diphenhydramine has been researched along with Bilateral Headache in 18 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " intranasal ketamine among ED patients with primary headache." | 9.30 | The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. ( April, MD; Benish, T; Casmaer, M; Hunter, CJ; Love, S; Summers, SM; Villalobos, D, 2019) |
| "We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison." | 9.27 | Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). ( Childress, KMS; Dothager, C; Gavard, JA; Laska, C; Lebovitz, S; Mostello, DJ, 2018) |
| "We conducted a single site, randomized, double-blind, placebo-controlled trial investigating the clinical efficacy of IV acetaminophen as an adjunct to a standard therapy with prochlorperazine and diphenhydramine for the treatment of patients who present to the ED with a chief complaint of "headache" or variants thereof." | 9.24 | Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. ( Hysell, MK; Meyering, SH; Stringer, RW, 2017) |
| "We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches." | 9.17 | A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches. ( Adewunmi, V; Bijur, PE; Campbell, C; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2013) |
| "This review found insufficient evidence to recommend the use of diphenhydramine as an adjunct therapy to prevent akathisia in ED patients treated with neuroleptics or metoclopramide for primary headache." | 5.41 | Adjuvant anticholinergic therapy for the prevention of akathisia in patients with primary headache in the emergency department: A systematic review. ( Campbell, S; Kirkland, SW; Meyer, J; Rowe, BH; Villa-Roel, C, 2023) |
| " intranasal ketamine among ED patients with primary headache." | 5.30 | The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. ( April, MD; Benish, T; Casmaer, M; Hunter, CJ; Love, S; Summers, SM; Villalobos, D, 2019) |
| "We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison." | 5.27 | Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). ( Childress, KMS; Dothager, C; Gavard, JA; Laska, C; Lebovitz, S; Mostello, DJ, 2018) |
| "We conducted a single site, randomized, double-blind, placebo-controlled trial investigating the clinical efficacy of IV acetaminophen as an adjunct to a standard therapy with prochlorperazine and diphenhydramine for the treatment of patients who present to the ED with a chief complaint of "headache" or variants thereof." | 5.24 | Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. ( Hysell, MK; Meyering, SH; Stringer, RW, 2017) |
| "We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches." | 5.17 | A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches. ( Adewunmi, V; Bijur, PE; Campbell, C; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2013) |
| "The utility of intravenous prochlorperazine as an antiemetic agent and abortive therapy for headache may be limited by the frequent occurrence of akathisia, the distressing effects of which have been shown to disrupt patient care." | 5.09 | Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial. ( Drotts, DL; Vinson, DR, 2001) |
| "Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications in an attempt to reduce the incidence and severity of these events." | 5.08 | Pretreatment regimens for adverse events related to infusion of amphotericin B. ( Cleary, JD; Goodwin, SD; Grasela, TH; Taylor, JW; Walawander, CA, 1995) |
| "Yet data are limited addressing treatment of headache in pregnancy." | 2.72 | Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review. ( Bushman, ET; Cozzi, G; Digre, K; Sinkey, RG; Smith, CH; Varner, MW, 2021) |
| "Cerebral venous thrombosis (CVT) is a rare, difficult-to-diagnose form of venous thromboembolic disease and is considered a type of stroke." | 1.51 | Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. ( Arthur, J; Chadwick, S; Duran-Gehring, P; Kumetz, C; McIntosh, M, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, J | 1 |
| Kirkland, SW | 1 |
| Campbell, S | 1 |
| Villa-Roel, C | 1 |
| Rowe, BH | 1 |
| Bushman, ET | 1 |
| Cozzi, G | 1 |
| Sinkey, RG | 1 |
| Smith, CH | 1 |
| Varner, MW | 1 |
| Digre, K | 1 |
| Zitek, T | 1 |
| Sigal, T | 1 |
| Sun, G | 1 |
| Martin Manuel, C | 1 |
| Tran, K | 1 |
| Meyering, SH | 1 |
| Stringer, RW | 1 |
| Hysell, MK | 1 |
| Childress, KMS | 1 |
| Dothager, C | 1 |
| Gavard, JA | 1 |
| Lebovitz, S | 1 |
| Laska, C | 1 |
| Mostello, DJ | 1 |
| Arthur, J | 1 |
| Duran-Gehring, P | 1 |
| Kumetz, C | 1 |
| Chadwick, S | 1 |
| McIntosh, M | 1 |
| Benish, T | 1 |
| Villalobos, D | 1 |
| Love, S | 1 |
| Casmaer, M | 1 |
| Hunter, CJ | 1 |
| Summers, SM | 1 |
| April, MD | 1 |
| Friedman, BW | 1 |
