Page last updated: 2024-10-26

diphenhydramine and Anasarca

diphenhydramine has been researched along with Anasarca in 36 studies

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

Research Excerpts

ExcerptRelevanceReference
"Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections)."7.81Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. ( Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E, 2015)
"Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice."7.69Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995)
"Treatment with diphenhydramine completely prevented the increases in lymph flow, lymph total protein concentration, total protein transport, weight and vasodilation produced by infusions of histamine, but not those produced by infusions of prostaglandin E1 or bradykinin."5.26Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs. ( Adamski, SW; Grega, GJ; Prasad, CM; Svensjö, E, 1982)
"Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections)."3.81Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma. ( Astudillo, PP; Chan, HS; Durairaj, P; Gallie, BL; Héon, E, 2015)
"A 46-year-old woman developed an anaphylactic reaction during percutaneous coronary intervention after she was pretreated with prednisone and diphenhydramine for a known allergy to iodine."3.71Potential anaphylactic shock with abciximab readministration. ( Hamel, D; Palisaitis, DA; Pharand, C, 2002)
"In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H1-antihistaminic structures were synthesized and their effects were investigated on lipid peroxidation in rat brain homogenates, antiinflammatory effection arachidonic acid- and 12-O-tetradecanoylphorbol-13- acetate-induced mouse ear edema and antiallergic effect on 48-h homologous passive cutaneous anaphylaxis in rats."3.69Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives. ( Akahoshi, F; Fukaya, C; Kajii, M; Kuwahara, S; Sakaue, Y; Sugiura, M; Sugiyama, N; Yakumaru, H, 1994)
"Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice."3.69Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995)
"Docetaxel is active for metastatic breast cancer."2.68Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996)
"Treatment with diphenhydramine significantly decreased the blood cTnI levels."1.35Effect of diphenhydramine on myocardial injury caused by organophosphate poisoning. ( Buyukokuroglu, M; Ciftci, IH; Saglam, H; Sahin, O; Yavuz, Y; Yurumez, Y, 2008)
"Pretreatment with diphenhydramine or methysergide significantly reduced trimucase-induced paw swelling, while aspirin had no effect."1.28Comparison of kinin-forming and amidolytic activities of four trimucases, oedema-producing and kinin-releasing enzymes, from Trimeresurus mucrosquamatus venom. ( Hsu, MF; Teng, CM; Wang, JP, 1992)
"Diphenhydramine was the most effective inhibitor of edema and increased vascular permeability induced by the venom."1.27Edema formation and degranulation of mast cells by Trimeresurus mucrosquamatus snake venom. ( Chen, IJ; Chiu, HF; Huang, HT; Teng, CM, 1984)
"Treatment with diphenhydramine completely prevented the increases in lymph flow, lymph total protein concentration, total protein transport, weight and vasodilation produced by infusions of histamine, but not those produced by infusions of prostaglandin E1 or bradykinin."1.26Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs. ( Adamski, SW; Grega, GJ; Prasad, CM; Svensjö, E, 1982)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199017 (47.22)18.7374
1990's11 (30.56)18.2507
2000's4 (11.11)29.6817
2010's3 (8.33)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Sugiyama, N1
Akahoshi, F1
Kuwahara, S1
Kajii, M1
Sakaue, Y1
Yakumaru, H1
Sugiura, M1
Fukaya, C1
LoGiudice, JA1
Holland, E1
Esposito, CP1
Diaz, JH1
Astudillo, PP1
Durairaj, P1
Chan, HS1
Héon, E1
Gallie, BL1
SALOMON, MI1
SCHEINBERG, D1
Ahmadi, A1
Khalili, M1
Nafarie, A1
Yazdani, A1
Nahri-Niknafs, B1
Cantrell, FL1
UEKI, S1
SATO, K1
DEREVIANKO, LD1
FUNCKE, AB1
MULDER, D1
DEJONGE, MC1
TERSTEEGE, HM1
HARMS, AF1
NAUTA, WT1
DONNER, R1
RUEMKE, CL1
SHUMACKER, HB1
RADIGAN, LR1
ZIPERMAN, HH1
HUGHES, RR1
Yavuz, Y1
Yurumez, Y1
Ciftci, IH1
Sahin, O1
Saglam, H1
Buyukokuroglu, M1
Prasad, CM1
Adamski, SW1
Svensjö, E1
Grega, GJ1
Chen, IJ1
Chiu, HF1
Huang, HT1
Teng, CM3
Miglets, AW1
Racey, G1
Hoffer, JL1
Wang, JP3
Raung, SL1
Chang, LC1
Kuo, SC1
Hudis, CA1
Seidman, AD1
Crown, JP1
Balmaceda, C1
Freilich, R1
Gilewski, TA1
Hakes, TB1
Currie, V1
Lebwohl, DE1
Baselga, J1
Raptis, G1
Gollub, M1
Robles, M1
Bruno, R1
Norton, L1
Desouza, IA1
Ribeiro-DaSilva, G1
Chaves, F1
León, G1
Alvarado, VH1
Gutiérrez, JM1
Yusin, JS1
Crawford, WW1
Klaustermeyer, WB1
Pharand, C1
Palisaitis, DA1
Hamel, D1
Molinaro, G1
Leroux, JC1
Damas, J1
Adam, A1
Kaplan, GW1
Hsu, MF1
Hoefflin, SM1
Tan, NH1
Saifuddin, MN1
Yong, WY1
Ando, K1
Isono, E1
Kubota, T1
Imokawa, H1
Inoue, H1
Ishida, H1
Ogino, Y1
Ikai, K1
Danno, K1
Horio, T1
Narumiya, S1
Filippos'iants, ST1
Aizawa, Y1
Iwasaki, M1
Emmett, EA1
Haber, K1
Fochtman, FW1
Manno, JE1
Winek, CL1
Cooper, JA1
Casadio, S1
Bruzzese, T1
Pala, G1
Coppi, G1
Turba, C1

