diphenhydramine has been researched along with Benign Neoplasms in 34 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions." | 9.13 | A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. ( Case, LD; Cruz, JM; Hurd, DD; Kennedy, LD; Pomper, GJ, 2008) |
| "289 consecutive cancer patients receiving cisplatin chemotherapy (much greater than 50 mg/m2) were randomised to receive one of the following intravenous antiemetic regimens: ondansetron 0." | 6.67 | Ondansetron + dexamethasone vs metoclopramide + dexamethasone + diphenhydramine in prevention of cisplatin-induced emesis. Italian Group For Antiemetic Research. ( , 1992) |
| "The topical gel known as "ABH gel," comprising lorazepam (Ativan(®)), diphenhydramine (Benadryl(®)), and haloperidol (Haldol(®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting." | 5.19 | A randomized trial of the effectiveness of topical "ABH Gel" (Ativan(®), Benadryl(®), Haldol(®)) vs. placebo in cancer patients with nausea. ( Coyne, PJ; Dodson, PW; Fletcher, DS; Parker, GG; Smith, TJ; Wan, W, 2014) |
| "Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions." | 5.13 | A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. ( Case, LD; Cruz, JM; Hurd, DD; Kennedy, LD; Pomper, GJ, 2008) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Temsirolimus (CCI-779) is a novel inhibitor of the mammalian target of rapamycin." | 2.75 | A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors. ( Fujisaka, Y; Horiike, A; Tamura, T; Yamada, Y; Yamamoto, N, 2010) |
| "Paclitaxel 135 mg/m2 was infused as a single dose over 1 hour or was divided into three doses infused over 1 hour on 3 consecutive days." | 2.68 | One-hour paclitaxel infusion schedules: a phase I/II comparative trial. ( Greco, FA; Hainsworth, JD, 1995) |
| "The present study was conducted to compare the pharmacokinetics and pharmacodynamics (PD) of paclitaxel between Phase I trials of 3- and 24-h infusions and to determine the most informative pharmacokinetic parameter to describe the PD." | 2.68 | Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion. ( Miyata, Y; Nakanomyo, H; Nishiwaki, Y; Ohtsu, T; Saijo, N; Sasaki, Y; Tamura, T, 1995) |
| "289 consecutive cancer patients receiving cisplatin chemotherapy (much greater than 50 mg/m2) were randomised to receive one of the following intravenous antiemetic regimens: ondansetron 0." | 2.67 | Ondansetron + dexamethasone vs metoclopramide + dexamethasone + diphenhydramine in prevention of cisplatin-induced emesis. Italian Group For Antiemetic Research. ( , 1992) |
| " Utilizing a 90-day BUD, lidocaine can be packaged separately from other magic mouthwash ingredients in individual dosage units and applied to the oral cavity using the swish-and-spit method." | 1.46 | Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations. ( Brown, SD; Huffman, J; Kirk, LM; Lewis, PO; Luu, Y; Ogle, A, 2017) |
| "We report three patients with advanced cancer pain refractory to adjuvants and oral, intravenous, and epidural opioids, who achieved sustained pain relief after the repeated administration of diphenhydramine." | 1.31 | Diphenhydramine as an analgesic adjuvant in refractory cancer pain. ( Fischberg, D; Gonzales, G; Khjainova, N; Kornick, C; Santiago-Palma, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (26.47) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 6 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Hamed, MM | 1 |
