diphenhydramine has been researched along with Acute Pain in 2 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friedman, BW | 2 |
| Irizarry, E | 2 |
| Cain, D | 1 |
| Caradonna, A | 1 |
| Minen, MT | 1 |
| Solorzano, C | 1 |
| Zias, E | 1 |
| Zybert, D | 1 |
| McGregor, M | 1 |
| Bijur, PE | 1 |
| Gallagher, EJ | 1 |
| Babbush, K | 1 |
| White, D | 1 |
| John Gallagher, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Placebo Controlled Trial of IV Metoclopramide for Acute Post-traumatic Headache[NCT03220958] | Phase 3 | 160 participants (Actual) | Interventional | 2017-08-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Improvement in this 0 to 10 verbal rating scale (NCT03220958)
Timeframe: 1 hour after medication administration
| Intervention | units on a scale (Mean) |
|---|---|
| Metoclopramide | 5.2 |
| Placebo | 3.8 |
"Number of days with any headache. Participants report the actual number of days they experienced headache. A day begins when they awake for the beginning of daily activities and ends when they go to sleep after completion of daily activities" (NCT03220958)
Timeframe: 7 days after ED visit
| Intervention | days (Mean) |
|---|---|
| Metoclopramide | 3.3 |
| Placebo | 3.3 |
Achieving a headache intensity of mild or none in the ED without use of rescue medication and maintaining a level of mild or none. Participants rate their headache as none, mild, moderate, or severe (NCT03220958)
Timeframe: 48 hours after medication administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Metoclopramide | 24 |
| Placebo | 18 |
2 trials available for diphenhydramine and Acute Pain
| Article | Year |
|---|---|
Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.
Topics: Acute Pain; Administration, Intravenous; Adult; Diphenhydramine; Dopamine D2 Receptor Antagonists; D | 2021 |
An exploratory study of IV metoclopramide+diphenhydramine for acute post-traumatic headache.
Topics: Acute Pain; Diphenhydramine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Dou | 2018 |