diphenhydramine has been researched along with Agitation, Psychomotor in 14 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review found insufficient evidence to recommend the use of diphenhydramine as an adjunct therapy to prevent akathisia in ED patients treated with neuroleptics or metoclopramide for primary headache." | 5.41 | Adjuvant anticholinergic therapy for the prevention of akathisia in patients with primary headache in the emergency department: A systematic review. ( Campbell, S; Kirkland, SW; Meyer, J; Rowe, BH; Villa-Roel, C, 2023) |
| "Fifty-nine elderly residents of long-term care facilities who had DSM-III diagnoses of dementia were studied in an 8-week randomized, double-blind comparison trial of haloperidol, oxazepam, and diphenhydramine to test the efficacy of these agents in the treatment of clinically significant behavioral disturbances in patients with dementia." | 5.06 | Pharmacologic treatment of noncognitive behavioral disturbances in elderly demented patients. ( Coccaro, EF; Duvvi, K; Giordani, B; Kramer, E; Nora, R; Patel, BM; Rice, CM; Thorne, A; Torres, J; Zemishlany, Z, 1990) |
| "A 54-year-old woman was undergoing chemotherapy with gemcitabine and oxaliplatin (GEMOX) for stage II-B pancreatic adenocarcinoma." | 3.74 | Successful amelioration of oxaliplatin-induced hyperexcitability syndrome with the antiepileptic pregabalin in a patient with pancreatic cancer. ( Hashmi, S; Saif, MW, 2008) |
| ", migraines) in the emergency department, but can cause serious adverse effects." | 2.72 | Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis. ( Alain, J; Berthelot, S; Mokhtari, A; Yip, O, 2021) |
| " Extrapyramidal side effects like tardive dyskinesia are known to develop with chronic use of metoclopramide, while acute akathisia is a lesser known side effect following IV administration." | 1.37 | Case of acute akathisia from intravenous metoclopramide. ( Lim, BL; Qiu, LM, 2011) |
| "57% of patients having complications (52 patients having 60 adverse events)." | 1.37 | Safety of intravenous sedation administered by the operating oral surgeon: the second 7 years of office practice. ( Rodgers, MS; Rodgers, SF, 2011) |
| "Diphenhydramine appears to cause mild inhibition of the cytochrome P450 (CYP) 2D6 enzyme." | 1.35 | Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. ( de Leon, J; Nikoloff, DM, 2008) |
| "Akathisia is a common but frequently unrecognized complication of antipsychotic medication." | 1.27 | Akathisia: the syndrome of motor restlessness. ( Friedman, JH; Wagner, RL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Jeffers, T | 1 |
| Darling, B | 1 |
| Edwards, C | 1 |
| Vadiei, N | 1 |
| Meyer, J | 1 |
| Kirkland, SW | 1 |
| Campbell, S | 1 |
| Villa-Roel, C | 1 |
| Rowe, BH | 1 |
| Mokhtari, A | 1 |
| Yip, O | 1 |
| Alain, J | 1 |
| Berthelot, S | 1 |
| Hayes, A | 1 |
| Russ, MJ | 1 |
| Qiu, LM | 1 |
| Lim, BL | 1 |
| Rodgers, SF | 1 |
| Rodgers, MS | 1 |
| Cummings, MR | 1 |
| Miller, BD | 1 |
| Saif, MW | 1 |
| Hashmi, S | 1 |
| de Leon, J | 1 |
| Nikoloff, DM | 1 |
| Jacobs, MB | 1 |
| Stanislav, SW | 1 |
| Childs, A | 1 |
| Herz, LR | 1 |
| Volicer, L | 1 |
| Ross, V | 1 |
| Rheaume, Y | 1 |
| Coccaro, EF | 1 |
| Kramer, E | 1 |
| Zemishlany, Z | 1 |
| Thorne, A | 1 |
| Rice, CM | 1 |
| Giordani, B | 1 |
| Duvvi, K | 1 |
| Patel, BM | 1 |
| Torres, J | 1 |
| Nora, R | 1 |
| Friedman, JH | 1 |
| Wagner, RL | 1 |
3 reviews available for diphenhydramine and Agitation, Psychomotor
| Article | Year |
|---|---|
Adjuvant anticholinergic therapy for the prevention of akathisia in patients with primary headache in the emergency department: A systematic review.
Topics: Adult; Antipsychotic Agents; Cholinergic Antagonists; Diphenhydramine; Emergency Service, Hospital; | 2023 |
Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Diphenhydramine; Drug-Related Side Effects and Adverse | 2021 |
Pharmacologic management of behavioral instability in medically ill pediatric patients.
Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Analgesics, Non-Narcotic; Behavior Therapy; Behav | 2004 |
2 trials available for diphenhydramine and Agitation, Psychomotor
| Article | Year |
|---|---|
Pharmacotherapy of agitation in dementia.
Topics: Dementia; Diphenhydramine; Double-Blind Method; Humans; Oxazepam; Psychomotor Agitation; Thiothixene | 1992 |
Pharmacologic treatment of noncognitive behavioral disturbances in elderly demented patients.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Diphenhydramine; D | 1990 |
9 other studies available for diphenhydramine and Agitation, Psychomotor
| Article | Year |
|---|---|
Efficacy of Combination Haloperidol, Lorazepam, and Diphenhydramine vs. Combination Haloperidol and Lorazepam in the Treatment of Acute Agitation: A Multicenter Retrospective Cohort Study.
Topics: Adult; Antipsychotic Agents; Diphenhydramine; Haloperidol; Humans; Hypotension; Lorazepam; Muscarini | 2022 |
Discontinuing the Use of PRN Intramuscular Medication for Agitation in an Acute Psychiatric Hospital.
Topics: Administration, Oral; Adult; Diphenhydramine; Drug Utilization; Female; Haloperidol; Hospitals, Psyc | 2016 |
Case of acute akathisia from intravenous metoclopramide.
Topics: Abdominal Pain; Adult; Akathisia, Drug-Induced; Diphenhydramine; Emergency Service, Hospital; Female | 2011 |
Safety of intravenous sedation administered by the operating oral surgeon: the second 7 years of office practice.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthetics, Intravenous; Conscious | 2011 |
Successful amelioration of oxaliplatin-induced hyperexcitability syndrome with the antiepileptic pregabalin in a patient with pancreatic cancer.
Topics: Adenocarcinoma; Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Antineoplastic Agents; Calc | 2008 |
Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports.
Topics: Adult; Cytochrome P-450 CYP2D6; Diphenhydramine; Genotype; Histamine H1 Antagonists; Humans; Male; P | 2008 |
Diltiazem and akathisia.
Topics: Akathisia, Drug-Induced; Angina Pectoris; Benzazepines; Diltiazem; Diphenhydramine; Humans; Male; Mi | 1983 |
Evaluating the usage of droperidol in acutely agitated persons with brain injury.
Topics: Adult; Antipsychotic Agents; Brain Injuries; Diphenhydramine; Droperidol; Female; Haloperidol; Human | 2000 |
Akathisia: the syndrome of motor restlessness.
Topics: Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Diphenhydramine; Haloperidol; Humans; Ma | 1987 |