| Adewunmi, V | 1 |
| Campbell, C | 1 |
| Solorzano, C | 1 |
| Esses, D | 1 |
| Bijur, PE | 1 |
| Gallagher, EJ | 1 |
| GOODMAN, EG | 1 |
| COONRAD, RW | 1 |
| WILLIAMS, HL | 1 |
| Vinson, DR | 2 |
| Hurtado, TR | 1 |
| Vandenberg, JT | 1 |
| Banwart, L | 1 |
| TUCKER, WI | 1 |
| O'NEILL, PB | 1 |
| Goodwin, SD | 1 |
| Cleary, JD | 1 |
| Walawander, CA | 1 |
| Taylor, JW | 1 |
| Grasela, TH | 1 |
| Watanabe, T | 1 |
| Funayama, M | 1 |
| Morita, M | 1 |
| Drotts, DL | 1 |
| Okuma, T | 1 |
| Kuba, K | 1 |
| Matsushita, T | 1 |
| Nakao, T | 1 |
| Fujii, S | 1 |
| Shimoda, Y | 1 |
| Rosner, S | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache[NCT01011673] | Phase 4 | 123 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
At baseline at at 60 minutes, all patients were asked to describe their pain on a scale from 0 to 10, with 0 representing no pain and 10 the worst imaginable. The primary outcome is the 60 minute score subtracted from the baseline score (NCT01011673)
Timeframe: Baseline, 60 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketorolac | 3.8 |
| Metoclopramide | 5.1 |
"24 hours after the emergency department visit, patients were asked, The next time you come to the Er with this type of headache, do you want to receive the same medication? Affirmative answers are tabulated here." (NCT01011673)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketorolac | 45 |
| Metoclopramide | 53 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
2 reviews available for diphenhydramine and Bilateral Headache
| Article | Year |
|---|---|
Adjuvant anticholinergic therapy for the prevention of akathisia in patients with primary headache in the emergency department: A systematic review.
Topics: Adult; Antipsychotic Agents; Cholinergic Antagonists; Diphenhydramine; Emergency Service, Hospital; | 2023 |
Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review.
Topics: Acupuncture Analgesia; Analgesics; Biofeedback, Psychology; Codeine; Complementary Therapies; Diphen | 2021 |
7 trials available for diphenhydramine and Bilateral Headache
| Article | Year |
|---|---|
I-FiBH trial: intravenous fluids in benign headaches-a randomised, single-blinded clinical trial.
Topics: Adolescent; Adult; Aged; Child; Diphenhydramine; Dopamine Antagonists; Female; Fluid Therapy; Headac | 2020 |
Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department.
Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics; Diphenhydramine; Double-Blind Method; | 2017 |
Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study).
Topics: Acetaminophen; Adult; Analgesics; Antiemetics; Codeine; Diphenhydramine; Double-Blind Method; Drug A | 2018 |
The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide.
Topics: Academic Medical Centers; Administration, Intranasal; Adult; Analgesics; Diphenhydramine; Emergency | 2019 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
Pretreatment regimens for adverse events related to infusion of amphotericin B.
Topics: Acetaminophen; Adrenal Cortex Hormones; Amphotericin B; Diphenhydramine; Fever; Headache; Heparin; H | 1995 |
Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antiemetics; Conscious Sedation; Diphenhydramine; Double | 2001 |
9 other studies available for diphenhydramine and Bilateral Headache
| Article | Year |
|---|---|
Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Cerebral Veins; Computed Tomogra | 2019 |
Prophylactic effect of benadryl on experimental histamine headache.
Topics: Cluster Headache; Diphenhydramine; Headache; Histamine | 1947 |
Use of benadryl in the syndrome of physical allergy of the head; a preliminary report.
Topics: Anaphylaxis; Diphenhydramine; Head; Headache; Hypersensitivity; Immune System Diseases; Physical Exa | 1945 |
Variations among emergency departments in the treatment of benign headache.
Topics: Adolescent; Adult; Aged; Algorithms; Analgesics, Non-Narcotic; Analgesics, Opioid; Antiemetics; Bino | 2003 |
Benadryl in histamine headache.
Topics: Cluster Headache; Diphenhydramine; Headache; Histamine; Humans | 1952 |
Fatal anaphylactic shock to hyoscine and diphenhydramine.
Topics: Adult; Anaphylaxis; Diphenhydramine; Drug Combinations; Fatal Outcome; Headache; Humans; Injections, | 1994 |
Study on 14 and 6 per second positive spikes during nocturnal sleep.
Topics: Adolescent; Adult; Age Factors; Brain; Brain Diseases; Craniocerebral Trauma; Diphenhydramine; Elect | 1968 |
The diagnosis and treatment of cerebral concussion.
Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele | 1967 |
A method of treatment for head pain.
Topics: Diphenhydramine; Headache; Humans; Infusions, Parenteral; Methods; Procaine | 1968 |