diphenhydramine has been researched along with Arrhythmias, Cardiac in 21 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous." | 5.40 | Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval. ( Chang, CC; Chen, CY; Chen, TY; Kuo, SC; Lin, TP; Yeh, YW, 2014) |
| "A 19-year-old woman presented with status epilepticus and ventricular dysrhythmias less than one hour after ingesting 5,000 mg dimenhydrinate (Dramamine)." | 3.68 | Fatality secondary to massive overdose of dimenhydrinate. ( McDonnell, KP; Winn, RE, 1993) |
| " It is suggested that the circulatory depression and the occurrence of ventricular arrhythmias following the administration of compound 48/80 result from activation of H1- and H2-receptors by elevated blood histamine levels due to release of the amine from tissues." | 3.68 | Circulatory depression and ventricular arrhythmias induced by compound 48/80 in anaesthetized rats. ( Dai, S, 1991) |
| "This report describes the first case of an adult to survive all the major complications of diphenhydramine hydrochloride overdose, including hyperpyrexia, status epilepticus, coma, and cardiac arrhythmias." | 3.67 | Survival in complicated diphenhydramine overdose. ( Cox, PM; D'Amato, SL; Rinder, CS; Rinder, HM, 1988) |
| "Overdosage of diphenhydramine may result in the development of anticholinergic symptoms, seizures, and coma." | 3.66 | Massive diphenhydramine overdose resulting in death. ( Anderson, GM; Krenzelok, EP; Mirick, M, 1982) |
| "When diagnosing and treating drug overdose caused by an unidentified substance, diphenhydramine toxicity should be considered when an anticholinergic toxidrome is present and a Brugada pattern is observed on the ECG." | 1.91 | Diphenhydramine overdose detected early by integration of toxidrome and electrocardiography and treated with venoarterial extracorporeal membrane oxygenation: a case report. ( Arai, R; Ihara, S; Kinoshita, K; Matsuoka, M; Murata, N; Okumura, Y; Yamaguchi, J, 2023) |
| "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous." | 1.40 | Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval. ( Chang, CC; Chen, CY; Chen, TY; Kuo, SC; Lin, TP; Yeh, YW, 2014) |
| "Amantadine hydrochloride is an antiviral medication used as therapy for parkinsonism and as a cognitive enhancer." | 1.35 | Cardiotoxicity after massive amantadine overdose. ( Kazzi, Z; Morgan, B; Patel, M; Schwartz, M, 2008) |
| "Antihistamines have traditionally been regarded as safe over the counter sedative-hypnotics." | 1.35 | Rare complications of diphenhydramine toxicity. ( Ramachandran, K; Sirop, P, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Matsuoka, M | 1 |
| Arai, R | 1 |
| Ihara, S | 1 |
| Murata, N | 1 |
| Yamaguchi, J | 1 |
| Okumura, Y | 1 |
| Kinoshita, K | 1 |
| Cherukuri, SV | 1 |
| Purvis, AW | 1 |
| Tosto, ST | 1 |
| Velayati, A | 1 |
| Chen, TY | 1 |
| Yeh, YW | 1 |
| Kuo, SC | 1 |
| Chen, CY | 1 |
| Lin, TP | 1 |
| Chang, CC | 1 |
| Bélanger, C | 1 |
| Visser, LC | 1 |
| Stern, JA | 1 |
| Schwartz, M | 1 |
| Patel, M | 1 |
| Kazzi, Z | 1 |
| Morgan, B | 1 |
| Sharma, AN | 1 |
| Hexdall, AH | 1 |
| Chang, EK | 1 |
| Nelson, LS | 1 |
| Hoffman, RS | 1 |
| de MESQUITA, QH | 1 |
| Dawson, A | 1 |
| Nine, JS | 1 |
| Rund, CR | 1 |
| Ramachandran, K | 1 |
| Sirop, P | 1 |
| Krenzelok, EP | 1 |
| Anderson, GM | 1 |
| Mirick, M | 1 |
| Winn, RE | 1 |
| McDonnell, KP | 1 |
| Hestand, HE | 1 |
| Teske, DW | 1 |
| Dai, S | 1 |
| Hue, V | 1 |
| Meneguz, C | 1 |
| Martinot, A | 1 |
| Leclerc, F | 1 |
| Fu, SX | 1 |
| Li, YS | 1 |
| Rinder, CS | 1 |
| D'Amato, SL | 1 |
| Rinder, HM | 1 |
| Cox, PM | 1 |
| Smolarz, W | 1 |
| Kośmider, S | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
1 review available for diphenhydramine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Fatality from diphenhydramine monointoxication: a case report and review of the infant, pediatric, and adult literature.