Trials

1 trial available for diphenhydramine and Anasarca

ArticleYear
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh

1996

Other Studies

35 other studies available for diphenhydramine and Anasarca

ArticleYear
Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives.
    Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13

    Topics: Administration, Topical; Aminophenols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidant

1994
Midwifery Management of a Birthing Person with Cervical Edema During Labor.
    Journal of midwifery & women's health, 2022, Volume: 67, Issue:5

    Topics: Diphenhydramine; Edema; Female; Humans; Ice; Labor, Obstetric; Midwifery; Pregnancy

2022
Hypersensitivity Reaction to Yellow Jacket Sting in a Previously Nonallergic Patient Taking an Angiotensin Receptor Blocker.
    Wilderness & environmental medicine, 2017, Volume: 28, Issue:2

    Topics: Aged; Angiotensin Receptor Antagonists; Animals; Anti-Allergic Agents; Diphenhydramine; Edema; Human

2017
Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2015, Volume: 19, Issue:1

    Topics: Anti-Allergic Agents; Antineoplastic Agents; Child, Preschool; Conjunctival Diseases; Diphenhydramin

2015
Benadryl treatment of angioneurotic edema.
    New York state journal of medicine, 1947, Volume: 47, Issue:12

    Topics: Angioedema; Diphenhydramine; Edema; Humans

1947
Generalized angioneurotic edema due to penicillin inhalations treated with benadryl.
    Journal of the American Medical Association, 1946, Sep-14, Volume: 132

    Topics: Angioedema; Diphenhydramine; Edema; Humans; Penicillins

1946
Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.
    Mini reviews in medicinal chemistry, 2012, Volume: 12, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Cotton Fiber; Diphenhydramine; Edema; Ethanolamine; Granuloma; Hi

2012
Envenomation by the Mexican beaded lizard: a case report.
    Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:3

    Topics: Adult; Anaphylaxis; Animals; Bites and Stings; Diphenhydramine; Edema; Emergency Treatment; Humans;

2003
[PHARMACOLOGICAL STUDIES ON A NEW ANTIPHLOGISTIC, OXYPHENBUTAZONE (TANDERIL)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1963, Sep-20, Volume: 59

    Topics: Acetylcholine; Animals; Autonomic Nervous System; Capillary Permeability; Diphenhydramine; Edema; Fo

1963
[APROPOS OF THE TREATMENT OF EXUDATIVE DIATHESIS IN CHILDREN].
    Voprosy okhrany materinstva i detstva, 1964, Volume: 9

    Topics: Central Nervous System Diseases; Child; Diphenhydramine; Disease Susceptibility; Edema; Humans; Hype

1964
INVESTIGATION OF 3-(10,11-DIHYDRO-5H-DIBENZO (A,D) CYCLOHEPTEN-5-YLOXY) TROPANE CITRATE (DIBENZHEPTROPINE CITRATE, BRONTINE). I. PHARMACOLOGICAL PROPERTIES. II. TOXICOLOGICAL PROPERTIES.
    Archives internationales de pharmacodynamie et de therapie, 1964, Mar-01, Volume: 148

    Topics: Acetylcholine; Albumins; Animals; Asthma; Atropine; Bronchi; Citric Acid; Cyproheptadine; Diphenhydr

1964
Studies in experimental frostbite. VI. Effect of rutin and benadryl with some notes on plaster casts and the role of edema.
    Angiology, 1951, Volume: 2, Issue:2

    Topics: Casts, Surgical; Diphenhydramine; Edema; Frostbite; Rutin

1951
Effect of diphenhydramine on myocardial injury caused by organophosphate poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:1

    Topics: Animals; Cholinesterase Inhibitors; Diphenhydramine; Edema; Fenthion; Heart; Histamine H1 Antagonist

2008
Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:2

    Topics: Alprostadil; Animals; Bradykinin; Diphenhydramine; Dogs; Drug Synergism; Edema; Female; Forelimb; Hi

1982
Edema formation and degranulation of mast cells by Trimeresurus mucrosquamatus snake venom.
    Toxicon : official journal of the International Society on Toxinology, 1984, Volume: 22, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Cell Membrane Permeability; Crotalid Veno

