |
| Broder, S | 1 |
| Murphy, WK | 1 |
| Fossella, FV | 1 |
| Winn, RJ | 1 |
| Shin, DM | 1 |
| Hynes, HE | 1 |
| Gross, HM | 1 |
| Davilla, E | 1 |
| Leimert, J | 1 |
| Dhingra, H | 1 |
| Raber, MN | 1 |
| Casper, ES | 1 |
| Cordon-Cardo, C | 1 |
| Houghton, AN | 1 |
| Steffens, TA | 1 |
| McCormack, P | 1 |
| Magill, GB | 1 |
| Hajdu, SI | 1 |
| Brennan, MF | 1 |
| Mori, K | 1 |
| Saito, Y | 1 |
| Tominaga, K | 1 |
| Cleri, LB | 1 |
| Kris, MG | 3 |
| Tyson, LB | 3 |
| Pisters, KM | 1 |
| Clark, RA | 3 |
| Gralla, RJ | 3 |
| Shepherd, FA | 1 |
| Latreille, J | 1 |
| Paul, K | 1 |
| Eisenhauer, E | 1 |
| Walton, GD | 1 |
| Schreeder, MT | 1 |
| Rizzo, J | 1 |
| Jobe, DR | 1 |
| Kuhn, J | 1 |
| Watanabe, A | 1 |
| Horio, Y | 1 |
| Minami, H | 1 |
| Shibagaki, T | 1 |
| Iwahara, T | 1 |
| Sakai, S | 1 |
| Shimokata, K | 1 |
| Roila, F | 1 |
| Basurto, C | 1 |
| Bracarda, S | 1 |
| Picciafuoco, M | 1 |
| Ballatori, E | 1 |
| Del Favero, A | 1 |
| Tonato, M | 1 |
| Navari, RM | 1 |
| Kelsen, DP | 2 |
| Reilly, LK | 1 |
| Groshen, S | 2 |
| Bosl, GJ | 1 |
| Kalman, LA | 1 |
| Fiore, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Dose-dense Sequential Chemotherapy With Epirubicin, CMF, and Weekly Docetaxel or Weekly Paclitaxel in Patients With Resected High-risk Breast Cancer: A Hellenic Cooperative Oncology Group (HeCOG) Study[NCT04829890] | 89 participants (Actual) | Observational | 2004-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 trials available for diphenhydramine and Cancer of Lung
| Article | Year |
|---|---|
A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents; Area Under Curve; Carcinoma, Renal Cell; C | 2010 |
Multicenter phase II trial of weekly paclitaxel for advanced or metastatic breast cancer: the Saitama Breast Cancer Clinical Study Group (SBCCSG-01).
Topics: Adult; Aged; Alopecia; Antiemetics; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Dexamethaso | 2003 |
Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcino | 2008 |
One-hour paclitaxel infusion schedules: a phase I/II comparative trial.
Topics: Blood Cell Count; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration | 1995 |
Treatment of HIV-associated Kaposi's sarcoma with paclitaxel.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cimetidine; Dexamethasone; Diphenhydramine; Drug Therapy, | 1995 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration Sche | 1993 |
Biological study of R24 mouse monoclonal antibody in patients undergoing thoracotomy for pulmonary metastases from soft tissue sarcoma.
Topics: Adult; Aged; Animals; Antibodies, Monoclonal; Chemotherapy, Adjuvant; Diphenhydramine; Epinephrine; | 1994 |
Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis.
Topics: Adult; Aged; Alprazolam; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non | 1993 |
Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin.
Topics: Administration, Oral; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Sm | 1995 |
Phase I dose-escalation trial of paclitaxel and ifosfamide in patients with advanced non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Co | 1996 |
Comparison of intermittent versus continuous infusion metoclopramide in control of acute nausea induced by cisplatin chemotherapy.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Dexamethasone; Diphenhydramine; Dr | 1989 |
Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients.
Topics: Adult; Aged; Antiemetics; Cisplatin; Clinical Trials as Topic; Dexamethasone; Diphenhydramine; Drug | 1985 |
Consecutive dose-finding trials adding lorazepam to the combination of metoclopramide plus dexamethasone: improved subjective effectiveness over the combination of diphenhydramine plus metoclopramide plus dexamethasone.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Cisplatin; Clinical Trials as | 1985 |
6 other studies available for diphenhydramine and Cancer of Lung
| Article | Year |
|---|---|
Anaphylactic reaction to patent blue V used in preoperative computed tomography-guided dye localization of small lung nodules.
Topics: Aged; Anaphylaxis; Colonic Neoplasms; Contrast Media; Crystalloid Solutions; Diphenhydramine; Humans | 2016 |
[CLINICAL STUDIES WITH VOYAL IN RADIATION INJURIES].
Topics: Breast Neoplasms; Diphenhydramine; Female; Humans; Lung Neoplasms; Radiation Injuries; Theophylline; | 1963 |
Preliminary experience with a modified premedication protocol that included intravenous diphenhydramine and calcium bromide for the prophylaxis of paclitaxel-related hypersensitivity reactions.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Bromides; Calcium Compounds; Carcinoma, Non-Small-Ce | 2007 |
Hepatic artery administration of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carc | 1999 |
[A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis].
Topics: Administration, Oral; Adult; Aged; Alprazolam; Antineoplastic Combined Chemotherapy Protocols; Carci | 1990 |
A pilot study of metoclopramide, dexamethasone, diphenhydramine and lorazepam in prevention of nausea and vomiting in cisplatin-treated male patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dexamethasone; Diphenhydramine; Drug Eval | 1990 |