| Darwish, SS | 1 |
| Herrmann, J | 1 |
| Abadi, AH | 1 |
| Engel, M | 1 |
| Kirk, LM | 1 |
| Brown, SD | 1 |
| Luu, Y | 1 |
| Ogle, A | 1 |
| Huffman, J | 1 |
| Lewis, PO | 1 |
| Tempero, M | 1 |
| Fletcher, DS | 1 |
| Coyne, PJ | 1 |
| Dodson, PW | 1 |
| Parker, GG | 1 |
| Wan, W | 1 |
| Smith, TJ | 1 |
| Kennedy, LD | 1 |
| Case, LD | 1 |
| Hurd, DD | 1 |
| Cruz, JM | 1 |
| Pomper, GJ | 1 |
| Fujisaka, Y | 1 |
| Yamada, Y | 1 |
| Yamamoto, N | 1 |
| Horiike, A | 1 |
| Tamura, T | 2 |
| Coulter, DW | 1 |
| Walko, C | 1 |
| Patel, J | 1 |
| Moats-Staats, BM | 1 |
| McFadden, A | 1 |
| Smith, SV | 1 |
| Khan, WA | 1 |
| Bridges, AS | 1 |
| Deal, AM | 1 |
| Oesterheld, J | 1 |
| Davis, IJ | 1 |
| Blatt, J | 1 |
| Thomas, RR | 1 |
| Quinn, MG | 1 |
| Schuler, B | 1 |
| Grem, JL | 1 |
| LATTANZI, A | 1 |
| Laman, CA | 1 |
| Silverstein, SB | 1 |
| Rodgers, GM | 1 |
| Bleicher, J | 1 |
| Bhaskara, A | 1 |
| Huyck, T | 1 |
| Constantino, S | 1 |
| Bardia, A | 1 |
| Loprinzi, CL | 1 |
| Silberstein, PT | 1 |
| Plezia, PM | 2 |
| Alberts, DS | 2 |
| Kessler, J | 1 |
| Aapro, MS | 1 |
| Graham, V | 1 |
| Surwit, EA | 1 |
| Greco, FA | 2 |
| Hainsworth, JD | 2 |
| Siegall, CB | 1 |
| Liggitt, D | 1 |
| Chace, D | 1 |
| Tepper, MA | 1 |
| Fell, HP | 1 |
| Purl, S | 1 |
| Johnson, L | 1 |
| Hanauer, S | 1 |
| Schroeder, L | 1 |
| Proeschel, C | 1 |
| Alberts, J | 1 |
| Bookman, MA | 1 |
| Kloth, DD | 1 |
| Kover, PE | 1 |
| Smolinski, S | 1 |
| Ozols, RF | 1 |
| Dinndorf, PA | 1 |
| McCabe, MA | 1 |
| Frierdich, S | 1 |
| Ohtsu, T | 1 |
| Sasaki, Y | 1 |
| Miyata, Y | 1 |
| Nakanomyo, H | 1 |
| Nishiwaki, Y | 1 |
| Saijo, N | 1 |
| Ballatori, E | 2 |
| Roila, F | 2 |
| Berto, P | 1 |
| De Angelis, V | 1 |
| Neri, C | 1 |
| Olivieri, A | 1 |
| Tonato, M | 2 |
| Del Favero, A | 2 |
| Turhal, NS | 1 |
| Erdal, S | 1 |
| Karacay, S | 1 |
| Santiago-Palma, J | 1 |
| Fischberg, D | 1 |
| Kornick, C | 1 |
| Khjainova, N | 1 |
| Gonzales, G | 1 |
| Adamski, P | 1 |
| Kessler, JF | 1 |
| Berens, PL | 1 |
| Chase, JL | 1 |
| Roe, DJ | 1 |
| Basurto, C | 1 |
| Bracarda, S | 1 |
| Picciafuoco, M | 1 |
| Culine, S | 1 |
| Azab, M | 1 |
| Pietri, F | 1 |
| Ghosn, M | 1 |
| Ben Amor, B | 1 |
| Lupera, H | 1 |
| Theodore, C | 1 |
| Renaux, J | 1 |
| Droz, JP | 1 |
| Wiernik, PH | 2 |
| Schwartz, EL | 2 |
| Strauman, JJ | 2 |
| Dutcher, JP | 2 |
| Lipton, RB | 2 |
| Paietta, E | 1 |
| Einzig, A | 1 |
| Furste, AB | 1 |
| Davis, MP | 1 |
| Gutterman, L | 1 |
| Pritchard, JD | 1 |
| Wheeler, W | 1 |
| Enck, RE | 1 |
| Sridhar, KS | 1 |
| Donnelly, E | 1 |
| Rhinehart, SN | 1 |
| Dugan, WM | 1 |
| Parashos, PJ | 1 |
| Triplett, WC | 1 |
| Minnick, DJ | 1 |
| Fry, MW | 1 |
| Macdonald, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia During Subcutaneous Implantable Venous Access Devices Insertion: Double Blind Randomized Study.[NCT03628430] | 120 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| An Open-label Randomized Clinical Trial to Compare the Toxicities and Efficacy of Pharmacokinetically-guided and BSA Fixed Dosing Strategy of Docetaxel and Paclitaxel in Chinese Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma, and Breast Cancer Patie[NCT01891123] | 300 participants (Anticipated) | Interventional | 2013-06-30 | Recruiting | |||