Topics: Accidents; Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Child, Preschool | 2006 |
20 other studies available for diphenhydramine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Diphenhydramine overdose detected early by integration of toxidrome and electrocardiography and treated with venoarterial extracorporeal membrane oxygenation: a case report.
Topics: Arrhythmias, Cardiac; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Electrocardiography; | 2023 |
IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine Overdose.
Topics: Arrhythmias, Cardiac; Diphenhydramine; Drug Overdose; Fat Emulsions, Intravenous; Female; Histamine | 2019 |
Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Depression; Diphenhydrami | 2014 |
ECG of the Month.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Bees; Diphenhydramine; Dog Diseases; Dogs; Electrocardio | 2016 |
Cardiotoxicity after massive amantadine overdose.
Topics: Adult; Amantadine; Antiparkinson Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; C | 2008 |
Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.
Topics: Acetaminophen; Adult; Arrhythmias, Cardiac; Aspirin; Diphenhydramine; Drug Combinations; Fatal Outco | 2003 |
[Treatment of paroxysmal tachycardia with diethylaminoethoxy-2-diphenyl (1262 F)].
Topics: Arrhythmias, Cardiac; Biphenyl Compounds; Diphenhydramine; Humans; Tachycardia, Paroxysmal | 1950 |
Diphenhydramine-associated wide complex dysrhythmia.
Topics: Arrhythmias, Cardiac; Diphenhydramine; Humans; Hypnotics and Sedatives; Respiration, Artificial; Sod | 2004 |
Rare complications of diphenhydramine toxicity.
Topics: Adult; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Female; Heart Rate; Histamine H1 | 2008 |
Massive diphenhydramine overdose resulting in death.
Topics: Adolescent; Arrhythmias, Cardiac; Diphenhydramine; Female; Gastric Lavage; Heart Arrest; Humans; Res | 1982 |
Fatality secondary to massive overdose of dimenhydrinate.
Topics: Adult; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Charcoal; Colon; Dimenhydrinate; Diphenh | 1993 |
Diphenhydramine hydrochloride intoxication.
Topics: Arrhythmias, Cardiac; Diphenhydramine; Humans; Infant; Male; Poisoning | 1977 |
Circulatory depression and ventricular arrhythmias induced by compound 48/80 in anaesthetized rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascula | 1991 |
[Antihistamines and antidepressants: poisoning with similar symptoms].
Topics: Arrhythmias, Cardiac; Child, Preschool; Diphenhydramine; Drug Combinations; Humans; Male; Methaqualo | 1990 |
[Analysis of the anti-arrhythmic activity of cimetidine in anesthetized guinea pigs].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Diphenhydramine; Femal | 1986 |
Survival in complicated diphenhydramine overdose.
Topics: Adult; Arrhythmias, Cardiac; Coma; Diphenhydramine; Female; Fever; Humans; Nonprescription Drugs; Ph | 1988 |
[Antiarrhythmic effect of sviomarin in experimental and clinical glycoside poisoning].
Topics: Animals; Arrhythmias, Cardiac; Digitalis Glycosides; Diphenhydramine; Dogs; Electrocardiography; Fem | 1969 |
Psychopharmacologic management of anxiety in the cardiac patient.
Topics: Anxiety; Arrhythmias, Cardiac; Barbiturates; Chloral Hydrate; Chlordiazepoxide; Diphenhydramine; Dru | 1971 |