1984
Phenothiazine induced lingual trauma.
    The Laryngoscope, 1983, Volume: 93, Issue:1

    Topics: Adult; Basal Ganglia Diseases; Diphenhydramine; Edema; Female; Humans; Thioridazine; Tongue

1983
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.
    European journal of pharmacology, 1995, Jan-05, Volume: 272, Issue:1

    Topics: Adrenalectomy; Animals; Anthraquinones; Bradykinin; Capillary Permeability; Cell Degranulation; Dexa

1995
The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:9

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Capsaicin; Cimetidi

1997
Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).
    Toxicon : official journal of the International Society on Toxinology, 1998, Volume: 36, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Bothrops; Dexamethasone; Diphenhydramine; Dose-Response Relations

1998
Facial edema, oral ulcers, and a cutaneous eruption following a dental procedure utilizing diflunisal and mepivacaine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:5

    Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Diflunisal; Diphenhydram

1999
Potential anaphylactic shock with abciximab readministration.
    Pharmacotherapy, 2002, Volume: 22, Issue:3

    Topics: Abciximab; Anaphylaxis; Anti-Inflammatory Agents; Antibodies, Monoclonal; Bradycardia; Diphenhydrami

2002
Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials.
    Biomaterials, 2002, Volume: 23, Issue:13

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Biocompatible Materi

2002
Acute idiopathic scrotal edema.
    Journal of pediatric surgery, 1977, Volume: 12, Issue:5

    Topics: Acute Disease; Adolescent; Child; Child, Preschool; Diagnosis, Differential; Diphenhydramine; Edema;

1977
Comparison of kinin-forming and amidolytic activities of four trimucases, oedema-producing and kinin-releasing enzymes, from Trimeresurus mucrosquamatus venom.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:4

    Topics: Amides; Animals; Aspirin; Crotalid Venoms; Diphenhydramine; Edema; Ileum; Kinins; Methysergide; Musc

1992
Decreasing prolonged swelling and pain associated with deep plane face lifts.
    Plastic and reconstructive surgery, 1992, Volume: 90, Issue:6

    Topics: Bupivacaine; Dexamethasone; Diphenhydramine; Edema; Humans; Pain, Postoperative; Postoperative Compl

1992
Rat paw oedema and mast cell degranulation caused by two phospholipase A2 enzymes isolated from Trimeresurus mucrosquamatus venom.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:12

    Topics: Animals; Cell Degranulation; Crotalid Venoms; Diphenhydramine; Dose-Response Relationship, Drug; Ede

1990
The edema inducing activity of phospholipase A2 enzymes.
    Biochemistry international, 1991, Volume: 23, Issue:1

    Topics: Animals; Dexamethasone; Diphenhydramine; Edema; Extremities; Histamine Antagonists; Hydrolysis; Mice

1991
[Study on ear burn model in mice and its significant application].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 96, Issue:6

    Topics: Animals; Bradykinin; Burns; Capillary Permeability; Dexamethasone; Diphenhydramine; Disease Models,

1990
Ear swelling in response to UVB irradiation.
    Archives of dermatological research, 1986, Volume: 278, Issue:6

    Topics: Animals; Betamethasone; Cimetidine; Diphenhydramine; Ear, External; Edema; Erythema; Indomethacin; M

1986
[Effect of polymyxin M on the content of histamine and serotonin in the blood and tissue of rats].
    Antibiotiki, 1966, Volume: 11, Issue:11

    Topics: Animals; Diphenhydramine; Ear; Edema; Hemorrhage; Histamine; Histamine H1 Antagonists; Histamine Rel

1966
[Relationship between the inhibition of ATPase activity and inflammatory edema by nonsteroid anti-inflammatory drugs. Approach to the screening test in vitro of nonsteroid anti-inflammatory drugs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Jul-20, Volume: 66, Issue:4

    Topics: Acetanilides; Adenosine Triphosphatases; Aminocaproates; Aminopyrine; Aminosalicylic Acids; Animals;

1970
Diphenhydramine photoallergy.
    Archives of dermatology, 1974, Volume: 110, Issue:2

    Topics: Aged; Australia; Diphenhydramine; Drug Eruptions; Edema; Erythema; Female; Humans; Insect Bites and

1974
Changes in renal size as related to blood pressure during an idiosyncratic reaction to radiographic contrast.
    The Journal of urology, 1974, Volume: 111, Issue:3

    Topics: Blood Pressure; Diatrizoate; Diphenhydramine; Drug Hypersensitivity; Edema; Female; Humans; Hydrocor

1974
Toxicity of the genus Dieffenbachia.
    Toxicology and applied pharmacology, 1969, Volume: 15

    Topics: Animals; Cortisone; Diphenhydramine; Edema; Eye Diseases; Female; Histamine; Male; Oxalates; Plant E

1969
Hypoglycemic activity and pharmacological picture of 4-(1-naphthyl)butylamine derivatives.
    Journal of medicinal chemistry, 1966, Volume: 9, Issue:5

    Topics: Acetylcholine; Animals; Atropine; Behavior, Animal; Blood Glucose; Blood Pressure; Butylamines; Chem

1966