| A Clinical Experience Trial to Detect the Plasma Paclitaxel Drug Concentration in Chinese Non -Small Cell Lung Cancer (NSCLC) Patients Treated With a Paclitaxel Plus Carboplatin (TC) Regimens, and Explore Individualized Treatment Using Pharmacokinetically[NCT02737709] | Phase 2 | 51 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to The study have difficulty in recruiting subjectes) | ||
| Effectiveness and Quality of Life Analysis of Palonosetron Against Ondansetron Combined With Dexamethasone and Fosaprepitant in Prevention of Acute and Delayed Emesis Associated to Chemotherapy Moderate and Highly Emetogenic in Breast Cancer.[NCT03606369] | Phase 2/Phase 3 | 560 participants (Anticipated) | Interventional | 2015-11-05 | Recruiting | ||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for diphenhydramine and Benign Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Cim | 2003 |
Combination antiemetics for cisplatin chemotherapy.
Topics: Antiemetics; Cisplatin; Dexamethasone; Diphenhydramine; Droperidol; Drug Evaluation; Drug Therapy, C | 1988 |
14 trials available for diphenhydramine and Benign Neoplasms
| Article | Year |
|---|---|
A randomized trial of the effectiveness of topical "ABH Gel" (Ativan(®), Benadryl(®), Haldol(®)) vs. placebo in cancer patients with nausea.
Topics: Administration, Topical; Adolescent; Adult; Aged; Antiemetics; Cross-Over Studies; Diphenhydramine; | 2014 |
A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Do | 2008 |
A Phase 1 clinical study of temsirolimus (CCI-779) in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents; Area Under Curve; Carcinoma, Renal Cell; C | 2010 |
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diphenhydramine | 2013 |
One-hour paclitaxel infusion schedules: a phase I/II comparative trial.
Topics: Blood Cell Count; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration | 1995 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Short-course intravenous prophylaxis for paclitaxel-related hypersensitivity reactions.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphen | 1997 |
Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion.
Topics: Agranulocytosis; Antineoplastic Agents, Phytogenic; Dexamethasone; Diphenhydramine; Dose-Response Re | 1995 |
Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion.
Topics: Agranulocytosis; Antineoplastic Agents, Phytogenic; Dexamethasone; Diphenhydramine; Dose-Response Re | 1995 |
Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion.
Topics: Agranulocytosis; Antineoplastic Agents, Phytogenic; Dexamethasone; Diphenhydramine; Dose-Response Re | 1995 |
Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion.
Topics: Agranulocytosis; Antineoplastic Agents, Phytogenic; Dexamethasone; Diphenhydramine; Dose-Response Re | 1995 |
Efficacy of treatment to relieve mucositis-induced discomfort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Antineoplastic Agents; Diphenhydrami | 2000 |
Ondansetron + dexamethasone vs metoclopramide + dexamethasone + diphenhydramine in prevention of cisplatin-induced emesis. Italian Group For Antiemetic Research.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antiemetics; Cisplatin; Clinical Protocols; De | 1992 |
Randomized crossover comparison of high-dose intravenous metoclopramide versus a five-drug antiemetic regimen.
Topics: Adult; Aged; Cisplatin; Dexamethasone; Diazepam; Diphenhydramine; Drug Therapy, Combination; Humans; | 1990 |
[A phase III trial comparing the antiemetic activity of tetracosactide with dexamethasone in combination with metoclopramide, diphenhydramine and clorazepate during chemotherapy including cisplatin].
Topics: Adult; Aged; Cisplatin; Clinical Trials as Topic; Clorazepate Dipotassium; Cosyntropin; Dexamethason | 1989 |
A pilot study comparing decadron (D)/ativan (A) versus reglan (R)/decadron (D)/benadryl (B) as antiemetic regimens.
Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials | 1988 |
The value of dexamethasone when added to combination drug therapy in the prevention of cisplatin-induced nausea and vomiting, evaluated by time-lapse video technology.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Dexamethasone; | 1986 |
17 other studies available for diphenhydramine and Benign Neoplasms
| Article | Year |
|---|---|
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; ErbB Receptors; Female; | 2017 |
Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics; Antineoplastic Agents; Diphenhydramine; Drug C | 2017 |
An Oncologist's Letter to Santa: Bring Me Drugs!
Topics: Administration, Intravenous; Antineoplastic Agents; Diphenhydramine; Drug Industry; Drugs, Generic; | 2018 |
[Clinical effectiveness of a new analgesic tetracompound with synergic action].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Diphenhydramine; Neoplasms; Pain Management; Par | 1958 |
Parenteral iron therapy: a single institution's experience over a 5-year period.
Topics: Acetaminophen; Anemia, Iron-Deficiency; Diphenhydramine; Female; Ferric Compounds; Ferric Oxide, Sac | 2005 |
Lorazepam, diphenhydramine, and haloperidol transdermal gel for rescue from chemotherapy-induced nausea/vomiting: results of two pilot trials.
Topics: Administration, Cutaneous; Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Clini | 2008 |
Immediate termination of intractable vomiting induced by cisplatin combination chemotherapy using an intensive five-drug antiemetic regimen.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dexamethasone; Diazepam; Dip | 1984 |
Prevention of immunotoxin-mediated vascular leak syndrome in rats with retention of antitumor activity.
Topics: Animals; Antibodies, Monoclonal; Blood Vessels; Cyclosporine; Dexamethasone; Diphenhydramine; Female | 1994 |
Diphenhydramine provides relief of cyclophosphamide-related symptoms.
Topics: Antineoplastic Agents, Alkylating; Cyclophosphamide; Diphenhydramine; Histamine H1 Antagonists; Huma | 1996 |
Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses.
Topics: Adolescent; Adult; Child; Chronic Disease; Diphenhydramine; Female; Hematologic Diseases; Histamine | 1998 |
Cost and cost-effectiveness analysis of ondansetron versus metoclopramide regimens: a hospital perspective from Italy.
Topics: Chemotherapy, Adjuvant; Cisplatin; Costs and Cost Analysis; Dexamethasone; Diphenhydramine; Dose-Res | 1994 |
Diphenhydramine as an analgesic adjuvant in refractory cancer pain.
Topics: Aged; Child; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Neoplasms | 2001 |
Antiemetic suppositories.
Topics: Administration, Rectal; Dexamethasone; Diphenhydramine; Drug Combinations; Humans; Metoclopramide; N | 1991 |
A pilot study of metoclopramide, dexamethasone, diphenhydramine and lorazepam in prevention of nausea and vomiting in cisplatin-treated male patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dexamethasone; Diphenhydramine; Drug Eval | 1990 |
Phase I clinical and pharmacokinetic study of taxol.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkaloids; Alopecia; Cimetidine; Dexamethasone; Diph | 1987 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |
An effective hypnotic in malignant disease.
Topics: Diphenhydramine; Humans; Methaqualone; Neoplasms; Palliative Care; Tranquilizing Agents | 1966 |